SK381192A3 - Imidazole derivatives with a lateral biphenylsulfonyl urea or biphenylsulfonyl urethane chain, method of preparation the same and a pharmaceutical composition containing said derivatives - Google Patents
Imidazole derivatives with a lateral biphenylsulfonyl urea or biphenylsulfonyl urethane chain, method of preparation the same and a pharmaceutical composition containing said derivatives Download PDFInfo
- Publication number
- SK381192A3 SK381192A3 SK3811-92A SK381192A SK381192A3 SK 381192 A3 SK381192 A3 SK 381192A3 SK 381192 A SK381192 A SK 381192A SK 381192 A3 SK381192 A3 SK 381192A3
- Authority
- SK
- Slovakia
- Prior art keywords
- carbon atoms
- group
- formula
- compound
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4207241 | 1992-03-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
SK279109B6 SK279109B6 (sk) | 1998-06-03 |
SK381192A3 true SK381192A3 (en) | 1998-06-03 |
Family
ID=6453463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK3811-92A SK381192A3 (en) | 1992-03-07 | 1992-12-21 | Imidazole derivatives with a lateral biphenylsulfonyl urea or biphenylsulfonyl urethane chain, method of preparation the same and a pharmaceutical composition containing said derivatives |
Country Status (25)
Country | Link |
---|---|
US (1) | US5604251A (tr) |
EP (1) | EP0560177B1 (tr) |
JP (1) | JP3542813B2 (tr) |
KR (1) | KR930019637A (tr) |
CN (1) | CN1036341C (tr) |
AT (1) | ATE230732T1 (tr) |
AU (1) | AU663565B2 (tr) |
BR (1) | BR9300761A (tr) |
CA (1) | CA2091135A1 (tr) |
CZ (1) | CZ281983B6 (tr) |
DE (1) | DE59310323D1 (tr) |
DK (1) | DK0560177T3 (tr) |
ES (1) | ES2187501T3 (tr) |
FI (1) | FI930970A (tr) |
HU (1) | HUT64041A (tr) |
IL (1) | IL104971A0 (tr) |
MA (1) | MA22814A1 (tr) |
NO (1) | NO303632B1 (tr) |
NZ (1) | NZ247059A (tr) |
PH (1) | PH31466A (tr) |
PL (1) | PL173023B1 (tr) |
RU (1) | RU2116300C1 (tr) |
SK (1) | SK381192A3 (tr) |
TW (1) | TW215434B (tr) |
ZA (1) | ZA931585B (tr) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4010797A1 (de) * | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
US5514696A (en) * | 1992-05-06 | 1996-05-07 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
CZ283315B6 (cs) * | 1992-12-17 | 1998-02-18 | Sankyo Company Limited | Bifenylové deriváty, způsob výroby a farmaceutické prostředky k léčení hypertense a srdečních onemocnění, které tyto deriváty obsahují |
FR2716883B1 (fr) * | 1994-03-04 | 1996-04-26 | Roussel Uclaf | Nouveaux dérivés tétrasubstitués de l'imidazole, leur préparation, nouveaux intermédiaires obtenus, leur application à titre de médicaments, compositions pharmaceutiques les renfermant. |
FR2716882B1 (fr) * | 1994-03-04 | 1996-04-05 | Roussel Uclaf | Utilisation de dérivés de l'imidazole au traitement d'affections impliquant les récepteurs AT1 et AT2 de l'Angiotensine, certains de ces produits, leur préparation, compositions pharmaceutiques. |
US5612359A (en) * | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
US5780473A (en) * | 1995-02-06 | 1998-07-14 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
US5760038A (en) * | 1995-02-06 | 1998-06-02 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
JPH09124620A (ja) * | 1995-10-11 | 1997-05-13 | Bristol Myers Squibb Co | 置換ビフェニルスルホンアミドエンドセリン拮抗剤 |
NZ330464A (en) | 1996-02-20 | 2000-04-28 | Bristol Myers Squibb Co | Methods for the preparation of biphenyl isoxazole sulfonamides |
US5856507A (en) * | 1997-01-21 | 1999-01-05 | Bristol-Myers Squibb Co. | Methods for the preparation of biphenyl isoxazole sulfonamides |
US5939446A (en) * | 1996-04-09 | 1999-08-17 | Bristol-Myers Squibb Co. | Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists |
ATE311872T1 (de) * | 1996-12-13 | 2005-12-15 | Zymogenetics Inc | Zusammensetzungen und verfahren zum stimulieren von knochenwachstum |
EP0855392A3 (de) | 1997-01-22 | 2000-01-05 | Hoechst Aktiengesellschaft | Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
TW536540B (en) * | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
AU6187898A (en) * | 1997-01-30 | 1998-08-25 | Bristol-Myers Squibb Company | Method for preventing or treating low renin hypertension by administering an endothelin antagonist |
