SK2232001A3 - Process for purifying human papillomavirus virus-like particles - Google Patents
Process for purifying human papillomavirus virus-like particles Download PDFInfo
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- SK2232001A3 SK2232001A3 SK223-2001A SK2232001A SK2232001A3 SK 2232001 A3 SK2232001 A3 SK 2232001A3 SK 2232001 A SK2232001 A SK 2232001A SK 2232001 A3 SK2232001 A3 SK 2232001A3
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- vlps
- hpv
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- 239000000725 suspension Substances 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 229940124856 vaccine component Drugs 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20051—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9656898P | 1998-08-14 | 1998-08-14 | |
| PCT/US1999/017930 WO2000009671A1 (en) | 1998-08-14 | 1999-08-10 | Process for purifying human papillomavirus virus-like particles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK2232001A3 true SK2232001A3 (en) | 2001-08-06 |
Family
ID=22257989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK223-2001A SK2232001A3 (en) | 1998-08-14 | 1999-08-10 | Process for purifying human papillomavirus virus-like particles |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6602697B1 (pt) |
| EP (1) | EP1105466B1 (pt) |
| JP (1) | JP4440471B2 (pt) |
| KR (1) | KR20010072470A (pt) |
| CN (1) | CN1354787A (pt) |
| AT (1) | ATE324436T1 (pt) |
| AU (1) | AU760633B2 (pt) |
| BR (1) | BR9913026A (pt) |
| CA (1) | CA2339034C (pt) |
| CY (1) | CY1105084T1 (pt) |
| CZ (1) | CZ2001570A3 (pt) |
| DE (1) | DE69931053T2 (pt) |
| DK (1) | DK1105466T3 (pt) |
| EA (1) | EA200100236A1 (pt) |
| ES (1) | ES2262333T3 (pt) |
| HR (1) | HRP20010113A2 (pt) |
| HU (1) | HUP0103091A3 (pt) |
| IL (1) | IL141130A0 (pt) |
| NZ (1) | NZ509610A (pt) |
| PL (1) | PL347472A1 (pt) |
| PT (1) | PT1105466E (pt) |
| SI (1) | SI1105466T1 (pt) |
| SK (1) | SK2232001A3 (pt) |
| WO (1) | WO2000009671A1 (pt) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2773698C (en) * | 1998-10-16 | 2015-05-19 | Glaxosmithkline Biologicals S.A. | Adjuvant systems comprising an immunostimulant adsorbed to a metallic salt particle and vaccines thereof |
| JP2000262280A (ja) * | 1999-03-18 | 2000-09-26 | Asahi Optical Co Ltd | ウィルスまたはウィルス性抗原の精製方法およびワクチンの製造方法 |
| US6436402B1 (en) * | 1999-10-15 | 2002-08-20 | Merck & Co., Inc. | Process for making human papillomavirus virus-like particles with improved properties |
| GB0206360D0 (en) * | 2002-03-18 | 2002-05-01 | Glaxosmithkline Biolog Sa | Viral antigens |
| MY139500A (en) * | 2003-11-12 | 2009-10-30 | Merck Sharp & Dohme | Optimized expression of hpv 58 l1 in yeast |
| EP2821135A1 (en) * | 2004-02-05 | 2015-01-07 | EMD Millipore Corporation | Porous adsorptive or chromatographic media |
| TWI349036B (en) * | 2004-03-24 | 2011-09-21 | Merck Sharp & Dohme | Optimized expression of hpv 52 l1 in yeast |
| DE602005022458D1 (de) | 2004-09-10 | 2010-09-02 | Asahi Glass Co Ltd | Impfstoff gegen humanes papillomavirus zur oralen verabreichung |
| EP1736538A1 (en) * | 2005-06-21 | 2006-12-27 | Cytos Biotechnology AG | Process for the preparative purification of virus-like-particles (VLPs) |
| JP2010502425A (ja) * | 2006-08-30 | 2010-01-28 | ジーイー・ヘルスケア・バイオサイエンス・コーポレイション | 膜を評価するシステム及び方法並びに膜濾過装置 |
| SG174845A1 (en) | 2006-09-29 | 2011-10-28 | Ligocyte Pharmaceuticals Inc | Norovirus vaccine formulations |
| AU2008302276B2 (en) | 2006-09-29 | 2013-10-10 | Takeda Vaccines, Inc. | Method of conferring a protective immune response to norovirus |
