SK285902B6 - Spôsob prípravy komprimovanej pevnej perorálnej liekovej formy valsartanu - Google Patents
Spôsob prípravy komprimovanej pevnej perorálnej liekovej formy valsartanu Download PDFInfo
- Publication number
- SK285902B6 SK285902B6 SK1784-98A SK178498A SK285902B6 SK 285902 B6 SK285902 B6 SK 285902B6 SK 178498 A SK178498 A SK 178498A SK 285902 B6 SK285902 B6 SK 285902B6
- Authority
- SK
- Slovakia
- Prior art keywords
- present
- weight
- active ingredient
- oral dosage
- valsartan
- Prior art date
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9613470.5A GB9613470D0 (en) | 1996-06-27 | 1996-06-27 | Small solid oral dosage form |
| PCT/EP1997/003172 WO1997049394A2 (fr) | 1996-06-27 | 1997-06-18 | Formes posologiques solides de valsartan administrees par voie orale |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK178498A3 SK178498A3 (en) | 1999-06-11 |
| SK285902B6 true SK285902B6 (sk) | 2007-10-04 |
Family
ID=10795969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1784-98A SK285902B6 (sk) | 1996-06-27 | 1997-06-18 | Spôsob prípravy komprimovanej pevnej perorálnej liekovej formy valsartanu |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | US6294197B1 (fr) |
| EP (7) | EP1774967A1 (fr) |
| JP (5) | JP2000506540A (fr) |
| KR (6) | KR20080014149A (fr) |
| CN (3) | CN1951372B (fr) |
| AR (2) | AR008618A1 (fr) |
| AT (3) | ATE446749T1 (fr) |
| BR (1) | BR9709956A (fr) |
| CA (2) | CA2673462C (fr) |
| CO (1) | CO4870755A1 (fr) |
| CY (1) | CY2553B1 (fr) |
| CZ (1) | CZ296850B6 (fr) |
| DE (3) | DE69739642D1 (fr) |
| DK (3) | DK1410797T3 (fr) |
| ES (3) | ES2335683T3 (fr) |
| GB (1) | GB9613470D0 (fr) |
| HK (2) | HK1019858A1 (fr) |
| HU (1) | HU229134B1 (fr) |
| ID (1) | ID17553A (fr) |
| IL (2) | IL127564A0 (fr) |
| MY (3) | MY123149A (fr) |
| NO (2) | NO317181B1 (fr) |
| NZ (2) | NZ333385A (fr) |
| PE (1) | PE87498A1 (fr) |
| PL (2) | PL188233B1 (fr) |
| PT (3) | PT914119E (fr) |
| RU (5) | RU2294743C2 (fr) |
| SI (2) | SI0914119T1 (fr) |
| SK (1) | SK285902B6 (fr) |
| TR (1) | TR199802698T2 (fr) |
| TW (1) | TW473394B (fr) |
| WO (1) | WO1997049394A2 (fr) |
| ZA (1) | ZA975673B (fr) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9613470D0 (en) * | 1996-06-27 | 1996-08-28 | Ciba Geigy Ag | Small solid oral dosage form |
| US20030045561A1 (en) * | 2001-02-06 | 2003-03-06 | Smithkline Beecham Corporation | Method of treating isolated systolic hypertension |
| ID25640A (id) * | 1998-03-04 | 2000-10-19 | Takeda Chemical Industries Ltd | Preparat pelepasan terus menerus untuk antagonistik aii, produksi dan penggunaannya |
| EP2263660B1 (fr) * | 1998-05-18 | 2017-09-27 | Takeda Pharmaceutical Company Limited | Comprimé se désintégrant dans la bouche |
| ATE371448T1 (de) * | 1998-07-10 | 2007-09-15 | Novartis Pharma Gmbh | Bluthochdruckgegenmittelkombination des valsartan und kalziumkanal blocker |
| TR200200764T2 (tr) | 1998-12-23 | 2002-07-22 | Novartis Ag | At-1 veya at-2 reseptörlerindeki artışın neden olduğu hastalıkların tedavisi için at-1 reseptör antagonisti veya at-2 reseptör modülatörünün kullanımı |
