SK281908B6 - Heteroarylsubstituované deriváty 1,3-dioxolan-4-ylmetoxyfenyl-1- piperazinylfenyl-2,4-dihydro-2-alkyl-3h-1,2,4-triazol-3-ónu, spôsob a medziprodukty na ich výrobu a farmaceutické prostriedky - Google Patents

Heteroarylsubstituované deriváty 1,3-dioxolan-4-ylmetoxyfenyl-1- piperazinylfenyl-2,4-dihydro-2-alkyl-3h-1,2,4-triazol-3-ónu, spôsob a medziprodukty na ich výrobu a farmaceutické prostriedky Download PDF

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Publication number
SK281908B6
SK281908B6 SK507-97A SK50797A SK281908B6 SK 281908 B6 SK281908 B6 SK 281908B6 SK 50797 A SK50797 A SK 50797A SK 281908 B6 SK281908 B6 SK 281908B6
Authority
SK
Slovakia
Prior art keywords
alkyl
triazol
substituted
formula
dioxolan
Prior art date
Application number
SK507-97A
Other languages
English (en)
Slovak (sk)
Other versions
SK50797A3 (en
Inventor
Jan Heeres
Leo Jacobus Jozef Backx
Robert Jozef Maria Hendrickx
Der Eycken Luc Alfons Leo Van
Chaffoy De Courcelles Didier Robert Guy Gabriel De
Original Assignee
Janssen Pharmaceutica N. V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/455,304 external-priority patent/US5521186A/en
Application filed by Janssen Pharmaceutica N. V. filed Critical Janssen Pharmaceutica N. V.
Publication of SK50797A3 publication Critical patent/SK50797A3/sk
Publication of SK281908B6 publication Critical patent/SK281908B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK507-97A 1994-10-27 1995-10-19 Heteroarylsubstituované deriváty 1,3-dioxolan-4-ylmetoxyfenyl-1- piperazinylfenyl-2,4-dihydro-2-alkyl-3h-1,2,4-triazol-3-ónu, spôsob a medziprodukty na ich výrobu a farmaceutické prostriedky SK281908B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94203120 1994-10-27
US08/455,304 US5521186A (en) 1994-10-27 1995-05-31 Apolipoprotein-β synthesis inhibitors
PCT/EP1995/004111 WO1996013499A1 (en) 1994-10-27 1995-10-19 Apolipoprotein-b synthesis inhibitors

Publications (2)

Publication Number Publication Date
SK50797A3 SK50797A3 (en) 1998-04-08
SK281908B6 true SK281908B6 (sk) 2001-09-11

Family

ID=26136684

Family Applications (1)

Application Number Title Priority Date Filing Date
SK507-97A SK281908B6 (sk) 1994-10-27 1995-10-19 Heteroarylsubstituované deriváty 1,3-dioxolan-4-ylmetoxyfenyl-1- piperazinylfenyl-2,4-dihydro-2-alkyl-3h-1,2,4-triazol-3-ónu, spôsob a medziprodukty na ich výrobu a farmaceutické prostriedky

Country Status (30)

Country Link
US (1) US5929075A (bg)
EP (1) EP0788496B1 (bg)
JP (1) JP3025907B2 (bg)
KR (1) KR100227231B1 (bg)
CN (1) CN1068000C (bg)
AP (1) AP779A (bg)
AT (1) ATE198889T1 (bg)
AU (1) AU697744C (bg)
BG (1) BG63694B1 (bg)
BR (1) BR9509436A (bg)
CA (1) CA2203274C (bg)
CY (1) CY2256B1 (bg)
CZ (1) CZ286476B6 (bg)
DE (3) DE69519995T2 (bg)
DK (1) DK0788496T3 (bg)
ES (1) ES2155535T3 (bg)
FI (1) FI119548B (bg)
GR (1) GR3035519T3 (bg)
HR (1) HRP950532B1 (bg)
HU (1) HU219862B (bg)
IL (1) IL115771A (bg)
LU (1) LU91306I2 (bg)
NO (1) NO311937B1 (bg)
NZ (1) NZ295353A (bg)
OA (1) OA10479A (bg)
PT (1) PT788496E (bg)
RO (1) RO118715B1 (bg)
SK (1) SK281908B6 (bg)
TR (1) TR199501295A2 (bg)
WO (1) WO1996013499A1 (bg)

Families Citing this family (24)

