KR930019637A - 비페닐설포닐우레아 또는 비페닐설포닐우레탄 측쇄를 갖는 이미다졸 유도체, 이의 제조방법 및 용도 - Google Patents
비페닐설포닐우레아 또는 비페닐설포닐우레탄 측쇄를 갖는 이미다졸 유도체, 이의 제조방법 및 용도 Download PDFInfo
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- KR930019637A KR930019637A KR1019930003270A KR930003270A KR930019637A KR 930019637 A KR930019637 A KR 930019637A KR 1019930003270 A KR1019930003270 A KR 1019930003270A KR 930003270 A KR930003270 A KR 930003270A KR 930019637 A KR930019637 A KR 930019637A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
Abstract
본 발명은 안지오텐신 Ⅱ수용체의 고활성 길항제인 하기 일반식(Ⅰ)의 화합물에 관한 것이다.
상기식에서,은, 예를 들면 에틸이고,는 예를 들면 메틸이며, n은 예를 들면 O이고,은 예를 들면 COOH이며,는 예를 들면
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (14)
- 하기 일반식(Ⅰ)의 화합물 및 생리학적으로 허용되는 이의 염.
-
- 상기식에서, a)은알킬이고, b)는는 1.알킬, 2.사이클로알킬, 3. 페닐 또는 4. 벤질이며, c)은 1. 수소, 2., 3,또는 4.이고, d)는 1., 2., 3., 4., 5., 6.또는 7.이며, e)는 1. 수소 또는 2.알킬이고, f)은 1. 수소 또는 2.이며, g)및는 동일하거나 상이하고, 1. 수소, 2.알킬, 3.사이클로알킬, 4.사이클로알킬-알킬, 5.아릴, 바람직하게는 페닐, 6.아릴-알킬, 7. 부분적으로 또는 완전히 수소화될 수 있는헤테로아릴, 8. 헤테로아릴 잔기가 부분적으로 또는 완전히 수소화 될 수 있는헤테로아릴-알킬, 9. 할로겐, 하이드록실,알킬, 메톡시, 니트로 및 시아노를 포함하는 시리즈 중에서 하나 또는 두개의 동일하거나 라디칼에 의해 차횐된 상기 5., 6., 7. 및 8. 에서 정의한 라디칼, 10.알케닐 또는알케노일, 11.사이클로알케닐, 12.사이클로알케닐-알킬. 13.아릴-알케닐, 14.헤티르아릴-알케닐 및 15.알키닐이며, h)은 수소이고, i) n은 0,1 또는 2이다.
- 제1항에 있어서,이 에틸 또는 n-프로필인 일반식(Ⅰ)의 화합물 또는 생물학적으로 허용되는 이의 염.
- 제1항에 있어서,이 n-프로필인 일반식(Ⅰ)의 화합물 또는 생리학적으로허용되는 이의 염.
- 제1항 내지 제3항 중의 어느 한 항에 있어서,가알킬이고이이며 n이 O이고가,또는이며이 수소 또는이고이 수소 또는알킬인 일반식(Ⅰ)의 화합물 및 생리학적으로 허용되는 이의 염.
- 일반식(Ⅱ)의 화합물을 일반식(Ⅲ)의 화합물을 알킬화하고, 일시적으로 도입된 보호 그룹을 다시 임의로 제거한 다음, 수득된 일반식 (Ⅰ)의 우레탄으로 임의로 전환시키고, 수득된 일반식 (Ⅰ)의 설폰아미드 또는 수득된 일반식(Ⅰ)의 우레탄을 일반식(Ⅰ)의 설포닐우레아로 임의로 전환시킨 다음 수득된 일반식(Ⅰ)의 화합물을 생리학적으로 허용되는 이의 염으로 전환시킴을 포함하여, 제1항에 청구된 일반식(Ⅰ)의 화합물 및 생리학적으로 허용되고 이의 염을 제조하는 방법.
