SK287641B6 - Farmaceutický prípravok na parenterálne podávanie so stabilizovaným pH a ampula s jeho obsahom - Google Patents
Farmaceutický prípravok na parenterálne podávanie so stabilizovaným pH a ampula s jeho obsahom Download PDFInfo
- Publication number
- SK287641B6 SK287641B6 SK1598-2002A SK15982002A SK287641B6 SK 287641 B6 SK287641 B6 SK 287641B6 SK 15982002 A SK15982002 A SK 15982002A SK 287641 B6 SK287641 B6 SK 287641B6
- Authority
- SK
- Slovakia
- Prior art keywords
- pharmaceutical composition
- concentration
- composition according
- methionine
- medroxyprogesterone acetate
- Prior art date
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- 238000007911 parenteral administration Methods 0.000 title claims abstract description 11
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 26
- 239000000203 mixture Substances 0.000 claims abstract description 66
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims abstract description 48
- 229960004452 methionine Drugs 0.000 claims abstract description 48
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 claims abstract description 47
- 229930195722 L-methionine Natural products 0.000 claims abstract description 47
- 238000009472 formulation Methods 0.000 claims abstract description 46
- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 claims abstract description 36
- 229960002985 medroxyprogesterone acetate Drugs 0.000 claims abstract description 35
- 239000007900 aqueous suspension Substances 0.000 claims abstract description 33
- UOACKFBJUYNSLK-XRKIENNPSA-N Estradiol Cypionate Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H](C4=CC=C(O)C=C4CC3)CC[C@@]21C)C(=O)CCC1CCCC1 UOACKFBJUYNSLK-XRKIENNPSA-N 0.000 claims abstract description 22
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- LVXHNCUCBXIIPE-UHFFFAOYSA-L disodium;hydrogen phosphate;hydrate Chemical compound O.[Na+].[Na+].OP([O-])([O-])=O LVXHNCUCBXIIPE-UHFFFAOYSA-L 0.000 description 4
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- 229940093915 gynecological organic acid Drugs 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
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- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
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- 230000005764 inhibitory process Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000012931 lyophilized formulation Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
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- 229960004616 medroxyprogesterone Drugs 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 description 1
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- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
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- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- 229940001482 sodium sulfite Drugs 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Endocrinology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/571,395 US6495534B2 (en) | 2000-05-15 | 2000-05-15 | Stabilized aqueous suspensions for parenteral use |
| PCT/EP2001/004643 WO2001087266A1 (en) | 2000-05-15 | 2001-04-25 | Stabilized aqueous suspensions for parenteral use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK15982002A3 SK15982002A3 (sk) | 2003-05-02 |
| SK287641B6 true SK287641B6 (sk) | 2011-05-06 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1598-2002A SK287641B6 (sk) | 2000-05-15 | 2001-04-25 | Farmaceutický prípravok na parenterálne podávanie so stabilizovaným pH a ampula s jeho obsahom |
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|---|---|
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| EP (1) | EP1282402B1 (cs) |
| JP (1) | JP4205341B2 (cs) |
| KR (1) | KR100828957B1 (cs) |
| CN (1) | CN100473376C (cs) |
| AR (3) | AR029924A1 (cs) |
| AT (1) | ATE313316T1 (cs) |
| AU (2) | AU2001267371B2 (cs) |
| BR (1) | BR0110841A (cs) |
| CA (1) | CA2409059C (cs) |
| CZ (1) | CZ303872B6 (cs) |
| DE (1) | DE60116084T2 (cs) |
| DK (1) | DK1282402T3 (cs) |
| EA (1) | EA007682B1 (cs) |
| EE (1) | EE05376B1 (cs) |
| ES (1) | ES2254443T3 (cs) |
| HK (1) | HK1054194B (cs) |
| HU (1) | HU229800B1 (cs) |
| IL (2) | IL152537A (cs) |
| IN (1) | IN224279B (cs) |
| MX (1) | MXPA02011195A (cs) |
| NO (1) | NO332215B1 (cs) |
| NZ (1) | NZ522324A (cs) |
| PE (1) | PE20011322A1 (cs) |
| PL (1) | PL203075B1 (cs) |
| SI (1) | SI1282402T1 (cs) |
| SK (1) | SK287641B6 (cs) |
| TW (1) | TWI256310B (cs) |
| WO (1) | WO2001087266A1 (cs) |
| ZA (1) | ZA200208738B (cs) |
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| US6495534B2 (en) * | 2000-05-15 | 2002-12-17 | Pharmacia & Upjohn Spa | Stabilized aqueous suspensions for parenteral use |
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| ATE345277T1 (de) | 2002-08-21 | 2006-12-15 | Pharmacia Corp | Injizierbare pharmazeutische suspension in einer phiole mit zwei kammern |
| WO2004043375A2 (en) * | 2002-11-08 | 2004-05-27 | Bristol-Myers Squibb Company | Pharmaceutical compositions and methods of using taxane derivatives |
| JP2006522133A (ja) * | 2003-03-31 | 2006-09-28 | アルザ・コーポレーション | 非水性単一相の媒体、及び、そのような媒体を利用するフォーミュレーション |
| KR101285137B1 (ko) * | 2003-09-03 | 2013-07-11 | 미스콘 트레이딩 에스.에이. | 자궁 내막증의 치료 방법 |
| US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
| US20050106214A1 (en) * | 2003-11-14 | 2005-05-19 | Guohua Chen | Excipients in drug delivery vehicles |
| JP2008513455A (ja) * | 2004-09-14 | 2008-05-01 | モレキュラー セラピューティクス インコーポレーティッド | 改良された生物薬剤学的性質をもつｄ−メチオニン製剤 |
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| EP1224940B2 (de) | 1997-09-23 | 2010-08-11 | Rentschler Biotechnologie GmbH | Flüssige Interferon-Beta Formulierungen |
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-
2000
- 2000-05-15 US US09/571,395 patent/US6495534B2/en not_active Expired - Lifetime
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2001
- 2001-04-25 WO PCT/EP2001/004643 patent/WO2001087266A1/en not_active Ceased
- 2001-04-25 KR KR1020027015431A patent/KR100828957B1/ko not_active Expired - Lifetime
- 2001-04-25 DE DE60116084T patent/DE60116084T2/de not_active Expired - Lifetime
- 2001-04-25 CZ CZ20023750A patent/CZ303872B6/cs not_active IP Right Cessation
- 2001-04-25 SK SK1598-2002A patent/SK287641B6/sk not_active IP Right Cessation
- 2001-04-25 SI SI200130485T patent/SI1282402T1/sl unknown
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- 2001-04-25 DK DK01945040T patent/DK1282402T3/da active
- 2001-04-25 EA EA200201208A patent/EA007682B1/ru not_active IP Right Cessation
- 2001-04-25 AT AT01945040T patent/ATE313316T1/de active
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- 2001-04-25 HK HK03106493.6A patent/HK1054194B/zh not_active IP Right Cessation
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- 2001-04-25 AU AU6737101A patent/AU6737101A/xx active Pending
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Owner name: PFIZER ITALIA S.R.L., ROME, IT Free format text: FORMER OWNER: PHARMACIA ITALIA S. P. A., MILAN, IT; PHARMACIA & UPJOHN COMPANY, KALAMAZOO, MI, US Effective date: 20110502 Owner name: PHARMACIA & UPJOHN COMPANY, KALAMAZOO, MI, US Free format text: FORMER OWNER: PHARMACIA ITALIA S. P. A., MILAN, IT; PHARMACIA & UPJOHN COMPANY, KALAMAZOO, MI, US Effective date: 20110502 |
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Expiry date: 20210425 |