SK288131B6 - CTLA4 mutant molecule or nucleic acid molecule, vector and host vector system, host cell, CTLA4 mutant protein, method for producing and use thereof, pharmaceutical composition and regulation method - Google Patents

CTLA4 mutant molecule or nucleic acid molecule, vector and host vector system, host cell, CTLA4 mutant protein, method for producing and use thereof, pharmaceutical composition and regulation method Download PDF

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Publication number
SK288131B6
SK288131B6 SK1570-2002A SK15702002A SK288131B6 SK 288131 B6 SK288131 B6 SK 288131B6 SK 15702002 A SK15702002 A SK 15702002A SK 288131 B6 SK288131 B6 SK 288131B6
Authority
SK
Slovakia
Prior art keywords
ctla4
ctla4 mutant
molecule
mutant molecule
cell
Prior art date
Application number
SK1570-2002A
Other languages
English (en)
Slovak (sk)
Other versions
SK15702002A3 (sk
Inventor
Robert J. Peach
Joseph R. Naemura
Peter S. Linsley
Jurgen Bajorath
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of SK15702002A3 publication Critical patent/SK15702002A3/sk
Publication of SK288131B6 publication Critical patent/SK288131B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SK1570-2002A 2000-05-26 2001-05-23 CTLA4 mutant molecule or nucleic acid molecule, vector and host vector system, host cell, CTLA4 mutant protein, method for producing and use thereof, pharmaceutical composition and regulation method SK288131B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57992700A 2000-05-26 2000-05-26
US21406500P 2000-06-26 2000-06-26
PCT/US2001/017139 WO2001092337A2 (en) 2000-05-26 2001-05-23 Soluble ctla4 mutant molecules and uses thereof

Publications (2)

Publication Number Publication Date
SK15702002A3 SK15702002A3 (sk) 2004-01-08
SK288131B6 true SK288131B6 (sk) 2013-10-02

Family

ID=26908652

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1570-2002A SK288131B6 (sk) 2000-05-26 2001-05-23 CTLA4 mutant molecule or nucleic acid molecule, vector and host vector system, host cell, CTLA4 mutant protein, method for producing and use thereof, pharmaceutical composition and regulation method

Country Status (41)

Country Link
EP (3) EP3029062A1 (nl)
JP (1) JP4328525B2 (nl)
KR (2) KR100895134B1 (nl)
CN (2) CN1309735C (nl)
AR (1) AR031699A1 (nl)
AT (1) ATE271066T1 (nl)
AU (2) AU2001263466C1 (nl)
BE (1) BE2011C041I2 (nl)
BR (1) BRPI0111191B8 (nl)
CA (1) CA2409748C (nl)
CY (2) CY2011019I1 (nl)
CZ (1) CZ304451B6 (nl)
DE (2) DE60104282T2 (nl)
DK (1) DK1248802T3 (nl)
EC (1) ECSP024365A (nl)
EE (2) EE05458B1 (nl)
EG (1) EG24459A (nl)
ES (2) ES2225549T3 (nl)
FR (1) FR11C0053I2 (nl)
GE (1) GEP20053658B (nl)
HK (2) HK1048126B (nl)
HU (2) HU228137B1 (nl)
IL (1) IL152315A (nl)
LT (1) LT5133B (nl)
LU (1) LU91902I2 (nl)
LV (1) LV12994B (nl)
MX (1) MXPA02011534A (nl)
MY (1) MY136113A (nl)
NO (2) NO330797B1 (nl)
PE (1) PE20011338A1 (nl)
PL (1) PL206267B1 (nl)
PT (1) PT1248802E (nl)
RU (1) RU2283847C2 (nl)
SI (1) SI1248802T1 (nl)
SK (1) SK288131B6 (nl)
TR (1) TR200402703T4 (nl)
TW (2) TWI319405B (nl)
UA (1) UA87432C2 (nl)
UY (1) UY26723A1 (nl)
WO (1) WO2001092337A2 (nl)
ZA (1) ZA200208944B (nl)

