SK287379B6 - Kapsuly na inhaláciu, ich použitie a spôsob výroby - Google Patents

Kapsuly na inhaláciu, ich použitie a spôsob výroby Download PDF

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Publication number
SK287379B6
SK287379B6 SK1620-2003A SK16202003A SK287379B6 SK 287379 B6 SK287379 B6 SK 287379B6 SK 16202003 A SK16202003 A SK 16202003A SK 287379 B6 SK287379 B6 SK 287379B6
Authority
SK
Slovakia
Prior art keywords
capsules
inhalation
excipient
tiotropium
powder
Prior art date
Application number
SK1620-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK16202003A3 (sk
Inventor
Karoline Bechtold-Peters
Dieter Hochrainer
Michael Trunk
Michael Walz
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7687020&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK287379(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg
Publication of SK16202003A3 publication Critical patent/SK16202003A3/sk
Publication of SK287379B6 publication Critical patent/SK287379B6/sk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/003—Particle size control by passing the aerosol trough sieves or filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK1620-2003A 2001-06-01 2002-05-27 Kapsuly na inhaláciu, ich použitie a spôsob výroby SK287379B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10126924A DE10126924A1 (de) 2001-06-01 2001-06-01 Inhalationskapseln
PCT/EP2002/005600 WO2002098874A2 (de) 2001-06-01 2002-05-27 Inhalationskapseln

Publications (2)

Publication Number Publication Date
SK16202003A3 SK16202003A3 (sk) 2004-05-04
SK287379B6 true SK287379B6 (sk) 2010-08-09

Family

ID=7687020

Family Applications (2)

Application Number Title Priority Date Filing Date
SK1620-2003A SK287379B6 (sk) 2001-06-01 2002-05-27 Kapsuly na inhaláciu, ich použitie a spôsob výroby
SK50049-2009A SK287346B6 (sk) 2001-06-01 2002-05-27 Kapsuly na inhaláciu a ich použitie

Family Applications After (1)

Application Number Title Priority Date Filing Date
SK50049-2009A SK287346B6 (sk) 2001-06-01 2002-05-27 Kapsuly na inhaláciu a ich použitie

Country Status (37)

