SK2232001A3 - Process for purifying human papillomavirus virus-like particles - Google Patents
Process for purifying human papillomavirus virus-like particles Download PDFInfo
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- SK2232001A3 SK2232001A3 SK223-2001A SK2232001A SK2232001A3 SK 2232001 A3 SK2232001 A3 SK 2232001A3 SK 2232001 A SK2232001 A SK 2232001A SK 2232001 A3 SK2232001 A3 SK 2232001A3
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- vlps
- hpv
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- 239000000725 suspension Substances 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 229940124856 vaccine component Drugs 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20051—Methods of production or purification of viral material
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9656898P | 1998-08-14 | 1998-08-14 | |
| PCT/US1999/017930 WO2000009671A1 (en) | 1998-08-14 | 1999-08-10 | Process for purifying human papillomavirus virus-like particles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK2232001A3 true SK2232001A3 (en) | 2001-08-06 |
Family
ID=22257989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK223-2001A SK2232001A3 (en) | 1998-08-14 | 1999-08-10 | Process for purifying human papillomavirus virus-like particles |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6602697B1 (ja) |
| EP (1) | EP1105466B1 (ja) |
| JP (1) | JP4440471B2 (ja) |
| KR (1) | KR20010072470A (ja) |
| CN (1) | CN1354787A (ja) |
| AT (1) | ATE324436T1 (ja) |
| AU (1) | AU760633B2 (ja) |
| BR (1) | BR9913026A (ja) |
| CA (1) | CA2339034C (ja) |
| CY (1) | CY1105084T1 (ja) |
| CZ (1) | CZ2001570A3 (ja) |
| DE (1) | DE69931053T2 (ja) |
| DK (1) | DK1105466T3 (ja) |
| EA (1) | EA200100236A1 (ja) |
| ES (1) | ES2262333T3 (ja) |
| HR (1) | HRP20010113A2 (ja) |
| HU (1) | HUP0103091A3 (ja) |
| IL (1) | IL141130A0 (ja) |
| NZ (1) | NZ509610A (ja) |
| PL (1) | PL347472A1 (ja) |
| PT (1) | PT1105466E (ja) |
| SI (1) | SI1105466T1 (ja) |
| SK (1) | SK2232001A3 (ja) |
| WO (1) | WO2000009671A1 (ja) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR200101055T2 (tr) * | 1998-10-16 | 2001-09-21 | Smithkline Beecham Biologicals S.A. | Adjuvan sistemler ve aşılar |
| JP2000262280A (ja) * | 1999-03-18 | 2000-09-26 | Asahi Optical Co Ltd | ウィルスまたはウィルス性抗原の精製方法およびワクチンの製造方法 |
| US6436402B1 (en) * | 1999-10-15 | 2002-08-20 | Merck & Co., Inc. | Process for making human papillomavirus virus-like particles with improved properties |
| GB0206360D0 (en) * | 2002-03-18 | 2002-05-01 | Glaxosmithkline Biolog Sa | Viral antigens |
| MY139500A (en) * | 2003-11-12 | 2009-10-30 | Merck Sharp & Dohme | Optimized expression of hpv 58 l1 in yeast |
| SG150501A1 (en) * | 2004-02-05 | 2009-03-30 | Millipore Corp | Porous adsorptive or chromatographic media |
| EP1730175B1 (en) * | 2004-03-24 | 2010-04-28 | Merck Sharp & Dohme Corp. | Optimized expression of hpv 52 l1 in yeast |
| WO2006028214A1 (ja) | 2004-09-10 | 2006-03-16 | Asahi Glass Company, Limited | 経口投与ワクチン |
| EP1736538A1 (en) * | 2005-06-21 | 2006-12-27 | Cytos Biotechnology AG | Process for the preparative purification of virus-like-particles (VLPs) |
| WO2008027861A1 (en) * | 2006-08-30 | 2008-03-06 | Ge Healthcare Bio-Sciences Corp. | System and method for characterizing membranes and membrane filtration devices |
| LT2601970T (lt) * | 2006-09-29 | 2017-04-25 | Takeda Vaccines, Inc. | Vakcinos prieš noro virusą kompozicijos |
