SK18482000A3 - Farmaceutická kombinácia obsahujúca inhibítor cox-2 a inhibítor inos - Google Patents

Farmaceutická kombinácia obsahujúca inhibítor cox-2 a inhibítor inos Download PDF

Info

Publication number
SK18482000A3
SK18482000A3 SK1848-2000A SK18482000A SK18482000A3 SK 18482000 A3 SK18482000 A3 SK 18482000A3 SK 18482000 A SK18482000 A SK 18482000A SK 18482000 A3 SK18482000 A3 SK 18482000A3
Authority
SK
Slovakia
Prior art keywords
alkyl
combination
group
aromatic ring
heterocyclic aromatic
Prior art date
Application number
SK1848-2000A
Other languages
English (en)
Slovak (sk)
Inventor
Peter Hamley
Alan Tinker
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of SK18482000A3 publication Critical patent/SK18482000A3/sk

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SK1848-2000A 1998-06-29 1999-06-23 Farmaceutická kombinácia obsahujúca inhibítor cox-2 a inhibítor inos SK18482000A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9802333A SE9802333D0 (sv) 1998-06-29 1998-06-29 Novel combination
PCT/SE1999/001144 WO2000000200A1 (en) 1998-06-29 1999-06-23 A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR AND A iNOS INHIBITOR

Publications (1)

Publication Number Publication Date
SK18482000A3 true SK18482000A3 (sk) 2001-07-10

Family

ID=20411898

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1848-2000A SK18482000A3 (sk) 1998-06-29 1999-06-23 Farmaceutická kombinácia obsahujúca inhibítor cox-2 a inhibítor inos

Country Status (22)