Country Link
EP (2) EP1508330A1 (enrdf_load_stackoverflow)
JP (3) JP4447311B2 (enrdf_load_stackoverflow)
KR (2) KR100921904B1 (enrdf_load_stackoverflow)
CN (3) CN101829072A (enrdf_load_stackoverflow)
AR (2) AR034346A1 (enrdf_load_stackoverflow)
AT (1) ATE285752T1 (enrdf_load_stackoverflow)
AU (2) AU2002344354B2 (enrdf_load_stackoverflow)
BG (1) BG65655B1 (enrdf_load_stackoverflow)
BR (1) BR0209366A (enrdf_load_stackoverflow)
CA (1) CA2448425C (enrdf_load_stackoverflow)
CH (1) CH1379220H1 (enrdf_load_stackoverflow)
CO (1) CO5540379A2 (enrdf_load_stackoverflow)
CZ (1) CZ300284B6 (enrdf_load_stackoverflow)
DE (2) DE10126924A1 (enrdf_load_stackoverflow)
EA (1) EA005188B1 (enrdf_load_stackoverflow)
EC (2) ECSP034868A (enrdf_load_stackoverflow)
EE (1) EE05416B1 (enrdf_load_stackoverflow)
EG (1) EG24227A (enrdf_load_stackoverflow)
ES (1) ES2236590B5 (enrdf_load_stackoverflow)
HR (1) HRP20030993B1 (enrdf_load_stackoverflow)
HU (3) HU230827B1 (enrdf_load_stackoverflow)
IL (2) IL158917A0 (enrdf_load_stackoverflow)
ME (1) ME00301B (enrdf_load_stackoverflow)
MX (1) MXPA03010990A (enrdf_load_stackoverflow)
MY (1) MY126253A (enrdf_load_stackoverflow)
NO (1) NO332857B3 (enrdf_load_stackoverflow)
NZ (1) NZ530356A (enrdf_load_stackoverflow)
PE (1) PE20030071A1 (enrdf_load_stackoverflow)
PL (2) PL205714B1 (enrdf_load_stackoverflow)
PT (1) PT1379220E (enrdf_load_stackoverflow)
RS (1) RS50353B (enrdf_load_stackoverflow)
SI (1) SI1379220T1 (enrdf_load_stackoverflow)
SK (2) SK287379B6 (enrdf_load_stackoverflow)
TW (1) TWI327921B (enrdf_load_stackoverflow)
UA (1) UA75659C2 (enrdf_load_stackoverflow)
WO (1) WO2002098874A2 (enrdf_load_stackoverflow)
ZA (1) ZA200308340B (enrdf_load_stackoverflow)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ519406A (en) 2000-10-12 2003-07-25 Boehringer Ingelheim Pharma Novel tiotropium-containing inhalation powder
DE10126924A1 (de) * 2001-06-01 2002-12-05 Boehringer Ingelheim Pharma Inhalationskapseln
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
WO2003094890A1 (en) * 2002-05-07 2003-11-20 Nektar Therapeutics Capsules for dry powder inhalers and methods of making and using same
US7763280B2 (en) 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
DE10255387A1 (de) * 2002-11-28 2004-06-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Tiotropium-haltige Pulverformulierung für die Inhalation
DE10258360A1 (de) * 2002-12-12 2004-06-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator mit Kapselkammer zum Aufnehmen einer mit Wirkstoff gefüllten Einwegkapsel
DE10352277A1 (de) * 2003-11-08 2005-06-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator
SE0303570L (sv) 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
SE0303269L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Medicinsk produkt
GB0503738D0 (en) * 2005-02-23 2005-03-30 Optinose As Powder delivery devices
RU2369411C2 (ru) * 2005-04-21 2009-10-10 Бёрингер Ингельхайм Интернациональ Гмбх Порошковый ингалятор
US7694676B2 (en) 2005-04-22 2010-04-13 Boehringer Ingelheim Gmbh Dry powder inhaler
JP4825455B2 (ja) * 2005-05-02 2011-11-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 粉末吸入器
DE102006016901A1 (de) 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Mundstück für einen Inhalator
DE102006016904A1 (de) 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator
GB0716026D0 (en) * 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
DE102007036411A1 (de) 2007-07-20 2009-02-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator
DE102007052871A1 (de) * 2007-11-02 2009-05-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kapsel zur Aufnahme von pharmazeutischen Wirkstoffformulierungen
EP2244686A1 (de) * 2008-02-08 2010-11-03 Boehringer Ingelheim International GmbH Verfahren und vorrichtung zur befüllung von kapseln
EP2172190A1 (en) * 2008-10-02 2010-04-07 Laboratorios Liconsa, S.A. Inhalable particles comprising tiotropium
WO2010097115A1 (en) 2009-02-26 2010-09-02 Glaxo Group Limited Pharmaceutical formulations comprising 4-{(1r)-2- [(6-{2-[(2,6-dichlorobenzyl)oxy] ethoxy}hexyl)amino]-1-hydroxyethyl}-2- (hydroxymethyl)phenol
WO2010110760A1 (en) * 2009-03-27 2010-09-30 Mahmut Bilgic Compositions comprising water with deuterium for the prevention or treatment of allergic diseases and a process for the preparation thereof
GB0921075D0 (en) 2009-12-01 2010-01-13 Glaxo Group Ltd Novel combination of the therapeutic agents
US9259376B2 (en) 2010-06-03 2016-02-16 Sima Patent Ve Lisanslama Hizmetleri Ltd. Sti. Process for dry powder formulations
DE202011102694U1 (de) 2011-06-29 2011-12-19 Zisser Gmbh Inhalationsgerät für Heimanwender
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
UA115989C2 (uk) 2012-07-05 2018-01-25 Арвен Айлак Санайі Ве Тіджарет А.С. Фармацевтична композиція для інгалятора сухого порошку, що містить антагоністи мускаринових рецепторів тривалої дії
DE202013000774U1 (de) 2013-01-21 2013-04-15 Rhinofilt GmbH Miniaturisiertes Inhalationsgerät zur Privatanwendung
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
CN108295042A (zh) * 2018-03-05 2018-07-20 上海祺宇生物科技有限公司 一种用于吸入药剂的植物空心胶囊及其胶囊剂
CN108451920A (zh) * 2018-03-14 2018-08-28 绍兴康可胶囊有限公司 一种吸雾式胶囊及其制备方法
CN114848605B (zh) * 2022-03-25 2023-08-11 上海方予健康医药科技有限公司 一种供吸入粉雾剂用的明胶胶囊

