SK279433B6 - Substituované bifenylpyridóny, spôsob ich výroby, - Google Patents

Substituované bifenylpyridóny, spôsob ich výroby, Download PDF

Info

Publication number
SK279433B6
SK279433B6 SK3380-92A SK338092A SK279433B6 SK 279433 B6 SK279433 B6 SK 279433B6 SK 338092 A SK338092 A SK 338092A SK 279433 B6 SK279433 B6 SK 279433B6
Authority
SK
Slovakia
Prior art keywords
group
carbon atoms
straight
branched alkyl
hydrogen atom
Prior art date
Application number
SK3380-92A
Other languages
English (en)
Slovak (sk)
Other versions
SK338092A3 (en
Inventor
Matthias M�Ller-Gliemann
Martin Beuck
Stanislav Kazda
Johannes-Peter Stasch
Andreas Knorr
Stefan Wohlfeil
Walter Hbsch
J�Rgen Dressel
Peter Fey
Rudolf Hanko
Thomas Krmer
Ulrich E. M�Ller
Siegfried Zaiss
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of SK338092A3 publication Critical patent/SK338092A3/sk
Publication of SK279433B6 publication Critical patent/SK279433B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
SK3380-92A 1991-11-12 1992-11-12 Substituované bifenylpyridóny, spôsob ich výroby, SK279433B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4137151 1991-11-12
DE4221583A DE4221583A1 (de) 1991-11-12 1992-07-01 Substituierte biphenylpyridone

Publications (2)

Publication Number Publication Date
SK338092A3 SK338092A3 (en) 1998-11-04
SK279433B6 true SK279433B6 (sk) 1998-11-04

Family

ID=25909023

Family Applications (1)

Application Number Title Priority Date Filing Date
SK3380-92A SK279433B6 (sk) 1991-11-12 1992-11-12 Substituované bifenylpyridóny, spôsob ich výroby,

Country Status (23)

