SK281540B6 - Analógy aprotinínu, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie - Google Patents
Analógy aprotinínu, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie Download PDFInfo
- Publication number
- SK281540B6 SK281540B6 SK264-93A SK26493A SK281540B6 SK 281540 B6 SK281540 B6 SK 281540B6 SK 26493 A SK26493 A SK 26493A SK 281540 B6 SK281540 B6 SK 281540B6
- Authority
- SK
- Slovakia
- Prior art keywords
- glu
- ala
- aprotinin
- gly
- thr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK236190A DK236190D0 (da) | 1990-10-01 | 1990-10-01 | Polypeptid |
DK111891A DK111891D0 (da) | 1991-06-12 | 1991-06-12 | Polypeptid |
PCT/DK1991/000299 WO1992006111A1 (en) | 1990-10-01 | 1991-10-01 | Aprotinin analogues |
Publications (2)
Publication Number | Publication Date |
---|---|
SK26493A3 SK26493A3 (en) | 1993-10-06 |
SK281540B6 true SK281540B6 (sk) | 2001-04-09 |
Family
ID=26065261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK264-93A SK281540B6 (sk) | 1990-10-01 | 1991-10-01 | Analógy aprotinínu, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0551329B1 (fi) |
JP (1) | JP3614850B2 (fi) |
KR (1) | KR100250391B1 (fi) |
AT (1) | ATE168414T1 (fi) |
AU (1) | AU659100B2 (fi) |
CA (1) | CA2092920A1 (fi) |
CZ (1) | CZ285225B6 (fi) |
DE (1) | DE69129809T2 (fi) |
DK (1) | DK0551329T3 (fi) |
ES (1) | ES2121787T3 (fi) |
FI (1) | FI105036B (fi) |
HU (1) | HU219302B (fi) |
IE (1) | IE913433A1 (fi) |
IL (1) | IL99585A0 (fi) |
MX (1) | MX9101382A (fi) |
NO (1) | NO309529B1 (fi) |
NZ (1) | NZ240014A (fi) |
PT (1) | PT99124B (fi) |
SK (1) | SK281540B6 (fi) |
UA (1) | UA34422C2 (fi) |
WO (1) | WO1992006111A1 (fi) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
EP1231274A3 (en) * | 1994-11-21 | 2002-10-09 | The University Of Leeds | Modified porteinase inhibitors |
AU738766B2 (en) * | 1994-11-21 | 2001-09-27 | University Of Leeds, The | Modified proteinase inhibitors |
DE19629982A1 (de) | 1996-07-25 | 1998-01-29 | Bayer Ag | Aprotinin-Varianten mit verbesserten Eigenschaften |
DE19725014A1 (de) * | 1997-06-13 | 1998-12-17 | Bayer Ag | Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten |
WO2001066801A2 (en) * | 2000-03-08 | 2001-09-13 | Complexe Hospitalier De La Sagamie | Very low density lipoprotein receptor polymorphisms and uses therefor |
WO2003103475A2 (en) | 2002-06-07 | 2003-12-18 | Dyax Corp. | Prevention and reduction of blood loss |
US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
SI2386310T1 (sl) | 2002-08-28 | 2019-03-29 | Dyax Corp. | Metode za ohranjanje organov in tkiv |
US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
WO2008077478A1 (en) * | 2006-12-22 | 2008-07-03 | Bayer Schering Pharma Aktiengesellschaft | Preparation and use of variants of the kunitz domain 2 of the human placental bikunin gene |
DE102007056231A1 (de) | 2007-09-08 | 2009-03-12 | Bayer Healthcare Ag | Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI) |
CN102307594A (zh) | 2009-01-06 | 2012-01-04 | 戴埃克斯有限公司 | 用激肽释放酶抑制剂治疗粘膜炎 |
HUE039605T2 (hu) | 2010-01-06 | 2019-01-28 | Dyax Corp | Plazma kallikreint kötõ proteinek |
KR102320178B1 (ko) | 2011-01-06 | 2021-11-02 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 결합 단백질 |