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DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
KR100208979B1 (ko) * 1992-06-12 1999-07-15 야스이 쇼사꾸 기도내 투여용 제제
US6228394B1 (en) * 1997-10-14 2001-05-08 Boehringer Ingelheim Pharmaceuticals, Inc. Supercritical fluid extraction of mould lubricant from hard shell capsules
DE19835346A1 (de) * 1998-08-05 2000-02-10 Boehringer Ingelheim Pharma Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren
JP2000143502A (ja) * 1998-11-11 2000-05-23 Shionogi Qualicaps Kk 吸入製剤
ES2192866T3 (es) * 1998-11-13 2003-10-16 Jago Res Ag Polvo seco para inhalacion.
DE19921693A1 (de) * 1999-05-12 2000-11-16 Boehringer Ingelheim Pharma Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika
EP1072258A1 (de) * 1999-07-28 2001-01-31 Greither, Peter Eine Kapsel für die Freisetzung von Bakterien, enthaltend ein Bakterienlyophilisat und ein Verfahren zu ihrer Herstellung
CA2387212A1 (en) * 1999-10-12 2001-04-19 Kaken Pharmaceutical Co., Ltd. Dry powder inhalation and a method for the preparation thereof
DE10126924A1 (de) * 2001-06-01 2002-12-05 Boehringer Ingelheim Pharma Inhalationskapseln

Also Published As

Publication number Publication date
JP4447311B2 (ja) 2010-04-07
MY126253A (en) 2006-09-29
CN1512875A (zh) 2004-07-14
NO20035265L (no) 2003-11-27
AR084804A2 (es) 2013-06-26
HU230058B1 (hu) 2015-06-29
IL158917A0 (en) 2004-05-12
KR100921904B1 (ko) 2009-10-16
UA75659C2 (en) 2006-05-15
TWI327921B (en) 2010-08-01
YU93503A (sh) 2006-05-25
NZ530356A (en) 2005-05-27
AU2008203057C8 (en) 2017-04-06
ATE285752T1 (de) 2005-01-15
AU2008203057C1 (en) 2017-05-18
MXPA03010990A (es) 2004-02-27
KR20040007638A (ko) 2004-01-24
WO2002098874A3 (de) 2003-09-12
HU231082B1 (hu) 2020-06-29
NO332857B1 (no) 2013-01-21
CN101697965A (zh) 2010-04-28
BR0209366A (pt) 2004-06-08
PL205714B1 (pl) 2010-05-31
IL158917A (en) 2008-11-03
CN101829072A (zh) 2010-09-15
RS50353B (sr) 2009-11-10
PT1379220E (pt) 2005-03-31
NO332857B3 (no) 2016-01-25
PL387118A1 (pl) 2004-12-13
CA2448425C (en) 2010-12-21
SK16202003A3 (sk) 2004-05-04
EP1379220B1 (de) 2004-12-29
ME00301B (me) 2011-05-10
ES2236590T3 (es) 2005-07-16
NO20035265D0 (no) 2003-11-27
ES2236590B5 (es) 2018-03-05
MEP42508A (en) 2011-02-10
PL364108A1 (en) 2004-12-13
EA200301275A1 (ru) 2004-06-24
EE05416B1 (et) 2011-06-15
HRP20030993A2 (en) 2005-08-31
JP2008050364A (ja) 2008-03-06
AU2008203057A1 (en) 2008-07-31
AR034346A1 (es) 2004-02-18
EG24227A (en) 2008-11-10
CO5540379A2 (es) 2005-07-29
HU230827B1 (hu) 2018-07-30
ZA200308340B (en) 2004-05-21
PL203801B1 (pl) 2009-11-30
HRP20030993B1 (en) 2011-10-31
ECSP11004868A (es) 2011-02-28
BG108380A (bg) 2004-11-30
SI1379220T1 (sl) 2005-04-30
PE20030071A1 (es) 2003-03-04
AU2008203057B2 (en) 2011-12-08
ECSP034868A (es) 2004-03-23
HUP0400666A2 (hu) 2005-03-29
CZ300284B6 (cs) 2009-04-08
EP1379220A2 (de) 2004-01-14
EP1508330A1 (de) 2005-02-23
HUP1500188A2 (en) 2005-03-29
EA005188B1 (ru) 2004-12-30
AU2002344354B2 (en) 2008-08-07
KR100952321B1 (ko) 2010-04-09
BG65655B1 (bg) 2009-05-29
CA2448425A1 (en) 2002-12-12
JP2005500279A (ja) 2005-01-06
DE50201898D1 (de) 2005-02-03
DE10126924A1 (de) 2002-12-05
CH1379220H1 (enrdf_load_stackoverflow) 2018-10-31
WO2002098874A2 (de) 2002-12-12
JP2006143747A (ja) 2006-06-08
EE200300595A (et) 2004-02-16
HUP0400666A3 (en) 2009-06-29
CZ20033579A3 (en) 2004-05-12
JP4787034B2 (ja) 2011-10-05
KR20090010140A (ko) 2009-01-28
SK287346B6 (sk) 2010-07-07

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Expiry date: 20220527