Country Link
US (1) US6248745B1 (OSRAM)
EP (1) EP1100505A1 (OSRAM)
JP (1) JP2002519324A (OSRAM)
KR (1) KR20010053252A (OSRAM)
CN (1) CN1313769A (OSRAM)
AU (1) AU4944799A (OSRAM)
BR (1) BR9911666A (OSRAM)
CA (1) CA2334515A1 (OSRAM)
CZ (1) CZ20004896A3 (OSRAM)
EE (1) EE200000766A (OSRAM)
ID (1) ID27394A (OSRAM)
IL (1) IL140022A0 (OSRAM)
IN (1) IN2000MU00721A (OSRAM)
IS (1) IS5794A (OSRAM)
MX (1) MXPA00012162A (OSRAM)
NO (1) NO20006559L (OSRAM)
PL (1) PL345028A1 (OSRAM)
SE (1) SE9802333D0 (OSRAM)
SK (1) SK18482000A3 (OSRAM)
TR (1) TR200003808T2 (OSRAM)
WO (1) WO2000000200A1 (OSRAM)
ZA (1) ZA200007076B (OSRAM)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ513964A (en) * 1999-12-08 2004-01-30 Pharmacia Corp Solid-state form of celecoxib having enhanced bioavailability
JP2003523958A (ja) 1999-12-23 2003-08-12 ニトロメド インコーポレーテッド ニトロソ化およびニトロシル化されたシクロオキシゲナーゼ−2の阻害剤、組成物ならびに使用法
EP1406609B1 (en) * 2000-12-21 2006-09-06 Nitromed, Inc. Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
US7012098B2 (en) * 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
US20030207846A1 (en) * 2002-01-07 2003-11-06 Pharmacia Corporation Treatment of pain, inflammation, and inflammation-related disorders with a combination of a cyclooxygenase-2 selective inhibitor and aspirin
EP1539134A4 (en) 2002-06-11 2007-04-11 Nitromed Inc SELECTIVE INHIBITORS OF CYCLOOXIGENASE-2 NITROSIS AND / OR NITROSYLES, COMPOSITIONS AND METHODS OF USE
US20040077691A1 (en) * 2002-06-21 2004-04-22 Medinox, Inc. Hydroxamate derivatives of non-steroidal anti-inflammatory drugs
US7163958B2 (en) 2002-07-03 2007-01-16 Nitromed Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
AU2003261281A1 (en) * 2002-07-29 2004-02-16 Nicox S.A. Cyclooxygenase- 2 selective inhibitors, compositions and methods of use
AU2003260033A1 (en) * 2002-08-29 2004-03-19 Schering Aktiengesellschaft Methods of treating acute respiratory distress syndrome
ES2275218T3 (es) 2003-05-07 2007-06-01 Osteologix A/S Sales de estroncio hidrosolubles para el tratamiento de afecciones de cartilagos y/o huesos.
US8173642B2 (en) 2005-10-25 2012-05-08 Shionogi & Co., Ltd. Aminodihydrothiazine derivatives
JP2007275193A (ja) * 2006-04-04 2007-10-25 Fujifilm Corp 光プローブおよび光断層画像化装置
EP2083579B1 (en) 2006-10-25 2014-02-12 Huawei Technologies Co., Ltd. Processing location update request method, network entity, congestion control method and apparatus
CN101626787A (zh) * 2007-01-19 2010-01-13 马林克罗特公司 诊断的和治疗的环氧合酶-2结合配体
MX2009011498A (es) 2007-04-24 2009-11-10 Shionogi & Co Derivados de aminodihidrotiazina sustituida con un grupo ciclico.
EP2151435A4 (en) 2007-04-24 2011-09-14 Shionogi & Co PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE
CA2716628A1 (en) * 2008-03-24 2009-10-01 Carolus Therapeutics, Inc. Methods and compositions for treating atherosclerosis and related conditions
KR101324426B1 (ko) 2008-06-13 2013-10-31 시오노기세야쿠 가부시키가이샤 β 세크레타제 저해 작용을 갖는 황 함유 복소환 유도체
EP2360155A4 (en) 2008-10-22 2012-06-20 Shionogi & Co 2-AMINOPYRIDIN-4-ON AND 2-AMINOPYRIDINE DERIVATIVE WITH BACE1-HEMDERING EFFECT
US8453441B2 (en) 2008-11-06 2013-06-04 Purdue Research Foundation System and method for pump-controlled cylinder cushioning
MY145791A (en) * 2009-05-25 2012-04-30 Liang Woon San A method for producing a nutraceutical composition and the nutraceutical produced by the method
RU2012129168A (ru) 2009-12-11 2014-01-20 Сионоги Энд Ко. Лтд. Производные оксазина
EP2518059A4 (en) * 2009-12-24 2013-05-29 Shionogi & Co 4-AMINO-1,3-THIAZINE OR OXAZINE DERIVATIVE
HUE028289T2 (en) 2010-01-13 2016-12-28 Basf Se New Mannanase Variants
EP2545181B1 (en) 2010-03-12 2014-11-12 Council Of Scientific & Industrial Research Process for the production of violacein and its derivative deoxyviolacein containing bioactive pigment from chromobacterium sp. (mtcc 5522)
DE102010030500A1 (de) 2010-06-24 2011-12-29 Heliatek Gmbh Verdampfbares organisch halbleitendes Material und dessen Verwendung in einem optoelektronischen Bauelement
JP5766198B2 (ja) 2010-10-29 2015-08-19 塩野義製薬株式会社 縮合アミノジヒドロピリミジン誘導体
CN103261199A (zh) 2010-10-29 2013-08-21 盐野义制药株式会社 萘啶衍生物
DE102011018604A1 (de) 2011-04-25 2014-02-13 Michael Friebe Medikamenteninfusor für die Anwendung in stark magnetischen Umgebungen
JPWO2012147763A1 (ja) 2011-04-26 2014-07-28 塩野義製薬株式会社 オキサジン誘導体およびそれを含有するbace1阻害剤
EP2713937A1 (de) 2011-06-01 2014-04-09 Josef Schweiger Verbundkrone/verbundbrücke und verfahren zu deren herstellung
WO2013050551A1 (en) 2011-10-07 2013-04-11 Lonza Ltd Regulatable promoter
DE102012201426A1 (de) 2012-02-01 2013-08-01 Leibniz-Institut Für Polymerforschung Dresden E.V. Verfahren zum verbinden von kunststoffen und verfahren zum lösen einer verbindung im kunststoffverbund und kunststoffverbund
DE102012007141A1 (de) 2012-04-10 2013-10-10 Bernhard Spindler Jalousierbarer Rollladenpanzer
DE102012106428A1 (de) 2012-07-17 2014-01-23 Reha Technology GmbH Vorrichtung zur therapeutischen Behandlung, System zur gerätegestützten Lokomotionstherapie und Verfahren zur Steuerung der Vorrichtung
WO2014024034A1 (es) 2012-08-08 2014-02-13 Choque Alberto Pati Compostaje de residuos sólidos, liquidos y lodos biodegradables mediante humus de lombriz (eisenia foetida y especies similares) y mezclas de humus de lombriz y material estomacal con alto contenido de microrganismos