| AU2008217189B2 (en) * | 2007-02-22 | 2013-06-13 | Baxalta GmbH | Method of purification of hydrophobic proteins |
| CA2683977C (en) * | 2007-03-14 | 2017-04-25 | Ligocyte Pharmaceuticals, Inc. | A method of norovirus virus-like particle purification comprising ion exchange chromatography |
| US9428555B2 (en) | 2007-04-29 | 2016-08-30 | Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. | Truncated L1 protein of Human Papillomavirus type 16 |
| US9364529B2 (en) | 2007-04-29 | 2016-06-14 | Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. | Truncated L1 protein of human papillomavirus type 18 |
| DK2154149T3 (da) * | 2007-05-29 | 2019-10-14 | Univ Xiamen | En trunkeret l1-protein af human papillomavirus 6 |
| US9433922B2 (en) * | 2007-08-14 | 2016-09-06 | Emd Millipore Corporation | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same |
| US20100266636A1 (en) * | 2007-09-18 | 2010-10-21 | Ligocyte Pharmaceuticals, Inc. | Method of conferring a protective immune response to norovirus |
| KR20100083150A (ko) * | 2007-09-18 | 2010-07-21 | 리고사이트 파머슈티컬즈 인코퍼레이티드 | 노로바이러스에 대한 보호면역반응을 제공하는 방법 |
| EP2011573B1 (en) * | 2007-11-05 | 2010-07-21 | Agilent Technologies, Inc. | Freezing a microfluidic chip |
| US20090130738A1 (en) * | 2007-11-19 | 2009-05-21 | Mikhail Kozlov | Media for membrane ion exchange chromatography |
| CN102177233B (zh) * | 2008-08-08 | 2015-04-15 | 莱戈赛特医药股份有限公司 | 用于增强交叉反应性的包含复合衣壳氨基酸序列的病毒样颗粒 |
| WO2011088225A1 (en) * | 2010-01-15 | 2011-07-21 | Bio-Rad Laboratories, Inc. | Surface neutralization of apatite |
| SG184833A1 (en) | 2010-04-14 | 2012-11-29 | Emd Millipore Corp | Methods of producing high titer, high purity virus stocks and methods of use thereof |
| US8895707B2 (en) | 2010-08-18 | 2014-11-25 | Bio-Rad Laboratories, Inc. | Elution of proteins from hydroxyapatite resins without resin deterioration |
| EP2670704B1 (en) | 2011-02-02 | 2018-12-12 | Bio-Rad Laboratories, Inc. | Apatite surface neutralization with alkali solutions |
| CR20190540A (es) | 2011-07-11 | 2022-04-04 | Takeda Vaccines Inc | FORMULACIONES PARENTERALES DE VACUNAS CONTRA LOS NOVOVIRUS (Divisional 2014-0069) |
| RU2642287C2 (ru) * | 2011-12-01 | 2018-01-24 | Юниверсити Оф Кейп Таун | Химерная частица hpv |
| US9815695B2 (en) | 2012-05-30 | 2017-11-14 | Bio-Rad Laboratories, Inc. | In situ restoration of apatite-based chromatography resins |
| JOP20130186B1 (ar) | 2012-06-22 | 2021-08-17 | Takeda Vaccines Montana Inc | تنقية الجزيئات الشبيهة بالفيروسات |
| KR101559622B1 (ko) * | 2012-07-30 | 2015-10-13 | 중앙대학교 산학협력단 | 인유두종바이러스 바이러스 유사입자의 고효율 정제방법 |
| JP6479305B2 (ja) * | 2013-07-12 | 2019-03-06 | 株式会社Ｕｍｎファーマ | ウイルス様粒子の精製方法 |
| WO2015200299A2 (en) | 2014-06-23 | 2015-12-30 | Bio-Rad Laboratories, Inc. | Apatite in-situ restoration |
| CN105392569B (zh) | 2014-06-23 | 2019-08-20 | 生物辐射实验室股份有限公司 | 磷灰石预处理 |
| CN105907729B (zh) * | 2015-05-05 | 2019-08-16 | 广东东阳光药业有限公司 | 一种制备人乳头瘤病毒l1蛋白类病毒样颗粒的方法 |
| CN108524929B (zh) * | 2017-03-06 | 2019-05-07 | 广州瑞贝斯药业有限公司 | 一种狂犬病疫苗的生产方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6078999A (ja) * | 1983-10-05 | 1985-05-04 | Chemo Sero Therapeut Res Inst | ＨＢｓ抗原の精製方法 |
| SE9000650L (sv) | 1989-02-28 | 1990-08-29 | Asahi Optical Co Ltd | Separation av celler eller virus |
| CA2189882C (en) | 1994-05-16 | 2005-09-20 | Kathrin U. Jansen | Papillomavirus vaccines |
