SK281938B6 - Indolové deriváty, spôsob ich prípravy, medziprodukty pri postupe ich výroby, farmaceutické prostriedky obsahujúce tieto deriváty a použitie týchto derivátov - Google Patents

Indolové deriváty, spôsob ich prípravy, medziprodukty pri postupe ich výroby, farmaceutické prostriedky obsahujúce tieto deriváty a použitie týchto derivátov Download PDF

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Publication number
SK281938B6
SK281938B6 SK1052-94A SK105294A SK281938B6 SK 281938 B6 SK281938 B6 SK 281938B6 SK 105294 A SK105294 A SK 105294A SK 281938 B6 SK281938 B6 SK 281938B6
Authority
SK
Slovakia
Prior art keywords
group
compound
formula
alkyl
carbon atoms
Prior art date
Application number
SK1052-94A
Other languages
English (en)
Slovak (sk)
Other versions
SK105294A3 (en
Inventor
John E. Macor
Jolanta T. Nowakowski
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of SK105294A3 publication Critical patent/SK105294A3/sk
Publication of SK281938B6 publication Critical patent/SK281938B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK1052-94A 1992-03-05 1993-03-03 Indolové deriváty, spôsob ich prípravy, medziprodukty pri postupe ich výroby, farmaceutické prostriedky obsahujúce tieto deriváty a použitie týchto derivátov SK281938B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84664092A 1992-03-05 1992-03-05
PCT/US1993/001667 WO1993018032A1 (en) 1992-03-05 1993-03-03 Indole derivatives as 5-ht1 agonists

Publications (2)

Publication Number Publication Date
SK105294A3 SK105294A3 (en) 1995-05-10
SK281938B6 true SK281938B6 (sk) 2001-09-11

Family

ID=25298499

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1052-94A SK281938B6 (sk) 1992-03-05 1993-03-03 Indolové deriváty, spôsob ich prípravy, medziprodukty pri postupe ich výroby, farmaceutické prostriedky obsahujúce tieto deriváty a použitie týchto derivátov

Country Status (30)

Country Link
US (2) US5594014A (de)
EP (1) EP0629199B1 (de)
JP (1) JPH07121943B2 (de)
KR (1) KR0179073B1 (de)
CN (4) CN1032309C (de)
AT (1) ATE218566T1 (de)
AU (1) AU666716B2 (de)
BR (1) BR9306012A (de)
CA (1) CA2117643C (de)
CZ (1) CZ282652B6 (de)
DE (1) DE69331988T2 (de)
DK (1) DK0629199T3 (de)
EG (1) EG20416A (de)
ES (1) ES2176199T3 (de)
FI (1) FI930968A (de)
HU (1) HU219489B (de)
IL (1) IL104941A (de)
MX (1) MX9301197A (de)
MY (1) MY109298A (de)
NO (1) NO302617B1 (de)
NZ (1) NZ249755A (de)
PL (1) PL172388B1 (de)
PT (1) PT629199E (de)
RU (1) RU2124012C1 (de)
SK (1) SK281938B6 (de)
TW (1) TW288010B (de)
UA (1) UA39866C2 (de)
WO (1) WO1993018032A1 (de)
YU (1) YU14893A (de)
ZA (1) ZA931539B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
JP2644088B2 (ja) 1992-04-07 1997-08-25 フアイザー・インコーポレイテツド ５−ｈｔ１作動薬としてのインドール誘導体
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
AU686654B2 (en) * 1993-08-31 1998-02-12 Pfizer Inc. 5-arylindole derivatives
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
GB9420503D0 (en) * 1994-10-11 1994-11-23 Pfizer Ltd Therapeutic agents
GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
DK0871619T3 (da) * 1995-12-29 2003-03-03 Boehringer Ingelheim Pharma Phenylthiazolderivater med antiherpesvirusegenskaber
US6288091B1 (en) 1995-12-29 2001-09-11 Boehringer Ingelheim Ltd. Antiherpes virus compounds and methods for their preparation and use
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
PT1339678E (pt) 2000-11-27 2007-11-30 Pfizer Prod Inc Agonistas selectivos do receptor ep4 no tratamento de osteoporose
HUP0303801A2 (hu) * 2001-04-20 2004-03-01 Wyeth Heterociklusos alkoxi-, alkil-tio- és alkil-amino-benzazol-származékok, mint 5-hidroxi-triptamin-6 ligandumok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
ITRM20020255A1 (it) * 2002-05-09 2003-11-10 Polifarma Spa Tautomero enolico dell'acido 3-indolilpiruvico, suoi sali e usi terapeutici.
ES2199086B1 (es) * 2002-07-31 2005-06-01 Cepa Schwarz Pharma Sl Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas.
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
KR20220137085A (ko) * 2020-02-04 2022-10-11 마인드셋 파마 인크. Cns 장애의 치료를 위한 세로토닌성 사이키델릭 작용제로서의 3-피롤리딘-인돌 유도체

