AP779A - Apolipoprotein-B synthesis inhibitors. - Google Patents

Apolipoprotein-B synthesis inhibitors. Download PDF

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Publication number
AP779A
AP779A APAP/P/1997/000968A AP9700968A AP779A AP 779 A AP779 A AP 779A AP 9700968 A AP9700968 A AP 9700968A AP 779 A AP779 A AP 779A
Authority
AP
ARIPO
Prior art keywords
methyl
amino
formula
phenyl
triazol
Prior art date
Application number
APAP/P/1997/000968A
Other languages
English (en)
Other versions
AP9700968A0 (en
Inventor
Jan Heeres
Leo Jacobus Josef Backx
Robert Josef Maria Hendrickx
Der Eycken Luc Alfons Leo Van
Courcelles Didier Robert Guy Gabriel Der Chaffoy De
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/455,304 external-priority patent/US5521186A/en
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AP9700968A0 publication Critical patent/AP9700968A0/xx
Application granted granted Critical
Publication of AP779A publication Critical patent/AP779A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
APAP/P/1997/000968A 1994-10-27 1995-10-19 Apolipoprotein-B synthesis inhibitors. AP779A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94203120 1994-10-27
US08/455,304 US5521186A (en) 1994-10-27 1995-05-31 Apolipoprotein-β synthesis inhibitors
PCT/EP1995/004111 WO1996013499A1 (en) 1994-10-27 1995-10-19 Apolipoprotein-b synthesis inhibitors

Publications (2)

Publication Number Publication Date
AP9700968A0 AP9700968A0 (en) 1997-04-30
AP779A true AP779A (en) 1999-11-03

Family

ID=26136684

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1997/000968A AP779A (en) 1994-10-27 1995-10-19 Apolipoprotein-B synthesis inhibitors.

Country Status (30)

Country Link
US (1) US5929075A (bg)
EP (1) EP0788496B1 (bg)
JP (1) JP3025907B2 (bg)
KR (1) KR100227231B1 (bg)
CN (1) CN1068000C (bg)
AP (1) AP779A (bg)
AT (1) ATE198889T1 (bg)
AU (1) AU697744C (bg)
BG (1) BG63694B1 (bg)
BR (1) BR9509436A (bg)
CA (1) CA2203274C (bg)
CY (1) CY2256B1 (bg)
CZ (1) CZ286476B6 (bg)
DE (3) DE122007000005I2 (bg)
DK (1) DK0788496T3 (bg)
ES (1) ES2155535T3 (bg)
FI (1) FI119548B (bg)
GR (1) GR3035519T3 (bg)
HR (1) HRP950532B1 (bg)
HU (1) HU219862B (bg)
IL (1) IL115771A (bg)
LU (1) LU91306I2 (bg)
NO (1) NO311937B1 (bg)
NZ (1) NZ295353A (bg)
OA (1) OA10479A (bg)
PT (1) PT788496E (bg)
RO (1) RO118715B1 (bg)
SK (1) SK281908B6 (bg)
TR (1) TR199501295A2 (bg)
WO (1) WO1996013499A1 (bg)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL340305A1 (en) * 1997-11-03 2001-01-29 Janssen Pharmaceutica Nv Composition of agents reducing the level of lipoides
CA2328970A1 (en) * 1998-04-27 1999-11-04 Valentin Florent Victor De Conde Pellets having a core coated with a lipid lowering agent and a polymer
CA2355822A1 (en) * 1998-12-22 2000-06-29 Janssen Pharmaceutica N.V. S-oxide lipid lowering compounds
DE19945982A1 (de) * 1999-09-24 2001-03-29 Knoll Ag Geschwindigkeitsbestimmte Partikel
US20050132022A1 (en) * 2003-12-12 2005-06-16 International Business Machines Corporation Computer system with LAN-based I/O
JP4994043B2 (ja) * 2004-01-21 2012-08-08 エランコ・アニマル・ヘルス・アイルランド・リミテッド ミトラタピデ経口用溶液
US7649002B2 (en) 2004-02-04 2010-01-19 Pfizer Inc (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
AU2005230397B2 (en) * 2004-04-09 2010-04-08 Elanco Animal Health Ireland Limited Intermittent dosing regimen for the treatment of overweight with MTP-inhibitors
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
JP2008542255A (ja) * 2005-05-27 2008-11-27 ファイザー・プロダクツ・インク 肥満症の治療または体重減量の維持のためのカンナビノイド−１受容体アンタゴニストおよびミクロソームトリグリセリド輸送タンパク質阻害物質の併用
US20080269233A1 (en) * 2005-08-04 2008-10-30 Mark David Andrews Piperidinoyl-Pyrrolidine and Piperidinoyl-Piperidine Compounds
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US8138188B2 (en) * 2006-02-23 2012-03-20 Pfizer Inc. Melanocortin type 4 receptor agonist piperidinoylpyrrolidines
US8383660B2 (en) 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
EP2084127A1 (en) 2006-11-13 2009-08-05 Pfizer Products Inc. Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
MX2009012739A (es) * 2007-05-25 2009-12-10 Janssen Pharmaceutica Nv Sintesis mejorada del metansulfonato(ester) de (2s-cis)-2-(bromometil)-2-(4-clorofenil)-1,3-dioxolan-4-metanol.
KR101280786B1 (ko) * 2008-08-06 2013-07-05 화이자 리미티드 멜라노코르틴 4 작용제로서 다이아제핀 및 다이아조칸 화합물
US9040539B2 (en) * 2010-05-19 2015-05-26 Sandoz Ag Process for the preparation of chiral triazolones
EP3762368B1 (en) 2018-03-08 2022-01-26 Incyte Corporation Aminopyrazine diol compounds as pi3k-y inhibitors
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006711A1 (en) * 1978-06-23 1980-01-09 Janssen Pharmaceutica N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)-methyl-1H-imidazoles and 1H-1,2,4-triazoles, processes for preparing them and compositions containing them

