SK1842003A3 - Novel heteroaryl derivatives and the use thereof as pharmaceuticals - Google Patents

Novel heteroaryl derivatives and the use thereof as pharmaceuticals Download PDF

Info

Publication number
SK1842003A3
SK1842003A3 SK1842003A SK1842003A SK1842003A3 SK 1842003 A3 SK1842003 A3 SK 1842003A3 SK 1842003 A SK1842003 A SK 1842003A SK 1842003 A SK1842003 A SK 1842003A SK 1842003 A3 SK1842003 A3 SK 1842003A3
Authority
SK
Slovakia
Prior art keywords
alkyl
radical
substituted
alkylamino
unsubstituted
Prior art date
Application number
SK1842003A
Other languages
English (en)
Slovak (sk)
Inventor
Peter Emig
Eckhard Gunther
Jurgen Schmidt
Bernd Nickel
Bernhard Kutscher
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Publication of SK1842003A3 publication Critical patent/SK1842003A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SK1842003A 2000-07-21 2001-07-18 Novel heteroaryl derivatives and the use thereof as pharmaceuticals SK1842003A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10035928A DE10035928A1 (de) 2000-07-21 2000-07-21 Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
PCT/EP2001/008261 WO2002008192A1 (de) 2000-07-21 2001-07-18 Neue heteroaryl-derivate und deren verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
SK1842003A3 true SK1842003A3 (en) 2004-10-05

Family

ID=7649980

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1842003A SK1842003A3 (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and the use thereof as pharmaceuticals

Country Status (23)

Country Link
US (5) US6890926B2 (hu)
EP (1) EP1305290A1 (hu)
JP (1) JP2004504381A (hu)
KR (1) KR20030022287A (hu)
CN (1) CN1443171A (hu)
AR (1) AR033678A1 (hu)
AU (2) AU2001279757B2 (hu)
BG (1) BG107508A (hu)
BR (1) BR0112589A (hu)
CA (1) CA2353369A1 (hu)
CZ (1) CZ2003415A3 (hu)
DE (1) DE10035928A1 (hu)
HU (1) HUP0300838A2 (hu)
IL (1) IL153361A0 (hu)
MX (1) MXPA02012565A (hu)
NO (1) NO20030298D0 (hu)
NZ (1) NZ524154A (hu)
PL (1) PL358788A1 (hu)
RU (1) RU2265602C2 (hu)
SK (1) SK1842003A3 (hu)
TW (1) TWI228505B (hu)
WO (1) WO2002008192A1 (hu)
ZA (1) ZA200210180B (hu)

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CN1668604A (zh) * 2002-07-17 2005-09-14 赞塔里斯有限公司 新颖的蒽衍生物及其作为药物的用途
EP1590329A1 (fr) * 2003-01-28 2005-11-02 Aventis Pharma S.A. Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation
PE20050226A1 (es) * 2003-06-04 2005-05-18 Aventis Pharma Sa Productos aril-heteroaromaticos y composiciones que los contienen
FR2855825B1 (fr) * 2003-06-04 2008-08-22 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
EP1706392A2 (en) * 2004-01-08 2006-10-04 Syngenta Participations AG Pesticidal heterocyclic dihaloallyl compounds
DE102004003428A1 (de) * 2004-01-23 2005-08-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue langwirksame Beta-2-Agonisten, und deren Verwendung als Arzneimittel
FR2871157A1 (fr) * 2004-06-04 2005-12-09 Aventis Pharma Sa Produits biaryl aromatiques, compositions les contenant et utilisation
CN1830964B (zh) * 2005-03-11 2011-06-15 中国科学院上海药物研究所 4-取代苯氨基-3-硝基喹啉类化合物及其制备方法和用途
CA2678577A1 (en) * 2007-02-26 2008-09-04 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
JP5451611B2 (ja) * 2007-07-26 2014-03-26 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１のサイクリックインヒビター
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
US8440658B2 (en) 2007-12-11 2013-05-14 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
CA2712500A1 (en) * 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2252598A2 (en) * 2008-02-11 2010-11-24 Vitae Pharmaceuticals, Inc. 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5730021B2 (ja) * 2008-02-15 2015-06-03 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロアルキルラクタム誘導体
JP5538356B2 (ja) * 2008-03-18 2014-07-02 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤
JP5538365B2 (ja) 2008-05-01 2014-07-02 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
EP2291371B1 (en) 2008-05-01 2015-06-10 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2300461B1 (en) * 2008-05-01 2013-04-17 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5451752B2 (ja) * 2008-05-01 2014-03-26 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
WO2010127237A2 (en) * 2009-04-30 2010-11-04 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2010010157A2 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1
EP2687525B1 (en) 2008-07-25 2015-09-23 Boehringer Ingelheim International GmbH Cyclic inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
JP5679997B2 (ja) 2009-02-04 2015-03-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
US8927539B2 (en) 2009-06-11 2015-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
US8883778B2 (en) 2009-07-01 2014-11-11 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
JP5860042B2 (ja) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
EP2585444B1 (en) 2010-06-25 2014-10-22 Boehringer Ingelheim International GmbH Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
CA2813671A1 (en) 2010-11-02 2012-05-10 Boehringer Ingelheim International Gmbh Pharmaceutical combinations for the treatment of metabolic disorders
WO2018033918A1 (en) * 2016-08-18 2018-02-22 Vidac Pharma Ltd. Piperazine derivatives, pharmaceutical compositions and methods of use thereof