| IL144216A0 (en) * | 1999-01-26 | 2002-05-23 | Novartis Ag | Use of angiotensin ii receptor antagonists for treating acute myocardial infarction |
| CN101011390A (zh) | 1999-01-26 | 2007-08-08 | 诺瓦提斯公司 | 血管紧张素ⅱ受体拮抗剂在治疗急性心肌梗塞中的应用 |
| CA2383252A1 (fr) * | 1999-08-24 | 2001-03-01 | Medicure International Inc. | Traitement des pathologies cardio-vasculaires et connexes |
| DE10066408B4 (de) * | 2000-03-24 | 2010-03-18 | 3M Espe Dental Ag | Verwendung feinkörniger Pulver für supragingivales Pulverstrahlen |
| CA2311734C (fr) * | 2000-04-12 | 2011-03-08 | Bristol-Myers Squibb Company | Forme pharmaceutique orale a dissolution ultra-rapide |
| US20020132839A1 (en) * | 2000-06-22 | 2002-09-19 | Ganter Sabina Maria | Tablet formulations comprising valsartan |
| AU2005200815B2 (en) * | 2000-06-22 | 2008-01-17 | Novartis Ag | Solid valsartan pharmaceutical compositions |
| RU2333757C2 (ru) * | 2000-06-22 | 2008-09-20 | Новартис Аг | Фармацевтические композиции |
| SK287558B6 (sk) | 2000-07-19 | 2011-02-04 | Novartis Ag | Soli valsartanu, ich použitie, spôsob ich výroby a farmaceutické prípravky obsahujúce tieto soli |
| US20060089389A1 (en) | 2000-08-22 | 2006-04-27 | Malcolm Allison | Combination |
| PE20020617A1 (es) * | 2000-08-22 | 2002-08-05 | Novartis Ag | Composicion que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina o un sensibilizante a la insulina |
| US8168616B1 (en) | 2000-11-17 | 2012-05-01 | Novartis Ag | Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension |
| WO2003013609A1 (fr) * | 2001-08-03 | 2003-02-20 | Takeda Chemical Industries, Ltd. | Medicaments a liberation continue |
| GB0209265D0 (en) | 2002-04-23 | 2002-06-05 | Novartis Ag | Organic compounds |
| EG24716A (en) * | 2002-05-17 | 2010-06-07 | Novartis Ag | Combination of organic compounds |
| DE10230272A1 (de) * | 2002-07-05 | 2004-01-22 | Solvay Pharmaceuticals Gmbh | AT1-Rezeptorantagonisten zur Prävention von Folgeschlaganfällen |
| EP1382334A1 (fr) * | 2002-07-11 | 2004-01-21 | Université de Picardie Jules Verne | Utilisation d'un agent bloquant du récepteur AT1 de l'angiotensine II, seul ou combiné avec un thiazide ou l'angiotensine II dans le traitement des accidents vasculaires cérébraux |
| US7199144B2 (en) * | 2003-04-21 | 2007-04-03 | Teva Pharmaceuticals Industries, Ltd. | Process for the preparation of valsartan and intermediates thereof |
| EP1950204A1 (fr) | 2003-03-17 | 2008-07-30 | Teva Pharmaceutical Industries Ltd. | Forme amorphe de valsartan |
| ATE393764T1 (de) * | 2003-03-17 | 2008-05-15 | Teva Pharma | Polymorphe formen von valsartan |
| US7378531B2 (en) * | 2003-04-21 | 2008-05-27 | Teva Pharmaceutical Industries Ltd | Process for the preparation of valsartan |
| WO2004094391A2 (fr) * | 2003-04-21 | 2004-11-04 | Teva Pharmaceutical Industries Ltd. | Procede de preparation du valsartan et de ses intermediaires |
| KR20080083071A (ko) | 2003-08-08 | 2008-09-12 | 아지노모토 가부시키가이샤 | 나테글리니드 함유 제제 |
| GB0325605D0 (en) * | 2003-11-03 | 2003-12-10 | Novartis Ag | Combination of organic compounds |
| EP1680095A2 (fr) * | 2003-11-03 | 2006-07-19 | Zentiva, a.s. | Preparation contenant du valsartan |
| JP2005187793A (ja) * | 2003-12-24 | 2005-07-14 | Rohm & Haas Electronic Materials Llc | 改良された接着剤 |
