SK282782B6 - Spôsob výroby v podstate enantiomérne čistého N-chráneného (1R,4S)-2-azabicyklo[2.2.1]hept-5-en-3-ónu - Google Patents

Spôsob výroby v podstate enantiomérne čistého N-chráneného (1R,4S)-2-azabicyklo[2.2.1]hept-5-en-3-ónu Download PDF

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Publication number
SK282782B6
SK282782B6 SK1844-99A SK184499A SK282782B6 SK 282782 B6 SK282782 B6 SK 282782B6 SK 184499 A SK184499 A SK 184499A SK 282782 B6 SK282782 B6 SK 282782B6
Authority
SK
Slovakia
Prior art keywords
formula
process according
hept
group
azabicyclo
Prior art date
Application number
SK1844-99A
Other languages
English (en)
Slovak (sk)
Other versions
SK184499A3 (en
Inventor
Michael John Dawson
Mahmoud Mahmoudian
Christopher John Wallis
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of SK184499A3 publication Critical patent/SK184499A3/sk
Publication of SK282782B6 publication Critical patent/SK282782B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SK1844-99A 1997-08-22 1998-08-20 Spôsob výroby v podstate enantiomérne čistého N-chráneného (1R,4S)-2-azabicyklo[2.2.1]hept-5-en-3-ónu SK282782B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9717928.7A GB9717928D0 (en) 1997-08-22 1997-08-22 Process for the enatioselective hydrolysis of n-derivatised lactams
PCT/EP1998/005291 WO1999010519A1 (en) 1997-08-22 1998-08-20 Process for preparing enantiomerically enriched n-derivatised lactams

Publications (2)

Publication Number Publication Date
SK184499A3 SK184499A3 (en) 2000-09-12
SK282782B6 true SK282782B6 (sk) 2002-12-03

Family

ID=10817952

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1844-99A SK282782B6 (sk) 1997-08-22 1998-08-20 Spôsob výroby v podstate enantiomérne čistého N-chráneného (1R,4S)-2-azabicyklo[2.2.1]hept-5-en-3-ónu

Country Status (35)

Country Link
US (1) US6340587B1 (ja)
EP (1) EP1003903B1 (ja)
JP (1) JP3565868B2 (ja)
KR (1) KR100479894B1 (ja)
CN (1) CN1133749C (ja)
AP (1) AP1104A (ja)
AR (1) AR016395A1 (ja)
AT (1) ATE233323T1 (ja)
AU (1) AU738897B2 (ja)
BR (1) BR9810472B1 (ja)
CA (1) CA2295017A1 (ja)
CZ (1) CZ294302B6 (ja)
DE (1) DE69811677T2 (ja)
DK (1) DK1003903T3 (ja)
EA (1) EA001964B1 (ja)
EE (1) EE03934B1 (ja)
ES (1) ES2193568T3 (ja)
GB (1) GB9717928D0 (ja)
HK (1) HK1025796A1 (ja)
HR (1) HRP990408B1 (ja)
HU (1) HU222657B1 (ja)
ID (1) ID25830A (ja)
IL (1) IL133541A (ja)
IN (1) IN183908B (ja)
IS (1) IS2201B (ja)
NO (1) NO320081B1 (ja)
NZ (1) NZ501880A (ja)
PL (1) PL191108B1 (ja)
PT (1) PT1003903E (ja)
RS (1) RS49542B (ja)
SI (1) SI1003903T1 (ja)
SK (1) SK282782B6 (ja)
TR (1) TR199903210T2 (ja)
TW (1) TW589301B (ja)
WO (1) WO1999010519A1 (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1095160B1 (de) * 1998-07-09 2004-01-28 Lonza AG Verfahren zur herstellung von (1r,4s)-2-azabicyclo 2.2.1 hept-5-en-3-on-derivaten
DE19962543A1 (de) * 1999-12-23 2001-07-05 Degussa Chromatographische Enantiomerentrennung von bicyclischen Lactamen
US6780635B2 (en) * 2001-12-27 2004-08-24 Council Of Scientific And Industrial Research Process for the preparation of optically active azabicyclo heptanone derivatives
EP1348765B1 (en) * 2002-03-28 2006-05-24 Council of Scientific and Industrial Research Process for the preparation of optically active azabicyclo heptanone derivatives
HU227663B1 (en) * 2007-07-09 2011-10-28 Univ Szegedi Resolution process
TR201807704T4 (tr) 2010-01-27 2018-06-21 Viiv Healthcare Co Anti-viral tedavi.
CN103695495B (zh) * 2014-01-14 2014-08-27 营口三征新科技化工有限公司 一种制备(1R,4s)-(-)-2-氮杂双环[2,2,1]庚-5-烯-3-酮的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0424064T3 (da) * 1989-10-16 1995-06-26 Chiroscience Ltd Chirale azabicycloheptanoner og fremgangsmåde til fremstilling deraf
GB9108384D0 (en) 1991-04-19 1991-06-05 Enzymatix Ltd Bicycloheptanes
SK284810B6 (sk) * 1997-05-13 2005-12-01 Lonza Ag Spôsob výroby (1S,4R)- alebo (1R,4S)-4-(2-amino-6-chlór-9-H- purín-9-yl)-2-cyklopentén-1-metanolu

