SK16396A3 - Amidine derivatives with nitric oxide synthetase activities - Google Patents
Amidine derivatives with nitric oxide synthetase activities Download PDFInfo
- Publication number
- SK16396A3 SK16396A3 SK163-96A SK16396A SK16396A3 SK 16396 A3 SK16396 A3 SK 16396A3 SK 16396 A SK16396 A SK 16396A SK 16396 A3 SK16396 A3 SK 16396A3
- Authority
- SK
- Slovakia
- Prior art keywords
- phenyl
- thiophenecarboximidamide
- amino
- ethyl
- compound
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Furan Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939316806A GB9316806D0 (en) | 1993-08-12 | 1993-08-12 | Pharmaceutically active compounds |
GB939319835A GB9319835D0 (en) | 1993-09-25 | 1993-09-25 | Pharmaceutically active compounds |
GB939325410A GB9325410D0 (en) | 1993-12-11 | 1993-12-11 | Pharmaceutically active compounds |
GB9401580A GB9401580D0 (en) | 1994-01-27 | 1994-01-27 | Pharmaceutically active compounds |
GB9411700A GB9411700D0 (en) | 1994-06-10 | 1994-06-10 | Pharmceutically active compounds |
PCT/GB1994/001767 WO1995005363A1 (en) | 1993-08-12 | 1994-08-12 | Amidine derivatives with nitric oxide synthetase activities |
Publications (1)
Publication Number | Publication Date |
---|---|
SK16396A3 true SK16396A3 (en) | 1996-09-04 |
Family
ID=27517202
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK163-96A SK16396A3 (en) | 1993-08-12 | 1994-08-12 | Amidine derivatives with nitric oxide synthetase activities |
Country Status (18)
Country | Link |
---|---|
US (2) | US5807885A (de) |
EP (1) | EP0713483B1 (de) |
JP (1) | JPH09501918A (de) |
AT (1) | ATE231126T1 (de) |
AU (1) | AU682381B2 (de) |
BR (1) | BR9407515A (de) |
CA (1) | CA2169280A1 (de) |
CZ (1) | CZ29996A3 (de) |
DE (1) | DE69432019T2 (de) |
FI (1) | FI960628A0 (de) |
HU (1) | HUT75876A (de) |
IL (1) | IL110643A (de) |
NO (1) | NO306459B1 (de) |
NZ (1) | NZ269571A (de) |
PL (1) | PL180081B1 (de) |
RU (1) | RU2130017C1 (de) |
SK (1) | SK16396A3 (de) |
WO (1) | WO1995005363A1 (de) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE177078T1 (de) * | 1993-10-21 | 1999-03-15 | Searle & Co | Amidino-derivate als no-synthetase inhibitoren |
MX9605366A (es) * | 1994-05-07 | 1997-12-31 | Astra Ab | Derivados de amidina biciclicos como inhibidores de la oxido nitrico sintetasa. |
JPH10500129A (ja) * | 1994-05-11 | 1998-01-06 | ジェス、オルセン | 片頭痛の治療におけるnoスカベンジャー、阻害剤または拮抗剤の使用 |
GB9418912D0 (en) * | 1994-09-20 | 1994-11-09 | Fisons Corp | Pharmaceutically active compounds |
WO1996021445A1 (en) * | 1995-01-13 | 1996-07-18 | The General Hospital Corporation | Methods of inhibiting neurodegenerative diseases |
TW397812B (en) * | 1995-02-11 | 2000-07-11 | Astra Ab | Bicyclic isothiourea derivatives useful in therapy |
ATE246678T1 (de) * | 1995-04-20 | 2003-08-15 | Searle & Co | Zyclische amidino mittel als stickstoffoxid- synthase inhibitoren |
CZ287969B6 (cs) * | 1995-08-10 | 2001-03-14 | Astra Pharmaceuticals Limited | Amidinový derivát, způsob jeho přípravy, farmaceutický prostředek s jeho obsahem a použití |
AU6945096A (en) * | 1995-09-14 | 1997-04-01 | Nippon Kayaku Kabushiki Kaisha | Nitrogen monoxide synthetase inhibitor comprising 2-aminopyridines as active ingredient |
TW458978B (en) * | 1995-11-07 | 2001-10-11 | Astra Ab | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase |
