RU2100350C1 - Производные бифенилпиридона и их соли - Google Patents

Производные бифенилпиридона и их соли Download PDF

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Publication number
RU2100350C1
RU2100350C1 RU9292004391A RU92004391A RU2100350C1 RU 2100350 C1 RU2100350 C1 RU 2100350C1 RU 9292004391 A RU9292004391 A RU 9292004391A RU 92004391 A RU92004391 A RU 92004391A RU 2100350 C1 RU2100350 C1 RU 2100350C1
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RU
Russia
Prior art keywords
alkyl
hydrogen
group
formula
unsubstituted
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RU9292004391A
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English (en)
Russian (ru)
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RU92004391A (ru
Inventor
Мюллер-Глиманн Маттиас
Бойк Мартин
Казда Станислав
Сташ Йоханнес-Петер
Кнорр Андреас
Вольфайль Стефан
Хюбш Вальтер
Дрессель Юрген
Фай Петер
Ханко Рудольф
Крэмер Томас
Мюллер Ульрих
Цайсс Хигфрид
Original Assignee
Байер Аг
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Publication of RU92004391A publication Critical patent/RU92004391A/ru
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Publication of RU2100350C1 publication Critical patent/RU2100350C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
RU9292004391A 1991-11-12 1992-11-11 Производные бифенилпиридона и их соли RU2100350C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DEP4137151.8 1991-11-12
DE4137151 1991-11-12
DE4221583A DE4221583A1 (de) 1991-11-12 1992-07-01 Substituierte biphenylpyridone
DEP4221583.8 1992-07-01

Publications (2)

Publication Number Publication Date
RU92004391A RU92004391A (ru) 1995-03-27
RU2100350C1 true RU2100350C1 (ru) 1997-12-27

Family

ID=25909023

Family Applications (1)

Application Number Title Priority Date Filing Date
RU9292004391A RU2100350C1 (ru) 1991-11-12 1992-11-11 Производные бифенилпиридона и их соли

Country Status (23)

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US (2) US5356911A (cg-RX-API-DMAC7.html)
EP (1) EP0542059B1 (cg-RX-API-DMAC7.html)
JP (1) JPH05255258A (cg-RX-API-DMAC7.html)
KR (1) KR930010030A (cg-RX-API-DMAC7.html)
CN (1) CN1038935C (cg-RX-API-DMAC7.html)
AT (1) ATE135700T1 (cg-RX-API-DMAC7.html)
AU (1) AU659235B2 (cg-RX-API-DMAC7.html)
CA (1) CA2082306A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ281937B6 (cg-RX-API-DMAC7.html)
DE (2) DE4221583A1 (cg-RX-API-DMAC7.html)
DK (1) DK0542059T3 (cg-RX-API-DMAC7.html)
ES (1) ES2086046T3 (cg-RX-API-DMAC7.html)
FI (1) FI925100L (cg-RX-API-DMAC7.html)
GR (1) GR3019398T3 (cg-RX-API-DMAC7.html)
HU (1) HUT67018A (cg-RX-API-DMAC7.html)
IL (1) IL103688A (cg-RX-API-DMAC7.html)
MX (1) MX9206305A (cg-RX-API-DMAC7.html)
MY (1) MY109880A (cg-RX-API-DMAC7.html)
NO (1) NO303541B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ245073A (cg-RX-API-DMAC7.html)
RU (1) RU2100350C1 (cg-RX-API-DMAC7.html)
SK (1) SK279433B6 (cg-RX-API-DMAC7.html)
TW (1) TW218874B (cg-RX-API-DMAC7.html)

Cited By (2)

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RU2265015C2 (ru) * 2000-09-13 2005-11-27 Эйсай Ко., Лтд. Соединения 1,2-дигидропиридина, способ их получения и их использование
RU2423351C2 (ru) * 2004-12-16 2011-07-10 Вертекс Фармасьютикалз Инкорпорейтед Пирид-2-оны, применимые как ингибиторы протеинкиназ семейства тес для лечения воспалительных, пролиферативных и иммунологически-опосредованных заболеваний

