ES2121787T3 - Analogos de aprotinina. - Google Patents

Analogos de aprotinina.

Info

Publication number
ES2121787T3
ES2121787T3 ES91917143T ES91917143T ES2121787T3 ES 2121787 T3 ES2121787 T3 ES 2121787T3 ES 91917143 T ES91917143 T ES 91917143T ES 91917143 T ES91917143 T ES 91917143T ES 2121787 T3 ES2121787 T3 ES 2121787T3
Authority
ES
Spain
Prior art keywords
aminoacid
replaced
residue
negatively charged
aminoacid residue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91917143T
Other languages
English (en)
Inventor
Soren Erik Bjorn
Kjeld Norris
Viggo Diness
Leif Norskov-Lauritsen
Niels Dyhr Christensen
Claus Bregengaard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK236190A external-priority patent/DK236190D0/da
Priority claimed from DK111891A external-priority patent/DK111891D0/da
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of ES2121787T3 publication Critical patent/ES2121787T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN ANALOGO DE APROTININA CON NEFROTOXICIDAD REDUCIDA, GARANTIZADO PORQUE, PARA PROPORCIONAR UNA CARGA NETA POSITIVA REDUCIDA, AL MENOS UN RESIDUO DE AMINOACIDOS POSITIVAMENTE CARGADO, FUERA DEL EMPLAZAMIENTO DE LIGANTE DE PROTEASAS SE ELIMINA O SUSTITUYE POR UN RESIDUO DE AMINOACIDOS NEUTRO O NEGATIVAMENTE CARGADO Y/O CARACTERIZADO PORQUE AL MENOS SE INSERTA O AÑADE UN RESIDUO DE AMINOACIDOS NEGATIVAMENTE CARGADO Y/O PORQUE AL MENOS UN RESIDUO DE AMINOACIDOS NEUTRO SE SUSTITUYE POR OTRO NEGATIVAMENTE CARGADO Y/O PORQUE, PARA PROPORCIONAR UNA ESTABILIDAD REDUCIDA, UNO O MAS RESIDUOS DE AMINOACIDOS SE SUPRIMEN, AÑADEN O SUSTITUYEN POR UNO O MAS OTROS RESIDUOS DE AMINOACIDOS.
ES91917143T 1990-10-01 1991-10-01 Analogos de aprotinina. Expired - Lifetime ES2121787T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK236190A DK236190D0 (da) 1990-10-01 1990-10-01 Polypeptid
DK111891A DK111891D0 (da) 1991-06-12 1991-06-12 Polypeptid

Publications (1)

Publication Number Publication Date
ES2121787T3 true ES2121787T3 (es) 1998-12-16

Family

ID=26065261

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91917143T Expired - Lifetime ES2121787T3 (es) 1990-10-01 1991-10-01 Analogos de aprotinina.

Country Status (21)

Country Link
EP (1) EP0551329B1 (es)
JP (1) JP3614850B2 (es)
KR (1) KR100250391B1 (es)
AT (1) ATE168414T1 (es)
AU (1) AU659100B2 (es)
CA (1) CA2092920A1 (es)
CZ (1) CZ285225B6 (es)
DE (1) DE69129809T2 (es)
DK (1) DK0551329T3 (es)
ES (1) ES2121787T3 (es)
FI (1) FI105036B (es)
HU (1) HU219302B (es)
IE (1) IE913433A1 (es)
IL (1) IL99585A0 (es)
MX (1) MX9101382A (es)
NO (1) NO309529B1 (es)
NZ (1) NZ240014A (es)
PT (1) PT99124B (es)
SK (1) SK281540B6 (es)
UA (1) UA34422C2 (es)
WO (1) WO1992006111A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
WO1996016173A2 (en) * 1994-11-21 1996-05-30 The University Of Leeds Modified proteinase inhibitors
AU738766B2 (en) * 1994-11-21 2001-09-27 University Of Leeds, The Modified proteinase inhibitors
DE19629982A1 (de) 1996-07-25 1998-01-29 Bayer Ag Aprotinin-Varianten mit verbesserten Eigenschaften
DE19725014A1 (de) * 1997-06-13 1998-12-17 Bayer Ag Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
CA2402310A1 (en) * 2000-03-08 2001-09-13 Complexe Hospitalier De La Sagamie Very low density lipoprotein receptor polymorphisms and uses therefor
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
AU2003243394B2 (en) 2002-06-07 2008-06-12 Takeda Pharmaceutical Company Limited Prevention and reduction of blood loss
EP2386310B1 (en) 2002-08-28 2018-11-07 Dyax Corp. Methods for preserving organs and tissues
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
WO2008077478A1 (en) * 2006-12-22 2008-07-03 Bayer Schering Pharma Aktiengesellschaft Preparation and use of variants of the kunitz domain 2 of the human placental bikunin gene
DE102007056231A1 (de) 2007-09-08 2009-03-12 Bayer Healthcare Ag Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI)
US8637454B2 (en) 2009-01-06 2014-01-28 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
LT3459564T (lt) 2010-01-06 2022-03-10 Takeda Pharmaceutical Company Limited Plazmos kalikreiną surišantys baltymai
KR102320178B1 (ko) 2011-01-06 2021-11-02 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 결합 단백질
AU2016366557B2 (en) 2015-12-11 2024-01-25 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2188322A (en) * 1986-03-26 1987-09-30 Bayer Ag Aprotinin and analogues thereof produced by a recombinant host
DE3724570A1 (de) * 1987-06-27 1989-01-05 Bayer Ag Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist
DK450187D0 (da) * 1987-08-28 1987-08-28 Novo Industri As Fremgangsmaade til fremstilling af proteiner
DK225488D0 (da) * 1988-04-26 1988-04-26 Novo Industri As Polypeptid
DE3930522A1 (de) * 1989-09-13 1991-03-21 Bayer Ag Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben

Also Published As

Publication number Publication date
MX9101382A (es) 1992-06-05
CA2092920A1 (en) 1992-04-02
NO931220D0 (no) 1993-03-31
HUT69955A (en) 1995-09-28
FI931457A0 (fi) 1993-03-31
DK0551329T3 (da) 1999-04-19
ATE168414T1 (de) 1998-08-15
NZ240014A (en) 1992-08-26
FI105036B (fi) 2000-05-31
CZ51793A3 (en) 1994-01-19
EP0551329A1 (en) 1993-07-21
AU659100B2 (en) 1995-05-11
JPH06501158A (ja) 1994-02-10
KR100250391B1 (ko) 2000-05-01
CZ285225B6 (cs) 1999-06-16
WO1992006111A1 (en) 1992-04-16
SK281540B6 (sk) 2001-04-09
DE69129809D1 (de) 1998-08-20
NO931220L (no) 1993-04-01
FI931457A (fi) 1993-03-31
JP3614850B2 (ja) 2005-01-26
HU219302B (en) 2001-03-28
AU8546091A (en) 1992-04-28
SK26493A3 (en) 1993-10-06
NO309529B1 (no) 2001-02-12
PT99124B (pt) 1999-03-31
IL99585A0 (en) 1992-08-18
EP0551329B1 (en) 1998-07-15
PT99124A (pt) 1992-08-31
IE913433A1 (en) 1992-04-08
UA34422C2 (uk) 2001-03-15
DE69129809T2 (de) 1998-11-19
HU9300943D0 (en) 1993-06-28

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