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US4656174A (en) * 1982-07-24 1987-04-07 Pfizer Inc. Quinoline therapeutic agents
FR2538388B1 (fr) 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments
EP0318235A3 (en) * 1987-11-25 1991-05-02 Takeda Chemical Industries, Ltd. Paf antagonist, 1,4-disubstituted piperazine compounds and production thereof
AU646519B2 (en) 1990-10-10 1994-02-24 Schering Corporation Pyridine and pyridine N-oxide derivatives of diaryl methyl piperidines or piperazines, and compositions and methods of use thereof
JPH09500109A (ja) * 1993-06-18 1997-01-07 メルク エンド カンパニー インコーポレーテッド ファルネシル蛋白質トランスフェラーゼの阻害剤
WO1997044036A1 (en) * 1996-05-20 1997-11-27 Darwin Discovery Limited Quinoline carboxamides as tnf inhibitors and as pde-iv inhibitors
WO1997044329A1 (en) 1996-05-20 1997-11-27 Teijin Limited Diarylalkyl cyclic diamine derivatives as chemokine receptor antagonists
PL325341A1 (en) * 1996-06-29 1998-07-20 Samjin Pharmaceutical Co Derivatives od piperazine and method of obtaining them
US5861395A (en) 1996-09-13 1999-01-19 Schering Corporation Compounds useful for inhibition of farnesyl proteins transferase
FR2753706B1 (fr) 1996-09-20 1998-10-30 Nouvelles amines cycliques n-substituees, leur procede de preparation et les compositions pharmaceutiques les renfermant
EP0957100B1 (en) * 1997-07-07 2004-10-27 Kowa Co., Ltd. Diamine derivatives and pharmaceutical containing the same
DE19743435A1 (de) 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidinderivate
CN1261098C (zh) * 1998-08-28 2006-06-28 西奥斯股份有限公司 p38－α激酶的抑制剂
AU3248600A (en) 1999-03-03 2000-09-21 Merck & Co., Inc. Inhibitors of prenyl-protein transferases
DE10035927A1 (de) * 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
US6610274B1 (en) * 2000-12-22 2003-08-26 Wallace J. Gardner Anti-inflammatory composition comprising tetracycline

Also Published As

Publication number Publication date
AU2001279757B2 (en) 2005-05-26
MXPA02012565A (es) 2003-09-22
CN1443171A (zh) 2003-09-17
NO20030298L (no) 2003-01-20
RU2265602C2 (ru) 2005-12-10
US6890926B2 (en) 2005-05-10
ZA200210180B (en) 2003-02-12
US6936615B2 (en) 2005-08-30
AU7975701A (en) 2002-02-05
NO20030298D0 (no) 2003-01-20
US20040132747A1 (en) 2004-07-08
HUP0300838A2 (hu) 2003-07-28
DE10035928A1 (de) 2002-03-07
CA2353369A1 (en) 2002-01-21
US7056912B2 (en) 2006-06-06
NZ524154A (en) 2005-02-25
US20050176744A1 (en) 2005-08-11
IL153361A0 (en) 2003-07-06
JP2004504381A (ja) 2004-02-12
BG107508A (bg) 2003-09-30
BR0112589A (pt) 2003-05-20
EP1305290A1 (de) 2003-05-02
CZ2003415A3 (cs) 2004-05-12
WO2002008192A1 (de) 2002-01-31
AR033678A1 (es) 2004-01-07
US20020103214A1 (en) 2002-08-01
US7026310B2 (en) 2006-04-11
PL358788A1 (en) 2004-08-23
US20050245523A1 (en) 2005-11-03
KR20030022287A (ko) 2003-03-15
US20040097530A1 (en) 2004-05-20
TWI228505B (en) 2005-03-01

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