SK287372B6 - Spôsob zvýšenia výťažku prostriedku obsahujúceho interferón-alfa - Google Patents
Spôsob zvýšenia výťažku prostriedku obsahujúceho interferón-alfa Download PDFInfo
- Publication number
- SK287372B6 SK287372B6 SK617-2001A SK6172001A SK287372B6 SK 287372 B6 SK287372 B6 SK 287372B6 SK 6172001 A SK6172001 A SK 6172001A SK 287372 B6 SK287372 B6 SK 287372B6
- Authority
- SK
- Slovakia
- Prior art keywords
- protein
- pyruvate
- isoform
- attached
- isoforms
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 56
- 108010047761 Interferon-alpha Proteins 0.000 title claims abstract description 21
- 102000006992 Interferon-alpha Human genes 0.000 title claims abstract description 21
- 239000000203 mixture Substances 0.000 title claims abstract description 13
- 230000001965 increasing effect Effects 0.000 title claims abstract description 10
- 102000001708 Protein Isoforms Human genes 0.000 claims abstract description 88
- 108010029485 Protein Isoforms Proteins 0.000 claims abstract description 88
- 239000000243 solution Substances 0.000 claims description 22
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 7
- 229930182817 methionine Natural products 0.000 claims description 7
- 239000003963 antioxidant agent Substances 0.000 claims description 3
- 230000003078 antioxidant effect Effects 0.000 claims description 3
- 239000003929 acidic solution Substances 0.000 claims 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 abstract description 57
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- 125000000101 thioether group Chemical group 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
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- 235000013162 Cocos nucifera Nutrition 0.000 description 1
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- 102000004877 Insulin Human genes 0.000 description 1
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- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 1
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- QEFRNWWLZKMPFJ-UHFFFAOYSA-N L-methionine sulphoxide Natural products CS(=O)CCC(N)C(O)=O QEFRNWWLZKMPFJ-UHFFFAOYSA-N 0.000 description 1
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- 108020004511 Recombinant DNA Proteins 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
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- 102000003978 Tissue Plasminogen Activator Human genes 0.000 description 1
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- 229910052802 copper Inorganic materials 0.000 description 1
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- 238000002347 injection Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 108010055511 interferon alfa-2c Proteins 0.000 description 1
- 229940047124 interferons Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
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- 239000011777 magnesium Substances 0.000 description 1
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- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
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- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
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- 239000003605 opacifier Substances 0.000 description 1
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- YPZRWBKMTBYPTK-UHFFFAOYSA-N oxidized gamma-L-glutamyl-L-cysteinylglycine Natural products OC(=O)C(N)CCC(=O)NC(C(=O)NCC(O)=O)CSSCC(C(=O)NCC(O)=O)NC(=O)CCC(N)C(O)=O YPZRWBKMTBYPTK-UHFFFAOYSA-N 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
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- 229960000187 tissue plasminogen activator Drugs 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19054298A | 1998-11-12 | 1998-11-12 | |
| PCT/US1999/020900 WO2000029440A1 (en) | 1998-11-12 | 1999-10-05 | Methods of conversion of interferon isoforms and products thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK6172001A3 SK6172001A3 (en) | 2001-10-08 |
| SK287372B6 true SK287372B6 (sk) | 2010-08-09 |
Family
ID=22701766
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK5003-2010A SK287564B6 (sk) | 1998-11-12 | 1999-10-05 | Spôsob zvýšenia výťažku prostriedku obsahujúceho interferón-alfa |