Country Link
US (2) US5356911A (cg-RX-API-DMAC7.html)
EP (1) EP0542059B1 (cg-RX-API-DMAC7.html)
JP (1) JPH05255258A (cg-RX-API-DMAC7.html)
KR (1) KR930010030A (cg-RX-API-DMAC7.html)
CN (1) CN1038935C (cg-RX-API-DMAC7.html)
AT (1) ATE135700T1 (cg-RX-API-DMAC7.html)
AU (1) AU659235B2 (cg-RX-API-DMAC7.html)
CA (1) CA2082306A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ281937B6 (cg-RX-API-DMAC7.html)
DE (2) DE4221583A1 (cg-RX-API-DMAC7.html)
DK (1) DK0542059T3 (cg-RX-API-DMAC7.html)
ES (1) ES2086046T3 (cg-RX-API-DMAC7.html)
FI (1) FI925100L (cg-RX-API-DMAC7.html)
GR (1) GR3019398T3 (cg-RX-API-DMAC7.html)
HU (1) HUT67018A (cg-RX-API-DMAC7.html)
IL (1) IL103688A (cg-RX-API-DMAC7.html)
MX (1) MX9206305A (cg-RX-API-DMAC7.html)
MY (1) MY109880A (cg-RX-API-DMAC7.html)
NO (1) NO303541B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ245073A (cg-RX-API-DMAC7.html)
RU (1) RU2100350C1 (cg-RX-API-DMAC7.html)
SK (1) SK279433B6 (cg-RX-API-DMAC7.html)
TW (1) TW218874B (cg-RX-API-DMAC7.html)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4129340A1 (de) * 1991-09-04 1993-03-11 Merck Patent Gmbh 1,2-dihydro-2-oxopyridine
US5674883A (en) * 1992-02-07 1997-10-07 Roussel Uclaf Derivatives of pyridone, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them
GB9218449D0 (en) 1992-08-29 1992-10-14 Boots Co Plc Therapeutic agents
DE4319041A1 (de) * 1992-10-23 1994-04-28 Bayer Ag Trisubstituierte Biphenyle
DE4319040A1 (de) * 1992-10-23 1994-04-28 Bayer Ag Alkoxymethylsubstituierte Pyridonbiphenyle
GB9604926D0 (en) 1996-03-08 1996-05-08 Sandoz Ltd Organic compounds
DE19619950A1 (de) 1996-04-17 1997-10-23 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide
EP0802192A1 (de) * 1996-04-17 1997-10-22 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide mit antiatherosklerotischer Wirkung und Verfahren zu ihrer Herstellung
TW418204B (en) * 1997-03-28 2001-01-11 Dev Center Biotechnology Novel 1,2,4-triazine-5-ketonyl benzene derivatives and the analogs, the preparation, and the pharmaceutical compositions as angiotension II receptor antogonists
HU222773B1 (hu) * 2000-04-21 2003-10-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás egy ismert tetrazolszármazék előállítására
GB0022483D0 (en) * 2000-09-13 2000-11-01 Eisai Co Ltd 1 2 Dihydropyridine compounds manufacturing method thereof and use thereof
JP5082033B2 (ja) * 2001-12-21 2012-11-28 エグゼリクシス パテント カンパニー エルエルシー Ｌｘｒのモジュレーター
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
DE60330126D1 (de) * 2002-02-14 2009-12-31 Pharmacia Corp Substituierte pyridinone als modulatoren für p38 map kinase
EP1628970A2 (en) * 2003-04-30 2006-03-01 The Institutes of Pharmaceutical Discovery, LLC Heterocycle substituted carboxylic acids as inhibitors of protein tyrosine phosphatase-1b
MY148809A (en) * 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
US20060122222A1 (en) * 2004-11-18 2006-06-08 The Institutes For Pharmaceutical Discovery, Llc Heterocycle substituted carboxylic acids
CA2591413A1 (en) * 2004-12-16 2006-06-22 Vertex Pharmaceuticals Incorporated Pyrid-2-ones useful as inhibitors of tec family protein kinases for the treatment of inflammatory, proliferative and immunologically-mediated diseases
DE102005030522A1 (de) * 2005-06-30 2007-01-04 Bayer Healthcare Ag Salz des Embusartans
EP1919906B1 (en) 2005-08-29 2011-10-12 Vertex Pharmaceuticals Incorporated 3, 5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
ATE548363T1 (de) * 2005-08-29 2012-03-15 Vertex Pharma 3,5-disubstituierte pyrid-2-one, die sich als inhibitoren der tec-familie von nicht-rezeptor- tyrosinkinasen eignen
JP5112317B2 (ja) * 2005-08-29 2013-01-09 バーテックス ファーマシューティカルズ インコーポレイテッド 非受容体型チロシンキナーゼのｔｅｃファミリーの阻害剤として有用な３，５−二置換ピリド−２−オン
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
ES2559319T3 (es) 2007-06-04 2016-02-11 Synergy Pharmaceuticals Inc. Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US8034782B2 (en) 2008-07-16 2011-10-11 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2203439B1 (en) 2007-09-14 2011-01-26 Ortho-McNeil-Janssen Pharmaceuticals, Inc. 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-ý1, 4'¨bipyridinyl-2'-ones
EP2205565B1 (en) 2007-09-14 2013-04-17 Janssen Pharmaceuticals, Inc. 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones
WO2009033702A1 (en) 2007-09-14 2009-03-19 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
EP2220083B1 (en) * 2007-11-14 2017-07-19 Janssen Pharmaceuticals, Inc. Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
EP2328910B1 (en) 2008-06-04 2014-08-06 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2439291T3 (es) 2008-09-02 2014-01-22 Janssen Pharmaceuticals, Inc. Derivados de 3-azabiciclo[3.1.0]hexilo como moduladores de receptores de glutamato metabotrópicos
JP5656848B2 (ja) 2008-10-16 2015-01-21 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体モジュレーターとしてのインドールおよびベンゾモルホリンの誘導体
EP2373649B1 (en) 2008-11-28 2013-01-23 Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
SG176018A1 (en) 2009-05-12 2011-12-29 Janssen Pharmaceuticals Inc 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
WO2010130424A1 (en) 2009-05-12 2010-11-18 Ortho-Mcneil-Janssen Pharmaceuticals, Inc 1,2,3-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
PL2496236T4 (pl) * 2009-11-06 2015-11-30 Aerpio Therapeutics Inc Inhibitory hydroksylazy prolilowej
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN103298810B (zh) 2010-11-08 2016-03-16 杨森制药公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
CN103261195B (zh) 2010-11-08 2015-09-02 杨森制药公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
US8993591B2 (en) 2010-11-08 2015-03-31 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
JP6137193B2 (ja) * 2011-12-21 2017-05-31 小野薬品工業株式会社 第ＸＩａ因子阻害剤としての新規ピリジノンおよびピリミジノン誘導体
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
BR112015030326A2 (pt) 2013-06-05 2017-08-29 Synergy Pharmaceuticals Inc Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
KR20200036063A (ko) 2014-01-21 2020-04-06 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
MX386697B (es) 2014-01-21 2025-03-19 Janssen Pharmaceutica Nv Combinaciones que comprenden agonistas ortostericos o moduladores alostericos positivos del receptor glutamatergico metabotropico de subtipo 2 y su uso
EP3702357B1 (en) 2014-12-10 2022-08-24 ONO Pharmaceutical Co., Ltd. Dihydroindolizinone derivative
US10322156B2 (en) * 2016-07-07 2019-06-18 Herbalife International Of America, Inc. Methods of treatment using purified (decolorized) aloe vera leaf dry juice
EP4288430A1 (en) 2021-02-02 2023-12-13 Liminal Biosciences Limited Gpr84 antagonists and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0407342A3 (en) 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
US5100897A (en) 1989-08-28 1992-03-31 Merck & Co., Inc. Substituted pyrimidinones as angiotensin ii antagonists
EP0424317A3 (en) 1989-10-19 1991-09-25 Ciba-Geigy Ag Pyrimidines
EP0435827A3 (en) 1989-12-28 1991-11-13 Ciba-Geigy Ag Diaza compounds
CA2037630C (en) 1990-03-07 2001-07-03 Akira Morimoto Nitrogen-containing heterocylic compounds, their production and use
KR100196559B1 (ko) * 1990-06-19 1999-06-15 기따사또 이찌로 안지오텐신ii 길항작용을 함유하는 피리딘 유도체
IL100917A0 (en) * 1991-02-16 1992-11-15 Fisons Plc Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them
CN1068109A (zh) * 1991-02-16 1993-01-20 菲索斯有限公司 新的血管紧张肽ii拮抗剂及其制剂的制备和应用
DE4129340A1 (de) * 1991-09-04 1993-03-11 Merck Patent Gmbh 1,2-dihydro-2-oxopyridine