DE102012214452B4 (de) 2012-08-14 2019-08-01 Henkel Ag & Co. Kgaa Vorrichtung zum Auftragen einer fadenförmigen Masse
DE102012016116A1 (de) 2012-08-15 2014-02-20 Josip Fellner 360° Bag ln Box Spendersystem
DE102012214554A1 (de) 2012-08-16 2014-02-20 Robert Bosch Gmbh Verfahren zur Überführung von Batterien in einen entladenen Zustand, Batteriemanagementsystem, Inverter, System zur Erzeugung einer Wechselspannung, Ladestromquelle und Kraftfahrzeug
DE102012108153A1 (de) 2012-09-03 2014-03-06 Ludwig-Maximilians-Universität München Rohling und Verfahren zur Herstellung einer Dentalrestauration durch substraktive Bearbeitung
JP2016501827A (ja) 2012-10-24 2016-01-21 塩野義製薬株式会社 Bace1阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体
DE102012112186A1 (de) 2012-12-12 2014-06-26 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Materialverbund, Verfahren zu dessen Herstellung, daraus hergestelltes System und Anwendung desselben
WO2014135249A2 (de) 2013-02-15 2014-09-12 Jochen Mertens Mixer mit massnahmen zur reduzierung des eintrages von luftsauerstoff in den mixer-inhalt
DE102013101712B4 (de) 2013-02-21 2020-05-28 Heliatek Gmbh Photoaktives organisches Material für optoelektronische Bauelemente
DE102013101713B4 (de) 2013-02-21 2020-10-01 Heliatek Gmbh Photoaktives, organisches Material für optoelektronische Bauelemente
DE102013102366A1 (de) 2013-03-10 2014-09-11 Informium Ag Vorrichtungen zur Herstellung und zum Auslesen eines Identifikationsmerkmals mit integriertem Kopierschutz
DE102013102365A1 (de) 2013-03-10 2014-09-11 Informium Ag Identifikationsmerkmal mit integriertem Kopierschutz
DE102013102364A1 (de) 2013-03-10 2014-09-11 Informium Ag Verfahren zur Herstellung eines Identifikationsmerkmals mit integriertem Kopierschutz
DE102013004288A1 (de) 2013-03-13 2014-09-18 Matthias Lietzau Fahrzeug Verbindungsfolie
DE202013002767U1 (de) 2013-03-22 2013-05-28 Lorenz-Montagesysteme Gmbh Ausgleichende Seitverbindung von Solarmodulen
DE102013005741B3 (de) 2013-04-05 2014-05-22 IOT - Innovative Oberflächentechnologien GmbH Vorrichtung zur Inertisierung bei UV-Bestrahlung in offenen Durchlaufanlagen
EP2792394B1 (de) 2013-04-16 2016-07-27 Jörg Beutler Interaktive Geschwindigkeitssteuerung
DE102013104501A1 (de) 2013-05-02 2014-11-06 B. Braun Avitum Ag Vorrichtung zur extrakorporalen Blutbehandlung
DE102013008359A1 (de) 2013-05-16 2014-11-20 Sew-Eurodrive Gmbh & Co Kg Energiespeicher, der aus in Reihe geschalten Energiespeicherzellen aufgebaut ist, und Schaltungsanordnung zur passiven Symmetrierung einer Reihenschaltung von Kondensatoren
DE102013008919B4 (de) 2013-05-24 2017-12-07 Magdeburger Windkraftanlagen GmbH Rotorsystem für die Energiewandlung von kinetischer Energie in Fluiden und Massenströmen
DE202013006258U1 (de) 2013-07-11 2013-10-11 IMM Ingenieurbüro GmbH Vorrichtung zum Erzeugen von heizbaren Flächen mit homogener Wärmeverteilung
DE102013110693B4 (de) 2013-09-27 2024-04-25 Heliatek Gmbh Photoaktives, organisches Material für optoelektronische Bauelemente
EP2873807A1 (de) 2013-11-18 2015-05-20 Siemens Aktiengesellschaft Abdeckplatte, Laufschaufel, Radscheibe, Bolzen und Gasturbine
WO2015075040A1 (de) 2013-11-19 2015-05-28 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zum verbinden von silikongummi mit einem substrat
EP2902692B1 (de) 2013-12-06 2017-10-25 MAGNA STEYR Engineering AG & Co KG Bauteil eines Tanksystems
DE202014100570U1 (de) 2014-02-10 2014-03-10 Schlaadt Plastics Gmbh Klappsystem zur Verbindung von Partikelschaumbauteilen mittels eines gegen Verlust gesicherten Steckelements
DE102014004280A1 (de) 2014-03-26 2015-10-01 Florian M. König Impulssignal-Erzeugungsvorrichtung für Zwecke der autonomen Batterieaufladung oder 120-/230-Volt-Lampenversorgung
DE202014003299U1 (de) 2014-04-14 2014-08-25 Antje Koss Stollenschuh mit Wechselstollensystem
DE202014004532U1 (de) 2014-05-28 2014-08-05 Hans-Dieter Cornelius Hygienevorlage
DE102015214641B4 (de) 2014-11-10 2024-10-24 Hermann Roth Zusammensetzung mit Säure und Isochinolinalkaloid
DE102014017938A1 (de) 2014-12-05 2016-06-09 Florian M. König Trichter-turbinenartige Vorrichtung mit elektromagnetischer Rotationssteuerung von Flüssigkeits-Mischvorgängen
DE102015000003A1 (de) 2015-01-02 2016-07-07 Solukon Ingenieure GbR (vertretungsberechtigte Gesellschafter: Andreas Hartmann, 86391 Stadtbergen und Dominik Schmid, 86165 Augsburg) Baubehälter für Produktionsanlagen zur Herstellung von Bauteilen in Schichtbauverfahren
DE102015008129A1 (de) 2015-01-22 2016-07-28 Liebherr-Hausgeräte Lienz Gmbh Verfahren zur Bestimmung der Dämmeigenschaft einer Wandung eines wärmeisolierten Behältnisses
DE102015000887A1 (de) 2015-01-23 2016-07-28 Arnulf Deinzer Zahnreinigungsgerät mit ausfahrbaren Borsten
DE102015015877A1 (de) 2015-12-09 2017-06-14 Bayerisches Zentrum für angewandte Energieforschung, e.V. (ZAE Bayern) Optisch schaltendes Element
DE102016006696A1 (de) 2016-05-27 2017-11-30 Christoph Jaeger Flugautosystem
DE202016004226U1 (de) 2016-07-06 2016-11-11 Helmut Senkel Schienensystem mit verfahrbaren Verbrauchern
CN106279585A (zh) * 2016-08-26 2017-01-04 宁波圣达精工智能科技有限公司 一种阻燃智能密集书架的制备方法
CN108832306B (zh) * 2018-06-13 2023-11-03 中国科学院国家天文台 一种fast反射面中心孔柔性封堵结构

