NO20014535L - Inhibitorer av IMPDH-enzym - Google Patents
Inhibitorer av IMPDH-enzymInfo
- Publication number
- NO20014535L NO20014535L NO20014535A NO20014535A NO20014535L NO 20014535 L NO20014535 L NO 20014535L NO 20014535 A NO20014535 A NO 20014535A NO 20014535 A NO20014535 A NO 20014535A NO 20014535 L NO20014535 L NO 20014535L
- Authority
- NO
- Norway
- Prior art keywords
- inhibitors
- impdh enzyme
- impdh
- enzyme
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 101710200424 Inosine-5'-monophosphate dehydrogenase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12550799P | 1999-03-19 | 1999-03-19 | |
US17488200P | 2000-01-07 | 2000-01-07 | |
PCT/US2000/007129 WO2000056331A1 (en) | 1999-03-19 | 2000-03-17 | Inhibitors of impdh enzyme |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20014535D0 NO20014535D0 (no) | 2001-09-18 |
NO20014535L true NO20014535L (no) | 2001-11-19 |
NO321932B1 NO321932B1 (no) | 2006-07-24 |
Family
ID=26823644
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20014535A NO321932B1 (no) | 1999-03-19 | 2001-09-18 | IMPDH-hemmende forbindelser og sammensetninger inneholdende disse samt deres anvendelse. |
Country Status (24)
Country | Link |
---|---|
US (4) | US6498178B2 (no) |
EP (2) | EP1964561A1 (no) |
JP (3) | JP4184610B2 (no) |
KR (1) | KR100652535B1 (no) |
CN (1) | CN1196687C (no) |
AP (1) | AP1498A (no) |
AR (1) | AR029341A1 (no) |
AU (1) | AU769383B2 (no) |
BG (1) | BG65563B1 (no) |
BR (1) | BR0009167A (no) |
CA (1) | CA2367017C (no) |
CZ (1) | CZ301802B6 (no) |
EA (1) | EA004141B1 (no) |
EE (1) | EE200100492A (no) |
ES (1) | ES2405316T3 (no) |
HU (1) | HUP0201214A3 (no) |
IL (2) | IL145475A0 (no) |
NO (1) | NO321932B1 (no) |
NZ (1) | NZ514540A (no) |
OA (1) | OA11848A (no) |
PL (1) | PL211562B1 (no) |
SK (1) | SK13332001A3 (no) |
TR (1) | TR200103428T2 (no) |
WO (1) | WO2000056331A1 (no) |
Families Citing this family (111)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EE04023B1 (et) * | 1996-10-18 | 2003-04-15 | Vertex Pharmaceuticals Incorporated | Seriinproteaaside, eriti C-hepatiidi viiruse NS3-proteaasi inhibiitorid |
US6420403B1 (en) | 1998-10-29 | 2002-07-16 | Edwin J. Iwanowicz | Inhibitors of IMPDH enzyme |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
ATE556713T1 (de) | 1999-01-13 | 2012-05-15 | Bayer Healthcare Llc | Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer |
SK13332001A3 (sk) * | 1999-03-19 | 2002-02-05 | Vertex Pharmaceuticals Incorporated | Inhibítory IMPDH enzýmu a ich použitie |
SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
SI2305255T1 (sl) * | 2001-12-03 | 2012-10-30 | Bayer Healthcare Llc | Arilsečninske spojine v kombinaciji z drugimi citostatičnimi ali citotoksičnimi sredstvi za zdravljenje človeških rakov |
WO2003068229A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
DK1478358T3 (da) | 2002-02-11 | 2013-10-07 | Bayer Healthcare Llc | Sorafenibtosylat til behandling af sygdomme kendetegnet ved unormal angiogenese |
US8110587B2 (en) | 2002-02-11 | 2012-02-07 | Bayer Healthcare Llc | Aryl ureas as kinase inhibitors |
ATE424198T1 (de) * | 2002-12-06 | 2009-03-15 | Vertex Pharma | Zusammensetzungen die eine kombination von diphenylharnstoff impdh-hemmern und apoptose- induzierenden antikrebsmitteln enthalten |
EP1594459B1 (en) | 2002-12-30 | 2010-02-17 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
ES2381548T3 (es) | 2003-04-11 | 2012-05-29 | Vertex Pharmaceuticals Incorporated | Inhibidores de serina proteasas, particularmente de la proteasa VHC NS3-NS4A |
US20070020704A1 (en) | 2003-05-20 | 2007-01-25 | Scott Wilhelm | Diaryl ureas with kinase inhibiting activity |