| SK617-2001A SK287372B6 (sk) | 1998-11-12 | 1999-10-05 | Spôsob zvýšenia výťažku prostriedku obsahujúceho interferón-alfa |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK5003-2010A SK287564B6 (sk) | 1998-11-12 | 1999-10-05 | Spôsob zvýšenia výťažku prostriedku obsahujúceho interferón-alfa |
Country Status (26)
| Country | Link |
|---|---|
| EP (2) | EP1129111B1 (cs) |
| JP (3) | JP4468585B2 (cs) |
| KR (1) | KR100922454B1 (cs) |
| CN (2) | CN100390197C (cs) |
| AR (1) | AR023906A1 (cs) |
| AT (2) | ATE409706T1 (cs) |
| AU (1) | AU766309B2 (cs) |
| BR (1) | BR9915257A (cs) |
| CA (1) | CA2348739C (cs) |
| CY (2) | CY1110444T1 (cs) |
| CZ (2) | CZ303110B6 (cs) |
| DE (2) | DE69939657D1 (cs) |
| DK (2) | DK1129111T3 (cs) |
| ES (2) | ES2348104T3 (cs) |
| HU (1) | HU228265B1 (cs) |
| ID (1) | ID28552A (cs) |
| IL (2) | IL142546A0 (cs) |
| NO (2) | NO329483B1 (cs) |
| NZ (1) | NZ511074A (cs) |
| PL (2) | PL200274B1 (cs) |
| PT (2) | PT1129111E (cs) |
| SI (2) | SI1894944T1 (cs) |
| SK (2) | SK287564B6 (cs) |
| TW (1) | TW577894B (cs) |
| WO (1) | WO2000029440A1 (cs) |
| ZA (1) | ZA200103010B (cs) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ID28552A (id) * | 1998-11-12 | 2001-05-31 | Schering Corp | Metode pengubahan isoform interferon dan produk-produk darinya |
| CN102264761A (zh) * | 2008-12-23 | 2011-11-30 | 先灵公司 | 重组生产的干扰素的提纯 |
| CA3184298A1 (en) * | 2020-04-20 | 2021-10-28 | Altum Pharmaceuticals Inc. | Recombinant interferon |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4530901A (en) | 1980-01-08 | 1985-07-23 | Biogen N.V. | Recombinant DNA molecules and their use in producing human interferon-like polypeptides |
| PH21848A (en) | 1980-01-08 | 1988-03-17 | Biogen Nv | Dna sequences and recombinant dna molecules |
| US4315852A (en) | 1980-11-26 | 1982-02-16 | Schering Corporation | Extraction of interferon from bacteria |
| US4364863A (en) * | 1980-12-29 | 1982-12-21 | Schering Corporation | Extraction of interferon from bacteria |
| EP0082481B2 (en) | 1981-12-23 | 1990-09-12 | Schering Corporation | Stabilised alpha-interferon formulations and their preparation |
| DE3515336C2 (de) * | 1985-04-27 | 1994-01-20 | Boehringer Ingelheim Int | Verfahren zur Herstellung und Reinigung von â-Interferon |
| US4847079A (en) | 1985-07-29 | 1989-07-11 | Schering Corporation | Biologically stable interferon compositions comprising thimerosal |
| US4732683A (en) | 1986-12-02 | 1988-03-22 | Biospectrum, Inc. | Purification method for alpha interferon |
| US4765903A (en) | 1987-10-06 | 1988-08-23 | Interferon Sciences, Inc. | Purification of monomeric interferon |
| US5272135A (en) | 1991-03-01 | 1993-12-21 | Chiron Ophthalmics, Inc. | Method for the stabilization of methionine-containing polypeptides |
| AU648214B2 (en) * | 1991-12-31 | 1994-04-14 | Lucky Limited | Recombinant gene coding for human alpha interferon and expression vector thereof, etc. |
| EP0679718B1 (en) * | 1994-04-09 | 2001-09-05 | F. Hoffmann-La Roche AG | Process for producing alpha-interferon |
| US5766582A (en) | 1994-10-11 | 1998-06-16 | Schering Corporation | Stable, aqueous alfa interferon solution formulations |
| ID28552A (id) * | 1998-11-12 | 2001-05-31 | Schering Corp | Metode pengubahan isoform interferon dan produk-produk darinya |
-
1999
- 1999-10-05 ID IDW00200101043A patent/ID28552A/id unknown
- 1999-10-05 PL PL348162A patent/PL200274B1/pl not_active IP Right Cessation
- 1999-10-05 DK DK99951431T patent/DK1129111T3/da active
- 1999-10-05 SI SI9931048T patent/SI1894944T1/sl unknown
- 1999-10-05 JP JP2000582425A patent/JP4468585B2/ja not_active Expired - Fee Related
- 1999-10-05 CN CNB998132136A patent/CN100390197C/zh not_active Expired - Fee Related
- 1999-10-05 DE DE69939657T patent/DE69939657D1/de not_active Expired - Lifetime
- 1999-10-05 AU AU63870/99A patent/AU766309B2/en not_active Ceased
- 1999-10-05 BR BR9915257-6A patent/BR9915257A/pt not_active Application Discontinuation
- 1999-10-05 SI SI9931022T patent/SI1129111T1/sl unknown
- 1999-10-05 HU HU0104113A patent/HU228265B1/hu unknown
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2006
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2010
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| Date | Code | Title | Description |
|---|---|---|---|
| TC4A | Change of owner's name |
Owner name: MERCK SHARP & DOHME CORP., RAHWAY, NJ, US Effective date: 20121108 |
|
| MM4A | Patent lapsed due to non-payment of maintenance fees |
Effective date: 20141005 |