DK0551329T3 - Aprotininanaloger - Google Patents

Aprotininanaloger

Info

Publication number
DK0551329T3
DK0551329T3 DK91917143T DK91917143T DK0551329T3 DK 0551329 T3 DK0551329 T3 DK 0551329T3 DK 91917143 T DK91917143 T DK 91917143T DK 91917143 T DK91917143 T DK 91917143T DK 0551329 T3 DK0551329 T3 DK 0551329T3
Authority
DK
Denmark
Prior art keywords
aminoacid
replaced
residue
negatively charged
aminoacid residue
Prior art date
Application number
DK91917143T
Other languages
English (en)
Inventor
Soren Erik Bjorn
Kjeld Norris
Viggo Diness
Leif Birkeve Norskov-Lauritsen
Niels Dyhr Christensen
Claus Bregengaard
Leif Norskov-Lauritsen
Soeren Erik Bjirn
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK236190A external-priority patent/DK236190D0/da
Priority claimed from DK111891A external-priority patent/DK111891D0/da
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of DK0551329T3 publication Critical patent/DK0551329T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK91917143T 1990-10-01 1991-10-01 Aprotininanaloger DK0551329T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK236190A DK236190D0 (da) 1990-10-01 1990-10-01 Polypeptid
DK111891A DK111891D0 (da) 1991-06-12 1991-06-12 Polypeptid
PCT/DK1991/000299 WO1992006111A1 (en) 1990-10-01 1991-10-01 Aprotinin analogues

Publications (1)

Publication Number Publication Date
DK0551329T3 true DK0551329T3 (da) 1999-04-19

Family

ID=26065261

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91917143T DK0551329T3 (da) 1990-10-01 1991-10-01 Aprotininanaloger

Country Status (21)

Country Link
EP (1) EP0551329B1 (da)
JP (1) JP3614850B2 (da)
KR (1) KR100250391B1 (da)
AT (1) ATE168414T1 (da)
AU (1) AU659100B2 (da)
CA (1) CA2092920A1 (da)
CZ (1) CZ285225B6 (da)
DE (1) DE69129809T2 (da)
DK (1) DK0551329T3 (da)
ES (1) ES2121787T3 (da)
FI (1) FI105036B (da)
HU (1) HU219302B (da)
IE (1) IE913433A1 (da)
IL (1) IL99585A0 (da)
MX (1) MX9101382A (da)
NO (1) NO309529B1 (da)
NZ (1) NZ240014A (da)
PT (1) PT99124B (da)
SK (1) SK281540B6 (da)
UA (1) UA34422C2 (da)
WO (1) WO1992006111A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
EP1231274A3 (en) * 1994-11-21 2002-10-09 The University Of Leeds Modified porteinase inhibitors
AU738766B2 (en) * 1994-11-21 2001-09-27 University Of Leeds, The Modified proteinase inhibitors
DE19629982A1 (de) * 1996-07-25 1998-01-29 Bayer Ag Aprotinin-Varianten mit verbesserten Eigenschaften
DE19725014A1 (de) * 1997-06-13 1998-12-17 Bayer Ag Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
AU2001243508A1 (en) 2000-03-08 2001-09-17 Complexe Hospitalier De La Sagamie Very low density lipoprotein receptor polymorphisms and uses therefor
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
DK1531791T3 (da) 2002-06-07 2010-11-01 Dyax Corp Forebyggelse og begrænsning af iskæmi
ES2395014T3 (es) 2002-08-28 2013-02-07 Dyax Corp. Métodos para conservar órganos y tejidos
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
WO2008077478A1 (en) * 2006-12-22 2008-07-03 Bayer Schering Pharma Aktiengesellschaft Preparation and use of variants of the kunitz domain 2 of the human placental bikunin gene
DE102007056231A1 (de) 2007-09-08 2009-03-12 Bayer Healthcare Ag Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI)
WO2010080833A1 (en) 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
RS57870B1 (sr) 2010-01-06 2018-12-31 Dyax Corp Proteini koji vezuju kalikrein plazme
KR102107695B1 (ko) 2011-01-06 2020-05-07 다이액스 코포레이션 혈장 칼리크레인 결합 단백질
BR112018011622A2 (pt) 2015-12-11 2018-11-27 Dyax Corp método para tratar ataque de angioedema hereditário (hae) ou reduzir a taxa de ataque de hae

