FI930970A - Imidazolderivat med bifenylsulfonylurea- eller bifenylsulfonyluretansidokedja, foerfaranden foer framstaellning av dessa och anvaendning av dessa - Google Patents
Imidazolderivat med bifenylsulfonylurea- eller bifenylsulfonyluretansidokedja, foerfaranden foer framstaellning av dessa och anvaendning av dessa Download PDFInfo
- Publication number
- FI930970A FI930970A FI930970A FI930970A FI930970A FI 930970 A FI930970 A FI 930970A FI 930970 A FI930970 A FI 930970A FI 930970 A FI930970 A FI 930970A FI 930970 A FI930970 A FI 930970A
- Authority
- FI
- Finland
- Prior art keywords
- dessa
- imidazolderivat
- bifenylsulphonyluretansidokedja
- bifenylsulfonylurea
- eller
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4207241 | 1992-03-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
FI930970A0 FI930970A0 (fi) | 1993-03-04 |
FI930970A true FI930970A (fi) | 1993-09-08 |
Family
ID=6453463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI930970A FI930970A (fi) | 1992-03-07 | 1993-03-04 | Imidazolderivat med bifenylsulfonylurea- eller bifenylsulfonyluretansidokedja, foerfaranden foer framstaellning av dessa och anvaendning av dessa |
Country Status (25)
Country | Link |
---|---|
US (1) | US5604251A (tr) |
EP (1) | EP0560177B1 (tr) |
JP (1) | JP3542813B2 (tr) |
KR (1) | KR930019637A (tr) |
CN (1) | CN1036341C (tr) |
AT (1) | ATE230732T1 (tr) |
AU (1) | AU663565B2 (tr) |
BR (1) | BR9300761A (tr) |
CA (1) | CA2091135A1 (tr) |
CZ (1) | CZ281983B6 (tr) |
DE (1) | DE59310323D1 (tr) |
DK (1) | DK0560177T3 (tr) |
ES (1) | ES2187501T3 (tr) |
FI (1) | FI930970A (tr) |
HU (1) | HUT64041A (tr) |
IL (1) | IL104971A0 (tr) |
MA (1) | MA22814A1 (tr) |
NO (1) | NO303632B1 (tr) |
NZ (1) | NZ247059A (tr) |
PH (1) | PH31466A (tr) |
PL (1) | PL173023B1 (tr) |
RU (1) | RU2116300C1 (tr) |
SK (1) | SK381192A3 (tr) |
TW (1) | TW215434B (tr) |
ZA (1) | ZA931585B (tr) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4010797A1 (de) * | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
US5514696A (en) * | 1992-05-06 | 1996-05-07 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
CZ283315B6 (cs) * | 1992-12-17 | 1998-02-18 | Sankyo Company Limited | Bifenylové deriváty, způsob výroby a farmaceutické prostředky k léčení hypertense a srdečních onemocnění, které tyto deriváty obsahují |
FR2716882B1 (fr) * | 1994-03-04 | 1996-04-05 | Roussel Uclaf | Utilisation de dérivés de l'imidazole au traitement d'affections impliquant les récepteurs AT1 et AT2 de l'Angiotensine, certains de ces produits, leur préparation, compositions pharmaceutiques. |
FR2716883B1 (fr) * | 1994-03-04 | 1996-04-26 | Roussel Uclaf | Nouveaux dérivés tétrasubstitués de l'imidazole, leur préparation, nouveaux intermédiaires obtenus, leur application à titre de médicaments, compositions pharmaceutiques les renfermant. |
US5612359A (en) * | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
US5780473A (en) * | 1995-02-06 | 1998-07-14 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
US5760038A (en) * | 1995-02-06 | 1998-06-02 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
JPH09124620A (ja) * | 1995-10-11 | 1997-05-13 | Bristol Myers Squibb Co | 置換ビフェニルスルホンアミドエンドセリン拮抗剤 |
SG87051A1 (en) | 1996-02-20 | 2002-03-19 | Bristol Myers Squibb Co | Process for preparing biphenyl isoxazole sulfonamide intermediates |
US5856507A (en) * | 1997-01-21 | 1999-01-05 | Bristol-Myers Squibb Co. | Methods for the preparation of biphenyl isoxazole sulfonamides |
US5939446A (en) * | 1996-04-09 | 1999-08-17 | Bristol-Myers Squibb Co. | Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists |
EP0944312B9 (en) * | 1996-12-13 | 2006-07-05 | ZymoGenetics, Inc. | Compositions and methods for stimulating bone growth |
EP0855392A3 (de) | 1997-01-22 | 2000-01-05 | Hoechst Aktiengesellschaft | Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
TW536540B (en) * | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
WO1998033781A1 (en) * | 1997-01-30 | 1998-08-06 | Bristol-Myers Squibb Company | Method for preventing or treating low renin hypertension by administering an endothelin antagonist |
