SK280552B6 - Spôsob prípravy klodronátových prípravkov - Google Patents

Spôsob prípravy klodronátových prípravkov Download PDF

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Publication number
SK280552B6
SK280552B6 SK606-96A SK60696A SK280552B6 SK 280552 B6 SK280552 B6 SK 280552B6 SK 60696 A SK60696 A SK 60696A SK 280552 B6 SK280552 B6 SK 280552B6
Authority
SK
Slovakia
Prior art keywords
weight
clodronate
disodium
tetrahydrate
water
Prior art date
Application number
SK606-96A
Other languages
English (en)
Slovak (sk)
Other versions
SK60696A3 (en
Inventor
Esko Pohjala
Heikki Nupponen
Kari Lehmussaari
Original Assignee
Leiras Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy filed Critical Leiras Oy
Publication of SK60696A3 publication Critical patent/SK60696A3/sk
Publication of SK280552B6 publication Critical patent/SK280552B6/sk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Ceramic Products (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
  • Glass Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Glanulating (AREA)
  • Seasonings (AREA)
SK606-96A 1993-11-12 1994-11-11 Spôsob prípravy klodronátových prípravkov SK280552B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI935019A FI94926C (fi) 1993-11-12 1993-11-12 Menetelmä klodronaattivalmisteen valmistamiseksi
PCT/FI1994/000509 WO1995013054A1 (en) 1993-11-12 1994-11-11 Process for preparing a clodronate preparation

Publications (2)

Publication Number Publication Date
SK60696A3 SK60696A3 (en) 1997-02-05
SK280552B6 true SK280552B6 (sk) 2000-03-13

Family

ID=8538945

Family Applications (1)

Application Number Title Priority Date Filing Date
SK606-96A SK280552B6 (sk) 1993-11-12 1994-11-11 Spôsob prípravy klodronátových prípravkov

Country Status (25)

Country Link
US (1) US5776499A (cs)
EP (1) EP0727983B1 (cs)
JP (1) JPH09504800A (cs)
KR (1) KR100352155B1 (cs)
CN (1) CN1040945C (cs)
AT (1) ATE202700T1 (cs)
AU (1) AU679586B2 (cs)
CA (1) CA2175994A1 (cs)
CZ (1) CZ286132B6 (cs)
DE (1) DE69427648T2 (cs)
DK (1) DK0727983T3 (cs)
ES (1) ES2160688T3 (cs)
FI (1) FI94926C (cs)
GR (1) GR3036470T3 (cs)
HU (1) HU220633B1 (cs)
IL (1) IL111596A (cs)
NO (1) NO312938B1 (cs)
NZ (1) NZ275833A (cs)
PL (1) PL176658B1 (cs)
PT (1) PT727983E (cs)
RU (1) RU2141323C1 (cs)
SK (1) SK280552B6 (cs)
TW (1) TW436297B (cs)
WO (1) WO1995013054A1 (cs)
ZA (1) ZA948974B (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI109088B (fi) * 1997-09-19 2002-05-31 Leiras Oy Tabletti ja menetelmä sen valmistamiseksi
DE19808634A1 (de) * 1998-02-24 1999-08-26 Schering Ag Mantel für eine pharmazeutische Zusammensetzung
AR021347A1 (es) * 1999-10-20 2002-07-17 Cipla Ltd Una composicion farmaceutica que contiene acido(s) bisfosfoncio o sal(es) del mismo y un proceso de preparacion de la misma
RO121891B1 (ro) 2001-07-04 2008-07-30 Sindan S.R.L. Compoziţie farmaceutică pentru profilaxia şi tratamentul dereglărilor metabolismului calciului şi procedeu de preparare
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
GB0616794D0 (en) 2006-08-24 2006-10-04 Arrow Int Ltd Solid dosage form
JP6864955B2 (ja) * 2015-12-22 2021-04-28 ストック カンパニー“チェペトスキー メカニカル プラント” チタン合金から棒材を製造する方法
MX2020005182A (es) 2017-11-22 2020-08-17 Inbiomotion Sl Tratamiento terapeutico del cancer de mama basado en el estado del c-maf.
TWI806467B (zh) 2022-03-03 2023-06-21 金兆豐數位科技股份有限公司 金融商品提昇報酬率多維度決策方法
IT202300007269A1 (it) 2023-04-14 2024-10-14 Univ Degli Studi Magna Graecia Di Catanzaro Formulazione farmaceutica composta da Peptide-C associato a un bisfosfonato in forma unica e suo uso nel trattamento dell’osteosarcopenia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0275468B1 (de) * 1986-12-20 1991-02-06 Roche Diagnostics GmbH Clodronat-haltige Arzneimittel und Verfahren zur Herstellung derselben
SE501389C2 (sv) * 1992-04-24 1995-01-30 Leiras Oy Farmaceutiskt preparat och förfarande för dess framställning
EP0625355B2 (de) * 1993-05-15 2003-06-25 Roche Diagnostics GmbH Tablette mit verbesserter Bioverfügbarkeit enthaltend Dichlormethylendiphosphonsäure als Wirkstoff

Also Published As

Publication number Publication date
NZ275833A (en) 1997-10-24
WO1995013054A1 (en) 1995-05-18
TW436297B (en) 2001-05-28
RU2141323C1 (ru) 1999-11-20
GR3036470T3 (en) 2001-11-30
SK60696A3 (en) 1997-02-05
KR100352155B1 (ko) 2002-12-31
DE69427648D1 (de) 2001-08-09
KR960705548A (ko) 1996-11-08
CA2175994A1 (en) 1995-05-18
HU9601257D0 (en) 1996-07-29
JPH09504800A (ja) 1997-05-13
ES2160688T3 (es) 2001-11-16
ATE202700T1 (de) 2001-07-15
CZ286132B6 (cs) 2000-01-12
PT727983E (pt) 2001-11-30
FI935019L (fi) 1995-05-13
PL314299A1 (en) 1996-09-02
IL111596A (en) 1998-12-06
DK0727983T3 (da) 2001-09-24
EP0727983B1 (en) 2001-07-04
FI94926C (fi) 1995-11-27
HU220633B1 (hu) 2002-03-28
ZA948974B (en) 1995-11-21
NO961906L (no) 1996-05-23
CN1040945C (zh) 1998-12-02
FI935019A0 (fi) 1993-11-12
DE69427648T2 (de) 2002-04-18
AU8108794A (en) 1995-05-29
FI94926B (fi) 1995-08-15
AU679586B2 (en) 1997-07-03
IL111596A0 (en) 1995-01-24
CZ132796A3 (en) 1996-10-16
NO312938B1 (no) 2002-07-22
US5776499A (en) 1998-07-07
CN1134664A (zh) 1996-10-30
NO961906D0 (no) 1996-05-10
EP0727983A1 (en) 1996-08-28
PL176658B1 (pl) 1999-07-30
HUT75228A (en) 1997-04-28

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