SK13332001A3 - Inhibítory IMPDH enzýmu a ich použitie - Google Patents

Info

Publication number

SK13332001A3

SK13332001A3 SK1333-2001A SK13332001A SK13332001A3 SK 13332001 A3 SK13332001 A3 SK 13332001A3 SK 13332001 A SK13332001 A SK 13332001A SK 13332001 A3 SK13332001 A3 SK 13332001A3

Authority

SK

Slovakia

Prior art keywords

branched

straight

alkyl

alkynyl

alkenyl

Prior art date

1999-03-19

Links

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• 239000003112 inhibitor Substances 0.000 title description 17
• 108090000790 Enzymes Proteins 0.000 title description 12
• 102000004190 Enzymes Human genes 0.000 title description 12
• 101150088003 IMPDH gene Proteins 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims description 60
• 101710200424 Inosine-5'-monophosphate dehydrogenase Proteins 0.000 claims description 54
• 239000008194 pharmaceutical composition Substances 0.000 claims description 43
• 125000000304 alkynyl group Chemical group 0.000 claims description 42
• 239000003795 chemical substances by application Substances 0.000 claims description 39
• 239000000126 substance Substances 0.000 claims description 39
• 241000124008 Mammalia Species 0.000 claims description 36
• 210000004027 cell Anatomy 0.000 claims description 26
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 24
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 24
• 229910052739 hydrogen Inorganic materials 0.000 claims description 22
• 239000002671 adjuvant Substances 0.000 claims description 21
• 201000010099 disease Diseases 0.000 claims description 21
• 239000001257 hydrogen Substances 0.000 claims description 21
• 230000002401 inhibitory effect Effects 0.000 claims description 21
• -1 nitro, cyano, amino Chemical group 0.000 claims description 21
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 20
• 206010028980 Neoplasm Diseases 0.000 claims description 17
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 16
• 241000700605 Viruses Species 0.000 claims description 15
• 239000003814 drug Substances 0.000 claims description 13
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• 230000001404 mediated effect Effects 0.000 claims description 12
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• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 11
• 239000002246 antineoplastic agent Substances 0.000 claims description 11
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 11
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• RUZLIIJDZBWWSA-INIZCTEOSA-N methyl 2-[[(1s)-1-(7-methyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidin-9-yl)ethyl]amino]benzoate Chemical group COC(=O)C1=CC=CC=C1N[C@@H](C)C1=CC(C)=CN2C(=O)C=C(N3CCOCC3)N=C12 RUZLIIJDZBWWSA-INIZCTEOSA-N 0.000 claims description 11
• 229910052717 sulfur Inorganic materials 0.000 claims description 11
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• 125000005842 heteroatom Chemical group 0.000 claims description 2
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• 125000004076 pyridyl group Chemical group 0.000 claims description 2
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• HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 15
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