SI9500134B - Postopek za pripravo čistih alkalijskih soli klavulanske kisline - Google Patents

Postopek za pripravo čistih alkalijskih soli klavulanske kisline Download PDF

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Publication number
SI9500134B
SI9500134B SI9500134A SI9500134A SI9500134B SI 9500134 B SI9500134 B SI 9500134B SI 9500134 A SI9500134 A SI 9500134A SI 9500134 A SI9500134 A SI 9500134A SI 9500134 B SI9500134 B SI 9500134B
Authority
SI
Slovenia
Prior art keywords
clavulanic acid
alkali salts
preparation procedure
pharmaceutically acceptable
pure alkali
Prior art date
Application number
SI9500134A
Other languages
English (en)
Slovenian (sl)
Other versions
SI9500134A1 (en
Inventor
Egidij Capuder
Original Assignee
Lek,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek, filed Critical Lek,
Priority to SI9500134A priority Critical patent/SI9500134B/sl
Priority to PCT/GB1996/000921 priority patent/WO1996033197A1/en
Priority to US08/930,527 priority patent/US6180782B1/en
Priority to RO97-01936A priority patent/RO116195B1/ro
Priority to DE69628002T priority patent/DE69628002T2/de
Priority to SK1437-97A priority patent/SK143797A3/sk
Priority to EE9700263A priority patent/EE9700263A/xx
Priority to UA97105123A priority patent/UA54389C2/uk
Priority to AU53401/96A priority patent/AU692091C/en
Priority to EP96910095A priority patent/EP0821687B1/en
Priority to PT96910095T priority patent/PT821687E/pt
Priority to CZ19973318A priority patent/CZ293279B6/cs
Priority to CN96194125A priority patent/CN1118469C/zh
Priority to DK96910095T priority patent/DK0821687T3/da
Priority to ES96910095T priority patent/ES2199286T3/es
Priority to JP8531550A priority patent/JPH11503744A/ja
Priority to HU9901055A priority patent/HUP9901055A3/hu
Priority to AT96910095T priority patent/ATE239736T1/de
Priority to RU97119069/04A priority patent/RU2166506C2/ru
Priority to CA002218648A priority patent/CA2218648A1/en
Priority to KR1019970707415A priority patent/KR19990007892A/ko
Priority to PL96322888A priority patent/PL183465B1/pl
Priority to TNTNSN96061A priority patent/TNSN96061A1/fr
Priority to YU24796A priority patent/YU49113B/sh
Priority to HRP9500134A priority patent/HRP960186A2/hr
Priority to ZA963119A priority patent/ZA963119B/xx
Priority to EG33996A priority patent/EG21091A/xx
Priority to JO19961902A priority patent/JO1902B1/en
Priority to DZ960066A priority patent/DZ2024A1/fr
Publication of SI9500134A1 publication Critical patent/SI9500134A1/sl
Priority to BG102043A priority patent/BG63395B1/bg
Priority to US09/738,434 priority patent/US6369219B2/en
Publication of SI9500134B publication Critical patent/SI9500134B/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
SI9500134A 1995-04-20 1995-04-20 Postopek za pripravo čistih alkalijskih soli klavulanske kisline SI9500134B (sl)

Priority Applications (31)