AU748334B2 (en) | 1997-10-16 | 2002-05-30 | Board Of Regents, The University Of Texas System | Models and treatments for cardiac hypertrophy in relation with NF-AT3 function |
DE19802969A1 (de) | 1998-01-27 | 1999-07-29 | Hoechst Marion Roussel De Gmbh | Verfahren zur Herstellung von S-Alkyl(Aryl)-substituierten Imidazol-Derivaten |
DE19820064A1 (de) * | 1998-05-06 | 1999-11-11 | Hoechst Marion Roussel De Gmbh | Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
DE19832429A1 (de) * | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19832428A1 (de) * | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
IL144708A0 (en) | 1999-03-19 | 2002-06-30 | Bristol Myers Squibb Co | Methods for the preparation of biphenyl isoxazole sulfonamide derivatives |
US20040106647A1 (en) * | 2002-06-28 | 2004-06-03 | Schneider Michael D. | Modulators of Cdk9 as a therapeutic target in cardiac hypertrophy |
US20040082613A1 (en) * | 2002-06-28 | 2004-04-29 | Schneider Michael D. | Modulators of Cdk9 as a therapeutic target in cardiac hypertrophy |
AU2004249114A1 (en) * | 2003-05-21 | 2004-12-29 | Board Of Regents, The University Of Texas System | Inhibition of protein kinase C-mu (PKD) as a treatment for cardiac hypertrophy and heart failure |
WO2006074147A2 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics, Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
US8309562B2 (en) * | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
AU2004253967B2 (en) * | 2003-07-03 | 2010-02-18 | Cytovia, Inc. | 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis |
EP1685107B1 (en) * | 2003-11-03 | 2008-09-10 | Myogen, Inc. | 1,4-dihydropyridine compounds, pharmaceutical compositions, and methods for the treatment of cardiovascular disease |
WO2005042487A1 (en) * | 2003-11-03 | 2005-05-12 | Myogen, Inc. | 1,4-dihydropyridine compounds, pharmaceutical compositions, and methods for the treatment of cardiovascular disease |
WO2005058280A2 (en) * | 2003-12-12 | 2005-06-30 | Myogen, Inc. | Enoximone formulations and their use in the treatment of cardiac hypertrophy and heart failure |
EP1737447A1 (en) * | 2004-03-22 | 2007-01-03 | Myogen, Inc. | (r)-enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases |
CA2560528A1 (en) * | 2004-03-22 | 2005-10-06 | Myogen, Inc. | (s) - enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases |
EP1776108A1 (en) * | 2004-06-23 | 2007-04-25 | Myogen, Inc. | Enoximone formulations and their use in the treatment of pde-iii mediated diseases |
US8258145B2 (en) * | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
EP1945242A2 (en) * | 2005-07-22 | 2008-07-23 | The Regents of the University of Colorado, A Body Corporate | Inhibition of extracellular signal-regulated kinase 1/2 as a treatment for cardiac hypertrophy and heart failure |
US20110105496A1 (en) * | 2005-12-20 | 2011-05-05 | Gamber Gabriel G | Methods For The Treatment Of Myosin Heavy Chain-Mediated Conditions Using 4,7-Dihydrothieno[2,3-B]Pyridine Compounds |
AU2007281261B2 (en) | 2006-08-01 | 2013-03-21 | Board Of Regents Of The University Of Texas System | Identification of a micro-RNA that activates expression of beta-myosin heavy chain |
US8440636B2 (en) | 2007-07-31 | 2013-05-14 | The Board Of Regents, The University Of Texas System | Micro-RNA family that modulates fibrosis and uses thereof |
US8202848B2 (en) | 2008-03-17 | 2012-06-19 | Board Of Regents, The University Of Texas System | Identification of micro-RNAS involved in neuromuscular synapse maintenance and regeneration |
WO2012064743A2 (en) | 2010-11-08 | 2012-05-18 | The Johns Hopkins University | Methods for improving heart function |
GB2605148A (en) * | 2021-03-23 | 2022-09-28 | Vicore Pharma Ab | New compounds |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5671074A (en) * | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative |
US4355044A (en) * | 1980-12-19 | 1982-10-19 | Bernardo Heller | D-Phenylalanine treatment |
US5138069A (en) * | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
US5015651A (en) * | 1988-01-07 | 1991-05-14 | E. I. Du Pont De Nemours And Company | Treatment of hypertension with 1,2,4-angiotensin II antagonists |
