SK279669B6 - Dna-fragment, plazmidy a mikroorganizmy obsahujúce - Google Patents
Dna-fragment, plazmidy a mikroorganizmy obsahujúce Download PDFInfo
- Publication number
- SK279669B6 SK279669B6 SK420-95A SK42095A SK279669B6 SK 279669 B6 SK279669 B6 SK 279669B6 SK 42095 A SK42095 A SK 42095A SK 279669 B6 SK279669 B6 SK 279669B6
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- SK
- Slovakia
- Prior art keywords
- biotin
- gene
- coli
- plasmid
- leu
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- 229960004198 guanidine Drugs 0.000 description 1
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 1
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical group O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 1
- 108010036413 histidylglycine Proteins 0.000 description 1
- 108010025306 histidylleucine Proteins 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000099 in vitro assay Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- JDNTWHVOXJZDSN-UHFFFAOYSA-N iodoacetic acid Chemical compound OC(=O)CI JDNTWHVOXJZDSN-UHFFFAOYSA-N 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 108010053037 kyotorphin Proteins 0.000 description 1
- 229940072205 lactobacillus plantarum Drugs 0.000 description 1
- 108010071185 leucyl-alanine Proteins 0.000 description 1
- 108010051673 leucyl-glycyl-phenylalanine Proteins 0.000 description 1
- 238000009630 liquid culture Methods 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 108010003700 lysyl aspartic acid Proteins 0.000 description 1
- 108010025153 lysyl-alanyl-alanine Proteins 0.000 description 1
- 108010044348 lysyl-glutamyl-aspartic acid Proteins 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 108010005942 methionylglycine Proteins 0.000 description 1
- 108010068488 methionylphenylalanine Proteins 0.000 description 1
- 239000006151 minimal media Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- FTQWRYSLUYAIRQ-UHFFFAOYSA-N n-[(octadecanoylamino)methyl]octadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)NCNC(=O)CCCCCCCCCCCCCCCCC FTQWRYSLUYAIRQ-UHFFFAOYSA-N 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 238000002414 normal-phase solid-phase extraction Methods 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 108010073025 phenylalanylphenylalanine Proteins 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- LYCRXMTYUZDUGA-UYRKPTJQSA-N pimeloyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCCCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LYCRXMTYUZDUGA-UYRKPTJQSA-N 0.000 description 1
- 239000013600 plasmid vector Substances 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 108010087846 prolyl-prolyl-glycine Proteins 0.000 description 1
- 108010090894 prolylleucine Proteins 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- FCHXJFJNDJXENQ-UHFFFAOYSA-N pyridoxal hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(C=O)=C1O FCHXJFJNDJXENQ-UHFFFAOYSA-N 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 108010026333 seryl-proline Proteins 0.000 description 1
- 108010071207 serylmethionine Proteins 0.000 description 1
- 235000021309 simple sugar Nutrition 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000004071 soot Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229960000344 thiamine hydrochloride Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 235000019190 thiamine hydrochloride Nutrition 0.000 description 1
- 239000011747 thiamine hydrochloride Substances 0.000 description 1
- 108010061238 threonyl-glycine Proteins 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 108010029384 tryptophyl-histidine Proteins 0.000 description 1
- 108010035534 tyrosyl-leucyl-alanine Proteins 0.000 description 1
- 108010003137 tyrosyltyrosine Proteins 0.000 description 1