Application Number Priority Date Filing Date Title
SI9500134A SI9500134B (sl) 1995-04-20 1995-04-20 Postopek za pripravo čistih alkalijskih soli klavulanske kisline
JP8531550A JPH11503744A (ja) 1995-04-20 1996-04-17 クラブラン酸塩の製造方法
CN96194125A CN1118469C (zh) 1995-04-20 1996-04-17 棒酸或其药学上可接受的盐或酯的制备和/或提纯方法
RO97-01936A RO116195B1 (ro) 1995-04-20 1996-04-17 Procedeu pentru prepararea acidului clavulanic purificat sau a unei sari sau ester, acceptabile farmaceutic
DE69628002T DE69628002T2 (de) 1995-04-20 1996-04-17 Herstellung von clavunalat-salzen
SK1437-97A SK143797A3 (en) 1995-04-20 1996-04-17 Preparation of clavulanate salts
EE9700263A EE9700263A (et) 1995-04-20 1996-04-17 Klavulaanhappe soolade valmistamine
AT96910095T ATE239736T1 (de) 1995-04-20 1996-04-17 Herstellung von clavunalat-salzen
AU53401/96A AU692091C (en) 1995-04-20 1996-04-17 Preparation of clavulanate salts
EP96910095A EP0821687B1 (en) 1995-04-20 1996-04-17 Preparation of clavulanate salts
PT96910095T PT821687E (pt) 1995-04-20 1996-04-17 Preparacao de sais clavulanato
CZ19973318A CZ293279B6 (cs) 1995-04-20 1996-04-17 Způsob přípravy klavulanátových solí
US08/930,527 US6180782B1 (en) 1995-04-20 1996-04-17 Preparation of clavulanate salts
DK96910095T DK0821687T3 (da) 1995-04-20 1996-04-17 Fremstilling af clavulanatsalte
ES96910095T ES2199286T3 (es) 1995-04-20 1996-04-17 Preparacion de sales clavulanato.
PCT/GB1996/000921 WO1996033197A1 (en) 1995-04-20 1996-04-17 Preparation of clavulanate salts
HU9901055A HUP9901055A3 (en) 1995-04-20 1996-04-17 Preparation of clavulanate salts
UA97105123A UA54389C2 (uk) 1995-04-20 1996-04-17 Спосіб одержання та/або очищення клавуланової кислоти або її фармацевтично прийнятної солі та спосіб її відокремлення у відфільтрованому ферментаційному бульйоні від домішки клавам-2-карбонової кислоти
RU97119069/04A RU2166506C2 (ru) 1995-04-20 1996-04-17 Способ получения и/или очистки клавулановой кислоты или ее фармацевтически приемлемой соли или эфира и способ ее отделения от содержащейся в отфильтрованном ферментационном бульоне примеси клавам-2-карбоновой кислоты
CA002218648A CA2218648A1 (en) 1995-04-20 1996-04-17 Preparation of clavulanate salts
KR1019970707415A KR19990007892A (ko) 1995-04-20 1996-04-17 클라블란산염의 제조방법
PL96322888A PL183465B1 (pl) 1995-04-20 1996-04-17 Sposób otrzymywania i/lub oczyszczania kwasy klawulanowego
YU24796A YU49113B (sh) 1995-04-20 1996-04-19 Postupak za dobijanje klavulanat soli
TNTNSN96061A TNSN96061A1 (fr) 1995-04-20 1996-04-19 Preparation de sels d'acide clavulanique.
HRP9500134A HRP960186A2 (en) 1995-04-20 1996-04-19 Preparation of clavulanate salts
ZA963119A ZA963119B (en) 1995-04-20 1996-04-19 Preparation of clavulanate salts
EG33996A EG21091A (en) 1995-04-20 1996-04-20 Preparation of calvulanate salts
JO19961902A JO1902B1 (en) 1995-04-20 1996-04-20 Prepare salts of Clavola Night
DZ960066A DZ2024A1 (fr) 1995-04-20 1996-04-27 Préparation de sels d'acide clavulanique.
BG102043A BG63395B1 (bg) 1995-04-20 1997-11-14 Метод за получаване и/или пречистване на клавуланова киселина или нейна фармацевтично приемлива солили естер
US09/738,434 US6369219B2 (en) 1995-04-20 2000-12-14 Preparation of clavulanate salts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI9500134A SI9500134B (sl) 1995-04-20 1995-04-20 Postopek za pripravo čistih alkalijskih soli klavulanske kisline

Publications (2)

Publication Number Publication Date
SI9500134A1 SI9500134A1 (en) 1996-10-31
SI9500134B true SI9500134B (sl) 2004-04-30

Family

ID=20431603

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9500134A SI9500134B (sl) 1995-04-20 1995-04-20 Postopek za pripravo čistih alkalijskih soli klavulanske kisline

Country Status (29)