| WO2005082329A2 (fr) * | 2004-02-19 | 2005-09-09 | Ranbaxy Laboratories Limited | Procede de preparation de formes posologiques solides de valsartan et d'hydrochlorthiazide |
| WO2005089720A1 (fr) * | 2004-03-10 | 2005-09-29 | Ranbaxy Laboratories Limited | Comprimes a base de valsartan et procede de preparation associe |
| WO2006029056A1 (fr) | 2004-09-02 | 2006-03-16 | Teva Pharmaceutical Industries Ltd. | Preparation d'olmesartan medoxomil |
| DE14172396T1 (de) | 2004-10-08 | 2015-01-08 | Forward Pharma A/S | Gesteuerte Freisetzung von pharmazeutischen Zusammensetzungen mit Fumarinsäureester |
| ATE478564T1 (de) * | 2004-10-15 | 2010-09-15 | Suedzucker Ag | Verbessertes trommelcoating-verfahren |
| EP1674080A1 (fr) * | 2004-12-24 | 2006-06-28 | KRKA, D.D., Novo Mesto | Composition pharmaceutique comprenant du valsartan |
| RS52607B (en) * | 2004-12-24 | 2013-04-30 | Krka Tovarna Zdravil D.D., Novo Mesto | SOLID PHARMACEUTICAL COMPOSITIONS CONTAINING VALSARTAN |
| FR2882260A1 (fr) * | 2005-02-21 | 2006-08-25 | Flamel Technologies Sa | Forme pharmaceutique orale multimicroparticulaire a liberation modifiee d'antagonistes des recepteurs de l'angiotensine ii |
| EP2808015A1 (fr) * | 2005-05-31 | 2014-12-03 | Mylan Laboratories, Inc | Compositions comportant du nebivolol |
| EP1812411A2 (fr) * | 2005-07-05 | 2007-08-01 | Teva Pharmaceutical Industries Ltd. | Procede de preparation de valsartan |
| GB0513888D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors II |
| US20080227836A1 (en) * | 2005-10-31 | 2008-09-18 | Lupin Ltd | Stable Solid Oral Dosage Forms of Valsartan |
| RU2309732C1 (ru) * | 2006-03-13 | 2007-11-10 | Олег Ильич Эпштейн | Спрессованная твердая оральная форма лекарственного препарата и способ получения твердой оральной формы лекарственного препарата |
| EP2007385A4 (fr) * | 2006-03-23 | 2010-08-18 | Sinai School Medicine | Composition cardiovasculaire et utilisation de ladite composition pour le traitement de la maladie d'alzheimer |
| EP2036574A4 (fr) | 2006-06-06 | 2009-07-01 | Oleg Iliich Epshtein | Préparation médicamenteuse destinée au traitement péroral de l'excès pondéral, du diabète sucré et de maladies accompagnées d'une perturbation de la tolérance du glucose |
| EP2043607A2 (fr) * | 2006-06-23 | 2009-04-08 | Usv Limited | Procédé de préparation de valsartan micronisé |
| GB0612540D0 (en) | 2006-06-23 | 2006-08-02 | Novartis Ag | Galenical formulations of organic compounds |
| PE20081364A1 (es) * | 2006-09-04 | 2008-12-04 | Novartis Ag | Composicion farmaceutica que comprende valsartan |
| EP1897537A1 (fr) * | 2006-09-04 | 2008-03-12 | Novartis AG | Composition contenant un antagoniste des récepteurs de l'angiotensine II |
| KR100963389B1 (ko) * | 2006-10-30 | 2010-06-14 | 한올바이오파마주식회사 | 시간차로 방출되는 치아자이드계 화합물과 안지오텐신―ⅱ―수용체 차단제를 포함하는 약학적 조성물 |
| WO2008064338A2 (fr) * | 2006-11-22 | 2008-05-29 | Rubicon Research Pvt. Ltd. | Formulation de valsartan pour administration pulsatile |
| WO2008120242A1 (fr) * | 2007-03-29 | 2008-10-09 | Alembic Limited | Formulations de comprimés de valsartan |
