CZ281937B6 - Substituované bifenylpyridony - Google Patents

Substituované bifenylpyridony Download PDF

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Publication number
CZ281937B6
CZ281937B6 CS923380A CS338092A CZ281937B6 CZ 281937 B6 CZ281937 B6 CZ 281937B6 CS 923380 A CS923380 A CS 923380A CS 338092 A CS338092 A CS 338092A CZ 281937 B6 CZ281937 B6 CZ 281937B6
Authority
CZ
Czechia
Prior art keywords
group
carbon atoms
straight
branched alkyl
optionally substituted
Prior art date
Application number
CS923380A
Other languages
Czech (cs)
English (en)
Inventor
Mathias Dr. Müller-Gliemann
Martin Dr. Beuck
Stanislav Prof. Dr. Kazda
Johannes Peter Dr. Stasch
Stefan Dr. Wohlfeil
Walter Dr. Hübsch
Jürgen Dressel Ph.D.
Peter Dr. Fey
Rudolf Dr. Hanko
Thomas Dr. Krämer
Ulrich Dr. Müller
Siegfried Dr. Zaiss
Andreas Dr. Knorr
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of CZ338092A3 publication Critical patent/CZ338092A3/cs
Publication of CZ281937B6 publication Critical patent/CZ281937B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
CS923380A 1991-11-12 1992-11-12 Substituované bifenylpyridony CZ281937B6 (cs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4137151 1991-11-12
DE4221583A DE4221583A1 (de) 1991-11-12 1992-07-01 Substituierte biphenylpyridone

Publications (2)

Publication Number Publication Date
CZ338092A3 CZ338092A3 (en) 1993-09-15
CZ281937B6 true CZ281937B6 (cs) 1997-04-16

Family

ID=25909023

Family Applications (1)

Application Number Title Priority Date Filing Date
CS923380A CZ281937B6 (cs) 1991-11-12 1992-11-12 Substituované bifenylpyridony

Country Status (23)

Country Link
US (2) US5356911A (cg-RX-API-DMAC7.html)
EP (1) EP0542059B1 (cg-RX-API-DMAC7.html)
JP (1) JPH05255258A (cg-RX-API-DMAC7.html)
KR (1) KR930010030A (cg-RX-API-DMAC7.html)
CN (1) CN1038935C (cg-RX-API-DMAC7.html)
AT (1) ATE135700T1 (cg-RX-API-DMAC7.html)
AU (1) AU659235B2 (cg-RX-API-DMAC7.html)
CA (1) CA2082306A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ281937B6 (cg-RX-API-DMAC7.html)
DE (2) DE4221583A1 (cg-RX-API-DMAC7.html)
DK (1) DK0542059T3 (cg-RX-API-DMAC7.html)
ES (1) ES2086046T3 (cg-RX-API-DMAC7.html)
FI (1) FI925100L (cg-RX-API-DMAC7.html)
GR (1) GR3019398T3 (cg-RX-API-DMAC7.html)
HU (1) HUT67018A (cg-RX-API-DMAC7.html)
IL (1) IL103688A (cg-RX-API-DMAC7.html)
MX (1) MX9206305A (cg-RX-API-DMAC7.html)
MY (1) MY109880A (cg-RX-API-DMAC7.html)
NO (1) NO303541B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ245073A (cg-RX-API-DMAC7.html)
RU (1) RU2100350C1 (cg-RX-API-DMAC7.html)
SK (1) SK279433B6 (cg-RX-API-DMAC7.html)
TW (1) TW218874B (cg-RX-API-DMAC7.html)

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DE19619950A1 (de) 1996-04-17 1997-10-23 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide
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US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
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ES2559319T3 (es) 2007-06-04 2016-02-11 Synergy Pharmaceuticals Inc. Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US8034782B2 (en) 2008-07-16 2011-10-11 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2203439B1 (en) 2007-09-14 2011-01-26 Ortho-McNeil-Janssen Pharmaceuticals, Inc. 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-ý1, 4'¨bipyridinyl-2'-ones
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PL2496236T4 (pl) * 2009-11-06 2015-11-30 Aerpio Therapeutics Inc Inhibitory hydroksylazy prolilowej
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CN103261195B (zh) 2010-11-08 2015-09-02 杨森制药公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
US8993591B2 (en) 2010-11-08 2015-03-31 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
JP6137193B2 (ja) * 2011-12-21 2017-05-31 小野薬品工業株式会社 第ＸＩａ因子阻害剤としての新規ピリジノンおよびピリミジノン誘導体
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KR20200036063A (ko) 2014-01-21 2020-04-06 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
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DE4129340A1 (de) * 1991-09-04 1993-03-11 Merck Patent Gmbh 1,2-dihydro-2-oxopyridine

Also Published As

Publication number Publication date
KR930010030A (ko) 1993-06-21
DE4221583A1 (de) 1993-05-13
AU659235B2 (en) 1995-05-11
MX9206305A (es) 1993-05-01
CN1072180A (zh) 1993-05-19
NZ245073A (en) 1996-02-27
CZ338092A3 (en) 1993-09-15
FI925100A7 (fi) 1993-05-13
CA2082306A1 (en) 1993-05-12
NO924172D0 (no) 1992-10-29
US5356911A (en) 1994-10-18
ES2086046T3 (es) 1996-06-16
CN1038935C (zh) 1998-07-01
TW218874B (cg-RX-API-DMAC7.html) 1994-01-11
IL103688A (en) 1997-02-18
FI925100L (fi) 1993-05-13
JPH05255258A (ja) 1993-10-05
RU2100350C1 (ru) 1997-12-27
NO303541B1 (no) 1998-07-27
EP0542059B1 (de) 1996-03-20
HU9203552D0 (en) 1993-01-28
SK338092A3 (en) 1998-11-04
SK279433B6 (sk) 1998-11-04
ATE135700T1 (de) 1996-04-15
HUT67018A (en) 1995-01-30
DK0542059T3 (da) 1996-07-22
IL103688A0 (en) 1993-04-04
FI925100A0 (fi) 1992-11-10
AU2823292A (en) 1993-05-13
NO924172L (no) 1993-05-14
DE59205752D1 (de) 1996-04-25
GR3019398T3 (en) 1996-06-30
US5599823A (en) 1997-02-04
EP0542059A1 (de) 1993-05-19
MY109880A (en) 1997-09-30

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Legal Events

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MM4A Patent lapsed due to non-payment of fee

Effective date: 19991112