| ATE496935T1 (de) * | 2007-02-22 | 2011-02-15 | Baxter Int | Verfahren zur aufreinigung hydrophober proteine |
| KR20150098681A (ko) * | 2007-03-14 | 2015-08-28 | 다케다 백신즈 인코포레이티드 | 바이러스 유사 입자 정제 |
| BRPI0811016B1 (pt) | 2007-04-29 | 2021-09-21 | Xiamen Innovax Biotech Co., Ltd. | Proteína li truncada do papiloma vírus humano tipo 16 |
| WO2008134935A1 (fr) | 2007-04-29 | 2008-11-13 | Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. | Protéines 18 l1 de type papillomavirus humain tronqué |
| BRPI0810951B8 (pt) * | 2007-05-29 | 2021-05-25 | Beijing Wantai Biological Pharmacy Entpr Co Ltd | proteína l1 do hpv6, polinucleotídeo, vetor, célula, partícula semelhante ao vírus (vlp) hpv6, método para produzir a proteína hpv6 l1 truncada, vacina para prevenção de condiloma acuminado ou de infecções por hpv, uso da proteína hpv6 l1 truncada, método para prevenção de condiloma acuminado ou infecções por hpv, método para obter uma vlp de uma proteína l1 do hpv6 e método para produzir uma vacina para a prevenção de condiloma acuminado ou de infecções por hpv |
| US9433922B2 (en) * | 2007-08-14 | 2016-09-06 | Emd Millipore Corporation | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same |
| US20100266636A1 (en) | 2007-09-18 | 2010-10-21 | Ligocyte Pharmaceuticals, Inc. | Method of conferring a protective immune response to norovirus |
| DE602007007927D1 (de) * | 2007-11-05 | 2010-09-02 | Agilent Technologies Inc | Einfrierung eines mikrofluidischen Chips |
| US20090130738A1 (en) * | 2007-11-19 | 2009-05-21 | Mikhail Kozlov | Media for membrane ion exchange chromatography |
| DK2324113T3 (en) | 2008-08-08 | 2018-04-16 | Takeda Vaccines Inc | VIRUS-LIKE PARTICLES INCLUDING COMPOSITE CAPSID AMINO ACID SEQUENCES FOR INCREASED CRYSTAL REACTIVITY |
| CA2787009C (en) * | 2010-01-15 | 2018-04-03 | Bio-Rad Laboratories, Inc. | Surface neutralization of apatite |
| US9644187B2 (en) | 2010-04-14 | 2017-05-09 | Emd Millipore Corporation | Methods of producing high titer, high purity virus stocks and methods of use thereof |
| US8895707B2 (en) | 2010-08-18 | 2014-11-25 | Bio-Rad Laboratories, Inc. | Elution of proteins from hydroxyapatite resins without resin deterioration |
| US9592540B2 (en) | 2011-02-02 | 2017-03-14 | Bio-Rad Laboratories, Inc. | Apatite surface neutralization with alkali solutions |
| WO2013009849A1 (en) | 2011-07-11 | 2013-01-17 | Ligocyte Pharmaceuticals, Inc. | Parenteral norovirus vaccine formulations |
| JP6228922B2 (ja) | 2011-12-01 | 2017-11-08 | ユニバーシティ・オブ・ケープ・タウンＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｐｅ Ｔｏｗｎ | Ｈｐｖキメラ粒子 |
| US9815695B2 (en) | 2012-05-30 | 2017-11-14 | Bio-Rad Laboratories, Inc. | In situ restoration of apatite-based chromatography resins |
| JOP20130186B1 (ar) | 2012-06-22 | 2021-08-17 | Takeda Vaccines Montana Inc | تنقية الجزيئات الشبيهة بالفيروسات |
| KR101559622B1 (ko) * | 2012-07-30 | 2015-10-13 | 중앙대학교 산학협력단 | 인유두종바이러스 바이러스 유사입자의 고효율 정제방법 |
| JP6479305B2 (ja) | 2013-07-12 | 2019-03-06 | 株式会社Ｕｍｎファーマ | ウイルス様粒子の精製方法 |
| WO2015200282A1 (en) | 2014-06-23 | 2015-12-30 | Bio-Rad Laboratories, Inc. | Apatite pretreatment |
| WO2015200299A2 (en) | 2014-06-23 | 2015-12-30 | Bio-Rad Laboratories, Inc. | Apatite in-situ restoration |
| CN105907729B (zh) * | 2015-05-05 | 2019-08-16 | 广东东阳光药业有限公司 | 一种制备人乳头瘤病毒l1蛋白类病毒样颗粒的方法 |
| CN108524929B (zh) * | 2017-03-06 | 2019-05-07 | 广州瑞贝斯药业有限公司 | 一种狂犬病疫苗的生产方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6078999A (ja) | 1983-10-05 | 1985-05-04 | Chemo Sero Therapeut Res Inst | ＨＢｓ抗原の精製方法 |