| TR200703568A1 (tr) | 2007-05-24 | 2008-07-21 | Sanovel �La� Sanay� Ve T�Caret Anon�M ��Rket� | Valsartan formülasyonları |
| US20100273873A1 (en) * | 2007-07-31 | 2010-10-28 | Katleen Rosa Francois Brys | Direct compressible dextrose |
| GB0715628D0 (en) * | 2007-08-10 | 2007-09-19 | Generics Uk Ltd | Solid valsartan composition |
| CN101396366B (zh) * | 2007-09-25 | 2010-10-13 | 浙江华海药业股份有限公司 | 含缬沙坦的固体口服制剂及其制备方法 |
| CL2008002829A1 (es) * | 2007-09-28 | 2009-06-26 | Novartis Ag | Combinacion farmaceutica de dosis oral fija que comprende aliskireno y valsartan; uso de la combinacion para tratar hipertension, angina, infarto al miocardio, arterioscleosis, nefropatia diabetica, insuficiencia renal, entre otras; metodos de preparacion de la combinacion en forma de bicapa y en forma se tableta sobre encapsulada. |
| US20100222334A1 (en) | 2007-10-09 | 2010-09-02 | Wayne Talamonti | Pharmaceutical Formulation of Valsartan |
| SI2217205T1 (sl) | 2007-11-06 | 2015-10-30 | Novartis Ag | Farmacevtske sestave na podlagi superstruktur zaviralca/blokatorja angiotenzinskih receptorjev (arb) in inhibitorja nevtralne endopeptidaze (nep) |
| EP2067470A1 (fr) * | 2007-12-03 | 2009-06-10 | Laboratorios Lesvi, S.L. | Compositions pharmaceutiques contenant du valsartan et procédé pour sa préparation |
| EP2240163A1 (fr) * | 2007-12-31 | 2010-10-20 | Lupin Limited | Compositions pharmaceutiques d'amlodipine et de valsartan |
| CA2713581A1 (fr) * | 2008-02-28 | 2009-09-03 | Novartis Ag | Formes pharmaceutiques orales solides de valsartan et procedes de preparation de telles formulations |
| US20090226515A1 (en) * | 2008-03-04 | 2009-09-10 | Pharma Pass Ii Llc | Statin compositions |
| US20090226516A1 (en) * | 2008-03-04 | 2009-09-10 | Pharma Pass Ii Llc | Sartan compositions |
| US20110117194A1 (en) * | 2008-04-29 | 2011-05-19 | Hanall Biopharma Co., Ltd. | Pharmaceutical formulation containing angiotensin-ii receptor blocker |
| AU2009257174A1 (en) * | 2008-06-09 | 2009-12-17 | Dimerix Bioscience Pty Ltd | Novel receptor hetero-dimers/-oligomers |
| KR101033975B1 (ko) * | 2008-10-10 | 2011-05-11 | 이희엽 | 직접압축법을 이용한 발사르탄 함유 고형 경구 제형의 제조방법 및 이에 따라 제조된 고형 경구 제형 |
| DE102008051783A1 (de) | 2008-10-17 | 2010-04-22 | Tiefenbacher Pharmachemikalien Alfred E. Tiefenbacher Gmbh & Co. Kg | Valsartan enthaltende Tablette |
| US9387249B2 (en) | 2008-12-23 | 2016-07-12 | Takeda Pharmaceutical Company Limited | Methods of treating hypertension with at least one angiotensin II receptor blocker and chlorthalidone |
| WO2010104485A2 (fr) | 2009-03-11 | 2010-09-16 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Préparations de valsartan |
| WO2011027021A1 (fr) * | 2009-09-01 | 2011-03-10 | Orion Corporation | Procédé de traitement de l'hypertension |
| KR101084783B1 (ko) * | 2009-09-01 | 2011-11-22 | 삼성에스디아이 주식회사 | 이차 전지 및 그의 제조 방법 |
| ES2364011B1 (es) | 2009-11-20 | 2013-01-24 | Gp Pharm, S.A. | Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados para el tratamiento de enfermedades cardiovasculares. |
| CN101897675B (zh) * | 2010-02-10 | 2012-11-21 | 温士顿医药股份有限公司 | 含有凡尔沙坦或其药学上可接受的盐的固体剂型口服医药组成物 |
| WO2011102702A2 (fr) | 2010-02-16 | 2011-08-25 | Krka, D. D., Novo Mesto | Procédé pour la préparation de formes posologiques solides orales comprenant du valsartan |