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WO2002002638A2 (en) 2000-07-03 2002-01-10 Bristol-Myers Squibb Company Methods for treating rheumatic diseases using a soluble ctla4 molecule
US20040022787A1 (en) 2000-07-03 2004-02-05 Robert Cohen Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID
MXPA03010568A (es) 2001-05-23 2005-03-07 Squibb Bristol Myers Co Metodos para proteger trasplantes alogenicos de celulas de isletas usando moleculas mutantes ctla4 solubles.
AU2003243152A1 (en) * 2002-04-19 2003-11-03 Bristol-Myers Squibb Company Methods for treating an autoimmune disease using a soluble ctla4 molecule and a dmard or nsaid
DE10232697A1 (de) * 2002-07-15 2004-02-05 Universitätsklinikum Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin Verwendung von CD152 zur Behandlung von Autoimmunkrankheiten und Entzündungen
ES2354610T5 (es) 2002-12-23 2020-09-14 Bristol Myers Squibb Co Mejora de la calidad del producto en procedimientos de cultivo de células de mamífero para la producción de proteína
JP4541157B2 (ja) * 2002-12-23 2010-09-08 ブリストル−マイヤーズ スクイブ カンパニー タンパク質を製造するための哺乳類細胞培養法
CA2511823A1 (en) 2002-12-30 2004-07-22 Amgen Inc. Combination therapy with co-stimulatory factors
WO2005044188A2 (en) 2003-10-27 2005-05-19 Amgen Inc. Compositions and methods to modulate an immune response to an immunogenic therapeutic agent
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
KR101398713B1 (ko) * 2005-12-20 2014-06-12 브리스톨-마이어스 스큅 컴퍼니 조성물 및 조성물의 제조 방법
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CN102822198B (zh) 2010-03-12 2016-08-31 艾伯维生物医疗股份有限公司 Ctla4蛋白和其用途
KR20130129438A (ko) 2011-02-23 2013-11-28 암젠 인크 Uvc 노출을 위한 세포 배양 배지 및 이와 관련된 방법
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CN104302309B (zh) * 2012-05-11 2017-07-28 米迪缪尼有限公司 Ctla‑4变体
US8735359B2 (en) 2012-05-24 2014-05-27 Orban Biotech Llc Combinations of modalities for the treatment of diabetes
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US20140112958A1 (en) 2012-10-24 2014-04-24 Mwm Biomodels Gmbh Pancreatic islets of transgenic LEA29Y animals for treating diabetes
CN104740608A (zh) * 2013-12-30 2015-07-01 上海中信国健药业股份有限公司 可溶性ctla4分子用于制备治疗类风湿性关节炎药物的用途
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US11401509B2 (en) 2015-11-09 2022-08-02 Bristol-Myers Squibb Company Methods of minimizing glycoprotein agregation in CHO cell production
CN116942793A (zh) * 2016-09-19 2023-10-27 昂科医药 Cd80和cd86结合蛋白组合物及其用途
CN107987153A (zh) * 2016-10-27 2018-05-04 广东香雪精准医疗技术有限公司 高亲和力的可溶性pd-1分子
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Also Published As

Publication number Publication date
EP1248802B1 (en) 2004-07-14
LV12994B (en) 2003-08-20
AU2001263466B2 (en) 2006-04-27
TWI314933B (en) 2009-09-21
GEP20053658B (en) 2005-11-10
CA2409748A1 (en) 2001-12-06
PT1248802E (pt) 2004-11-30
AU2001263466C1 (en) 2006-10-26
ECSP024365A (es) 2003-03-31
CY1117625T1 (el) 2017-04-26
KR20030009502A (ko) 2003-01-29
EP1536234A3 (en) 2009-06-03
CN1441810A (zh) 2003-09-10
PL366231A1 (en) 2005-01-24
ES2571852T3 (es) 2016-05-27
NO20025656D0 (no) 2002-11-25
HUP0302201A2 (hu) 2003-10-28
WO2001092337A3 (en) 2002-05-10
EG24459A (en) 2009-07-16
CA2409748C (en) 2008-09-16
SK15702002A3 (sk) 2004-01-08
DE60104282D1 (de) 2004-08-19
BRPI0111191B1 (pt) 2019-12-31
TWI319405B (en) 2010-01-11
PE20011338A1 (es) 2002-01-13
UA87432C2 (uk) 2009-07-27
LT2002114A (en) 2003-12-29
RU2283847C2 (ru) 2006-09-20
HK1048126A1 (en) 2003-03-21
CZ304451B6 (cs) 2014-05-14
EE05458B1 (et) 2011-08-15
AR031699A1 (es) 2003-10-01
ZA200208944B (en) 2004-02-13
DE122011100063I1 (de) 2012-06-14
EP3029062A1 (en) 2016-06-08
AU6346601A (en) 2001-12-11
KR100895134B1 (ko) 2009-05-04
HUS1300012I1 (hu) 2016-08-29
SI1248802T1 (en) 2005-02-28
EP1536234A2 (en) 2005-06-01
BR0111191A (pt) 2004-07-06
MY136113A (en) 2008-08-29
CZ20023892A3 (cs) 2003-09-17
NO2011027I1 (no) 2012-01-09
PL206267B1 (pl) 2010-07-30
KR20070094019A (ko) 2007-09-19
LU91902I2 (fr) 2012-01-16
MXPA02011534A (es) 2004-08-12
EE200200659A (et) 2004-06-15
UY26723A1 (es) 2001-12-28
ES2225549T3 (es) 2005-03-16
EP1248802B9 (en) 2005-05-11
CY2011019I2 (el) 2016-12-14
EP1248802A2 (en) 2002-10-16
ATE271066T1 (de) 2004-07-15
BE2011C041I2 (nl) 2020-08-20
FR11C0053I2 (fr) 2013-01-11
NO2011027I2 (nl) 2011-12-15
HU228137B1 (en) 2012-12-28
TW200906857A (en) 2009-02-16
EP1536234B1 (en) 2016-03-16
WO2001092337A2 (en) 2001-12-06
TR200402703T4 (tr) 2004-11-22
NO330797B1 (no) 2011-07-18
IL152315A (en) 2010-04-15
EE05557B1 (et) 2012-08-15
FR11C0053I1 (nl) 2012-01-13
DK1248802T3 (da) 2004-11-15
HUP0302201A3 (en) 2010-01-28
CN1309735C (zh) 2007-04-11
NO20025656L (no) 2002-11-25
HK1071931A1 (zh) 2005-08-05
LT5133B (lt) 2004-05-25
CY2011019I1 (el) 2016-12-14
DE60104282T2 (de) 2005-10-13
BRPI0111191B8 (pt) 2021-05-25
EE201100050A (et) 2011-10-17
KR100889887B1 (ko) 2009-03-24
HK1048126B (zh) 2005-03-04
IL152315A0 (en) 2003-05-29
JP4328525B2 (ja) 2009-09-09
CN101255192A (zh) 2008-09-03
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