HUP0302750A2 - Eljárás taxinszármazékok előállítására 10-dezacetilbaccatin III-ból - Google Patents
Eljárás taxinszármazékok előállítására 10-dezacetilbaccatin III-bólInfo
- Publication number
- HUP0302750A2 HUP0302750A2 HU0302750A HUP0302750A HUP0302750A2 HU P0302750 A2 HUP0302750 A2 HU P0302750A2 HU 0302750 A HU0302750 A HU 0302750A HU P0302750 A HUP0302750 A HU P0302750A HU P0302750 A2 HUP0302750 A2 HU P0302750A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- iii
- compound
- taxanes
- groups
- Prior art date
Links
- YWLXLRUDGLRYDR-ZHPRIASZSA-N 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-ZHPRIASZSA-N 0.000 title abstract 4
- 229940123237 Taxane Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- -1 trichloroacetyl group Chemical group 0.000 abstract 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 230000021736 acetylation Effects 0.000 abstract 1
- 238000006640 acetylation reaction Methods 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000000160 oxazolidinyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
A találmány tárgya eljárás taxánok előállítására dezacetilbaccatin IIImegjelölésű vegyületből. A találmány értelmében úgy járnak el, hogy i)10-deacetilbaccatin III jelölésű vegyület 7- és 10-helyzetűhidroxilcsoportjait egyidejűleg megvédik triklóracetilcsoporttal; ii)a 13-helyzetű hidroxilcsoportot ezután észterezik valamely (VII)általános képletű vegyülettel - a képletben R jelentése terc-butoxikarbonil-, benzoil- vagy egyenes vagy elágazó láncú alifássavból leszármaztatható csoport és R1 jelentése fenilcsoport vagyegyenes vagy elágazó láncú alkil- vagy alkenilcsoport - végzettreagáltatás útján; iii) a triklóracetilcsoportokat mintvédőcsoportokat eltávolítják; iv) azoknál a vegyületeknél, amelyeknélR2 jelentése acetilcsoport, a 10-helyzetű hidroxilcsoportot adottesetben szelektív acetilezésnek vetik alá; és v) az oxazolidingyűrűtsavas hidrolízisnek vetik alá. A találmány továbbá az új (IV)általános képletű köztitermékekre vonatkozik. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999MI000417A IT1308636B1 (it) | 1999-03-02 | 1999-03-02 | Procedimento per la preparazione di tassani da 10-desacetilbaccatinaiii. |
PCT/EP2000/001471 WO2000052003A1 (en) | 1999-03-02 | 2000-02-23 | A process for the preparation of taxanes from 10-deacetylbaccatin iii |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0302750A2 true HUP0302750A2 (hu) | 2003-12-29 |
HUP0302750A3 HUP0302750A3 (en) | 2005-02-28 |
HU229346B1 HU229346B1 (en) | 2013-11-28 |
Family
ID=11382101
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0302750A HU229346B1 (en) | 1999-03-02 | 2000-02-23 | A process for the preparation of taxanes from 10-deacetylbaccatin iii |
Country Status (23)
Country | Link |
---|---|
US (2) | US6500966B1 (hu) |
EP (1) | EP1157018B1 (hu) |
JP (1) | JP2002538155A (hu) |
KR (1) | KR100660663B1 (hu) |
CN (2) | CN1295223C (hu) |
AT (1) | ATE231499T1 (hu) |
AU (1) | AU759566B2 (hu) |
BR (1) | BR0008633A (hu) |
CA (1) | CA2361187C (hu) |
CZ (1) | CZ301702B6 (hu) |
DE (1) | DE60001265T2 (hu) |
DK (1) | DK1157018T3 (hu) |
ES (1) | ES2189747T3 (hu) |
HK (2) | HK1042490A1 (hu) |
HU (1) | HU229346B1 (hu) |
IL (1) | IL145216A0 (hu) |
IT (1) | IT1308636B1 (hu) |
NO (1) | NO327909B1 (hu) |
PL (1) | PL195906B1 (hu) |
PT (1) | PT1157018E (hu) |
