SK284157B6 - 3'-N-Oxid, 3'-N-dimetylamín, 9-oxím-deriváty erytromycínu A a spôsob ich prípravy - Google Patents

3'-N-Oxid, 3'-N-dimetylamín, 9-oxím-deriváty erytromycínu A a spôsob ich prípravy Download PDF

Info

Publication number
SK284157B6
SK284157B6 SK974-99A SK97499A SK284157B6 SK 284157 B6 SK284157 B6 SK 284157B6 SK 97499 A SK97499 A SK 97499A SK 284157 B6 SK284157 B6 SK 284157B6
Authority
SK
Slovakia
Prior art keywords
group
lower alkyl
oxime
atoms
aryl
Prior art date
Application number
SK974-99A
Other languages
English (en)
Slovak (sk)
Other versions
SK97499A3 (en
Inventor
Yi-Yin Ku
David A. Riley
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of SK97499A3 publication Critical patent/SK97499A3/sk
Publication of SK284157B6 publication Critical patent/SK284157B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SK974-99A 1997-02-13 1998-02-03 3'-N-Oxid, 3'-N-dimetylamín, 9-oxím-deriváty erytromycínu A a spôsob ich prípravy SK284157B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/800,009 US5864023A (en) 1997-02-13 1997-02-13 3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives
PCT/US1998/001929 WO1998035976A1 (en) 1997-02-13 1998-02-03 3'-n-oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives

Publications (2)

Publication Number Publication Date
SK97499A3 SK97499A3 (en) 2000-01-18
SK284157B6 true SK284157B6 (sk) 2004-10-05

Family

ID=25177295

Family Applications (1)

Application Number Title Priority Date Filing Date
SK974-99A SK284157B6 (sk) 1997-02-13 1998-02-03 3'-N-Oxid, 3'-N-dimetylamín, 9-oxím-deriváty erytromycínu A a spôsob ich prípravy

Country Status (25)

Country Link
US (1) US5864023A (zh)
EP (1) EP0966477B1 (zh)
JP (1) JP2001512456A (zh)
KR (1) KR100561326B1 (zh)
CN (1) CN1326865C (zh)
AR (1) AR012032A1 (zh)
AT (1) ATE252108T1 (zh)
AU (1) AU725274B2 (zh)
BG (1) BG64099B1 (zh)
BR (1) BR9807349A (zh)
CA (1) CA2279932C (zh)
CZ (1) CZ294481B6 (zh)
DE (1) DE69818977T2 (zh)
DK (1) DK0966477T3 (zh)
ES (1) ES2212266T3 (zh)
HU (1) HUP0001330A3 (zh)
IL (1) IL130697A0 (zh)
NO (1) NO993876D0 (zh)
NZ (1) NZ336482A (zh)
PL (1) PL187357B1 (zh)
PT (1) PT966477E (zh)
SK (1) SK284157B6 (zh)
TR (1) TR199901874T2 (zh)
WO (1) WO1998035976A1 (zh)
ZA (1) ZA98986B (zh)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100317907B1 (ko) * 1998-11-24 2001-12-24 김 완 주 신규한 중간체, 이를 이용한 마크로라이드계 항생제의제조방법
US6437106B1 (en) 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
KR20010008496A (ko) * 1999-07-01 2001-02-05 유충식 6-오-메틸 에리트로마이신의 제조방법
KR100336447B1 (ko) * 1999-11-24 2002-05-15 민경윤 클라리스로마이신의 개선된 제조방법
WO2001044262A1 (en) * 1999-12-16 2001-06-21 Teva Pharmaceutical Industries Ltd. Processes for preparing clarithromycin polymorphs and novel polymorph iv
CA2397092A1 (en) * 2000-01-11 2001-07-19 Teva Pharmaceutical Industries Ltd. Processes for preparing clarithromycin polymorphs
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
WO2001064224A1 (en) 2000-02-29 2001-09-07 Teva Pharmaceutical Industries Ltd. Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
ATE338053T1 (de) * 2000-03-15 2006-09-15 Hanmi Pharm Ind Co Ltd Verfahren zur herstellung von clarythromycin mit nicht pharmazeutischer qualität
KR20000037126A (ko) * 2000-04-08 2000-07-05 김용규 6-메틸 에리스로마이신 ａ의 제조방법
US20020068078A1 (en) * 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020197314A1 (en) * 2001-02-23 2002-12-26 Rudnic Edward M. Anti-fungal composition
CA2533292C (en) * 2003-07-21 2013-12-31 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
EP1648418A4 (en) * 2003-07-21 2011-11-16 Middlebrook Pharmaceuticals Inc ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION
AU2004258949B2 (en) * 2003-07-21 2011-02-10 Shionogi, Inc. Antibiotic product, use and formulation thereof
CA2535177A1 (en) * 2003-08-11 2005-02-24 Advancis Pharmaceutical Corporation Robust pellet
EP1653924A4 (en) 2003-08-12 2009-09-09 Middlebrook Pharmaceuticals In ANTIBIOTICS, USE AND FORMULATION ASSOCIATED
CA2535780A1 (en) * 2003-08-29 2005-03-17 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
US8460710B2 (en) * 2003-09-15 2013-06-11 Shionogi, Inc. Antibiotic product, use and formulation thereof
JP2007517039A (ja) * 2003-12-24 2007-06-28 アドバンシス ファーマスーティカル コーポレイション 変性放出製剤の吸収増強
CA2572292A1 (en) * 2004-07-02 2006-02-09 Advancis Pharmaceutical Corporation Tablet for pulsed delivery
US7694523B2 (en) * 2004-07-19 2010-04-13 Earthrenew, Inc. Control system for gas turbine in material treatment unit
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) * 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
US20090054634A1 (en) * 2007-08-09 2009-02-26 Vinod Kumar Kansal Process for the preparation of clarithromycin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
JPS60214796A (ja) * 1984-04-06 1985-10-28 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシン類の製法
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
US4670549A (en) * 1985-03-18 1987-06-02 Taisho Pharmaceutical Co., Ltd. Method for selective methylation of erythromycin a derivatives
JPS61229895A (ja) * 1985-04-03 1986-10-14 Nippon Zeon Co Ltd 保護化デス−ｎ−メチルエリスロマイシン誘導体
EP0254534A3 (en) * 1986-07-24 1991-04-17 William S. Robinson Erythromycin derivatives and compositions and use for inhibiting virus replication and disease
DE3782994T2 (de) * 1986-09-18 1993-04-08 Taisho Pharma Co Ltd Erythromycin-a-derivate und verfahren zu ihrer herstellung.
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
JP2751385B2 (ja) * 1988-05-19 1998-05-18 大正製薬株式会社 エリスロマイシンａオキシム及びその塩の製造方法