| SE9000650L (sv) | 1989-02-28 | 1990-08-29 | Asahi Optical Co Ltd | Separation av celler eller virus |
| CN1152935A (zh) * | 1994-05-16 | 1997-06-25 | 麦克公司 | 乳头状瘤病毒疫苗 |
| PL319294A1 (en) * | 1994-09-22 | 1997-08-04 | Merck & Co Inc | Dna encoding the human papilloma virus of 6 a type |
| AR004464A1 (es) * | 1994-11-14 | 1998-12-16 | Merck Sharp & Dohme | Un metodo para producir una proteina de capside de papilomavirus |
| IL117459A (en) * | 1995-03-22 | 2005-11-20 | Merck & Co Inc | Dna encoding human papillomavirus type 18 |
| IL117591A0 (en) * | 1995-03-30 | 1996-07-23 | Merck & Co Inc | Synthetic DNA encoding human papillomavirus type 11 L1 protein |
| WO1997008298A1 (en) * | 1995-08-30 | 1997-03-06 | Genzyme Corporation | Chromatographic purification of adenovirus and aav |
-
1999
- 1999-08-10 SI SI9930901T patent/SI1105466T1/sl unknown
- 1999-08-10 EP EP99940950A patent/EP1105466B1/en not_active Expired - Lifetime
- 1999-08-10 DE DE1999631053 patent/DE69931053T2/de not_active Expired - Lifetime
- 1999-08-10 JP JP2000565108A patent/JP4440471B2/ja not_active Expired - Lifetime
- 1999-08-10 NZ NZ50961099A patent/NZ509610A/xx not_active IP Right Cessation
- 1999-08-10 US US09/762,662 patent/US6602697B1/en not_active Expired - Lifetime
- 1999-08-10 EA EA200100236A patent/EA200100236A1/ru unknown
- 1999-08-10 DK DK99940950T patent/DK1105466T3/da active
- 1999-08-10 KR KR1020017001885A patent/KR20010072470A/ko not_active Application Discontinuation
- 1999-08-10 ES ES99940950T patent/ES2262333T3/es not_active Expired - Lifetime
- 1999-08-10 BR BR9913026A patent/BR9913026A/pt not_active Application Discontinuation
- 1999-08-10 HU HU0103091A patent/HUP0103091A3/hu unknown
- 1999-08-10 SK SK223-2001A patent/SK2232001A3/sk unknown
- 1999-08-10 CZ CZ2001570A patent/CZ2001570A3/cs unknown
- 1999-08-10 AT AT99940950T patent/ATE324436T1/de active
- 1999-08-10 CA CA 2339034 patent/CA2339034C/en not_active Expired - Lifetime
- 1999-08-10 PT PT99940950T patent/PT1105466E/pt unknown
- 1999-08-10 CN CN99811968A patent/CN1354787A/zh active Pending
- 1999-08-10 AU AU54698/99A patent/AU760633B2/en not_active Expired
- 1999-08-10 PL PL34747299A patent/PL347472A1/xx unknown
- 1999-08-10 WO PCT/US1999/017930 patent/WO2000009671A1/en active IP Right Grant
- 1999-08-10 IL IL14113099A patent/IL141130A0/xx unknown
-
2001
- 2001-02-14 HR HR20010113A patent/HRP20010113A2/hr not_active Application Discontinuation
-
2006
- 2006-07-11 CY CY20061100963T patent/CY1105084T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ2001570A3 (cs) | 2001-09-12 |
| HRP20010113A2 (en) | 2002-02-28 |
| DE69931053T2 (de) | 2006-11-23 |
| CY1105084T1 (el) | 2009-11-04 |
| WO2000009671A1 (en) | 2000-02-24 |
| PL347472A1 (en) | 2002-04-08 |
| BR9913026A (pt) | 2001-09-25 |
| EP1105466A4 (en) | 2002-05-15 |
| KR20010072470A (ko) | 2001-07-31 |
| AU760633B2 (en) | 2003-05-22 |
| AU5469899A (en) | 2000-03-06 |
| DK1105466T3 (da) | 2006-08-14 |
| HUP0103091A3 (en) | 2002-03-28 |
| IL141130A0 (en) | 2002-02-10 |
| HUP0103091A2 (hu) | 2001-12-28 |
| CA2339034C (en) | 2010-10-12 |
| ES2262333T3 (es) | 2006-11-16 |
| CA2339034A1 (en) | 2000-02-24 |
| EP1105466B1 (en) | 2006-04-26 |
| EP1105466A1 (en) | 2001-06-13 |
| SI1105466T1 (sl) | 2006-08-31 |
| DE69931053D1 (de) | 2006-06-01 |
| NZ509610A (en) | 2002-10-25 |
| PT1105466E (pt) | 2006-07-31 |
| US6602697B1 (en) | 2003-08-05 |
| EA200100236A1 (ru) | 2001-08-27 |
| CN1354787A (zh) | 2002-06-19 |
| JP2003520188A (ja) | 2003-07-02 |
| JP4440471B2 (ja) | 2010-03-24 |
| ATE324436T1 (de) | 2006-05-15 |
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