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
BE889931A (fr) * 1980-08-12 1982-02-11 Glaxo Group Ltd Derives indoliques, leur preparation et leurs applications en tant que medicaments
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
IL96891A0 (en) * 1990-01-17 1992-03-29 Merck Sharp & Dohme Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
CA2042295A1 (fr) * 1990-05-15 1991-11-16 Jacques Chauveau Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant
NZ238424A (en) * 1990-06-07 1993-12-23 Wellcome Found 3,5-substituted indole derivatives; medicaments and preparatory processes.
HUT64326A (en) * 1990-10-15 1993-12-28 Pfizer Process for production indole derivatives and pharmaceutical preparations containing these compounds
US5208248A (en) * 1991-01-11 1993-05-04 Merck Sharpe & Dohme, Ltd. Indazole-substituted five-membered heteroaromatic compounds
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
TW263508B (de) * 1991-02-12 1995-11-21 Pfizer

Also Published As

Publication number Publication date
CA2117643A1 (en) 1993-09-16
NO943261L (no) 1994-09-02
DK0629199T3 (da) 2002-07-15
DE69331988T2 (de) 2002-09-19
CN1082815C (zh) 2002-04-17
CZ282652B6 (cs) 1997-08-13
WO1993018032A1 (en) 1993-09-16
NO943261D0 (no) 1994-09-02
ES2176199T3 (es) 2002-12-01
ZA931539B (en) 1994-09-05
IL104941A (en) 1998-06-15
HU9300593D0 (en) 1993-05-28
JPH07500353A (ja) 1995-01-12
DE69331988D1 (de) 2002-07-11
CA2117643C (en) 2000-03-14
AU3733093A (en) 1993-10-05
EG20416A (en) 1999-02-28
RU94040914A (ru) 1996-08-10
ATE218566T1 (de) 2002-06-15
CZ212594A3 (en) 1995-06-14
PT629199E (pt) 2002-09-30
CN1136566A (zh) 1996-11-27
RU2124012C1 (ru) 1998-12-27
HU219489B (hu) 2001-04-28
MY109298A (en) 1996-12-31
NZ249755A (en) 1996-08-27
EP0629199B1 (de) 2002-06-05
BR9306012A (pt) 1997-11-18
KR950700291A (ko) 1995-01-16
KR0179073B1 (ko) 1999-03-20
CN1082044A (zh) 1994-02-16
HUT64061A (en) 1993-11-29
SK105294A3 (en) 1995-05-10
UA39866C2 (uk) 2001-07-16
TW288010B (de) 1996-10-11
US5594014A (en) 1997-01-14
FI930968A0 (fi) 1993-03-04
CN1136565A (zh) 1996-11-27
FI930968A (fi) 1993-09-06
IL104941A0 (en) 1993-07-08
YU14893A (sh) 1996-05-20
AU666716B2 (en) 1996-02-22
PL172388B1 (pl) 1997-09-30
JPH07121943B2 (ja) 1995-12-25
NO302617B1 (no) 1998-03-30
MX9301197A (es) 1993-09-01
CN1044910C (zh) 1999-09-01
CN1136432A (zh) 1996-11-27
EP0629199A1 (de) 1994-12-21
CN1032309C (zh) 1996-07-17
US5717102A (en) 1998-02-10
CN1044909C (zh) 1999-09-01

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