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL326353A1 (en) * 1995-10-17 1998-09-14 Astra Pharma Prod Pharmaceutically active quinozolinic compounds

Also Published As

Publication number Publication date
NO20006559D0 (no) 2000-12-21
CZ20004896A3 (en) 2001-06-13
CN1313769A (zh) 2001-09-19
MXPA00012162A (es) 2001-05-01
ZA200007076B (en) 2002-02-28
SE9802333D0 (sv) 1998-06-29
KR20010053252A (ko) 2001-06-25
US6248745B1 (en) 2001-06-19
IS5794A (is) 2000-12-27
NO20006559L (no) 2001-02-28
TR200003808T2 (tr) 2001-06-21
BR9911666A (pt) 2001-03-20
PL345028A1 (en) 2001-11-19
EE200000766A (et) 2002-06-17
JP2002519324A (ja) 2002-07-02
IN2000MU00721A (OSRAM) 2005-03-18
WO2000000200A1 (en) 2000-01-06
ID27394A (id) 2001-04-05
CA2334515A1 (en) 2000-01-06
AU4944799A (en) 2000-01-17
EP1100505A1 (en) 2001-05-23
IL140022A0 (en) 2002-02-10

Similar Documents

Publication Publication Date Title
SK18482000A3 (sk) Farmaceutická kombinácia obsahujúca inhibítor cox-2 a inhibítor inos
US6046191A (en) Combination
AU715380B2 (en) Pyrazolopyrimidines for treatment of neuronal and other disorders
KR20240021884A (ko) 암을 치료하기 위한 parp 억제제와 조합된 atr 억제제의 용도
JPH11349482A (ja) 医 薬
JP2016006070A (ja) Hdac阻害剤と代謝拮抗剤の組み合わせ
US20100137398A1 (en) Use of hdac inhibitors for the treatment of gastrointestinal cancers
US3705946A (en) Method of treating hyperuricemia
US20230174548A1 (en) Symbiotic prodrugs for the treatment of cancer and other diseases
KR20220035143A (ko) 사이클릭 디옥시리보뉴클레오티드 화합물
US6495586B2 (en) Scytonemin and methods of using thereof
US4188393A (en) Treating spastic conditions or relaxing muscles
US20100056460A1 (en) Combination of organic compounds
US5849774A (en) Treatment of sepsis-induced acute renal failure
WO2021177332A1 (ja) Nlrp3インフラマソーム阻害剤及び炎症性疾患の予防又は治療のための医薬組成物
US4333945A (en) Thiazoline and imidazoline derivatives useful as minor tranquilizers
WO2025208233A1 (en) Dual parp/hdac inhibitor for treating breast cancer, ovarian cancer, and prostate cancer
US20250101059A1 (en) ANTI-inflammatory Compounds, pharmaceutical compositions, and methods of treating disorders associated with inflammation
JPS6323969B2 (OSRAM)
CN118286210A (zh) 一种艾曲波帕的用途
CA2229074A1 (en) Nitric oxide synthase (nos) inhibitors
US20090281159A1 (en) Use of hdac inhibitors for the treatment of lymphomas
IE920333A1 (en) Pyrimido-benzothiazine derivatives for the treatment of inflammation, allergy and cardiovascular disease