RU (1) | RU2233276C2 (hu) |
SK (1) | SK286880B6 (hu) |
WO (1) | WO2000052003A1 (hu) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1318678B1 (it) | 2000-08-10 | 2003-08-27 | Indena Spa | Procedimento per la preparazione di derivati della baccatina iii. |
US6900342B2 (en) * | 2002-05-10 | 2005-05-31 | Dabur India Limited | Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof |
CN1303077C (zh) * | 2004-01-16 | 2007-03-07 | 桂林晖昂生化药业有限责任公司 | 合成紫杉烷的制备工艺 |
US7446126B2 (en) * | 2004-10-08 | 2008-11-04 | Indena S.P.A. | Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel |
EP1712552A1 (en) * | 2005-04-11 | 2006-10-18 | INDENA S.p.A. | Semisynthesis process for the preparation of 10-deacetyl-n-debenzoyl-paclitaxel |
EP1647552A1 (en) * | 2004-10-08 | 2006-04-19 | INDENA S.p.A. | Semisynthesis process for the preparation of 10-deacetyl-n-debenzoyl-paclitaxel |
ITMI20050614A1 (it) * | 2005-04-12 | 2006-10-13 | Indena Spa | Processo per la purificazione della 10-deacetilbaccatina iii dalla 10-deacetil-2-debenzoil-2-pentenoilbaccatina iii |
KR101009467B1 (ko) | 2006-03-13 | 2011-01-19 | 주식회사 셀트리온화학연구소 | 도세탁셀의 합성에 유용한 탁산 유도체 및 그 제조방법 |
KR100847331B1 (ko) * | 2006-12-14 | 2008-07-21 | 한미약품 주식회사 | 도세탁셀의 제조방법 및 이에 사용되는 중간체 |
ITMI20062479A1 (it) * | 2006-12-21 | 2008-06-22 | Indena Spa | Processo per la preparazione di secotassani |
JP4833126B2 (ja) * | 2007-03-26 | 2011-12-07 | Ntn株式会社 | 潤滑剤劣化検出装置および検出装置付き軸受 |
WO2011134067A1 (en) * | 2010-04-29 | 2011-11-03 | 6570763 Canada Inc. | Novel amino acid molecule and uses thereof |
WO2016098015A1 (en) * | 2014-12-16 | 2016-06-23 | Khashayar Karimian | New efficient methods for the synthesis of taxane derivatives such as docetaxel and their structural analogous, and a method for the preparation thereof |
CN107056767B (zh) * | 2015-12-04 | 2022-07-15 | 江苏恩华络康药物研发有限公司 | 用于制备水溶性紫杉烷类衍生物的方法及中间体 |
CN115232092A (zh) * | 2022-05-19 | 2022-10-25 | 无锡紫杉药业有限公司 | 一种10-乙酰多西他赛的制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE34277E (en) | 1988-04-06 | 1993-06-08 | Centre National De La Recherche Scientifique | Process for preparing taxol |
MX9102128A (es) | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
US5990325A (en) | 1993-03-05 | 1999-11-23 | Florida State University | Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof |
FR2696459B1 (fr) | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé de préparation de dérivés du taxane. |
FR2696460B1 (fr) | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé de préparation de dérivés du taxane. |
RO115875B1 (ro) * | 1994-07-26 | 2000-07-28 | Indena Spa | Derivati de taxan, procedeu pentru prepararea acestora, intermediar pentru prepararea acestora si compozitie farmaceutica care ii contine |
JP2964475B2 (ja) * | 1994-11-17 | 1999-10-18 | 田辺製薬株式会社 | バッカチン誘導体及びその製法 |
GB9512471D0 (en) * | 1995-06-20 | 1995-08-23 | Pharmacia Spa | Method for the preparation of taxol and its derivatives |
KR100225535B1 (ko) | 1996-08-27 | 1999-10-15 | 정지석 | 파클리탁셀의 제조방법 |
US7288665B1 (en) * | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
-
1999
- 1999-03-02 IT IT1999MI000417A patent/IT1308636B1/it active
-
2000
- 2000-02-23 BR BR0008633-9A patent/BR0008633A/pt not_active Application Discontinuation
- 2000-02-23 AU AU38060/00A patent/AU759566B2/en not_active Ceased
- 2000-02-23 KR KR1020017011048A patent/KR100660663B1/ko active IP Right Grant