Also Published As

Publication number Publication date
KR930010030A (ko) 1993-06-21
DE4221583A1 (de) 1993-05-13
AU659235B2 (en) 1995-05-11
MX9206305A (es) 1993-05-01
CN1072180A (zh) 1993-05-19
NZ245073A (en) 1996-02-27
CZ338092A3 (en) 1993-09-15
FI925100A7 (fi) 1993-05-13
CA2082306A1 (en) 1993-05-12
NO924172D0 (no) 1992-10-29
US5356911A (en) 1994-10-18
ES2086046T3 (es) 1996-06-16
CN1038935C (zh) 1998-07-01
TW218874B (cg-RX-API-DMAC7.html) 1994-01-11
IL103688A (en) 1997-02-18
FI925100L (fi) 1993-05-13
JPH05255258A (ja) 1993-10-05
RU2100350C1 (ru) 1997-12-27
NO303541B1 (no) 1998-07-27
EP0542059B1 (de) 1996-03-20
HU9203552D0 (en) 1993-01-28
SK338092A3 (en) 1998-11-04
ATE135700T1 (de) 1996-04-15
HUT67018A (en) 1995-01-30
DK0542059T3 (da) 1996-07-22
CZ281937B6 (cs) 1997-04-16
IL103688A0 (en) 1993-04-04
FI925100A0 (fi) 1992-11-10
AU2823292A (en) 1993-05-13
NO924172L (no) 1993-05-14
DE59205752D1 (de) 1996-04-25
GR3019398T3 (en) 1996-06-30
US5599823A (en) 1997-02-04
EP0542059A1 (de) 1993-05-19
MY109880A (en) 1997-09-30

Similar Documents

Publication Publication Date Title
SK279433B6 (sk) Substituované bifenylpyridóny, spôsob ich výroby,
CZ15793A3 (en) Sulfonylbenzyl-substituted pyridones
CZ280248B6 (cs) Substituované azoly, způsob jejich výroby, přípravky obsahující tyto sloučeniny a jejich použití
CZ297692A3 (en) Substituted derivatives of imidazolyl-propenoic acid
SK46693A3 (en) Sulfonylbenzyl substituted benzopyridones and pyridopyridones
CZ29793A3 (en) Phenylacetic acid substituted amides
CZ297792A3 (en) Cyclically substituted derivatives of imidazolyl-propenoic acid
SK46793A3 (en) Regenarative melting tank and method of working
CZ298892A3 (en) Derivatives of imidazolyl-propenoic acid
SK18893A3 (en) Imidazolyl substituted amides of phenylacetic acid
CZ51693A3 (en) Propenoyl-imidazole derivatives
HU216829B (hu) Kétszeresen kondenzált pirrolcsoporttal helyettesített fenil-ciklohexán-karbonsav-származékok és az ezeket tartalmazó gyógyszerkészítmények, valamint eljárás előállításukra
SK106693A3 (en) Benzimidazole derivatives, process of their production and pharmaceutical agents with the content of those
SK66793A3 (en) Imidazolyl substituted derivatives of phenylpropane and cinnamon acid
SK35094A3 (en) Phenylglycinamides heterocyclic substituted derivatives of phenylacetic acid, method of their production, medicines contains these matters, method of their production and using of these matters
SK14393A3 (en) Sulfonylbenzene substituted derivatives of imidazolylpropene acid
SK281028B6 (sk) Imidazolyl substituované deriváty cyklohexánu, spôsob ich výroby, medziprodukt spôsobu výroby, ich použitie na výrobu liečiv a liečivo
SK14293A3 (en) Sulfonylbenzyl substituted imidazopyridines
SK14493A3 (en) Sulfonylbenzyl substituted imidazoles
SK27593A3 (en) Cycloalkyl and heterocyclyl substituted derivatives of imidazolylpropenoic acid
PL176171B1 (pl) Trójpodstawione bifenyle i sposób wytwarzania trójpodstawionych bifenyli
NO et al. 3rd Phase, Bangalore 560078 (IN).
JPH0753550A (ja) スルホニルベンジル−置換されたベンズイミダゾール類、それらの製造方法および薬品におけるそれらの使用