Also Published As

Publication number Publication date
CN1133749C (zh) 2004-01-07
HRP990408A2 (en) 2000-04-30
CA2295017A1 (en) 1999-03-04
NO996368L (no) 2000-02-21
BR9810472B1 (pt) 2011-01-11
JP3565868B2 (ja) 2004-09-15
DE69811677T2 (de) 2003-10-16
IN183908B (ja) 2000-05-13
JP2001504354A (ja) 2001-04-03
HRP990408B1 (en) 2006-05-31
DE69811677D1 (de) 2003-04-03
PL191108B1 (pl) 2006-03-31
GB9717928D0 (en) 1997-10-29
HUP0002661A3 (en) 2001-12-28
EA199901059A1 (ru) 2000-08-28
AU9738698A (en) 1999-03-16
HUP0002661A2 (hu) 2000-12-28
CN1261405A (zh) 2000-07-26
IL133541A (en) 2003-10-31
NZ501880A (en) 2001-08-31
EP1003903A1 (en) 2000-05-31
AP1104A (en) 2002-09-04
PT1003903E (pt) 2003-06-30
EE200000075A (et) 2000-10-16
EE03934B1 (et) 2002-12-16
TW589301B (en) 2004-06-01
AU738897B2 (en) 2001-09-27
KR100479894B1 (ko) 2005-03-30
HU222657B1 (hu) 2003-09-29
EP1003903B1 (en) 2003-02-26
BR9810472A (pt) 2000-09-19
AR016395A1 (es) 2001-07-04
HK1025796A1 (en) 2000-11-24
KR20010014078A (ko) 2001-02-26
SI1003903T1 (en) 2003-08-31
EA001964B1 (ru) 2001-10-22
ES2193568T3 (es) 2003-11-01
YU69399A (sh) 2002-06-19
PL337647A1 (en) 2000-08-28
IS2201B (is) 2007-02-15
WO1999010519A1 (en) 1999-03-04
IS5297A (is) 1999-12-14
RS49542B (sr) 2007-02-05
ATE233323T1 (de) 2003-03-15
US6340587B1 (en) 2002-01-22
CZ471699A3 (cs) 2000-06-14
IL133541A0 (en) 2001-04-30
NO996368D0 (no) 1999-12-21
NO320081B1 (no) 2005-10-17
SK184499A3 (en) 2000-09-12
TR199903210T2 (xx) 2000-07-21
DK1003903T3 (da) 2003-06-10
AP9901721A0 (en) 1999-12-31
CZ294302B6 (cs) 2004-11-10
ID25830A (id) 2000-11-09

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Expiry date: 20180820