- 2000-02-23 AT AT00916860T patent/ATE231499T1/de active
- 2000-02-23 EP EP00916860A patent/EP1157018B1/en not_active Expired - Lifetime
- 2000-02-23 IL IL14521600A patent/IL145216A0/xx not_active IP Right Cessation
- 2000-02-23 CN CNB2003101149087A patent/CN1295223C/zh not_active Expired - Fee Related
- 2000-02-23 CZ CZ20013146A patent/CZ301702B6/cs not_active IP Right Cessation
- 2000-02-23 CN CNB008044236A patent/CN1133632C/zh not_active Expired - Fee Related
- 2000-02-23 CA CA002361187A patent/CA2361187C/en not_active Expired - Fee Related
- 2000-02-23 WO PCT/EP2000/001471 patent/WO2000052003A1/en active IP Right Grant
- 2000-02-23 US US09/913,891 patent/US6500966B1/en not_active Ceased
- 2000-02-23 HU HU0302750A patent/HU229346B1/hu unknown
- 2000-02-23 RU RU2001124274/04A patent/RU2233276C2/ru not_active IP Right Cessation
- 2000-02-23 DE DE60001265T patent/DE60001265T2/de not_active Expired - Lifetime
- 2000-02-23 DK DK00916860T patent/DK1157018T3/da active
- 2000-02-23 PT PT00916860T patent/PT1157018E/pt unknown
- 2000-02-23 US US11/025,830 patent/USRE40120E1/en not_active Expired - Lifetime
- 2000-02-23 SK SK1226-2001A patent/SK286880B6/sk not_active IP Right Cessation
- 2000-02-23 JP JP2000602230A patent/JP2002538155A/ja active Pending
- 2000-02-23 ES ES00916860T patent/ES2189747T3/es not_active Expired - Lifetime
- 2000-02-23 PL PL00349607A patent/PL195906B1/pl unknown
-
2001
- 2001-08-30 NO NO20014211A patent/NO327909B1/no not_active IP Right Cessation
-
2002
- 2002-05-31 HK HK02104134A patent/HK1042490A1/xx not_active IP Right Cessation
-
2004
- 2004-10-18 HK HK04108044A patent/HK1065309A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0302750A2 (hu) | Eljárás taxinszármazékok előállítására 10-dezacetilbaccatin III-ból | |
KR100290663B1 (ko) | 박카틴iii및10-데아세틸박카틴iii의신규한에스테르화방법 | |
US6900342B2 (en) | Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof | |
RU94040356A (ru) | Способ получения производных таксана | |
HUP9903808A2 (hu) | Eljárás szubsztituált aril-tejsavat tartalmazó 24 gyűrűatomos ciklodepszipeptidek előállítására | |
RU2001124274A (ru) | Способ получения таксанов из 10-деацетилбаккатина iii | |
JP2002538155A5 (hu) | ||
US8263793B2 (en) | Preparation of taxanes from 9-dihydro-13-acetylbaccatin III | |
HUP0202448A2 (hu) | Eljárás paclitaxel C-4-metil-karbonát-analóg előállítására | |
HUP0302765A2 (hu) | Eljárás taxánszármazékok előállítására | |
KR20070108181A (ko) | 파클리탁셀 제조 방법 | |
HUP0500615A2 (hu) | Eljárás paclitaxel előállítására | |
PT1114815E (pt) | Processo para a preparacao de taxol | |
RU2005102395A (ru) | Способ получения паклитаксела | |
Shen et al. | An Efficient Semi‐Synthetic Method to Construct Docetaxel via Sterically Crowded Linear Side Chain Esterification | |
CA2672911C (en) | Semi-synthetic process for the preparation of taxane derivatives | |
AR009349A1 (es) | Un procedimiento para preparar paclitaxel, un derivado de taxano y un derivado de oxazolidina utilizables como intermediarios y procedimientos para prepararlos. | |
Jin et al. | Semi-synthesis of 1-Deoxypaclitaxel and its Analogues from 1-Deoxybaccatin VI | |
ATE260267T1 (de) | Verfahren zur herstellung von c-4-deacetyltaxanen | |
IL153043A (en) | Intermediate for baccatin iii derivatives and methods for the production thereof |