NZ544789A (en) | 2003-07-18 | 2010-01-29 | Vertex Pharma | Dithia-azaspiro-nonane and decane derivatives as inhibitors of serine proteases |
BR122016015715B8 (pt) | 2003-07-23 | 2021-05-25 | Bayer Healthcare Llc | composições farmacêuticas de metilamida de ácido 4[4-[3-(4-cloro-3-trifluorometilfenil)-ureido]-3-fluorofenóxi)-piridina-2-carboxílico |
DE10336185A1 (de) * | 2003-08-07 | 2005-02-24 | Bayer Chemicals Ag | Enantiomerenangereicherte 1-Phenylethylamine |
US7156615B2 (en) * | 2003-08-21 | 2007-01-02 | Siemens Vdo Automotive Inc. | Fan shroud structure for reducing resonance, improving stiffness and manufacturability |
UY28500A1 (es) | 2003-09-05 | 2005-04-29 | Vertex Pharma | Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc. |
US20050120398A1 (en) * | 2003-09-12 | 2005-06-02 | Vertex Pharmaceuticals Incorporated | Animal model for HCV infection |
TW200526686A (en) | 2003-09-18 | 2005-08-16 | Vertex Pharma | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
RU2006115558A (ru) | 2003-10-10 | 2007-11-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Ингибиторы сериновых протеаз, особенно hcv ns3-ns4a протеазы |
EP1678202B1 (en) * | 2003-10-27 | 2012-06-13 | Vertex Pharmaceuticals Incorporated | Hcv ns3-ns4a protease resistance mutants |
EP1944042A1 (en) | 2003-10-27 | 2008-07-16 | Vertex Pharmceuticals Incorporated | Combinations for HCV treatment |
US7683033B2 (en) | 2004-02-04 | 2010-03-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
WO2005095333A1 (en) * | 2004-03-23 | 2005-10-13 | Vertex Pharmaceuticals Incorporated | Polymorphic forms of (1-{3-[3-(4-cyano-3-methoxy-phenyl)ureido]-phenyl}-ethyl)-carbamic acid-2-cyano-1-ethyl-ethyl ester |
JP2007535565A (ja) | 2004-04-30 | 2007-12-06 | バイエル ファーマシューティカルス コーポレーション | 癌の治療に有用な置換ピラゾリル尿素誘導体 |
US20070219224A1 (en) * | 2004-05-21 | 2007-09-20 | Uab Research Foundation, The | Compositions and Methods Relating to Pyrimidine Synthesis Inhibitors |
CA2571710A1 (en) | 2004-06-24 | 2006-11-02 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
EP1804821A4 (en) * | 2004-10-01 | 2009-07-15 | Vertex Pharma | INHIBITION OF HCV NS3-NS4A PROTEASE |
TW201424733A (zh) | 2004-10-29 | 2014-07-01 | Vertex Pharma | 劑量型式 |
KR20080015433A (ko) * | 2005-05-09 | 2008-02-19 | 버텍스 파마슈티칼스 인코포레이티드 | 바이아릴 우레아 및 이의 유사체의 제조 방법 |
JP2009505945A (ja) * | 2005-05-26 | 2009-02-12 | バーテックス ファーマシューティカルズ インコーポレイテッド | (s)−1−シアノブタン−2−イル(s)−1−(3−(3−(3−メトキシ−4−(オキサゾール−5−イル)フェニル)ウレイド)フェニル)エチルカルバメートの多形形態 |
AR055105A1 (es) | 2005-07-29 | 2007-08-08 | Tibotec Pharm Ltd | Inhibidores macrociclicos del virus de la hepatitis c |
MY139988A (en) | 2005-07-29 | 2009-11-30 | Tibotec Pharm Ltd | Macrocylic inhibitors of hepatitis c virus |
PE20070210A1 (es) | 2005-07-29 | 2007-04-16 | Tibotec Pharm Ltd | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
PE20070211A1 (es) | 2005-07-29 | 2007-05-12 | Medivir Ab | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
WO2007014925A1 (en) | 2005-07-29 | 2007-02-08 | Tibotec Pharmaceuticals Ltd. | Macrocylic inhibitors of hepatitis c virus |
EA014293B1 (ru) | 2005-07-29 | 2010-10-29 | Тиботек Фармасьютикалз Лтд. | Макроциклические ингибиторы вируса гепатита с |
JO2768B1 (en) | 2005-07-29 | 2014-03-15 | تيبوتيك فارماسيوتيكالز ليمتد | Large cyclic inhibitors of hepatitis C virus |
BRPI0614696A2 (pt) | 2005-07-29 | 2011-04-12 | Tibotec Pharm Ltd | inibidores macrocìclicos de vìrus da hepatite c |
EP1919899B1 (en) | 2005-07-29 | 2011-01-19 | Tibotec Pharmaceuticals | Macrocyclic inhibitors of hepatitis c virus |
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