SK283734B6 - Kryštálové modifikácie 1-(2,6-difluórbenzyl)-1H-1,2,3-triazol-4- karboxamidu, farmaceutické prípravky, ktoré ich obsahujú, a ich použitie - Google Patents

Kryštálové modifikácie 1-(2,6-difluórbenzyl)-1H-1,2,3-triazol-4- karboxamidu, farmaceutické prípravky, ktoré ich obsahujú, a ich použitie Download PDF

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Publication number
SK283734B6
SK283734B6 SK1094-98A SK109498A SK283734B6 SK 283734 B6 SK283734 B6 SK 283734B6 SK 109498 A SK109498 A SK 109498A SK 283734 B6 SK283734 B6 SK 283734B6
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SK
Slovakia
Prior art keywords
weak
light
crystal modification
medium
strong
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Application number
SK1094-98A
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English (en)
Slovak (sk)
Other versions
SK109498A3 (en
Inventor
Robert Portmann
Urs Christoph Hofmeier
Andreas Burkhard
Walter Scherrer
Martin Szelagiewicz
Original Assignee
Novartis Ag
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Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SK109498A3 publication Critical patent/SK109498A3/sk
Publication of SK283734B6 publication Critical patent/SK283734B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK1094-98A 1997-06-10 1998-06-08 Kryštálové modifikácie 1-(2,6-difluórbenzyl)-1H-1,2,3-triazol-4- karboxamidu, farmaceutické prípravky, ktoré ich obsahujú, a ich použitie SK283734B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH140497 1997-06-10
PCT/EP1998/003428 WO1998056773A1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic

Publications (2)

Publication Number Publication Date
SK109498A3 SK109498A3 (en) 1998-12-02
SK283734B6 true SK283734B6 (sk) 2003-12-02

Family

ID=4209650

Family Applications (2)

Application Number Title Priority Date Filing Date
SK1094-98A SK283734B6 (sk) 1997-06-10 1998-06-08 Kryštálové modifikácie 1-(2,6-difluórbenzyl)-1H-1,2,3-triazol-4- karboxamidu, farmaceutické prípravky, ktoré ich obsahujú, a ich použitie
SK1093-98A SK283685B6 (sk) 1997-06-10 1998-06-08 Kryštálová modifikácia 1-(2,6-difluórbenzyl)-1H-1,2,3-triazol-4- karboxamidu, farmaceutické prípravky, ktoré ju obsahujú, a jej použitie

Family Applications After (1)

Application Number Title Priority Date Filing Date
SK1093-98A SK283685B6 (sk) 1997-06-10 1998-06-08 Kryštálová modifikácia 1-(2,6-difluórbenzyl)-1H-1,2,3-triazol-4- karboxamidu, farmaceutické prípravky, ktoré ju obsahujú, a jej použitie

Country Status (37)

Country Link
US (6) US6740669B1 (es)
EP (2) EP0994864B1 (es)
JP (2) JP3672574B2 (es)
KR (2) KR100425656B1 (es)
CN (3) CN1159300C (es)
AR (4) AR012946A1 (es)
AT (2) ATE232852T1 (es)
AU (2) AU725528B2 (es)
BR (2) BR9804946A (es)
CA (3) CA2614926C (es)
CO (2) CO4940448A1 (es)
CY (1) CY2007014I1 (es)
CZ (2) CZ292481B6 (es)
DE (3) DE69813560T2 (es)
DK (2) DK0994864T3 (es)
ES (2) ES2197485T3 (es)
FR (1) FR07C0037I2 (es)
HK (3) HK1028241A1 (es)
HU (2) HU226107B1 (es)
ID (2) ID27660A (es)
IL (2) IL125732A (es)
LU (1) LU91345I2 (es)
MY (2) MY125854A (es)
NL (1) NL300284I2 (es)
NO (2) NO329314B1 (es)
NZ (2) NZ331371A (es)
PE (2) PE79799A1 (es)
PL (2) PL192114B1 (es)
PT (1) PT994864E (es)
RU (2) RU2198167C2 (es)
SI (2) SI0994863T1 (es)
SK (2) SK283734B6 (es)
TR (2) TR199801630T1 (es)
TW (2) TW403740B (es)
UY (1) UY25844A1 (es)
WO (2) WO1998056772A1 (es)
ZA (2) ZA984967B (es)