-
- 상기식에서,및 n은 제1항에서 정의한 바와 같고, U는 이탈 그룹이다.
- 제1항 내지 제4항 중 어느 한 항에 있어서, 약제로 사용하기 위한 화합물.
- 제1항 내지 제4항 중 어느 한 항에 있어서, 고혈압 치료용 약제로 사용하기 위한 화합물.
- 제1항 내지 제4항 중의 어느 한 항에 청구된 화합물을 포함하는 약제학적 제제
- 제1항에 청구된 일반식(Ⅰ)의 화합물을 생리학적으로 허용되는 부형제 및, 경우에 따라 기타 첨가제 또는 보조제와 함께 적합한 투여 형태로 만드는 것을 포함하여, 제8항에 청구된 조성물을 제조하는 방법.
- ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4207241 | 1992-03-07 | ||
DEP4207241.7 | 1992-03-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR930019637A true KR930019637A (ko) | 1993-10-18 |
Family
ID=6453463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019930003270A KR930019637A (ko) | 1992-03-07 | 1993-03-05 | 비페닐설포닐우레아 또는 비페닐설포닐우레탄 측쇄를 갖는 이미다졸 유도체, 이의 제조방법 및 용도 |
Country Status (25)
Country | Link |
---|---|
US (1) | US5604251A (ko) |
EP (1) | EP0560177B1 (ko) |
JP (1) | JP3542813B2 (ko) |
KR (1) | KR930019637A (ko) |
CN (1) | CN1036341C (ko) |
AT (1) | ATE230732T1 (ko) |
AU (1) | AU663565B2 (ko) |
BR (1) | BR9300761A (ko) |
CA (1) | CA2091135A1 (ko) |
CZ (1) | CZ281983B6 (ko) |
DE (1) | DE59310323D1 (ko) |
DK (1) | DK0560177T3 (ko) |
ES (1) | ES2187501T3 (ko) |
FI (1) | FI930970A (ko) |
HU (1) | HUT64041A (ko) |
IL (1) | IL104971A0 (ko) |
MA (1) | MA22814A1 (ko) |
NO (1) | NO303632B1 (ko) |
NZ (1) | NZ247059A (ko) |
PH (1) | PH31466A (ko) |
PL (1) | PL173023B1 (ko) |
RU (1) | RU2116300C1 (ko) |
SK (1) | SK279109B6 (ko) |
TW (1) | TW215434B (ko) |
ZA (1) | ZA931585B (ko) |
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RU2109736C1 (ru) * | 1992-12-17 | 1998-04-27 | Санкио Компани Лимитед | Производные бифенила и способ их получения |
FR2716883B1 (fr) * | 1994-03-04 | 1996-04-26 | Roussel Uclaf | Nouveaux dérivés tétrasubstitués de l'imidazole, leur préparation, nouveaux intermédiaires obtenus, leur application à titre de médicaments, compositions pharmaceutiques les renfermant. |
FR2716882B1 (fr) * | 1994-03-04 | 1996-04-05 | Roussel Uclaf | Utilisation de dérivés de l'imidazole au traitement d'affections impliquant les récepteurs AT1 et AT2 de l'Angiotensine, certains de ces produits, leur préparation, compositions pharmaceutiques. |
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DE19802969A1 (de) | 1998-01-27 | 1999-07-29 | Hoechst Marion Roussel De Gmbh | Verfahren zur Herstellung von S-Alkyl(Aryl)-substituierten Imidazol-Derivaten |
DE19820064A1 (de) * | 1998-05-06 | 1999-11-11 | Hoechst Marion Roussel De Gmbh | Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
DE19832428A1 (de) * | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19832429A1 (de) * | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
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-
1992
- 1992-08-21 TW TW081106607A patent/TW215434B/zh active