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EE200000186A (et) * 1997-11-03 2001-04-16 Janssen Pharmaceutica N.V. Osake, selliste osakeste valmistamismeetod ja kasutamine, farmatseutiline doosivorm ja selle valmistamismeetod, tahke dispersioon ja farmatseutiline pakend
CA2328970A1 (en) * 1998-04-27 1999-11-04 Valentin Florent Victor De Conde Pellets having a core coated with a lipid lowering agent and a polymer
EP1140917B1 (en) * 1998-12-22 2003-03-26 Janssen Pharmaceutica N.V. S-oxide lipid lowering compounds
DE19945982A1 (de) 1999-09-24 2001-03-29 Knoll Ag Geschwindigkeitsbestimmte Partikel
US20050132022A1 (en) * 2003-12-12 2005-06-16 International Business Machines Corporation Computer system with LAN-based I/O
CA2552988A1 (en) * 2004-01-21 2005-08-04 Janssen Pharmaceutica Nv Mitratapide oral solution
US7649002B2 (en) 2004-02-04 2010-01-19 Pfizer Inc (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
AU2005230397B2 (en) * 2004-04-09 2010-04-08 Elanco Animal Health Ireland Limited Intermittent dosing regimen for the treatment of overweight with MTP-inhibitors
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
WO2006129193A2 (en) * 2005-05-27 2006-12-07 Pfizer Products Inc. Combination of a cannabinoid-1- receptor-antagonist and a microsomal triglyceride transfer protein inhibitor for treating obesity or mainataining weight loss
JP2009503050A (ja) * 2005-08-04 2009-01-29 ファイザー・リミテッド ピペリジノイル−ピロリジンおよびピペリジノイル−ピペリジン化合物
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
MX2008010899A (es) * 2006-02-23 2008-11-27 Pfizer Ltd Piperidinoilpirrolidinas agonistas del receptor de melanocortina tipo 4.
US8383660B2 (en) 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
KR20090064478A (ko) 2006-11-13 2009-06-18 화이자 프로덕츠 인크. 디아릴, 디피리디닐 및 아릴-피리디닐 유도체, 및 이들의 용도
EP2094643B1 (en) 2006-12-01 2012-02-29 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
CA2685797C (en) * 2007-05-25 2015-04-14 Janssen Pharmaceutica N.V. Improved synthesis of (2s-cis)-2-(bromomethyl)-2-(4-chlorophenyl)-1,3-dioxolane-4-methanol methanesulfonate(ester)
US8592403B2 (en) * 2008-08-06 2013-11-26 Pfizer Limited Diazepine and diazocane compounds as MC4 agonists
BR112012029227B1 (pt) * 2010-05-19 2020-01-07 Sandoz Ag Processo para a preparação de um composto quiral, composto quiral e uso de um composto
LT3762368T (lt) 2018-03-08 2022-06-10 Incyte Corporation Aminopirazindiolio junginiai, kaip pi3k-γ inhibitoriai
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4218458A (en) * 1978-06-23 1980-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4313953A (en) * 1978-06-23 1982-02-02 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4766125A (en) * 1981-06-23 1988-08-23 Janssen Pharmaceutica N.V. N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia
US4619931A (en) * 1983-02-28 1986-10-28 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (en) * 1985-12-03 1991-11-26 Alfonsus Guilielmus Knaeps Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
CA1331757C (en) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
AU6359594A (en) * 1993-03-04 1994-09-26 Cytoven International N.V. Pharmaceutical tryptophan containing dipeptide compositions and methods of use thereof
US5521186A (en) * 1994-10-27 1996-05-28 Janssen Pharmaceutica N.V. Apolipoprotein-β synthesis inhibitors

Also Published As

Publication number Publication date
CY2256B1 (en) 2003-07-04
GR3035519T3 (en) 2001-06-29
US5929075A (en) 1999-07-27
AU3868095A (en) 1996-05-23
SK50797A3 (en) 1998-04-08
HRP950532B1 (en) 2001-06-30
DK0788496T3 (da) 2001-06-18
AP779A (en) 1999-11-03
CA2203274A1 (en) 1996-05-09
OA10479A (en) 2002-04-09
BG63694B1 (bg) 2002-09-30
CZ119897A3 (cs) 1998-03-18
CZ286476B6 (en) 2000-04-12
CN1068000C (zh) 2001-07-04
RO118715B1 (ro) 2003-09-30
EP0788496B1 (en) 2001-01-24
KR100227231B1 (ko) 1999-11-01
CA2203274C (en) 2002-02-19
NZ295353A (en) 1998-08-26
MX9703074A (es) 1997-07-31
FI971784A (fi) 1997-04-25
NO971895L (no) 1997-04-24
PT788496E (pt) 2001-07-31
BG101402A (bg) 1997-10-31
DE122007000005I1 (de) 2007-04-26
DE69519995D1 (en) 2001-03-01
FI119548B (fi) 2008-12-31
BR9509436A (pt) 1998-01-06
IL115771A (en) 2000-02-29
ATE198889T1 (de) 2001-02-15
LU91306I2 (fr) 2007-03-19
HRP950532A2 (en) 1997-08-31
HUT77360A (hu) 1998-03-30
IL115771A0 (en) 1996-01-19
AP9700968A0 (en) 1997-04-30
DE122007000005I2 (de) 2008-04-24
EP0788496A1 (en) 1997-08-13
AU697744C (en) 2002-08-22
CN1161695A (zh) 1997-10-08
AU697744B2 (en) 1998-10-15
TR199501295A2 (tr) 1996-06-21
ES2155535T3 (es) 2001-05-16
NO971895D0 (no) 1997-04-24
JP3025907B2 (ja) 2000-03-27
FI971784A0 (fi) 1997-04-25
WO1996013499A1 (en) 1996-05-09
NO311937B1 (no) 2002-02-18
HU219862B (hu) 2001-08-28
JPH09511759A (ja) 1997-11-25
DE69519995T2 (de) 2001-08-23

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Legal Events

Date Code Title Description
PC4A Assignment and transfer of rights

Owner name: ELANCO ANIMAL HEALTH IRELAND LIMITED, DUBLIN, IE

Free format text: FORMER OWNER: JANSSEN PHARMACEUTICA N. V., BEERSE, BE

Effective date: 20110707

SPCT Transfer of rights of an spc

Owner name: ELANCO ANIMAL HEALTH IRELAND LIMITED, IE

Free format text: PRODUCT NAME: MITRATAPID; REGISTRATION NO/DATE: EU/2/06/063/001-003 20061124; FORMER OWNER: JANSSENPHARMACEUTICA N.V., BE

Spc suppl protection certif: 5994-2007 60

Filing date: 20070504

Extension date: 20201020

MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20121019