Also Published As

Publication number Publication date
PT966477E (pt) 2004-03-31
HUP0001330A2 (hu) 2000-08-28
BG64099B1 (bg) 2003-12-31
KR100561326B1 (ko) 2006-03-16
BR9807349A (pt) 2000-04-25
CZ270499A3 (cs) 1999-11-17
NO993876L (no) 1999-08-11
SK97499A3 (en) 2000-01-18
BG103673A (en) 2000-02-29
AU725274B2 (en) 2000-10-12
CN1326865C (zh) 2007-07-18
IL130697A0 (en) 2000-06-01
DE69818977T2 (de) 2004-08-12
CZ294481B6 (cs) 2005-01-12
HUP0001330A3 (en) 2000-09-28
EP0966477A1 (en) 1999-12-29
ZA98986B (en) 1998-08-05
TR199901874T2 (xx) 2000-04-21
CN1246864A (zh) 2000-03-08
JP2001512456A (ja) 2001-08-21
NO993876D0 (no) 1999-08-11
KR20000070985A (ko) 2000-11-25
DE69818977D1 (en) 2003-11-20
NZ336482A (en) 2001-02-23
ATE252108T1 (de) 2003-11-15
CA2279932C (en) 2008-04-22
CA2279932A1 (en) 1998-08-20
EP0966477B1 (en) 2003-10-15
ES2212266T3 (es) 2004-07-16
PL187357B1 (pl) 2004-06-30
US5864023A (en) 1999-01-26
AR012032A1 (es) 2000-09-27
AU6260898A (en) 1998-09-08
PL335301A1 (en) 2000-04-10
WO1998035976A1 (en) 1998-08-20
DK0966477T3 (da) 2004-02-23

Similar Documents

Publication Publication Date Title
SK284157B6 (sk) 3'-N-Oxid, 3'-N-dimetylamín, 9-oxím-deriváty erytromycínu A a spôsob ich prípravy
US5872229A (en) Process for 6-O-alkylation of erythromycin derivatives
EP0158467B1 (en) Method for selective methylation of erythromycin a derivatives
EP1040107B1 (en) 6-o-alkyl derivatives of erythronolide b
EP0891370A1 (en) 2'-protected 3'-dimethylamine, 9-etheroxime erythromycin a derivatives
WATANABE et al. CHEMICAL MODIFICATION OF ERYTHROMYCINS. IX. 1) SELECTIVE METHYLATION AT THE C-6 HYDROXYL GROUP OF ERYTHROMYCIN A OXIME DERIVATIVES AND PREPARATION OF CLARITHROMYCIN
KR100336447B1 (ko) 클라리스로마이신의 개선된 제조방법
MXPA99007519A (en) 3'-n-oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives
AU2002357482B2 (en) Method for the production of desclarithromycin, and intermediate products
KR20010032613A (ko) 6-ｏ-알킬 에리트로마이신 ｃ의 화학적 합성 방법
CA2250736C (en) 2'-protected 3'-dimethylamine, 9-etheroxime erythromycin a derivatives
KR20010010096A (ko) 클라리스로마이신의 제조방법 및 이에 사용되는 중간체
CA2526732A1 (en) Q-alkyl macrolide and azalide derivatives and regioselective process for their preparation
WO2005021567A1 (en) O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
KR20000037127A (ko) 에리스로마이신 ａ 6-메틸 유도체의 제조방법
KR20010100197A (ko) 에리스로마이신 에이 9-오-트로필옥심 유도체를 이용한클라리스로마이신의 제조방법
MXPA00005402A (en) 6-o-alkyl derivatives of erythronolide b
MXPA00005404A (en) Chemical synthesis of 6-o-alkyl erythromycin c

Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20100203