SK285312B6 - Polymorf (III) donepezil hydrochloridu, spôsob jeho výroby a terapeutický prostriedok s jeho obsahom - Google Patents

Polymorf (III) donepezil hydrochloridu, spôsob jeho výroby a terapeutický prostriedok s jeho obsahom Download PDF

Info

Publication number
SK285312B6
SK285312B6 SK1676-98A SK167698A SK285312B6 SK 285312 B6 SK285312 B6 SK 285312B6 SK 167698 A SK167698 A SK 167698A SK 285312 B6 SK285312 B6 SK 285312B6
Authority
SK
Slovakia
Prior art keywords
polymorph
donepezil hydrochloride
iii
donepezil
hydrochloric acid
Prior art date
Application number
SK1676-98A
Other languages
English (en)
Slovak (sk)
Other versions
SK167698A3 (en
Inventor
Akio Imai
Hideaki Watanabe
Takashi Kajima
Yasushi Ishihama
Akiyo Ohtsuka
Tomohide Tanaka
Yukio Narabu
Original Assignee
Eisai Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP1996/003881 external-priority patent/WO1997046526A1/fr
Application filed by Eisai Co., Ltd. filed Critical Eisai Co., Ltd.
Publication of SK167698A3 publication Critical patent/SK167698A3/sk
Publication of SK285312B6 publication Critical patent/SK285312B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
SK1676-98A 1996-06-07 1997-06-06 Polymorf (III) donepezil hydrochloridu, spôsob jeho výroby a terapeutický prostriedok s jeho obsahom SK285312B6 (sk)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP14629396 1996-06-07
PCT/JP1996/003881 WO1997046526A1 (fr) 1996-06-07 1996-12-27 Polymorphes stables d'hydrochlorure de 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methyl-piperidine), dit hydrochlorure de donepezil et procede pour leur production
US08/774,802 US6140321A (en) 1996-06-07 1996-12-30 Polymorphs of donepezil hydrochloride and process for production
PCT/JP1997/001932 WO1997046527A1 (fr) 1996-06-07 1997-06-06 Polymorphes de chlorhydrate de donepezil, et leur procede de production

Publications (2)

Publication Number Publication Date
SK167698A3 SK167698A3 (en) 1999-06-11
SK285312B6 true SK285312B6 (sk) 2006-10-05

Family

ID=27307991

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1676-98A SK285312B6 (sk) 1996-06-07 1997-06-06 Polymorf (III) donepezil hydrochloridu, spôsob jeho výroby a terapeutický prostriedok s jeho obsahom

Country Status (12)

Country Link
EP (2) EP1019374B1 (fr)
AU (1) AU731282B2 (fr)
CA (1) CA2252806C (fr)
DK (1) DK1019374T3 (fr)
ES (1) ES2188946T3 (fr)
HK (1) HK1020952A1 (fr)
NO (1) NO321267B1 (fr)
NZ (1) NZ333197A (fr)
RU (1) RU2190603C2 (fr)
SI (1) SI9720038B (fr)
SK (1) SK285312B6 (fr)
WO (1) WO1997046527A1 (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE241358T1 (de) 1997-03-03 2003-06-15 Eisai Co Ltd Verwendung von cholinesterasehemmer zur behandlung von konzentrationsstörungen
GB9716879D0 (en) * 1997-08-08 1997-10-15 Shire Int Licensing Bv Treatment of attention deficit disorders
ATE260896T1 (de) 1997-12-05 2004-03-15 Eisai Co Ltd Donepezil polykristalle und verfharen zu ihrer herstellung
US6193993B1 (en) * 1998-03-03 2001-02-27 Eisai Co., Ltd. Suppository containing an antidementia medicament
PL346242A1 (en) * 1998-06-16 2002-01-28 Lilly Co Eli Methods for increasing levels of acetylcholine
TR200003704T2 (tr) 1998-06-16 2001-06-21 Eli Lilly And Company Asetilkolin düzeylerini arttırma
US6288108B1 (en) 1998-06-16 2001-09-11 Eli Lilly And Company Methods for increasing levels of acetylcholine
PT1311272E (pt) 2000-03-03 2007-02-28 Eisai R&D Man Co Ltd Novos métodos utilizando inibidores de colinesterase
SI21223A (sl) * 2002-06-19 2003-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Farmacevtska formulacija s stabiliziranim amorfnim donepezilijevim kloridom
IL150509A (en) 2002-07-01 2007-07-04 Joseph Kaspi Pharmaceutical preparations containing donafazil hydrochloride
AU2003287433A1 (en) * 2002-11-01 2004-06-07 Oregon Health And Science University Treatment of hyperkinetic movement disorder with donepezil
US7186842B2 (en) 2003-02-12 2007-03-06 Usv, Ltd. Polymorph of (1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-y1] methyl piperidine hydrochloride (Donepezil hydrochloride) and a process for producing thereof
US20050288330A1 (en) * 2004-06-29 2005-12-29 Avinash Naidu Process for producing a polymorphic form of (1-Benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine hydrochloride (donepezil hydrochloride)
WO2004092137A1 (fr) * 2003-04-16 2004-10-28 Hetero Drugs Limited Nouvelles formes cristallines de chlorhydrate de donepezil
EP1771416A1 (fr) * 2004-07-28 2007-04-11 USV Limited Nouveau polymorphe de (1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine hydrochlorure (hydrochlorure de donepezil) et son procede de production
WO2006015338A2 (fr) * 2004-07-30 2006-02-09 Dr. Reddy's Laboratories Ltd. Forme cristalline de chlorhydrate de donepezil
RS51271B (sr) * 2004-10-19 2010-12-31 Krka Tovarna Zdravil D.D. Čvrsta farmaceutska kompozicija koja sadrži donepezil hidrohlorid
EP1858847A1 (fr) * 2005-02-28 2007-11-28 Ranbaxy Laboratories Limited Chlorhydrate de donepezil de formule i stable et son procede de preparation et d'utilisation dans des compositions pharmaceutiques
WO2006097341A1 (fr) * 2005-03-17 2006-09-21 Synthon B.V. Procede de preparation du monohydrate d'hydrochlorure de donepezil cristallin
WO2006111983A2 (fr) * 2005-04-21 2006-10-26 Jubilant Organosys Limited Nouvelle forme polymorphe de chlorhydrate de (l-benzyl-4-[(5,6-dimethoxy-l- indanone)-2-yl]methyl piperidine et procede permettant de preparer celle-ci
GB0515803D0 (en) * 2005-07-30 2005-09-07 Pliva Hrvatska D O O Intermediate compounds
HU227474B1 (en) * 2005-12-20 2011-07-28 Richter Gedeon Nyrt Process for industrial scale production of high purity donepezil hydrochloride polymorph i.
SI2032521T1 (sl) 2006-06-27 2010-02-26 Sandoz Ag Nov postopek za pripravo soli
US8247563B2 (en) 2006-12-11 2012-08-21 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors
DE102007037932A1 (de) 2007-08-11 2009-02-12 Alfred E. Tiefenbacher Gmbh & Co.Kg Donepezilhydrochlorid in amorpher Form enthaltende Tablette
CN102603612A (zh) * 2007-09-28 2012-07-25 天津和美生物技术有限公司 多奈哌齐盐的多晶型物及其制备和应用
JP5562337B2 (ja) * 2008-12-17 2014-07-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 ドネペジルの多形結晶及びその製造方法
DE102010010998A1 (de) 2010-03-10 2011-09-15 Stada Arzneimittel Ag Feste pharmazeutische Zusammensetzung, umfassend Donepezil-Hydrochlorid der kristallinen polymorphen Form I
WO2011151359A1 (fr) 2010-06-02 2011-12-08 Noscira, S.A. Traitement combiné comprenant un inhibiteur de la cholinestérase et un dérivé de thiadiazolidinedione
EP2502620A1 (fr) 2011-03-24 2012-09-26 Krka Tovarna Zdravil, D.D., Novo Mesto Composition pharmaceutique solide comportant du donépézil
CN110393440B (zh) * 2019-06-28 2021-08-13 顾美红 一种即热式烧水机

