SK286880B6 - Spôsob prípravy taxánov a medziprodukty - Google Patents

Spôsob prípravy taxánov a medziprodukty Download PDF

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Publication number
SK286880B6
SK286880B6 SK1226-2001A SK12262001A SK286880B6 SK 286880 B6 SK286880 B6 SK 286880B6 SK 12262001 A SK12262001 A SK 12262001A SK 286880 B6 SK286880 B6 SK 286880B6
Authority
SK
Slovakia
Prior art keywords
formula
phenyl
preparation
process according
iii
Prior art date
Application number
SK1226-2001A
Other languages
English (en)
Slovak (sk)
Other versions
SK12262001A3 (sk
Inventor
Ezio Bombardelli
Original Assignee
Indena S. P. A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena S. P. A. filed Critical Indena S. P. A.
Publication of SK12262001A3 publication Critical patent/SK12262001A3/sk
Publication of SK286880B6 publication Critical patent/SK286880B6/sk

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Seasonings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SK1226-2001A 1999-03-02 2000-02-23 Spôsob prípravy taxánov a medziprodukty SK286880B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI000417A IT1308636B1 (it) 1999-03-02 1999-03-02 Procedimento per la preparazione di tassani da 10-desacetilbaccatinaiii.
PCT/EP2000/001471 WO2000052003A1 (en) 1999-03-02 2000-02-23 A process for the preparation of taxanes from 10-deacetylbaccatin iii

Publications (2)

Publication Number Publication Date
SK12262001A3 SK12262001A3 (sk) 2001-12-03
SK286880B6 true SK286880B6 (sk) 2009-07-06

Family

ID=11382101

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1226-2001A SK286880B6 (sk) 1999-03-02 2000-02-23 Spôsob prípravy taxánov a medziprodukty

Country Status (23)

Country Link
US (2) US6500966B1 (ja)
EP (1) EP1157018B1 (ja)
JP (1) JP2002538155A (ja)
KR (1) KR100660663B1 (ja)
CN (2) CN1133632C (ja)
AT (1) ATE231499T1 (ja)
AU (1) AU759566B2 (ja)
BR (1) BR0008633A (ja)
CA (1) CA2361187C (ja)
CZ (1) CZ301702B6 (ja)
DE (1) DE60001265T2 (ja)
DK (1) DK1157018T3 (ja)
ES (1) ES2189747T3 (ja)
HK (2) HK1042490A1 (ja)
HU (1) HU229346B1 (ja)
IL (1) IL145216A0 (ja)
IT (1) IT1308636B1 (ja)
NO (1) NO327909B1 (ja)
PL (1) PL195906B1 (ja)
PT (1) PT1157018E (ja)
RU (1) RU2233276C2 (ja)
SK (1) SK286880B6 (ja)
WO (1) WO2000052003A1 (ja)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1318678B1 (it) * 2000-08-10 2003-08-27 Indena Spa Procedimento per la preparazione di derivati della baccatina iii.
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
CN1303077C (zh) * 2004-01-16 2007-03-07 桂林晖昂生化药业有限责任公司 合成紫杉烷的制备工艺
EP1712552A1 (en) * 2005-04-11 2006-10-18 INDENA S.p.A. Semisynthesis process for the preparation of 10-deacetyl-n-debenzoyl-paclitaxel
EP1647552A1 (en) * 2004-10-08 2006-04-19 INDENA S.p.A. Semisynthesis process for the preparation of 10-deacetyl-n-debenzoyl-paclitaxel
US7446126B2 (en) * 2004-10-08 2008-11-04 Indena S.P.A. Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel
ITMI20050614A1 (it) * 2005-04-12 2006-10-13 Indena Spa Processo per la purificazione della 10-deacetilbaccatina iii dalla 10-deacetil-2-debenzoil-2-pentenoilbaccatina iii
KR101009467B1 (ko) 2006-03-13 2011-01-19 주식회사 셀트리온화학연구소 도세탁셀의 합성에 유용한 탁산 유도체 및 그 제조방법
KR100847331B1 (ko) * 2006-12-14 2008-07-21 한미약품 주식회사 도세탁셀의 제조방법 및 이에 사용되는 중간체
ITMI20062479A1 (it) * 2006-12-21 2008-06-22 Indena Spa Processo per la preparazione di secotassani
JP4833126B2 (ja) * 2007-03-26 2011-12-07 Ntn株式会社 潤滑剤劣化検出装置および検出装置付き軸受
WO2011134067A1 (en) * 2010-04-29 2011-11-03 6570763 Canada Inc. Novel amino acid molecule and uses thereof
WO2016098015A1 (en) * 2014-12-16 2016-06-23 Khashayar Karimian New efficient methods for the synthesis of taxane derivatives such as docetaxel and their structural analogous, and a method for the preparation thereof
CN107056767B (zh) * 2015-12-04 2022-07-15 江苏恩华络康药物研发有限公司 用于制备水溶性紫杉烷类衍生物的方法及中间体
CN115232092A (zh) * 2022-05-19 2022-10-25 无锡紫杉药业有限公司 一种10-乙酰多西他赛的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE34277E (en) 1988-04-06 1993-06-08 Centre National De La Recherche Scientifique Process for preparing taxol
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5990325A (en) 1993-03-05 1999-11-23 Florida State University Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof
FR2696460B1 (fr) 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696459B1 (fr) 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
ATE176464T1 (de) * 1994-07-26 1999-02-15 Indena Spa Semisynthetisch taxal derivate mit antitumor wirkung
JP2964475B2 (ja) * 1994-11-17 1999-10-18 田辺製薬株式会社 バッカチン誘導体及びその製法
GB9512471D0 (en) * 1995-06-20 1995-08-23 Pharmacia Spa Method for the preparation of taxol and its derivatives
KR100225535B1 (ko) 1996-08-27 1999-10-15 정지석 파클리탁셀의 제조방법
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes

Also Published As

Publication number Publication date
SK12262001A3 (sk) 2001-12-03
KR20010102444A (ko) 2001-11-15
ITMI990417A1 (it) 2000-09-02
DE60001265D1 (de) 2003-02-27
CZ20013146A3 (cs) 2002-01-16
CZ301702B6 (cs) 2010-06-02
CN1295223C (zh) 2007-01-17
EP1157018B1 (en) 2003-01-22
BR0008633A (pt) 2001-12-26
CN1133632C (zh) 2004-01-07
HUP0302750A2 (hu) 2003-12-29
ES2189747T3 (es) 2003-07-16
CA2361187C (en) 2009-01-27
AU759566B2 (en) 2003-04-17
CN1502614A (zh) 2004-06-09
NO327909B1 (no) 2009-10-19
DK1157018T3 (da) 2003-05-05
NO20014211D0 (no) 2001-08-30
PT1157018E (pt) 2003-06-30
IL145216A0 (en) 2002-06-30
KR100660663B1 (ko) 2006-12-21
CN1342154A (zh) 2002-03-27
US6500966B1 (en) 2002-12-31
HK1042490A1 (en) 2002-08-16
USRE40120E1 (en) 2008-02-26
CA2361187A1 (en) 2000-09-08
NO20014211L (no) 2001-08-30
WO2000052003A1 (en) 2000-09-08
ATE231499T1 (de) 2003-02-15
AU3806000A (en) 2000-09-21
DE60001265T2 (de) 2003-08-28
IT1308636B1 (it) 2002-01-09
HU229346B1 (en) 2013-11-28
HUP0302750A3 (en) 2005-02-28
RU2233276C2 (ru) 2004-07-27
HK1065309A1 (en) 2005-02-18
JP2002538155A (ja) 2002-11-12
EP1157018A1 (en) 2001-11-28
PL195906B1 (pl) 2007-11-30

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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20190223