JP2001520170A (ja) | 1997-10-16 | 2001-10-30 | ボード・オヴ・リージェンツ,ザ・ユニヴァーシティ・オヴ・テキサス・システム | Nf−at3機能に関連した心肥大動物モデルと治療法 |
DE19802969A1 (de) | 1998-01-27 | 1999-07-29 | Hoechst Marion Roussel De Gmbh | Verfahren zur Herstellung von S-Alkyl(Aryl)-substituierten Imidazol-Derivaten |
DE19820064A1 (de) * | 1998-05-06 | 1999-11-11 | Hoechst Marion Roussel De Gmbh | Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
DE19832428A1 (de) * | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19832429A1 (de) * | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
AU3718900A (en) | 1999-03-19 | 2000-10-09 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
US20040106647A1 (en) * | 2002-06-28 | 2004-06-03 | Schneider Michael D. | Modulators of Cdk9 as a therapeutic target in cardiac hypertrophy |
US20040082613A1 (en) * | 2002-06-28 | 2004-04-29 | Schneider Michael D. | Modulators of Cdk9 as a therapeutic target in cardiac hypertrophy |
US20050112128A1 (en) * | 2003-05-21 | 2005-05-26 | Myogen, Inc. And Board Of Regents, The University Of Texas System | Inhibition of protein kinase c-mu (PKD) as a treatment for cardiac hypertrophy and heart failure |
AU2004253967B2 (en) * | 2003-07-03 | 2010-02-18 | Cytovia, Inc. | 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis |
US8309562B2 (en) * | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
CA2544763A1 (en) * | 2003-11-03 | 2005-05-12 | Myogen, Inc. | 1,4-dihydropyridine compounds, pharmaceutical compositions, and methods for the treatment of cardiovascular disease |
AU2004285962A1 (en) * | 2003-11-03 | 2005-05-12 | Myogen, Inc. | 1,4-dihydropyridine compounds, pharmaceutical compositions, and methods for the treatment of cardiovascular disease |
US20060018970A1 (en) * | 2003-12-12 | 2006-01-26 | Myogen, Inc. | Enoximone formulations and their use in the treatment of cardiac hypertrophy and heart failure |
WO2005092333A1 (en) * | 2004-03-22 | 2005-10-06 | Myogen, Inc. | (r)-enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases |
EP1737448A1 (en) * | 2004-03-22 | 2007-01-03 | Myogen, Inc. | (s) - enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases |
WO2006007213A1 (en) * | 2004-06-23 | 2006-01-19 | Myogen, Inc. | Enoximone formulations and their use in the treatment of pde-iii mediated diseases |
US8258145B2 (en) * | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
CA2592900A1 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
WO2007014033A2 (en) * | 2005-07-22 | 2007-02-01 | The Regents Of The University Of Colorado, A Body Corporate | Inhibition of extracellular signal-regulated kinase 1/2 as a treatment for cardiac hypertrophy and heart failure |
JP2009520833A (ja) * | 2005-12-20 | 2009-05-28 | ギリード・コロラド・インコーポレーテッド | 4,7−ジヒドロチエノ[2,3−b]ピリジン化合物及び医薬組成物 |
EP2434017A3 (en) | 2006-08-01 | 2012-09-05 | Board of Regents of the University of Texas System | Identification of a micro-RNA that activates expression of beta-myosin heavy chain |
US8440636B2 (en) | 2007-07-31 | 2013-05-14 | The Board Of Regents, The University Of Texas System | Micro-RNA family that modulates fibrosis and uses thereof |
EP2265291B1 (en) | 2008-03-17 | 2016-10-19 | The Board of Regents of The University of Texas System | Identification of micro-rnas involved in neuromuscular synapse maintenance and regeneration |
US9539427B2 (en) | 2010-11-08 | 2017-01-10 | The Johns Hopkins University | Methods for improving heart function |
GB2605148A (en) * | 2021-03-23 | 2022-09-28 | Vicore Pharma Ab | New compounds |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5671074A (en) * | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative |
US4355044A (en) * | 1980-12-19 | 1982-10-19 | Bernardo Heller | D-Phenylalanine treatment |
CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
US5138069A (en) * | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
US5015651A (en) * | 1988-01-07 | 1991-05-14 | E. I. Du Pont De Nemours And Company | Treatment of hypertension with 1,2,4-angiotensin II antagonists |
US5064825A (en) * | 1989-06-01 | 1991-11-12 | Merck & Co., Inc. | Angiotensin ii antagonists |
