NO931220D0 - Aprotininanaloger - Google Patents

Aprotininanaloger

Info

Publication number
NO931220D0
NO931220D0 NO931220A NO931220A NO931220D0 NO 931220 D0 NO931220 D0 NO 931220D0 NO 931220 A NO931220 A NO 931220A NO 931220 A NO931220 A NO 931220A NO 931220 D0 NO931220 D0 NO 931220D0
Authority
NO
Norway
Prior art keywords
aminoacid
replaced
residue
negatively charged
aminoacid residue
Prior art date
Application number
NO931220A
Other languages
English (en)
Other versions
NO309529B1 (no
NO931220L (no
Inventor
Soeren Erik Bjoern
Kjeld Norris
Viggo Diness
Leif Noerskov-Lauritsen
Niels CHRISTENSEN
Claus Bregengaard
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK236190A external-priority patent/DK236190D0/da
Priority claimed from DK111891A external-priority patent/DK111891D0/da
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of NO931220D0 publication Critical patent/NO931220D0/no
Publication of NO931220L publication Critical patent/NO931220L/no
Publication of NO309529B1 publication Critical patent/NO309529B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO931220A 1990-10-01 1993-03-31 Aprotininanaloger NO309529B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK236190A DK236190D0 (da) 1990-10-01 1990-10-01 Polypeptid
DK111891A DK111891D0 (da) 1991-06-12 1991-06-12 Polypeptid
PCT/DK1991/000299 WO1992006111A1 (en) 1990-10-01 1991-10-01 Aprotinin analogues

Publications (3)

Publication Number Publication Date
NO931220D0 true NO931220D0 (no) 1993-03-31
NO931220L NO931220L (no) 1993-04-01
NO309529B1 NO309529B1 (no) 2001-02-12

Family

ID=26065261

Family Applications (1)

Application Number Title Priority Date Filing Date
NO931220A NO309529B1 (no) 1990-10-01 1993-03-31 Aprotininanaloger

Country Status (21)

Country Link
EP (1) EP0551329B1 (no)
JP (1) JP3614850B2 (no)
KR (1) KR100250391B1 (no)
AT (1) ATE168414T1 (no)
AU (1) AU659100B2 (no)
CA (1) CA2092920A1 (no)
CZ (1) CZ285225B6 (no)
DE (1) DE69129809T2 (no)
DK (1) DK0551329T3 (no)
ES (1) ES2121787T3 (no)
FI (1) FI105036B (no)
HU (1) HU219302B (no)
IE (1) IE913433A1 (no)
IL (1) IL99585A0 (no)
MX (1) MX9101382A (no)
NO (1) NO309529B1 (no)
NZ (1) NZ240014A (no)
PT (1) PT99124B (no)
SK (1) SK281540B6 (no)
UA (1) UA34422C2 (no)
WO (1) WO1992006111A1 (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
AU738766B2 (en) * 1994-11-21 2001-09-27 University Of Leeds, The Modified proteinase inhibitors
RU2182598C2 (ru) * 1994-11-21 2002-05-20 Новартис Аг Модифицированные ингибиторы протеиназы
DE19629982A1 (de) * 1996-07-25 1998-01-29 Bayer Ag Aprotinin-Varianten mit verbesserten Eigenschaften
DE19725014A1 (de) * 1997-06-13 1998-12-17 Bayer Ag Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
US6833240B2 (en) 2000-03-08 2004-12-21 Mcgill University Very low density lipoprotein receptor polymorphisms and uses therefor
EP2298278B1 (en) 2002-06-07 2015-11-11 Dyax Corp. Prevention and reduction of blood loss and inflammatory response
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
ES2709103T3 (es) 2002-08-28 2019-04-15 Dyax Corp Métodos para conservar órganos y tejidos
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
WO2008077478A1 (en) * 2006-12-22 2008-07-03 Bayer Schering Pharma Aktiengesellschaft Preparation and use of variants of the kunitz domain 2 of the human placental bikunin gene
DE102007056231A1 (de) 2007-09-08 2009-03-12 Bayer Healthcare Ag Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI)
AU2010203712A1 (en) 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
RS62853B1 (sr) 2010-01-06 2022-02-28 Takeda Pharmaceuticals Co Proteini koji vezuju kalikrein plazme
AU2012204202A1 (en) 2011-01-06 2013-07-11 Dyax Corp. Plasma kallikrein binding proteins
US11286307B2 (en) 2015-12-11 2022-03-29 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2188322A (en) * 1986-03-26 1987-09-30 Bayer Ag Aprotinin and analogues thereof produced by a recombinant host
DE3724570A1 (de) * 1987-06-27 1989-01-05 Bayer Ag Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist
DK450187D0 (da) * 1987-08-28 1987-08-28 Novo Industri As Fremgangsmaade til fremstilling af proteiner
DK225488D0 (da) * 1988-04-26 1988-04-26 Novo Industri As Polypeptid
DE3930522A1 (de) * 1989-09-13 1991-03-21 Bayer Ag Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben

Also Published As

Publication number Publication date
JPH06501158A (ja) 1994-02-10
IE913433A1 (en) 1992-04-08
AU659100B2 (en) 1995-05-11
UA34422C2 (uk) 2001-03-15
SK281540B6 (sk) 2001-04-09
NZ240014A (en) 1992-08-26
CZ285225B6 (cs) 1999-06-16
FI105036B (fi) 2000-05-31
PT99124A (pt) 1992-08-31
DK0551329T3 (da) 1999-04-19
NO309529B1 (no) 2001-02-12
CA2092920A1 (en) 1992-04-02
EP0551329A1 (en) 1993-07-21
NO931220L (no) 1993-04-01
EP0551329B1 (en) 1998-07-15
AU8546091A (en) 1992-04-28
HUT69955A (en) 1995-09-28
WO1992006111A1 (en) 1992-04-16
CZ51793A3 (en) 1994-01-19
DE69129809D1 (de) 1998-08-20
ES2121787T3 (es) 1998-12-16
SK26493A3 (en) 1993-10-06
HU9300943D0 (en) 1993-06-28
HU219302B (en) 2001-03-28
JP3614850B2 (ja) 2005-01-26
FI931457A (fi) 1993-03-31
PT99124B (pt) 1999-03-31
DE69129809T2 (de) 1998-11-19
MX9101382A (es) 1992-06-05
FI931457A0 (fi) 1993-03-31
KR100250391B1 (ko) 2000-05-01
ATE168414T1 (de) 1998-08-15
IL99585A0 (en) 1992-08-18

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Legal Events

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Free format text: LAPSED IN APRIL 2003