- 1992-12-21 CZ CS923811A patent/CZ281983B6/cs not_active IP Right Cessation
- 1992-12-21 SK SK3811-92A patent/SK279109B6/sk unknown
-
1993
- 1993-03-02 DE DE59310323T patent/DE59310323D1/de not_active Expired - Lifetime
- 1993-03-02 EP EP93103301A patent/EP0560177B1/de not_active Expired - Lifetime
- 1993-03-02 DK DK93103301T patent/DK0560177T3/da active
- 1993-03-02 ES ES93103301T patent/ES2187501T3/es not_active Expired - Lifetime
- 1993-03-02 AT AT93103301T patent/ATE230732T1/de active
- 1993-03-04 FI FI930970A patent/FI930970A/fi unknown
- 1993-03-04 NZ NZ247059A patent/NZ247059A/en unknown
- 1993-03-05 NO NO930817A patent/NO303632B1/no unknown
- 1993-03-05 CA CA002091135A patent/CA2091135A1/en not_active Abandoned
- 1993-03-05 RU RU93004577A patent/RU2116300C1/ru active
- 1993-03-05 ZA ZA931585A patent/ZA931585B/xx unknown
- 1993-03-05 CN CN93102412A patent/CN1036341C/zh not_active Expired - Fee Related
- 1993-03-05 PH PH45819A patent/PH31466A/en unknown
- 1993-03-05 JP JP04476993A patent/JP3542813B2/ja not_active Expired - Lifetime
- 1993-03-05 HU HU9300618A patent/HUT64041A/hu unknown
- 1993-03-05 KR KR1019930003270A patent/KR930019637A/ko not_active Application Discontinuation
- 1993-03-05 BR BR9300761A patent/BR9300761A/pt not_active Application Discontinuation
- 1993-03-05 PL PL93297955A patent/PL173023B1/pl unknown
- 1993-03-05 AU AU34011/93A patent/AU663565B2/en not_active Ceased
- 1993-03-05 MA MA23107A patent/MA22814A1/fr unknown
- 1993-03-07 IL IL104971A patent/IL104971A0/xx unknown
-
1995
- 1995-06-07 US US08/479,561 patent/US5604251A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
IL104971A0 (en) | 1993-07-08 |
ES2187501T3 (es) | 2003-06-16 |
CZ281983B6 (cs) | 1997-04-16 |
ATE230732T1 (de) | 2003-01-15 |
FI930970A0 (fi) | 1993-03-04 |
CA2091135A1 (en) | 1993-09-08 |
FI930970A (fi) | 1993-09-08 |
JPH069572A (ja) | 1994-01-18 |
NO930817L (no) | 1993-09-08 |
NZ247059A (en) | 1995-03-28 |
AU3401193A (en) | 1993-09-09 |
CZ381192A3 (en) | 1993-12-15 |
MA22814A1 (fr) | 1993-10-01 |
PL297955A1 (en) | 1993-09-20 |
EP0560177B1 (de) | 2003-01-08 |
EP0560177A1 (de) | 1993-09-15 |
AU663565B2 (en) | 1995-10-12 |
JP3542813B2 (ja) | 2004-07-14 |
PH31466A (en) | 1998-11-03 |
DE59310323D1 (de) | 2003-02-13 |
RU2116300C1 (ru) | 1998-07-27 |
SK381192A3 (en) | 1998-06-03 |
DK0560177T3 (da) | 2003-04-14 |
PL173023B1 (pl) | 1998-01-30 |
CN1036341C (zh) | 1997-11-05 |
BR9300761A (pt) | 1993-09-14 |
ZA931585B (en) | 1993-09-27 |
US5604251A (en) | 1997-02-18 |
CN1076192A (zh) | 1993-09-15 |
TW215434B (ko) | 1993-11-01 |
HU9300618D0 (en) | 1993-05-28 |
HUT64041A (en) | 1993-11-29 |
NO303632B1 (no) | 1998-08-10 |
SK279109B6 (sk) | 1998-06-03 |
NO930817D0 (no) | 1993-03-05 |
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