| JPH10506014A (ja) * | 1994-09-22 | 1998-06-16 | メルク エンド カンパニー インコーポレーテッド | ヒトパピローマウイルス６ａ型をコードするＤＮＡ |
| AR004464A1 (es) * | 1994-11-14 | 1998-12-16 | Merck Sharp & Dohme | Un metodo para producir una proteina de capside de papilomavirus |
| IL117459A (en) * | 1995-03-22 | 2005-11-20 | Merck & Co Inc | Dna encoding human papillomavirus type 18 |
| IL117591A0 (en) * | 1995-03-30 | 1996-07-23 | Merck & Co Inc | Synthetic DNA encoding human papillomavirus type 11 L1 protein |
| WO1997008298A1 (en) * | 1995-08-30 | 1997-03-06 | Genzyme Corporation | Chromatographic purification of adenovirus and aav |
-
1999
- 1999-08-10 PL PL34747299A patent/PL347472A1/xx unknown
- 1999-08-10 WO PCT/US1999/017930 patent/WO2000009671A1/en active IP Right Grant
- 1999-08-10 US US09/762,662 patent/US6602697B1/en not_active Expired - Lifetime
- 1999-08-10 NZ NZ50961099A patent/NZ509610A/xx not_active IP Right Cessation
- 1999-08-10 AT AT99940950T patent/ATE324436T1/de active
- 1999-08-10 CA CA 2339034 patent/CA2339034C/en not_active Expired - Lifetime
- 1999-08-10 EA EA200100236A patent/EA200100236A1/ru unknown
- 1999-08-10 PT PT99940950T patent/PT1105466E/pt unknown
- 1999-08-10 BR BR9913026A patent/BR9913026A/pt not_active Application Discontinuation
- 1999-08-10 KR KR1020017001885A patent/KR20010072470A/ko not_active Application Discontinuation
- 1999-08-10 EP EP99940950A patent/EP1105466B1/en not_active Expired - Lifetime
- 1999-08-10 CN CN99811968A patent/CN1354787A/zh active Pending
- 1999-08-10 AU AU54698/99A patent/AU760633B2/en not_active Expired
- 1999-08-10 ES ES99940950T patent/ES2262333T3/es not_active Expired - Lifetime
- 1999-08-10 SK SK223-2001A patent/SK2232001A3/sk unknown
- 1999-08-10 SI SI9930901T patent/SI1105466T1/sl unknown
- 1999-08-10 IL IL14113099A patent/IL141130A0/xx unknown
- 1999-08-10 DK DK99940950T patent/DK1105466T3/da active
- 1999-08-10 JP JP2000565108A patent/JP4440471B2/ja not_active Expired - Lifetime
- 1999-08-10 HU HU0103091A patent/HUP0103091A3/hu unknown
- 1999-08-10 CZ CZ2001570A patent/CZ2001570A3/cs unknown
- 1999-08-10 DE DE1999631053 patent/DE69931053T2/de not_active Expired - Lifetime
-
2001
- 2001-02-14 HR HR20010113A patent/HRP20010113A2/hr not_active Application Discontinuation
-
2006
- 2006-07-11 CY CY20061100963T patent/CY1105084T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU5469899A (en) | 2000-03-06 |
| CZ2001570A3 (cs) | 2001-09-12 |
| DK1105466T3 (da) | 2006-08-14 |
| AU760633B2 (en) | 2003-05-22 |
| CA2339034C (en) | 2010-10-12 |
| DE69931053D1 (de) | 2006-06-01 |
| JP2003520188A (ja) | 2003-07-02 |
| PT1105466E (pt) | 2006-07-31 |
| IL141130A0 (en) | 2002-02-10 |
| CN1354787A (zh) | 2002-06-19 |
| JP4440471B2 (ja) | 2010-03-24 |
| ES2262333T3 (es) | 2006-11-16 |
| EP1105466B1 (en) | 2006-04-26 |
| HUP0103091A3 (en) | 2002-03-28 |
| KR20010072470A (ko) | 2001-07-31 |
| BR9913026A (pt) | 2001-09-25 |
| CA2339034A1 (en) | 2000-02-24 |
| NZ509610A (en) | 2002-10-25 |
| HRP20010113A2 (en) | 2002-02-28 |
| DE69931053T2 (de) | 2006-11-23 |
| SI1105466T1 (sl) | 2006-08-31 |
| PL347472A1 (en) | 2002-04-08 |
| CY1105084T1 (el) | 2009-11-04 |
| EP1105466A4 (en) | 2002-05-15 |
| WO2000009671A1 (en) | 2000-02-24 |
| HUP0103091A2 (hu) | 2001-12-28 |
| US6602697B1 (en) | 2003-08-05 |
| EA200100236A1 (ru) | 2001-08-27 |
| ATE324436T1 (de) | 2006-05-15 |
| EP1105466A1 (en) | 2001-06-13 |
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