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Publication number Priority date Publication date Assignee Title
TW403740B (en) 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
AU2003249658A1 (en) * 2002-05-31 2003-12-19 Schering Corporation Xanthine phosphodiesterase v inhibitor polymorphs
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20090069390A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched rufinamide
CA2736703A1 (en) * 2008-10-13 2010-04-22 Cipla Limited Process for the preparation of rufinamide
CN101768124B (zh) * 2008-12-30 2012-01-04 北京本草天源药物研究院 一种药物晶体及其制备方法和用途
IT1395736B1 (it) 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
BR112012004539A2 (pt) * 2009-09-04 2020-09-15 Tactical Therapeutics, Inc. composto, composto de orotato, polimorfo de forma 1 e poliformo de forma 2
JP2013525413A (ja) * 2010-04-30 2013-06-20 ラボラトリオス レスヴィ，エス．エル． ルフィナマイド中間体の改良された製造方法
EP2465853A1 (en) 2010-12-14 2012-06-20 Laboratorios Lesvi, S.L. Polymorph of rufinamide and process for obtaining it
ITMI20110718A1 (it) 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
US10206874B2 (en) 2012-07-20 2019-02-19 Hetero Research Foundation Rufinamide solid dispersion
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

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US4156734A (en) 1976-02-13 1979-05-29 Merck & Co., Inc. Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
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US4536518A (en) 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4346097A (en) * 1980-09-30 1982-08-24 Warner-Lambert Company Method for treating convulsions with pyrazole-4-carboxamide derivatives
US4789680A (en) * 1982-12-23 1988-12-06 Ciba-Geigy Corporation Aralkyltriazole compounds
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US4511572A (en) * 1983-03-18 1985-04-16 The University Of Kentucky Research Foundation Triazoline anticonvulsant drugs
FI93544C (fi) * 1985-04-18 1995-04-25 Ciba Geigy Ag Menetelmä fluorattujen, antikonvulsiivisesti vaikuttavien 1-bentsyyli-1H-1,2,3-triatsoliyhdisteiden valmistamiseksi
CA2002864C (en) 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
JPH02214504A (ja) 1989-02-15 1990-08-27 Nissan Chem Ind Ltd 光学活性キノキサリン化合物の晶析法
EP0484437A4 (en) 1989-07-27 1994-06-01 Searle & Co Renal-selective prodrugs for the treatment of hypertension
IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
JP2550456B2 (ja) 1990-11-06 1996-11-06 山之内製薬株式会社 縮合ピラジン誘導体
JP2753911B2 (ja) 1991-12-06 1998-05-20 キッセイ薬品工業株式会社 Ｎ−ｔｅｒｔ−ブチル−１−メチル−３，３−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法
DE4217952A1 (de) 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
US5248699A (en) 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
US5631373A (en) 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
GB9418443D0 (en) 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
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DK0812320T3 (da) 1995-02-22 2003-04-14 Aventis Pharma Ltd Amorft piretanid, polymorfe former deraf, fremgangsmåde til fremstilling deraf og deres anvendelse
CZ294775B6 (cs) * 1996-07-11 2005-03-16 Novartis Ag Způsob přípravy 1-substituovaných 4-kyan-1,2,3-triazolů
TW403740B (en) 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide

Also Published As

Publication number Publication date
ATE237599T1 (de) 2003-05-15
TW403740B (en) 2000-09-01
BR9804946A (pt) 1999-08-24
EP0994863A1 (en) 2000-04-26
CA2614926A1 (en) 1998-12-17
TW526195B (en) 2003-04-01
HK1028031A1 (en) 2001-02-02
CN1572789A (zh) 2005-02-02
NL300284I2 (nl) 2007-11-01
US6455556B2 (en) 2002-09-24
ATE232852T1 (de) 2003-03-15
NZ331371A (en) 2000-08-25
CN1298708C (zh) 2007-02-07
TR199801630T1 (xx) 1999-06-21
US8076362B2 (en) 2011-12-13
HK1028242A1 (en) 2001-02-09
UY25844A1 (es) 2001-08-27
DE69811500T2 (de) 2004-04-01
DE122007000051I2 (de) 2009-02-19
RU2194041C2 (ru) 2002-12-10
EP0994864B1 (en) 2003-04-16
PE80999A1 (es) 1999-09-06
ES2192779T3 (es) 2003-10-16
CA2614926C (en) 2010-02-09
ID21014A (id) 1999-04-08
BR9804947A (pt) 1999-08-24
NO329314B1 (no) 2010-09-27
CA2256013C (en) 2007-10-16
RU2198167C2 (ru) 2003-02-10
KR19990087835A (ko) 1999-12-27
KR19990087836A (ko) 1999-12-27
AU725517B2 (en) 2000-10-12
SK109398A3 (en) 1998-12-02
HUP0000798A2 (hu) 2000-10-30
CZ292260B6 (cs) 2003-08-13
CN1217716A (zh) 1999-05-26
TR199801631T1 (xx) 1999-06-21
AU725528B2 (en) 2000-10-12
US20100310655A1 (en) 2010-12-09
AU8437298A (en) 1998-12-30
CN1132820C (zh) 2003-12-31
LU91345I9 (es) 2018-12-31
CA2256013A1 (en) 1998-12-17
MY120156A (en) 2005-09-30
CZ253498A3 (cs) 1999-04-14
WO1998056773A1 (en) 1998-12-17
HU225153B1 (en) 2006-07-28
CO4940452A1 (es) 2000-07-24
CA2256015A1 (en) 1998-12-17
AR012945A1 (es) 2000-11-22
HK1028241A1 (en) 2001-02-09
FR07C0037I1 (es) 2007-08-17
CY2007014I2 (el) 2009-11-04
DE69813560D1 (de) 2003-05-22
FR07C0037I2 (es) 2008-05-16
US7750028B2 (en) 2010-07-06
SK109498A3 (en) 1998-12-02
HUP0002113A3 (en) 2002-09-30
MY125854A (en) 2006-08-30
CZ292481B6 (cs) 2003-09-17
PE79799A1 (es) 1999-09-03
CN1159300C (zh) 2004-07-28
US20040167186A1 (en) 2004-08-26
CZ253398A3 (cs) 1999-04-14
IL125732A (en) 2002-12-01
CO4940448A1 (es) 2000-07-24
HUP0002113A2 (hu) 2001-02-28
WO1998056772A1 (en) 1998-12-17
ZA984966B (en) 1999-01-11
NO983667L (no) 1998-12-17
DE69813560T2 (de) 2004-02-05
US6740669B1 (en) 2004-05-25
ZA984967B (en) 1999-01-11
CN1259127A (zh) 2000-07-05
PL191943B1 (pl) 2006-07-31
PT994864E (pt) 2003-07-31
DE122007000051I1 (de) 2007-11-08
LU91345I2 (fr) 2007-09-04
HU226107B1 (en) 2008-04-28
SI0994863T1 (en) 2003-08-31
DK0994863T3 (da) 2003-05-26
DE69811500D1 (de) 2003-03-27
NO983666D0 (no) 1998-08-11
KR100425656B1 (ko) 2004-05-17
NO983666L (no) 1998-12-17
JP3672574B2 (ja) 2005-07-20
DK0994864T3 (da) 2003-07-21
JP3672575B2 (ja) 2005-07-20
SK283685B6 (sk) 2003-12-02
PL330798A1 (en) 1999-06-07
PL192114B1 (pl) 2006-08-31
NZ331370A (en) 2000-08-25
ID27660A (id) 2001-04-19
SI0994864T1 (en) 2003-10-31
AR012946A1 (es) 2000-11-22
HUP0000798A3 (en) 2000-10-30
PL330764A1 (en) 1999-05-24
EP0994863B1 (en) 2003-02-19
AR061004A2 (es) 2008-07-30
AU8437198A (en) 1998-12-30
CY2007014I1 (el) 2009-11-04
IL125732A0 (en) 1999-04-11
JP2000516259A (ja) 2000-12-05
AR061005A2 (es) 2008-07-30
US20060116520A1 (en) 2006-06-01
JP2000516258A (ja) 2000-12-05
KR100409168B1 (ko) 2004-01-31
IL125733A (en) 2002-12-01
US20030125568A1 (en) 2003-07-03
ES2197485T3 (es) 2004-01-01
EP0994864A1 (en) 2000-04-26
IL125733A0 (en) 1999-04-11
NO329315B1 (no) 2010-09-27
NL300284I1 (nl) 2007-10-01
NO983667D0 (no) 1998-08-11
CA2256015C (en) 2008-06-03
US20010037029A1 (en) 2001-11-01

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Expiry date: 20180608