| AR083417A1 (es) | 2010-10-14 | 2013-02-21 | Novartis Ag | Composiciones farmaceuticas que contienen un dgat1 inhibidor |
| JP5882796B2 (ja) | 2011-03-31 | 2016-03-09 | キヤノン株式会社 | 振動体の駆動方法、振動装置、該振動装置を有する駆動装置、及び光学機器 |
| GB201116993D0 (en) * | 2011-10-03 | 2011-11-16 | Ems Sa | Pharmaceutical compositions of antihypertensives |
| MX2014007933A (es) | 2011-12-26 | 2014-07-30 | Novartis Ag | Comprimidos y agentes recubiertos en seco. |
| WO2013098576A1 (fr) | 2011-12-31 | 2013-07-04 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Composition pharmaceutique de valsartan à libération immédiate |
| WO2013098578A1 (fr) | 2011-12-31 | 2013-07-04 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Composition pharmaceutique d'hydrochlorothiazide de valsartan à libération immédiate |
| JP6018420B2 (ja) * | 2012-06-05 | 2016-11-02 | ニプロ株式会社 | アンジオテンシンｉｉ受容体拮抗薬およびサイアザイド系利尿薬を含む医薬組成物 |
| WO2014038895A1 (fr) * | 2012-09-06 | 2014-03-13 | 한국콜마주식회사 | Forme posologique orale solide contenant du valsartan et son procédé de préparation |
| JP2014062064A (ja) * | 2012-09-21 | 2014-04-10 | Ohara Yakuhin Kogyo Kk | バルサルタン含有錠剤の製造方法 |
| JP6238831B2 (ja) * | 2014-04-25 | 2017-11-29 | 沢井製薬株式会社 | バルサルタン含有錠剤及びその製造方法 |
| JP6141472B2 (ja) * | 2016-03-02 | 2017-06-07 | 大原薬品工業株式会社 | バルサルタン含有錠剤の製造方法 |
| WO2018002673A1 (fr) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Nouvelles formulations d'antagonistes du récepteur de l'angiotensine ii |
| CN117542473A (zh) | 2018-06-14 | 2024-02-09 | 阿斯利康(英国)有限公司 | 用血管紧张素ii受体阻滞剂医药组合物治疗高血压的方法 |
| EP4295839A1 (fr) | 2022-06-20 | 2023-12-27 | KRKA, d.d., Novo mesto | Combinaison de valsartan et d'indapamide |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3200039A (en) | 1962-05-28 | 1965-08-10 | Pfizer & Co C | Non-granulated tablets with 20% sorbitol in a particle size of from about 100mu to about 2000mu |
| GB1422176A (en) | 1973-05-05 | 1976-01-21 | Beecham Group Ltd | Pharmaceutical tablets |
| AU528098B2 (en) | 1978-11-16 | 1983-04-14 | Beecham Group Plc | Analgesic tablet |
| US4353887A (en) | 1979-08-16 | 1982-10-12 | Ciba-Geigy Corporation | Divisible tablet having controlled and delayed release of the active substance |
| US4238485A (en) * | 1979-10-29 | 1980-12-09 | Merck & Co., Inc. | Novel pharmaceutical compositions |
| EP0070127A3 (fr) | 1981-07-10 | 1983-08-17 | Beecham Group Plc | Comprimés |
| US4543359A (en) * | 1982-10-01 | 1985-09-24 | Eaton Laboratories, Inc. | Treating cardiac arrhythmias with dantrolene sodium |
| HU187215B (en) * | 1983-01-26 | 1985-11-28 | Egyt Gyogyszervegyeszeti Gyar | Method for producing pharmaceutical product of high actor content and prolonged effect |
| US4609675A (en) * | 1984-08-17 | 1986-09-02 | The Upjohn Company | Stable, high dose, high bulk density ibuprofen granulations for tablet and capsule manufacturing |
| US4743612A (en) * | 1986-10-17 | 1988-05-10 | Berlex Laboratories, Inc. | Prodrug derivatives of the cardiotonic agent 4-ethyl-1,3-dihydro-5-(4-(2-methyl-1H-imidazol-1-yl)benzoyl)-2H-imidazol-2-one, composition containing them, and method of using them to treat cardiac failure |