DE4010797A1 (de) * | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
US5135197A (en) * | 1990-08-30 | 1992-08-04 | Qualtec Data Products, Inc. | Equipment security method and apparatus |
US5126342A (en) * | 1990-10-01 | 1992-06-30 | Merck & Co., Inc. | Imidazole angiotensin ii antagonists incorporating acidic functional groups |
US5087634A (en) * | 1990-10-31 | 1992-02-11 | G. D. Searle & Co. | N-substituted imidazol-2-one compounds for treatment of circulatory disorders |
CA2058198A1 (en) * | 1991-01-04 | 1992-07-05 | Adalbert Wagner | Azole derivatives, process for their preparation, and their use |
US5236928A (en) * | 1991-03-19 | 1993-08-17 | Merck & Co., Inc. | Imidazole derivatives bearing acidic functional groups at the 5-position, their compositions and methods of use as angiotensin II antagonists |
JPH06510762A (ja) * | 1991-08-19 | 1994-12-01 | イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー | アンジオテンシン2受容体遮断イミダゾリノン誘導体 |
DE4221009A1 (de) * | 1992-06-26 | 1994-01-05 | Bayer Ag | Imidazolyl-substituierte Cyclohexanderivate |
CZ283315B6 (cs) * | 1992-12-17 | 1998-02-18 | Sankyo Company Limited | Bifenylové deriváty, způsob výroby a farmaceutické prostředky k léčení hypertense a srdečních onemocnění, které tyto deriváty obsahují |
-
1992
- 1992-08-21 TW TW081106607A patent/TW215434B/zh active
- 1992-12-21 CZ CS923811A patent/CZ281983B6/cs not_active IP Right Cessation
- 1992-12-21 SK SK3811-92A patent/SK381192A3/sk unknown
-
1993
- 1993-03-02 EP EP93103301A patent/EP0560177B1/de not_active Expired - Lifetime
- 1993-03-02 AT AT93103301T patent/ATE230732T1/de active
- 1993-03-02 ES ES93103301T patent/ES2187501T3/es not_active Expired - Lifetime
- 1993-03-02 DE DE59310323T patent/DE59310323D1/de not_active Expired - Lifetime
- 1993-03-02 DK DK93103301T patent/DK0560177T3/da active
- 1993-03-04 FI FI930970A patent/FI930970A/fi unknown
- 1993-03-04 NZ NZ247059A patent/NZ247059A/en unknown
- 1993-03-05 ZA ZA931585A patent/ZA931585B/xx unknown
- 1993-03-05 PL PL93297955A patent/PL173023B1/pl unknown
- 1993-03-05 KR KR1019930003270A patent/KR930019637A/ko not_active Application Discontinuation
- 1993-03-05 CN CN93102412A patent/CN1036341C/zh not_active Expired - Fee Related
- 1993-03-05 HU HU9300618A patent/HUT64041A/hu unknown
- 1993-03-05 RU RU93004577A patent/RU2116300C1/ru active
- 1993-03-05 JP JP04476993A patent/JP3542813B2/ja not_active Expired - Lifetime
- 1993-03-05 MA MA23107A patent/MA22814A1/fr unknown
- 1993-03-05 AU AU34011/93A patent/AU663565B2/en not_active Ceased
- 1993-03-05 BR BR9300761A patent/BR9300761A/pt not_active Application Discontinuation
- 1993-03-05 CA CA002091135A patent/CA2091135A1/en not_active Abandoned
- 1993-03-05 PH PH45819A patent/PH31466A/en unknown
- 1993-03-05 NO NO930817A patent/NO303632B1/no unknown
- 1993-03-07 IL IL104971A patent/IL104971A0/xx unknown
-
1995
- 1995-06-07 US US08/479,561 patent/US5604251A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH069572A (ja) | 1994-01-18 |
PH31466A (en) | 1998-11-03 |
SK279109B6 (sk) | 1998-06-03 |
CZ281983B6 (cs) | 1997-04-16 |
MA22814A1 (fr) | 1993-10-01 |
TW215434B (tr) | 1993-11-01 |
ZA931585B (en) | 1993-09-27 |
RU2116300C1 (ru) | 1998-07-27 |
NO930817D0 (no) | 1993-03-05 |
CA2091135A1 (en) | 1993-09-08 |
BR9300761A (pt) | 1993-09-14 |
ATE230732T1 (de) | 2003-01-15 |
DK0560177T3 (da) | 2003-04-14 |
NO930817L (no) | 1993-09-08 |
CZ381192A3 (en) | 1993-12-15 |
HUT64041A (en) | 1993-11-29 |
NO303632B1 (no) | 1998-08-10 |
US5604251A (en) | 1997-02-18 |
AU3401193A (en) | 1993-09-09 |
AU663565B2 (en) | 1995-10-12 |
HU9300618D0 (en) | 1993-05-28 |
FI930970A0 (fi) | 1993-03-04 |
EP0560177A1 (de) | 1993-09-15 |
EP0560177B1 (de) | 2003-01-08 |
FI930970A (fi) | 1993-09-08 |
CN1076192A (zh) | 1993-09-15 |
ES2187501T3 (es) | 2003-06-16 |
KR930019637A (ko) | 1993-10-18 |
CN1036341C (zh) | 1997-11-05 |
DE59310323D1 (de) | 2003-02-13 |
NZ247059A (en) | 1995-03-28 |
PL173023B1 (pl) | 1998-01-30 |
IL104971A0 (en) | 1993-07-08 |
PL297955A1 (en) | 1993-09-20 |
JP3542813B2 (ja) | 2004-07-14 |
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