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DE4129340A1 (de) * 1991-09-04 1993-03-11 Merck Patent Gmbh 1,2-dihydro-2-oxopyridine
US5674883A (en) * 1992-02-07 1997-10-07 Roussel Uclaf Derivatives of pyridone, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them
GB9218449D0 (en) 1992-08-29 1992-10-14 Boots Co Plc Therapeutic agents
DE4319041A1 (de) * 1992-10-23 1994-04-28 Bayer Ag Trisubstituierte Biphenyle
DE4319040A1 (de) * 1992-10-23 1994-04-28 Bayer Ag Alkoxymethylsubstituierte Pyridonbiphenyle
GB9604926D0 (en) 1996-03-08 1996-05-08 Sandoz Ltd Organic compounds
DE19619950A1 (de) 1996-04-17 1997-10-23 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide
EP0802192A1 (de) * 1996-04-17 1997-10-22 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide mit antiatherosklerotischer Wirkung und Verfahren zu ihrer Herstellung
TW418204B (en) * 1997-03-28 2001-01-11 Dev Center Biotechnology Novel 1,2,4-triazine-5-ketonyl benzene derivatives and the analogs, the preparation, and the pharmaceutical compositions as angiotension II receptor antogonists
HU222773B1 (hu) * 2000-04-21 2003-10-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás egy ismert tetrazolszármazék előállítására
JP5082033B2 (ja) * 2001-12-21 2012-11-28 エグゼリクシス パテント カンパニー エルエルシー Ｌｘｒのモジュレーター
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
DE60330126D1 (de) * 2002-02-14 2009-12-31 Pharmacia Corp Substituierte pyridinone als modulatoren für p38 map kinase
EP1628970A2 (en) * 2003-04-30 2006-03-01 The Institutes of Pharmaceutical Discovery, LLC Heterocycle substituted carboxylic acids as inhibitors of protein tyrosine phosphatase-1b
MY148809A (en) * 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
US20060122222A1 (en) * 2004-11-18 2006-06-08 The Institutes For Pharmaceutical Discovery, Llc Heterocycle substituted carboxylic acids
DE102005030522A1 (de) * 2005-06-30 2007-01-04 Bayer Healthcare Ag Salz des Embusartans
EP1919906B1 (en) 2005-08-29 2011-10-12 Vertex Pharmaceuticals Incorporated 3, 5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
ATE548363T1 (de) * 2005-08-29 2012-03-15 Vertex Pharma 3,5-disubstituierte pyrid-2-one, die sich als inhibitoren der tec-familie von nicht-rezeptor- tyrosinkinasen eignen
JP5112317B2 (ja) * 2005-08-29 2013-01-09 バーテックス ファーマシューティカルズ インコーポレイテッド 非受容体型チロシンキナーゼのｔｅｃファミリーの阻害剤として有用な３，５−二置換ピリド−２−オン
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
ES2559319T3 (es) 2007-06-04 2016-02-11 Synergy Pharmaceuticals Inc. Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US8034782B2 (en) 2008-07-16 2011-10-11 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2203439B1 (en) 2007-09-14 2011-01-26 Ortho-McNeil-Janssen Pharmaceuticals, Inc. 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-ý1, 4'¨bipyridinyl-2'-ones
EP2205565B1 (en) 2007-09-14 2013-04-17 Janssen Pharmaceuticals, Inc. 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones
WO2009033702A1 (en) 2007-09-14 2009-03-19 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
EP2220083B1 (en) * 2007-11-14 2017-07-19 Janssen Pharmaceuticals, Inc. Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
EP2328910B1 (en) 2008-06-04 2014-08-06 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2439291T3 (es) 2008-09-02 2014-01-22 Janssen Pharmaceuticals, Inc. Derivados de 3-azabiciclo[3.1.0]hexilo como moduladores de receptores de glutamato metabotrópicos
JP5656848B2 (ja) 2008-10-16 2015-01-21 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体モジュレーターとしてのインドールおよびベンゾモルホリンの誘導体
EP2373649B1 (en) 2008-11-28 2013-01-23 Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
SG176018A1 (en) 2009-05-12 2011-12-29 Janssen Pharmaceuticals Inc 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
WO2010130424A1 (en) 2009-05-12 2010-11-18 Ortho-Mcneil-Janssen Pharmaceuticals, Inc 1,2,3-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
PL2496236T4 (pl) * 2009-11-06 2015-11-30 Aerpio Therapeutics Inc Inhibitory hydroksylazy prolilowej
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN103298810B (zh) 2010-11-08 2016-03-16 杨森制药公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
CN103261195B (zh) 2010-11-08 2015-09-02 杨森制药公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
US8993591B2 (en) 2010-11-08 2015-03-31 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
JP6137193B2 (ja) * 2011-12-21 2017-05-31 小野薬品工業株式会社 第ＸＩａ因子阻害剤としての新規ピリジノンおよびピリミジノン誘導体
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KR20200036063A (ko) 2014-01-21 2020-04-06 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2265015C2 (ru) * 2000-09-13 2005-11-27 Эйсай Ко., Лтд. Соединения 1,2-дигидропиридина, способ их получения и их использование
RU2423351C2 (ru) * 2004-12-16 2011-07-10 Вертекс Фармасьютикалз Инкорпорейтед Пирид-2-оны, применимые как ингибиторы протеинкиназ семейства тес для лечения воспалительных, пролиферативных и иммунологически-опосредованных заболеваний

Also Published As

Publication number Publication date
KR930010030A (ko) 1993-06-21
DE4221583A1 (de) 1993-05-13
AU659235B2 (en) 1995-05-11
MX9206305A (es) 1993-05-01
CN1072180A (zh) 1993-05-19
NZ245073A (en) 1996-02-27
CZ338092A3 (en) 1993-09-15
FI925100A7 (fi) 1993-05-13
CA2082306A1 (en) 1993-05-12
NO924172D0 (no) 1992-10-29
US5356911A (en) 1994-10-18
ES2086046T3 (es) 1996-06-16
CN1038935C (zh) 1998-07-01
TW218874B (cg-RX-API-DMAC7.html) 1994-01-11
IL103688A (en) 1997-02-18
FI925100L (fi) 1993-05-13
JPH05255258A (ja) 1993-10-05
NO303541B1 (no) 1998-07-27
EP0542059B1 (de) 1996-03-20
HU9203552D0 (en) 1993-01-28
SK338092A3 (en) 1998-11-04
SK279433B6 (sk) 1998-11-04
ATE135700T1 (de) 1996-04-15
HUT67018A (en) 1995-01-30
DK0542059T3 (da) 1996-07-22
CZ281937B6 (cs) 1997-04-16
IL103688A0 (en) 1993-04-04
FI925100A0 (fi) 1992-11-10
AU2823292A (en) 1993-05-13
NO924172L (no) 1993-05-14
DE59205752D1 (de) 1996-04-25
GR3019398T3 (en) 1996-06-30
US5599823A (en) 1997-02-04
EP0542059A1 (de) 1993-05-19
MY109880A (en) 1997-09-30

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