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi

Also Published As

Publication number Publication date
SI9720038A (sl) 1999-06-30
NO321267B1 (no) 2006-04-10
NO985721L (no) 1999-01-28
SI9720038B (sl) 2010-06-30
NO985721D0 (no) 1998-12-07
SK167698A3 (en) 1999-06-11
EP1211243B1 (fr) 2009-10-14
EP1211243A1 (fr) 2002-06-05
HK1020952A1 (en) 2000-05-26
WO1997046527A1 (fr) 1997-12-11
DK1019374T3 (da) 2003-04-07
RU2190603C2 (ru) 2002-10-10
ES2188946T3 (es) 2003-07-01
EP1019374B1 (fr) 2003-01-02
AU731282B2 (en) 2001-03-29
CA2252806A1 (fr) 1997-12-11
NZ333197A (en) 2001-03-30
CA2252806C (fr) 2005-11-22
AU2979297A (en) 1998-01-05
EP1019374A1 (fr) 2000-07-19

Similar Documents

Publication Publication Date Title
SK285312B6 (sk) Polymorf (III) donepezil hydrochloridu, spôsob jeho výroby a terapeutický prostriedok s jeho obsahom
KR100545851B1 (ko) 염산 도네페질의 다형결정 및 그 제법
US5985864A (en) Polymorphs of donepezil hydrochloride and process for production
KR100629825B1 (ko) ＥｔＯ2Ｃ-ＣＨ2-(Ｒ)Ｃｇｌ-Ａｚｅ-Ｐａｂ-ＯＨ의 결정질형태
KR100523366B1 (ko) 티에닐아졸일알콕시에탄아민, 이의 제조방법 및 이의 용도
NO171453B (no) Fremgangsmaate for fremstilling av krystallinsk paroxetin-hydroklorid-hemihydrat
CA2107223C (fr) Chlorhydrate de tiagabine monohydrate cristallin, sa preparation et son utilisation
JPH1053576A (ja) 塩酸ドネペジルの多形結晶およびその製造法
AU636041B2 (en) New oxazolopyridine compounds, process for preparing these and pharmaceutical compositions containing them
US6538012B2 (en) Amlodipine hemimaleate
US4528299A (en) 1-(2,3-Dimethyl-4-methoxyphenyl)-2-methyl-3-(1-pyrrolidinyl)-1-propanone and anti-spastic use thereof
CZ296619B6 (cs) Modifikace donepezilhydrochloridu, zpusob její výroby a pouzití
SK281980B6 (sk) Kryštallický (+)l-hydrogenvínan, spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahom a jeho použitie
KR100522574B1 (ko) 염산도네페질의다형결정및그제법
JPH08511782A (ja) Ｎ−置換アザ複素環式カルボン酸類とそのエステル類
WO1994006772A1 (fr) Derive de 3-azabicyclo[3.2.1]octane, procede de production et utilisation

Legal Events

Date Code Title Description
MK4A Expiry of patent

Expiry date: 20170606