US6140322A (en) * | 1995-11-07 | 2000-10-31 | Astra Aktiebolag | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase |
WO1997046515A1 (fr) * | 1996-06-04 | 1997-12-11 | Chugai Seiyaku Kabushiki Kaisha | Benzenes substitues ne presentant pas d'effets inhibiteurs |
US5929085A (en) * | 1996-11-06 | 1999-07-27 | Astra Aktiebolag | Amidine and isothiourea derivatives, compositions containing them and their use as inhibitors of nitric oxide synthase |
EP0949242A4 (de) * | 1996-12-24 | 2004-09-08 | Chugai Seiyakukabushiki Kaisha | Aromatische aminderivate mit nos-hemmender wirkung |
FR2761066B1 (fr) * | 1997-03-24 | 2000-11-24 | Sod Conseils Rech Applic | Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
US6335445B1 (en) * | 1997-03-24 | 2002-01-01 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them |
US6809088B2 (en) * | 1997-03-24 | 2004-10-26 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them |
FR2764889B1 (fr) * | 1997-06-20 | 2000-09-01 | Sod Conseils Rech Applic | Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
GB9708805D0 (en) | 1997-05-01 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
EP0980362B1 (de) * | 1997-05-02 | 2006-08-16 | Schering Aktiengesellschaft | Substituierte heterocyclen und deren verwendung in arzneimitteln |
SE9701681D0 (sv) | 1997-05-05 | 1997-05-05 | Astra Ab | New compounds |
SE9701682D0 (sv) * | 1997-05-05 | 1997-05-05 | Astra Ab | Compounds |
US6232336B1 (en) | 1997-07-03 | 2001-05-15 | The United States Of America As Represented By The Department Of Health And Human Services | Nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same |
US5981556A (en) * | 1997-07-22 | 1999-11-09 | G.D. Searle & Co. | 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors |
TW460460B (en) * | 1997-11-04 | 2001-10-21 | Chugai Pharmaceutical Co Ltd | Heterocyclic compounds having NOS inhibitory activities |
GB9810876D0 (en) | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
JP2002517502A (ja) | 1998-06-10 | 2002-06-18 | ジー・ディー・サール・アンド・カンパニー | 複素二環状及び三環状一酸化窒素シンターゼ阻害剤 |
FR2783519B1 (fr) * | 1998-09-23 | 2003-01-24 | Sod Conseils Rech Applic | Nouveaux derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
FR2784678B1 (fr) * | 1998-09-23 | 2002-11-29 | Sod Conseils Rech Applic | Nouveaux derives de n-(iminomethyl)amines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
US7115557B2 (en) | 1998-09-25 | 2006-10-03 | Sciaticon Ab | Use of certain drugs for treating nerve root injury |
SE9803710L (sv) | 1998-09-25 | 2000-03-26 | A & Science Invest Ab | Användning av vissa substanser för behandling av nervrotsskador |
IL142388A0 (en) | 1998-10-08 | 2002-03-10 | Smithkline Beecham Plc | Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents) |
FR2801053B1 (fr) * | 1999-11-16 | 2004-06-25 | Sod Conseils Rech Applic | Nouveaux derives d'amidines, leur preparation et leur application a titre de medicaments |
SE9904677D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Ab | Novel compounds |
SE9904676D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Ab | Novel compounds |
KR20010068667A (ko) * | 2000-01-07 | 2001-07-23 | 박선호 | 신규 알리파틱아마이드계 항종양 물질 |
US20040087798A1 (en) * | 2000-03-14 | 2004-05-06 | Akira Yamada | Novel amide compounds |
DE60108089T2 (de) * | 2000-03-16 | 2006-03-02 | Societe De Conseils De Recherches Et D`Applications Scientifiques (S.C.R.A.S.) | Heterozyklische oder Benzol-Derivate von Liponsäure, deren Herstellung und Ederen Verwendung als Heilmittel |