- 235000011912 vitamin B7 Nutrition 0.000 description 1
- 239000011735 vitamin B7 Substances 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system
- C12P17/186—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system containing a 2-oxo-thieno[3,4-d]imidazol nucleus, e.g. Biotin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
Landscapes
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH312492 | 1992-10-02 | ||
CH213493 | 1993-07-15 | ||
PCT/EP1993/002688 WO1994008023A2 (de) | 1992-10-02 | 1993-10-01 | Biotechnologisches verfahren zur herstellung von biotin |
Publications (2)
Publication Number | Publication Date |
---|---|
SK42095A3 SK42095A3 (en) | 1995-11-08 |
SK279669B6 true SK279669B6 (sk) | 1999-02-11 |
Family
ID=25689605
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK420-95A SK279669B6 (sk) | 1992-10-02 | 1993-10-01 | Dna-fragment, plazmidy a mikroorganizmy obsahujúce |
Country Status (16)
Country | Link |
---|---|
US (1) | US6083712A (ko) |
EP (2) | EP0667909B1 (ko) |
JP (2) | JP3566287B2 (ko) |
KR (1) | KR100200542B1 (ko) |
AT (1) | ATE163198T1 (ko) |
AU (1) | AU4820293A (ko) |
CA (1) | CA2145400C (ko) |
CZ (1) | CZ285533B6 (ko) |
DE (1) | DE59308149D1 (ko) |
DK (1) | DK0667909T3 (ko) |
ES (1) | ES2112995T3 (ko) |
FI (1) | FI117515B (ko) |
HU (1) | HU219827B (ko) |
PL (2) | PL177635B1 (ko) |
SK (1) | SK279669B6 (ko) |
WO (1) | WO1994008023A2 (ko) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5859335A (en) * | 1994-12-08 | 1999-01-12 | Novartis Finance Corporation | Enhanced biotin biosynthesis in plant tissue |
US5869719A (en) * | 1995-03-08 | 1999-02-09 | Novartis Finance Corporation | Transgenic plants having increased biotin content |
WO1997016560A1 (en) * | 1995-11-02 | 1997-05-09 | Takeda Chemical Industries, Ltd. | Microorganism resistant to threonine analogue and production of biotin |
US6361978B1 (en) | 1996-05-06 | 2002-03-26 | Roche Vitamins, Inc. | Production of biotin |
EP0853127B1 (en) * | 1996-09-27 | 2004-11-03 | DSM IP Assets B.V. | Biotin biosynthetic genes II |
US6737256B2 (en) | 1997-07-14 | 2004-05-18 | Roche Vitamins Inc. | Overcoming DAPA aminotransferase bottlenecks in biotin vitamers biosynthesis |
DE19731274A1 (de) | 1997-07-22 | 1999-01-28 | Basf Ag | Verfahren zur Herstellung von Biotin |
CN100342008C (zh) * | 1997-10-24 | 2007-10-10 | 茵维特罗根公司 | 利用具重组位点的核酸进行重组克隆 |
EP1728866B1 (en) * | 1999-09-08 | 2009-11-11 | Xenogen Corporation | Luciferase expression cassettes and methods of use |
US6660907B2 (en) | 2000-07-10 | 2003-12-09 | Pioneer Hi-Bred International, Inc. | Genes encoding SCIP-1 orthologs and methods of use |
US7198924B2 (en) | 2000-12-11 | 2007-04-03 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
WO2002090596A1 (en) * | 2001-05-07 | 2002-11-14 | Paradigm Genetics, Inc. | Methods for the identification of inhibitors of biotim synthase expression or activity in plants |
DE602004027538D1 (de) | 2003-12-01 | 2010-07-15 | Life Technologies Corp | Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon |
US20110104752A1 (en) * | 2008-03-14 | 2011-05-05 | Merck Serono S.A. | Variation of Recombinant Expression Titres By Optimising Bacterial Ribosome Binding Sites |
GB0920775D0 (en) * | 2009-11-26 | 2010-01-13 | King S College | Cells |
WO2018022595A1 (en) * | 2016-07-25 | 2018-02-01 | Invista Textiles (U.K.) Limited | Materials and methods utilizing biotin producing mutant hosts for the production of 7-carbon chemicals |
KR102712136B1 (ko) * | 2021-11-15 | 2024-09-27 | 씨제이제일제당 (주) | 바이오틴 신타제 활성을 갖는 폴리펩티드 변이체 및 이를 이용한 바이오틴 생산 방법 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0740922B2 (ja) * | 1985-03-05 | 1995-05-10 | 株式会社資生堂 | ビオチン生産性微生物 |
CA1317245C (en) * | 1985-08-26 | 1993-05-04 | Eric F. Fisher | System for biotin synthesis |
