SK285971B6 - Spôsob prípravy buniek na výrobu biologických materiálov - Google Patents
Spôsob prípravy buniek na výrobu biologických materiálov Download PDFInfo
- Publication number
- SK285971B6 SK285971B6 SK965-2000A SK9652000A SK285971B6 SK 285971 B6 SK285971 B6 SK 285971B6 SK 9652000 A SK9652000 A SK 9652000A SK 285971 B6 SK285971 B6 SK 285971B6
- Authority
- SK
- Slovakia
- Prior art keywords
- cells
- production
- cell
- batch
- bioreactor
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 63
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 239000012620 biological material Substances 0.000 title claims description 15
- 238000000034 method Methods 0.000 claims abstract description 34
- 238000012258 culturing Methods 0.000 claims abstract description 4
- 239000000758 substrate Substances 0.000 claims description 17
- 230000001419 dependent effect Effects 0.000 claims description 9
- 230000012010 growth Effects 0.000 claims description 8
- 241000700605 Viruses Species 0.000 claims description 7
- 239000002054 inoculum Substances 0.000 claims description 5
- 238000010923 batch production Methods 0.000 claims description 4
- 238000004873 anchoring Methods 0.000 claims description 3
- 229960000074 biopharmaceutical Drugs 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 128
- 239000000969 carrier Substances 0.000 description 15
- 239000001963 growth medium Substances 0.000 description 9
- 238000004113 cell culture Methods 0.000 description 7
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 5
- 102000004142 Trypsin Human genes 0.000 description 4
- 108090000631 Trypsin Proteins 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- 239000012588 trypsin Substances 0.000 description 4
- 108091005804 Peptidases Proteins 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 102000035195 Peptidases Human genes 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 239000012510 hollow fiber Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000009331 sowing Methods 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 108010044467 Isoenzymes Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000001902 propagating effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000013190 sterility testing Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 210000000352 storage cell Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 239000005723 virus inoculator Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Sustainable Development (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97204110 | 1997-12-24 | ||
| PCT/EP1998/008522 WO1999033955A1 (en) | 1997-12-24 | 1998-12-17 | Preparation of cells for production of biologicals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK9652000A3 SK9652000A3 (en) | 2000-12-11 |
| SK285971B6 true SK285971B6 (sk) | 2007-12-06 |
Family
ID=8229133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK965-2000A SK285971B6 (sk) | 1997-12-24 | 1998-12-17 | Spôsob prípravy buniek na výrobu biologických materiálov |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20070148753A1 (cs) |
| EP (2) | EP1801201B1 (cs) |
| JP (1) | JP4478328B2 (cs) |
| KR (1) | KR100683429B1 (cs) |
| CN (1) | CN1185339C (cs) |
| AT (2) | ATE356197T1 (cs) |
| AU (1) | AU758209B2 (cs) |
| BR (1) | BR9814490A (cs) |
| CA (1) | CA2316739C (cs) |
| CZ (1) | CZ299719B6 (cs) |
| DE (2) | DE69842245D1 (cs) |
| DK (2) | DK1060241T4 (cs) |
| ES (2) | ES2365631T3 (cs) |
| HU (1) | HUP0100538A3 (cs) |
| ID (1) | ID26784A (cs) |
| IL (1) | IL136736A (cs) |
| NO (1) | NO329385B1 (cs) |
| NZ (1) | NZ505371A (cs) |
| PL (1) | PL196042B1 (cs) |
| PT (2) | PT1801201E (cs) |
| RU (1) | RU2230784C2 (cs) |
| SK (1) | SK285971B6 (cs) |
| TR (1) | TR200001960T2 (cs) |
| UA (1) | UA72732C2 (cs) |
| WO (1) | WO1999033955A1 (cs) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107460154A (zh) | 2009-12-23 | 2017-12-12 | 赛诺菲巴斯德有限公司 | 用于培养贴壁细胞的方法 |
| CA3087569A1 (en) | 2018-01-09 | 2019-07-18 | Synthetic Biologics, Inc. | Alkaline phosphatase agents for treatment of neurodevelopmental disorders |
| CA3094174A1 (en) | 2018-03-20 | 2019-09-26 | Synthetic Biologics, Inc. | Alkaline phosphatase agents for treatment of radiation disorders |
| WO2019183208A1 (en) | 2018-03-20 | 2019-09-26 | Synthetic Biologics, Inc. | Intestinal alkaline phosphatase formulations |
| US12071607B2 (en) * | 2018-06-01 | 2024-08-27 | Lonza Ltd. | Midscale model for organic growth and phasing |