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2188322A (en) * 1986-03-26 1987-09-30 Bayer Ag Aprotinin and analogues thereof produced by a recombinant host
DE3724570A1 (de) * 1987-06-27 1989-01-05 Bayer Ag Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist
DK225488D0 (da) * 1988-04-26 1988-04-26 Novo Industri As Polypeptid
DK450187D0 (da) * 1987-08-28 1987-08-28 Novo Industri As Fremgangsmaade til fremstilling af proteiner
DE3930522A1 (de) * 1989-09-13 1991-03-21 Bayer Ag Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben

Also Published As

Publication number Publication date
PT99124B (pt) 1999-03-31
NO931220D0 (no) 1993-03-31
AU659100B2 (en) 1995-05-11
CZ285225B6 (cs) 1999-06-16
KR100250391B1 (ko) 2000-05-01
PT99124A (pt) 1992-08-31
HU9300943D0 (en) 1993-06-28
NZ240014A (en) 1992-08-26
IL99585A0 (en) 1992-08-18
SK281540B6 (sk) 2001-04-09
SK26493A3 (en) 1993-10-06
UA34422C2 (uk) 2001-03-15
DE69129809D1 (de) 1998-08-20
NO309529B1 (no) 2001-02-12
NO931220L (no) 1993-04-01
MX9101382A (es) 1992-06-05
EP0551329A1 (en) 1993-07-21
WO1992006111A1 (en) 1992-04-16
CZ51793A3 (en) 1994-01-19
DE69129809T2 (de) 1998-11-19
CA2092920A1 (en) 1992-04-02
EP0551329B1 (en) 1998-07-15
IE913433A1 (en) 1992-04-08
HU219302B (en) 2001-03-28
HUT69955A (en) 1995-09-28
JP3614850B2 (ja) 2005-01-26
ATE168414T1 (de) 1998-08-15
FI105036B (fi) 2000-05-31
ES2121787T3 (es) 1998-12-16
FI931457A (fi) 1993-03-31
AU8546091A (en) 1992-04-28
JPH06501158A (ja) 1994-02-10
FI931457A0 (fi) 1993-03-31

Similar Documents

Publication Publication Date Title
DK0551329T3 (da) Aprotininanaloger
RS49685B (sr) Novi oblik jedinjenja
DE69109083T2 (de) Glasfaserzusammensetzungen.
SE8903042D0 (sv) Pharmaceutical compositions comprising cyklosporins
DE68913050D1 (de) Antithrombotische zusammensetzung.
DE69400872D1 (de) Kraftstoffzusammensetzungen
DK331989A (da) Kompressor
NO910656L (no) Sperrevaeske-tetningsanordning for turbokompressor.
DE68905762T2 (de) Perorale zusammensetzungen.
ATE210149T1 (de) Entzündungshemmende zusammensetzung und methode, in welchen des-tyr dynorphin und analoge benutzt werden
DK0437556T3 (da) Substitutionsanaloger af magaininpeptider
ITTO910894A1 (it) "un procedimento per preparare dipeptidi".
NO902871D0 (no) Fremgangsmaate for innfoering av et peptid i cytosol.
DE69130265D1 (de) Positive arbeitende Photolackzusammensetzung
DE58902491D1 (de) Neue difluormethyl-thiadiazolyl-oxyessigsaeureamiden.
IT9020008A0 (it) Composizioni polimeriche autoestinguenti
DE69014171D1 (de) Schwundarm härtbare Zusammensetzung auf Basis von ungesättigten Polyesterbasen.
DE69113895T2 (de) Anaerob härtende Zusammensetzungen.
RU93005177A (ru) Аналоги апротинина, днк, вектор, клетка, способ получения аналогов, фармацевтическая композиция, применение аналогов
DE9303608U1 (de) Akkubetriebener Kleinkompressor
FI945105A (fi) 17alfa- ja 17beta-substituoitu estra-1,3,5(10)-trieeni-3-karboksyylihappo
NO891483D0 (no) Arcelin fra lagringsproteiner fra phaseolus vulgaris.
NO962204D0 (no) Dobbeltkjedede hemoregulatoriske peptider
NL7902932A (nl) Aan somatostatine structureel verwante peptiden.
IT8607101V0 (it) Calza formata da due corpi di maglia inseriti l'uno nell'altro.