US5110731A (en) * | 1985-08-26 | 1992-05-05 | Amgen, Inc. | System for biotin synthesis |
JPS62155081A (ja) * | 1985-12-27 | 1987-07-10 | Shiseido Co Ltd | 新規微生物およびそれを用いる醗酵法によるビオチンの製造法 |
AU616380B2 (en) * | 1986-09-30 | 1991-10-31 | Transgene S.A. | Cloning of the bioA, bioD, bioF, bioC, and bioH genes of Bacillus sphaericus, vectors and transformed cells and method for preparing biotin |
CA1322735C (en) * | 1987-11-07 | 1993-10-05 | Shinichiro Haze | Microorganism having low acetate forming capability, and process for production of useful substrate using same |
GB2216530B (en) * | 1988-03-22 | 1992-07-08 | Mini Agriculture & Fisheries | Genetic material for expression of biotin synthetase enzymes |
JP3006847B2 (ja) * | 1990-03-27 | 2000-02-07 | 株式会社資生堂 | 新規微生物およびそれを用いるビオチン類の製造方法 |
JPH04169180A (ja) * | 1990-11-02 | 1992-06-17 | Shiseido Co Ltd | 新規微生物及びそれを用いるビオチン活性物質の製造方法 |
JP3290473B2 (ja) * | 1991-09-13 | 2002-06-10 | 株式会社資生堂 | ビオチンオペロン |
JP3192704B2 (ja) * | 1991-10-17 | 2001-07-30 | 株式会社資生堂 | デスチオビオチンからビオチンへの変換方法 |
US5374543A (en) * | 1992-10-02 | 1994-12-20 | Amgen Inc. | Enhanced indole biosynthesis |
US5445952A (en) * | 1993-01-22 | 1995-08-29 | Basf Aktiengesellschaft | Method to produce biotin |
-
1993
- 1993-10-01 EP EP93920855A patent/EP0667909B1/de not_active Expired - Lifetime
- 1993-10-01 AT AT93920855T patent/ATE163198T1/de active
- 1993-10-01 KR KR1019950701255A patent/KR100200542B1/ko not_active IP Right Cessation
- 1993-10-01 US US08/411,768 patent/US6083712A/en not_active Expired - Lifetime
- 1993-10-01 PL PL93308301A patent/PL177635B1/pl unknown
- 1993-10-01 CA CA002145400A patent/CA2145400C/en not_active Expired - Lifetime
- 1993-10-01 ES ES93920855T patent/ES2112995T3/es not_active Expired - Lifetime
- 1993-10-01 AU AU48202/93A patent/AU4820293A/en not_active Abandoned
- 1993-10-01 WO PCT/EP1993/002688 patent/WO1994008023A2/de active IP Right Grant
- 1993-10-01 HU HU9500951A patent/HU219827B/hu unknown
- 1993-10-01 SK SK420-95A patent/SK279669B6/sk not_active IP Right Cessation
- 1993-10-01 DE DE59308149T patent/DE59308149D1/de not_active Expired - Lifetime
- 1993-10-01 DK DK93920855T patent/DK0667909T3/da active
- 1993-10-01 PL PL93333484A patent/PL179166B1/pl unknown
- 1993-10-01 JP JP50871694A patent/JP3566287B2/ja not_active Expired - Fee Related
- 1993-10-01 EP EP97107803A patent/EP0798384A1/de not_active Withdrawn
- 1993-10-01 CZ CZ95809A patent/CZ285533B6/cs not_active IP Right Cessation
-
1995
- 1995-03-31 FI FI951547A patent/FI117515B/fi not_active IP Right Cessation
-
2003
- 2003-09-04 JP JP2003312645A patent/JP3577075B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PL308301A1 (en) | 1995-07-24 |
WO1994008023A2 (de) | 1994-04-14 |
DE59308149D1 (de) | 1998-03-19 |
CZ80995A3 (en) | 1995-09-13 |
KR100200542B1 (ko) | 1999-06-15 |
CZ285533B6 (cs) | 1999-08-11 |
HU219827B (hu) | 2001-08-28 |
CA2145400C (en) | 2005-08-09 |
DK0667909T3 (da) | 1998-09-23 |
HU9500951D0 (en) | 1995-05-29 |
PL177635B1 (pl) | 1999-12-31 |
FI117515B (fi) | 2006-11-15 |
JPH08501694A (ja) | 1996-02-27 |
FI951547A0 (fi) | 1995-03-31 |
ATE163198T1 (de) | 1998-02-15 |
ES2112995T3 (es) | 1998-04-16 |
AU4820293A (en) | 1994-04-26 |
CA2145400A1 (en) | 1994-04-14 |
SK42095A3 (en) | 1995-11-08 |
EP0667909A1 (de) | 1995-08-23 |
FI951547A (fi) | 1995-03-31 |
JP2004000283A (ja) | 2004-01-08 |
EP0798384A1 (de) | 1997-10-01 |
KR950703648A (ko) | 1995-09-20 |
HUT71781A (en) | 1996-02-28 |
JP3566287B2 (ja) | 2004-09-15 |
US6083712A (en) | 2000-07-04 |
JP3577075B2 (ja) | 2004-10-13 |
PL179166B1 (pl) | 2000-07-31 |
EP0667909B1 (de) | 1998-02-11 |
WO1994008023A3 (de) | 1994-06-23 |
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Expiry date: 20131001 |