| WO2020227263A1 (en) | 2019-05-06 | 2020-11-12 | Synthetic Biologics, Inc. | Alkaline phosphate-based oncology treatments |
| CN114127260A (zh) * | 2019-07-16 | 2022-03-01 | 信达生物制药(苏州)有限公司 | 高密度连续接种的细胞培养方法及其应用 |
| EP4339274B1 (en) | 2022-09-13 | 2025-03-26 | Sartorius Stedim Biotech GmbH | Method for operating a bioprocess installation for production of a bioproduct |
| CN116064409A (zh) * | 2023-01-06 | 2023-05-05 | 四川阿思科力生物科技有限公司 | 一种大规模高产量细胞连续培养和收获的生产工艺 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60151458A (ja) | 1984-01-20 | 1985-08-09 | Nippon Piston Ring Co Ltd | カムシヤフト |
| US4664912A (en) * | 1984-10-01 | 1987-05-12 | Wiktor Tadeusz J | Process for the large scale production of rabies vaccine |
| DE3833925A1 (de) * | 1988-03-11 | 1989-09-21 | Inst Angewandte Biotechnologie | Verfahren und herstellung von virus und viralem antigen und vorrichtung hierzu |
| US5017490A (en) | 1989-03-10 | 1991-05-21 | Baxter International Inc. | Method for in vitro reproduction and growth of cells in culture medium |
| DE3930140A1 (de) * | 1989-09-09 | 1991-03-21 | Bayer Ag | Verfahren zur herstellung von biologischen materialien in zellkulturen und vorrichtungen |
| EP0564539A4 (en) * | 1990-12-13 | 1996-03-06 | Us Commerce | Sustained and continuous production of high titers of recombinant viral vectors and transduced target cells for use in gene therapy |
| DE19612966B4 (de) | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
| US8188315B2 (en) * | 2004-04-02 | 2012-05-29 | Samsung Mobile Display Co., Ltd. | Organic light emitting device and flat panel display device comprising the same |
| KR100669716B1 (ko) * | 2004-07-14 | 2007-01-16 | 삼성에스디아이 주식회사 | 페닐카르바졸 화합물 및 이를 이용한 유기 전계 발광 소자 |
| KR100573137B1 (ko) * | 2004-04-02 | 2006-04-24 | 삼성에스디아이 주식회사 | 플루오렌계 화합물 및 이를 이용한 유기 전계 발광 소자 |
| KR100787425B1 (ko) * | 2004-11-29 | 2007-12-26 | 삼성에스디아이 주식회사 | 페닐카바졸계 화합물 및 이를 이용한 유기 전계 발광 소자 |
| JP4184332B2 (ja) * | 2004-11-22 | 2008-11-19 | 本田技研工業株式会社 | 可変気筒式内燃機関の制御装置 |
-
1998
- 1998-12-17 CZ CZ20002343A patent/CZ299719B6/cs not_active IP Right Cessation
- 1998-12-17 AU AU24179/99A patent/AU758209B2/en not_active Ceased
- 1998-12-17 EP EP07103139A patent/EP1801201B1/en not_active Expired - Lifetime
- 1998-12-17 KR KR1020007007068A patent/KR100683429B1/ko not_active Expired - Fee Related
- 1998-12-17 DE DE69842245T patent/DE69842245D1/de not_active Expired - Lifetime
- 1998-12-17 CN CNB988126354A patent/CN1185339C/zh not_active Expired - Fee Related
- 1998-12-17 PT PT07103139T patent/PT1801201E/pt unknown
- 1998-12-17 AT AT98966693T patent/ATE356197T1/de active
- 1998-12-17 PL PL98341401A patent/PL196042B1/pl not_active IP Right Cessation
- 1998-12-17 NZ NZ505371A patent/NZ505371A/en not_active IP Right Cessation
- 1998-12-17 PT PT98966693T patent/PT1060241E/pt unknown
- 1998-12-17 DK DK98966693.8T patent/DK1060241T4/da active
- 1998-12-17 UA UA2000074455A patent/UA72732C2/uk unknown
- 1998-12-17 DK DK07103139.7T patent/DK1801201T3/da active
- 1998-12-17 JP JP2000526613A patent/JP4478328B2/ja not_active Expired - Fee Related
- 1998-12-17 AT AT07103139T patent/ATE507284T1/de active
- 1998-12-17 EP EP98966693A patent/EP1060241B2/en not_active Expired - Lifetime
- 1998-12-17 IL IL13673698A patent/IL136736A/en not_active IP Right Cessation
- 1998-12-17 TR TR2000/01960T patent/TR200001960T2/xx unknown
- 1998-12-17 RU RU2000119783/13A patent/RU2230784C2/ru not_active IP Right Cessation
- 1998-12-17 CA CA2316739A patent/CA2316739C/en not_active Expired - Fee Related
- 1998-12-17 BR BR9814490-1A patent/BR9814490A/pt not_active IP Right Cessation
- 1998-12-17 ES ES07103139T patent/ES2365631T3/es not_active Expired - Lifetime
- 1998-12-17 WO PCT/EP1998/008522 patent/WO1999033955A1/en active IP Right Grant
- 1998-12-17 SK SK965-2000A patent/SK285971B6/sk not_active IP Right Cessation
- 1998-12-17 ES ES98966693T patent/ES2281148T5/es not_active Expired - Lifetime
- 1998-12-17 DE DE69837287T patent/DE69837287T3/de not_active Expired - Lifetime
- 1998-12-17 HU HU0100538A patent/HUP0100538A3/hu not_active Application Discontinuation
- 1998-12-17 ID IDW20001431A patent/ID26784A/id unknown
-
2000
- 2000-06-21 NO NO20003215A patent/NO329385B1/no not_active IP Right Cessation
-
2007
- 2007-01-18 US US11/654,556 patent/US20070148753A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TC4A | Change of owner's name |
Owner name: ABBOTT BIOLOGICALS B.V., CP WEESP, NL Effective date: 20120830 |
|
| MM4A | Patent lapsed due to non-payment of maintenance fees |
Effective date: 20131217 |