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4313953A (en) * 1978-06-23 1982-02-02 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4766125A (en) * 1981-06-23 1988-08-23 Janssen Pharmaceutica N.V. N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia
US4619931A (en) * 1983-02-28 1986-10-28 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (en) * 1985-12-03 1991-11-26 Alfonsus Guilielmus Knaeps Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
CA1331757C (en) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
AU6359594A (en) * 1993-03-04 1994-09-26 Cytoven International N.V. Pharmaceutical tryptophan containing dipeptide compositions and methods of use thereof
US5521186A (en) * 1994-10-27 1996-05-28 Janssen Pharmaceutica N.V. Apolipoprotein-β synthesis inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006711A1 (en) * 1978-06-23 1980-01-09 Janssen Pharmaceutica N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)-methyl-1H-imidazoles and 1H-1,2,4-triazoles, processes for preparing them and compositions containing them

Also Published As

Publication number Publication date
HRP950532A2 (en) 1997-08-31
AU697744B2 (en) 1998-10-15
JPH09511759A (ja) 1997-11-25
KR100227231B1 (ko) 1999-11-01
JP3025907B2 (ja) 2000-03-27
LU91306I2 (fr) 2007-03-19
HU219862B (hu) 2001-08-28
PT788496E (pt) 2001-07-31
CZ286476B6 (en) 2000-04-12
DE122007000005I2 (de) 2008-04-24
MX9703074A (es) 1997-07-31
ATE198889T1 (de) 2001-02-15
DE122007000005I1 (de) 2007-04-26
FI119548B (fi) 2008-12-31
AU697744C (en) 2002-08-22
HRP950532B1 (en) 2001-06-30
OA10479A (en) 2002-04-09
FI971784A (fi) 1997-04-25
EP0788496B1 (en) 2001-01-24
TR199501295A2 (tr) 1996-06-21
BG63694B1 (bg) 2002-09-30
DE69519995D1 (en) 2001-03-01
BG101402A (bg) 1997-10-31
ES2155535T3 (es) 2001-05-16
GR3035519T3 (en) 2001-06-29
SK281908B6 (sk) 2001-09-11
CN1068000C (zh) 2001-07-04
DE69519995T2 (de) 2001-08-23
SK50797A3 (en) 1998-04-08
CN1161695A (zh) 1997-10-08
IL115771A0 (en) 1996-01-19
BR9509436A (pt) 1998-01-06
CZ119897A3 (cs) 1998-03-18
RO118715B1 (ro) 2003-09-30
AU3868095A (en) 1996-05-23
DK0788496T3 (da) 2001-06-18
HUT77360A (hu) 1998-03-30
CY2256B1 (en) 2003-07-04
NO971895D0 (no) 1997-04-24
CA2203274C (en) 2002-02-19
CA2203274A1 (en) 1996-05-09
NZ295353A (en) 1998-08-26
AP9700968A0 (en) 1997-04-30
FI971784A0 (fi) 1997-04-25
NO971895L (no) 1997-04-24
IL115771A (en) 2000-02-29
WO1996013499A1 (en) 1996-05-09
EP0788496A1 (en) 1997-08-13
NO311937B1 (no) 2002-02-18
US5929075A (en) 1999-07-27

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