ES2118221T3 - Derivados de carbamato y su uso en medicina. - Google Patents

Derivados de carbamato y su uso en medicina.

Info

Publication number
ES2118221T3
ES2118221T3 ES93902222T ES93902222T ES2118221T3 ES 2118221 T3 ES2118221 T3 ES 2118221T3 ES 93902222 T ES93902222 T ES 93902222T ES 93902222 T ES93902222 T ES 93902222T ES 2118221 T3 ES2118221 T3 ES 2118221T3
Authority
ES
Spain
Prior art keywords
pct
carbamate
derivatives
medicine
date jul
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93902222T
Other languages
English (en)
Inventor
David Trist
Giorgio Pentassuglia
Maria Elvira Tranquillini
Antonella Ursini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline SpA
Original Assignee
Glaxo Wellcome SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome SpA filed Critical Glaxo Wellcome SpA
Application granted granted Critical
Publication of ES2118221T3 publication Critical patent/ES2118221T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Abstract

UNOS COMPONENTES DE FORMULA GENERAL (I) EN LOS QUE R1 REPRESENTA UN GRUPO FENILO, CICLOALQUILO C3 A 7, CICLOALQUILO ENLAZADO C7 A 11 O ALQUILO C1 A 6, EL CUAL PUEDE SER SUSTITUIDO POR UN GRUPO HIDROXI, FENILO, ALCOXICARBONILO C1 A 6, CICLOALQUILO C3 A 7, O CICLOALQUILO ENLAZADO C7 A 11, O R1 REPRESENTA EL GRUPO XYR4 EN EL QUE X ES UNA CADENA DE ALQUILENO RAMIFICADA O RECTA, Y ES C=O, C(OR5)2, O C(SR5)2 Y R4 ES UN ALQUILO C1 A 6, UN FENILO OPCIONALMENTE SUSTITUIDO, CICLOALQUILO C3 A 7 O CICLOALQUILO ENLAZADO C7 A 11. R2 REPRESENTA UN FENILO SUSTITUIDO O INSUSTITUIDO (EN EL QUE LOS SUSTITUYENTES PUEDEN SER 1 O 2 DE HALO, ALQUILO C1 A 4 , NITRO, CIANO, TRIFLUOROMETIL, TRIFLUOROMETOXI, TIOALQUILO C1 A 4 O (CH2)NR6, EN EL QUE R6 ES HIDROXI, ALCOXI C1 A 4, CO2R7 O NR8R9). R3 REPRESENTA UN FENILO SUSTITUIDO OPCIONALMENTE POR UNO O DOS ATOMOS HALOGENOS; R7 REPRESENTA HIDROGENO O UN GRUPO ALQUILO C1 A 4 ; R8 Y R9 REPRESENTAN INDEPENDIENTEMENTE HIDROGENO O UN GRUPO ALQUILO C1 A 4. R10 REPRESENTA HIDROGENO O UN ATOMO HALOGENO; M ES 0, 1 O 2 ; N ES 0 O 1. DICHOS COMPUESTOS SON ANTAGONISTAS DE GASTRINA Y RECEPTORES CCKB.
ES93902222T 1992-01-21 1993-01-15 Derivados de carbamato y su uso en medicina. Expired - Lifetime ES2118221T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929201181A GB9201181D0 (en) 1992-01-21 1992-01-21 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2118221T3 true ES2118221T3 (es) 1998-09-16

Family

ID=10708915

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93902222T Expired - Lifetime ES2118221T3 (es) 1992-01-21 1993-01-15 Derivados de carbamato y su uso en medicina.

Country Status (17)

Country Link
US (1) US5486514A (es)
EP (1) EP0623118B1 (es)
JP (1) JPH07503710A (es)
CN (1) CN1077952A (es)
AT (1) ATE166053T1 (es)
AU (1) AU3410693A (es)
CA (1) CA2127436A1 (es)
DE (1) DE69318541T2 (es)
DK (1) DK0623118T3 (es)
ES (1) ES2118221T3 (es)
GB (1) GB9201181D0 (es)
GR (1) GR3027609T3 (es)
IL (1) IL104448A0 (es)
MX (1) MX9300262A (es)
TW (1) TW221993B (es)
WO (1) WO1993014075A1 (es)
ZA (1) ZA93376B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9308421D0 (en) * 1993-04-23 1993-06-09 Glaxo Spa Chemical compounds
GB9314981D0 (en) * 1993-07-20 1993-09-01 Glaxo Spa Chemical compounds
GB9315018D0 (en) * 1993-07-20 1993-09-01 Glaxo Spa Chemical compounds
GB9314977D0 (en) * 1993-07-20 1993-09-01 Glaxo Spa Chemical compounds
PT728748E (pt) * 1993-12-28 2002-06-28 Shionogi & Co Novos derivados da benzodiazepina

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2641280B1 (fr) * 1988-12-29 1994-01-21 Roussel Uclaf Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments

Also Published As

Publication number Publication date
EP0623118B1 (en) 1998-05-13
ATE166053T1 (de) 1998-05-15
CA2127436A1 (en) 1993-07-22
CN1077952A (zh) 1993-11-03
ZA93376B (en) 1993-09-08
DK0623118T3 (da) 1999-01-25
MX9300262A (es) 1993-12-01
GR3027609T3 (en) 1998-11-30
GB9201181D0 (en) 1992-03-11
JPH07503710A (ja) 1995-04-20
EP0623118A1 (en) 1994-11-09
DE69318541D1 (de) 1998-06-18
DE69318541T2 (de) 1998-11-26
IL104448A0 (en) 1993-05-13
AU3410693A (en) 1993-08-03
US5486514A (en) 1996-01-23
TW221993B (es) 1994-04-01
WO1993014075A1 (en) 1993-07-22

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