US5064825A (en) * | 1989-06-01 | 1991-11-12 | Merck & Co., Inc. | Angiotensin ii antagonists |
DE4010797A1 (de) * | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
US5135197A (en) * | 1990-08-30 | 1992-08-04 | Qualtec Data Products, Inc. | Equipment security method and apparatus |
US5126342A (en) * | 1990-10-01 | 1992-06-30 | Merck & Co., Inc. | Imidazole angiotensin ii antagonists incorporating acidic functional groups |
US5087634A (en) * | 1990-10-31 | 1992-02-11 | G. D. Searle & Co. | N-substituted imidazol-2-one compounds for treatment of circulatory disorders |
CA2058198A1 (en) * | 1991-01-04 | 1992-07-05 | Adalbert Wagner | Azole derivatives, process for their preparation, and their use |
US5236928A (en) * | 1991-03-19 | 1993-08-17 | Merck & Co., Inc. | Imidazole derivatives bearing acidic functional groups at the 5-position, their compositions and methods of use as angiotensin II antagonists |
CZ36294A3 (en) * | 1991-08-19 | 1994-07-13 | Du Pont | Substituted imidazilonone derivatives and pharmaceutical preparations based thereon |
DE4221009A1 (de) * | 1992-06-26 | 1994-01-05 | Bayer Ag | Imidazolyl-substituierte Cyclohexanderivate |
CZ283315B6 (cs) * | 1992-12-17 | 1998-02-18 | Sankyo Company Limited | Bifenylové deriváty, způsob výroby a farmaceutické prostředky k léčení hypertense a srdečních onemocnění, které tyto deriváty obsahují |
-
1992
- 1992-08-21 TW TW081106607A patent/TW215434B/zh active
- 1992-12-21 SK SK3811-92A patent/SK381192A3/sk unknown
- 1992-12-21 CZ CS923811A patent/CZ281983B6/cs not_active IP Right Cessation
-
1993
- 1993-03-02 DE DE59310323T patent/DE59310323D1/de not_active Expired - Lifetime
- 1993-03-02 DK DK93103301T patent/DK0560177T3/da active
- 1993-03-02 EP EP93103301A patent/EP0560177B1/de not_active Expired - Lifetime
- 1993-03-02 ES ES93103301T patent/ES2187501T3/es not_active Expired - Lifetime
- 1993-03-02 AT AT93103301T patent/ATE230732T1/de active
- 1993-03-04 NZ NZ247059A patent/NZ247059A/en unknown
- 1993-03-04 FI FI930970A patent/FI930970A/fi unknown
- 1993-03-05 NO NO930817A patent/NO303632B1/no unknown
- 1993-03-05 MA MA23107A patent/MA22814A1/fr unknown
- 1993-03-05 HU HU9300618A patent/HUT64041A/hu unknown
- 1993-03-05 CA CA002091135A patent/CA2091135A1/en not_active Abandoned
- 1993-03-05 BR BR9300761A patent/BR9300761A/pt not_active Application Discontinuation
- 1993-03-05 AU AU34011/93A patent/AU663565B2/en not_active Ceased
- 1993-03-05 PL PL93297955A patent/PL173023B1/pl unknown
- 1993-03-05 PH PH45819A patent/PH31466A/en unknown
- 1993-03-05 ZA ZA931585A patent/ZA931585B/xx unknown
- 1993-03-05 RU RU93004577A patent/RU2116300C1/ru active
- 1993-03-05 CN CN93102412A patent/CN1036341C/zh not_active Expired - Fee Related
- 1993-03-05 JP JP04476993A patent/JP3542813B2/ja not_active Expired - Lifetime
- 1993-03-05 KR KR1019930003270A patent/KR930019637A/ko not_active Application Discontinuation
- 1993-03-07 IL IL104971A patent/IL104971A0/xx unknown
-
1995
- 1995-06-07 US US08/479,561 patent/US5604251A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
RU2116300C1 (ru) | 1998-07-27 |
SK279109B6 (sk) | 1998-06-03 |
CZ381192A3 (en) | 1993-12-15 |
EP0560177A1 (de) | 1993-09-15 |
NZ247059A (en) | 1995-03-28 |
NO303632B1 (no) | 1998-08-10 |
AU3401193A (en) | 1993-09-09 |
FI930970A0 (fi) | 1993-03-04 |
NO930817D0 (no) | 1993-03-05 |
CA2091135A1 (en) | 1993-09-08 |
SK381192A3 (en) | 1998-06-03 |
DE59310323D1 (de) | 2003-02-13 |
ES2187501T3 (es) | 2003-06-16 |
AU663565B2 (en) | 1995-10-12 |
DK0560177T3 (da) | 2003-04-14 |
TW215434B (tr) | 1993-11-01 |
US5604251A (en) | 1997-02-18 |
PL297955A1 (en) | 1993-09-20 |
CN1036341C (zh) | 1997-11-05 |
PH31466A (en) | 1998-11-03 |
HUT64041A (en) | 1993-11-29 |
KR930019637A (ko) | 1993-10-18 |
CZ281983B6 (cs) | 1997-04-16 |
PL173023B1 (pl) | 1998-01-30 |
JPH069572A (ja) | 1994-01-18 |
NO930817L (no) | 1993-09-08 |
MA22814A1 (fr) | 1993-10-01 |
CN1076192A (zh) | 1993-09-15 |
IL104971A0 (en) | 1993-07-08 |
BR9300761A (pt) | 1993-09-14 |
EP0560177B1 (de) | 2003-01-08 |
ATE230732T1 (de) | 2003-01-15 |
ZA931585B (en) | 1993-09-27 |
HU9300618D0 (en) | 1993-05-28 |
JP3542813B2 (ja) | 2004-07-14 |
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