| DE3705055A1 (de) * | 1987-02-18 | 1988-09-01 | Boehringer Ingelheim Kg | Verwendung von 2-(3-fluor-4-methylphenylimino)-imidazolidin zur behandlung der koronaren herzkrankheit |
| JP2518854B2 (ja) * | 1987-06-19 | 1996-07-31 | 旭化成工業株式会社 | 固形製剤の製法 |
| DE3739779A1 (de) * | 1987-11-24 | 1989-06-08 | Beiersdorf Ag | Pharmazeutische praeparate |
| SE506179C2 (sv) * | 1989-01-23 | 1997-11-17 | Ciba Geigy Ag | Farmaceutisk lågkomposition av benazepril och ett tiaziddiuretikum |
| GB8909793D0 (en) | 1989-04-28 | 1989-06-14 | Beecham Group Plc | Pharmaceutical formulation |
| EP0443983B1 (fr) * | 1990-02-19 | 1996-02-28 | Ciba-Geigy Ag | Composés acylés |
| CA2092565A1 (fr) * | 1990-09-28 | 1992-03-29 | Robert T. Sims | Compositions renfermant de l'ibuprofene et un diuretique |
| ATE216577T1 (de) * | 1992-01-29 | 2002-05-15 | Takeda Chemical Industries Ltd | Schnellösliche tablette und ihre herstellung |
| ZA931063B (en) | 1992-02-17 | 1993-09-23 | Ciba Geigy | Treatment of glaucoma. |
| US5395627A (en) * | 1992-09-04 | 1995-03-07 | Akzo N.V. | Pharmaceutical granulate |
| IT1255522B (it) * | 1992-09-24 | 1995-11-09 | Ubaldo Conte | Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita' |
| WO1994009778A1 (fr) | 1992-10-26 | 1994-05-11 | Merck & Co., Inc. | Combinaisons d'antagonistes et de diuretiques recepteurs de l'angiotensine ii |
| EP0676967A4 (fr) | 1992-12-30 | 1996-10-02 | Fmc Corp | Excipient a liberation, prolongee, facile a produire, a base de glucomannane de konjac. |
| JP3057471B2 (ja) * | 1993-06-07 | 2000-06-26 | 武田薬品工業株式会社 | アンジオテンシンｉｉ介在性諸疾患の予防または治療剤 |
| US5464854A (en) | 1993-11-11 | 1995-11-07 | Depadova; Anathony S. | Method of modifying ovarian hormone-regulated AT1 receptor activity as treatment of incapacitating symptom(s) of P.M.S. |
| AT401871B (de) * | 1994-01-28 | 1996-12-27 | Gebro Broschek Gmbh | Verfahren zur herstellung von s(+)-ibuprofen- partikeln mit verbesserten fliesseigenschaften und deren verwendung zur arzneimittelherstellung |
| JP3534130B2 (ja) * | 1994-03-01 | 2004-06-07 | 旭化成ケミカルズ株式会社 | 医薬品組成物 |
| GB9404010D0 (en) * | 1994-03-02 | 1994-04-20 | Opt Tel Services Limited | Telephone dialling monitoring and route selecting apparatus |
| CA2184712A1 (fr) * | 1994-03-17 | 1995-09-21 | Marc De Gasparo | Traitement de la nephropathie diabetique a l'aide de valsartan |
| GB9408117D0 (en) | 1994-04-23 | 1994-06-15 | Smithkline Beecham Corp | Pharmaceutical formulations |
| DE19502065C2 (de) * | 1995-01-14 | 1996-05-02 | Prophyta Biolog Pflanzenschutz | Pilzisolat mit fungizider Wirkung |
| US5994348A (en) * | 1995-06-07 | 1999-11-30 | Sanofi | Pharmaceutical compositions containing irbesartan |
| FR2735365B1 (fr) * | 1995-06-14 | 1997-09-05 | Sanofi Sa | Utilisation d'un antagoniste de l'angiotensine ii et d'un derive du benzofurane pour la preparation d'un medicament utile dans le traitement des affections cardiovasculaires |
| GB9613470D0 (en) * | 1996-06-27 | 1996-08-28 | Ciba Geigy Ag | Small solid oral dosage form |
| JP2011123241A (ja) * | 2009-12-10 | 2011-06-23 | Canon Inc | 撮影システム |
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