NZ744233A (en) | 2015-12-11 | 2023-11-24 | Takeda Pharmaceuticals Co | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2188322A (en) * | 1986-03-26 | 1987-09-30 | Bayer Ag | Aprotinin and analogues thereof produced by a recombinant host |
DE3724570A1 (de) * | 1987-06-27 | 1989-01-05 | Bayer Ag | Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist |
DK225488D0 (da) * | 1988-04-26 | 1988-04-26 | Novo Industri As | Polypeptid |
DK450187D0 (da) * | 1987-08-28 | 1987-08-28 | Novo Industri As | Fremgangsmaade til fremstilling af proteiner |
DE3930522A1 (de) * | 1989-09-13 | 1991-03-21 | Bayer Ag | Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben |
-
1991
- 1991-09-27 IL IL99585A patent/IL99585A0/xx unknown
- 1991-09-30 NZ NZ240014A patent/NZ240014A/en unknown
- 1991-09-30 PT PT99124A patent/PT99124B/pt not_active IP Right Cessation
- 1991-09-30 IE IE343391A patent/IE913433A1/en not_active Application Discontinuation
- 1991-10-01 WO PCT/DK1991/000299 patent/WO1992006111A1/en active IP Right Grant
- 1991-10-01 AU AU85460/91A patent/AU659100B2/en not_active Ceased
- 1991-10-01 UA UA93002097A patent/UA34422C2/uk unknown
- 1991-10-01 DK DK91917143T patent/DK0551329T3/da active
- 1991-10-01 MX MX9101382A patent/MX9101382A/es not_active IP Right Cessation
- 1991-10-01 CA CA002092920A patent/CA2092920A1/en not_active Abandoned
- 1991-10-01 ES ES91917143T patent/ES2121787T3/es not_active Expired - Lifetime
- 1991-10-01 EP EP91917143A patent/EP0551329B1/en not_active Expired - Lifetime
- 1991-10-01 AT AT91917143T patent/ATE168414T1/de not_active IP Right Cessation
- 1991-10-01 CZ CZ93517A patent/CZ285225B6/cs not_active IP Right Cessation
- 1991-10-01 DE DE69129809T patent/DE69129809T2/de not_active Expired - Fee Related
- 1991-10-01 JP JP51609991A patent/JP3614850B2/ja not_active Expired - Fee Related
- 1991-10-01 SK SK264-93A patent/SK281540B6/sk unknown
- 1991-10-01 HU HU9300943A patent/HU219302B/hu not_active IP Right Cessation
-
1993
- 1993-03-31 KR KR1019930701001A patent/KR100250391B1/ko not_active IP Right Cessation
- 1993-03-31 FI FI931457A patent/FI105036B/fi active
- 1993-03-31 NO NO931220A patent/NO309529B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CZ285225B6 (cs) | 1999-06-16 |
NO931220L (no) | 1993-04-01 |
PT99124B (pt) | 1999-03-31 |
IL99585A0 (en) | 1992-08-18 |
ES2121787T3 (es) | 1998-12-16 |
CA2092920A1 (en) | 1992-04-02 |
NO931220D0 (no) | 1993-03-31 |
AU8546091A (en) | 1992-04-28 |
JPH06501158A (ja) | 1994-02-10 |
SK26493A3 (en) | 1993-10-06 |
CZ51793A3 (en) | 1994-01-19 |
DE69129809D1 (de) | 1998-08-20 |
IE913433A1 (en) | 1992-04-08 |
FI105036B (fi) | 2000-05-31 |
ATE168414T1 (de) | 1998-08-15 |
WO1992006111A1 (en) | 1992-04-16 |
HU219302B (en) | 2001-03-28 |
FI931457A (fi) | 1993-03-31 |
KR100250391B1 (ko) | 2000-05-01 |
JP3614850B2 (ja) | 2005-01-26 |
EP0551329B1 (en) | 1998-07-15 |
UA34422C2 (uk) | 2001-03-15 |
EP0551329A1 (en) | 1993-07-21 |
MX9101382A (es) | 1992-06-05 |
DE69129809T2 (de) | 1998-11-19 |
DK0551329T3 (da) | 1999-04-19 |
HU9300943D0 (en) | 1993-06-28 |
NO309529B1 (no) | 2001-02-12 |
NZ240014A (en) | 1992-08-26 |
HUT69955A (en) | 1995-09-28 |
FI931457A0 (fi) | 1993-03-31 |
PT99124A (pt) | 1992-08-31 |
AU659100B2 (en) | 1995-05-11 |
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