FR2812198B1 (fr) * | 2000-07-28 | 2008-07-18 | Sod Conseils Rech Applic | DERIVES D'AMIDINES INHIBITEURS DE PHOSPHATASES cdc25 |
US6344473B1 (en) | 2000-08-07 | 2002-02-05 | G.D. Searle & Co. | Imidazoles useful as nitric oxide synthase inhibitors |
US6770636B2 (en) * | 2000-08-18 | 2004-08-03 | Boehringer Ingelheim Pharma Kg | Phenyl-and phenylalkyl-substituted ethanolamines and ethylenediamines |
DZ3415A1 (fr) | 2000-08-31 | 2002-03-07 | Chiron Corp | Guanidinobenzamides comme mc4-r agonistes. |
WO2002020511A1 (en) * | 2000-09-05 | 2002-03-14 | Astrazeneca Ab | Amidine derivatives which are inhibitors of nitric oxide synthase |
UA75093C2 (en) | 2000-10-06 | 2006-03-15 | Dimensional Pharm Inc | Aminopyridinyl-,aminoguanidinyl-, and alkoxyguanidinesubstituted phenylsubstituted phenylacetamides as protease inhibitors |
EP1767525A1 (de) | 2001-04-09 | 2007-03-28 | Novartis Vaccines and Diagnostics, Inc. | Guanidinoverbindungen als Melanocortin-4-Rezeptor (MC4-R) Agonisten |
US6514960B1 (en) | 2001-08-27 | 2003-02-04 | Hedonist Biochemical Technologies Co., Ltd. | Use of bismuth subgallate in inhibition of production of nitric oxide synthase |
DE10162114A1 (de) * | 2001-12-12 | 2003-06-26 | Schering Ag | Neue Amidin-Derivate und deren Verwendung in Arzneimitteln |
US20030207814A1 (en) * | 2002-02-04 | 2003-11-06 | Chiron Corporation | Novel guanidinyl derivatives |
US20050124652A1 (en) * | 2002-02-04 | 2005-06-09 | Rustum Boyce | Guanidino compounds |
US20030195187A1 (en) * | 2002-02-04 | 2003-10-16 | Chiron Corporation | Guanidino compounds |
WO2003072056A2 (en) * | 2002-02-25 | 2003-09-04 | Chiron Corporation | Intranasal administration of mc4-r agonists |
MXPA04011557A (es) * | 2002-05-23 | 2005-07-05 | Chiron Corp | Compuestos de quinazolinona sustituida. |
FR2842808B1 (fr) * | 2002-07-25 | 2004-09-10 | Sod Conseils Rech Applic | Nouveaux derives d'arylimidazoles, leur preparation et leurs applications therapeutiques |
JP2007501861A (ja) * | 2003-05-23 | 2007-02-01 | カイロン コーポレイション | Mc4−rアゴニストとしてのグアニジノ置換キナゾリノン化合物 |
MXPA06005736A (es) * | 2003-11-19 | 2006-12-14 | Chiron Corp | Compuestos de quinazolinona con bioacumulacion reducida. |
KR101238525B1 (ko) | 2004-12-31 | 2013-02-28 | 레디 유에스 테라퓨틱스 인코포레이티드 | Cetp 저해제로서의 신규 벤질아민 유도체 |
US8604055B2 (en) | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
US7914705B2 (en) * | 2005-01-10 | 2011-03-29 | Robert Eliot Sisson | Flowable electrical conductive liquid |
CA2845284C (en) | 2011-08-18 | 2018-03-06 | Dr. Reddy's Laboratories Ltd. | Substituted heterocyclic amine compounds as cholesteryl ester-transfer protein (cetp) inhibitors |
KR101803866B1 (ko) | 2011-09-27 | 2017-12-04 | 닥터 레디스 레보러터리즈 리미티드 | 동맥경화증 치료에 유용한 콜레스테릴 에스테르-전달 단백질(cetp) 억제제로서 5-벤질아미노메틸-6-아미노피라졸로[3,4-b]피리딘 유도체 |
RU2480452C1 (ru) * | 2012-01-11 | 2013-04-27 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная химико-фармацевтическая академия" Министерства здравоохранения Российской Федерации (ГБОУ ВПО СПХФА Минздрава России) | Способ получения n-4-нитрофенилбензамидина |
US8735606B2 (en) * | 2012-08-30 | 2014-05-27 | Northwestern University | Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors |
EP2740474A1 (de) | 2012-12-05 | 2014-06-11 | Instituto Europeo di Oncologia S.r.l. | Cyclopropylaminderivate als Hemmer von Histon-Demethylase-KDM1A |
EP3277659A1 (de) | 2015-03-30 | 2018-02-07 | University of Innsbruck | Diphenethylaminderivate, die unter anderem als analgetika verwendbar sind, und verfahren zu deren herstellung |
RU2684117C1 (ru) * | 2018-10-29 | 2019-04-04 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) | Способ получения N-(нафталин-2-ил)бензамидина |
RU2694263C1 (ru) * | 2019-02-14 | 2019-07-11 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) | Анальгезирующее и противовоспалительное средство с противомикробной активностью |
EP4009972A4 (de) * | 2019-08-09 | 2023-03-08 | University of Utah Research Foundation | »trpswitch - chemo-optogenetischer ligand mit schrittfunktion |
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GB1180629A (en) * | 1967-07-14 | 1970-02-04 | Delalande Sa | Di-Amidines derived from Aromatic Diamines and process for obtaining same |
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-
1994
- 1994-08-12 AT AT94923776T patent/ATE231126T1/de not_active IP Right Cessation
- 1994-08-12 EP EP94923776A patent/EP0713483B1/de not_active Expired - Lifetime
- 1994-08-12 US US08/586,761 patent/US5807885A/en not_active Expired - Fee Related
- 1994-08-12 WO PCT/GB1994/001767 patent/WO1995005363A1/en active IP Right Grant
- 1994-08-12 JP JP7506814A patent/JPH09501918A/ja not_active Ceased
- 1994-08-12 SK SK163-96A patent/SK16396A3/sk unknown
- 1994-08-12 DE DE69432019T patent/DE69432019T2/de not_active Expired - Fee Related
- 1994-08-12 NZ NZ269571A patent/NZ269571A/en unknown
- 1994-08-12 CA CA002169280A patent/CA2169280A1/en not_active Abandoned
- 1994-08-12 RU RU96104356A patent/RU2130017C1/ru active
- 1994-08-12 BR BR9407515A patent/BR9407515A/pt not_active Application Discontinuation
- 1994-08-12 AU AU73875/94A patent/AU682381B2/en not_active Ceased
- 1994-08-12 PL PL94312961A patent/PL180081B1/pl unknown
- 1994-08-12 HU HU9600310A patent/HUT75876A/hu unknown
- 1994-08-12 CZ CZ96299A patent/CZ29996A3/cs unknown
- 1994-08-12 IL IL11064394A patent/IL110643A/en not_active IP Right Cessation
-
1996
- 1996-02-09 NO NO960534A patent/NO306459B1/no not_active IP Right Cessation
- 1996-02-12 FI FI960628A patent/FI960628A0/fi unknown
-
1998
- 1998-07-08 US US09/111,926 patent/US6030985A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
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NO960534D0 (no) | 1996-02-09 |
BR9407515A (pt) | 1997-01-07 |
CA2169280A1 (en) | 1995-02-23 |
US6030985A (en) | 2000-02-29 |
ATE231126T1 (de) | 2003-02-15 |
AU682381B2 (en) | 1997-10-02 |
EP0713483A1 (de) | 1996-05-29 |
FI960628A (fi) | 1996-02-12 |
WO1995005363A1 (en) | 1995-02-23 |
JPH09501918A (ja) | 1997-02-25 |
EP0713483B1 (de) | 2003-01-15 |
DE69432019T2 (de) | 2003-11-27 |
HUT75876A (en) | 1997-05-28 |
DE69432019D1 (de) | 2003-02-20 |
NO306459B1 (no) | 1999-11-08 |
RU2130017C1 (ru) | 1999-05-10 |
PL180081B1 (pl) | 2000-12-29 |
CZ29996A3 (en) | 1996-09-11 |
PL312961A1 (en) | 1996-05-27 |
IL110643A0 (en) | 1994-11-11 |
NZ269571A (en) | 1996-11-26 |
IL110643A (en) | 1998-07-15 |
AU7387594A (en) | 1995-03-14 |
NO960534L (no) | 1996-04-11 |
HU9600310D0 (en) | 1996-04-29 |
US5807885A (en) | 1998-09-15 |
FI960628A0 (fi) | 1996-02-12 |
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