Country Link
US (2) US6180782B1 (hr)
EP (1) EP0821687B1 (hr)
JP (1) JPH11503744A (hr)
KR (1) KR19990007892A (hr)
CN (1) CN1118469C (hr)
AT (1) ATE239736T1 (hr)
BG (1) BG63395B1 (hr)
CA (1) CA2218648A1 (hr)
CZ (1) CZ293279B6 (hr)
DE (1) DE69628002T2 (hr)
DK (1) DK0821687T3 (hr)
DZ (1) DZ2024A1 (hr)
EE (1) EE9700263A (hr)
EG (1) EG21091A (hr)
ES (1) ES2199286T3 (hr)
HR (1) HRP960186A2 (hr)
HU (1) HUP9901055A3 (hr)
JO (1) JO1902B1 (hr)
PL (1) PL183465B1 (hr)
PT (1) PT821687E (hr)
RO (1) RO116195B1 (hr)
RU (1) RU2166506C2 (hr)
SI (1) SI9500134B (hr)
SK (1) SK143797A3 (hr)
TN (1) TNSN96061A1 (hr)
UA (1) UA54389C2 (hr)
WO (1) WO1996033197A1 (hr)
YU (1) YU49113B (hr)
ZA (1) ZA963119B (hr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
SI9500265A1 (en) * 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
PL333247A1 (en) * 1996-11-11 1999-11-22 Gist Brocades Bv Method of manufacturing of salts and esters of clavulan acid
AT404728B (de) * 1996-11-27 1999-02-25 Biochemie Gmbh Verfahren zur herstellung von clavulansäure-aminsalzen
AR015825A1 (es) * 1997-05-28 2001-05-30 Gist Brocades Bv Produccion fermentativa de acido clavulanico bajo condiciones controladas de fosfato
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
US20040146918A1 (en) * 2000-02-18 2004-07-29 Weiner Michael L. Hybrid nucleic acid assembly
WO2001087891A1 (en) 2000-05-13 2001-11-22 Smithkline Beecham P.L.C. Process for the purification of a salt of clavulanic acid
CN105384758B (zh) * 2015-12-01 2018-05-01 国药集团威奇达药业有限公司 克拉维酸胺盐的制备方法
CN109305978A (zh) * 2017-07-26 2019-02-05 山东睿鹰先锋制药有限公司 一种制备克拉维酸盐的新方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110165A (en) 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
US4144242A (en) 1975-02-07 1979-03-13 Glaxo Laboratories Limited Process for the purification of clavulanic acid
GB1578739A (en) 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
US4454069A (en) 1979-08-24 1984-06-12 Beecham Group Limited Clavulanic acid salts and their preparation from the tertiary butyl amine salt
DE3063683D1 (en) 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
AR245221A1 (es) * 1984-10-27 1993-12-30 Beecham Group Plc Un metodo para la produccion de acido clavulanico por fermentacion de s. clavuligerus
AT399155B (de) 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9305565D0 (en) 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
RO112113B1 (ro) * 1993-03-26 1997-05-30 Gist Brocades Nv Saruri diaminice ale acidului clavulanic si procedeu pentru prepararea acestora
GB9401969D0 (en) * 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9426261D0 (en) 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
PL321871A1 (en) 1995-02-25 1997-12-22 Spurcourt Ltd Clavulanic salts and compositions containing them as well as method of obtaining such salts
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
PL333247A1 (en) * 1996-11-11 1999-11-22 Gist Brocades Bv Method of manufacturing of salts and esters of clavulan acid

Also Published As

Publication number Publication date
AU692091B2 (en) 1998-05-28
ES2199286T3 (es) 2004-02-16
DE69628002T2 (de) 2004-03-04
JO1902B1 (en) 1996-07-25
BG63395B1 (bg) 2001-12-29
KR19990007892A (ko) 1999-01-25
EE9700263A (et) 1998-04-15
US20010025104A1 (en) 2001-09-27
BG102043A (en) 1998-11-30
ZA963119B (en) 1996-10-24
HUP9901055A2 (hu) 1999-08-30
CZ331897A3 (cs) 1998-03-18
PL322888A1 (en) 1998-03-02
PT821687E (pt) 2003-09-30
AU5340196A (en) 1996-11-07
RU2166506C2 (ru) 2001-05-10
WO1996033197A1 (en) 1996-10-24
SK143797A3 (en) 1998-05-06
ATE239736T1 (de) 2003-05-15
CN1118469C (zh) 2003-08-20
US6180782B1 (en) 2001-01-30
HRP960186A2 (en) 1997-12-31
PL183465B1 (pl) 2002-06-28
DE69628002D1 (de) 2003-06-12
CA2218648A1 (en) 1996-10-24
YU24796A (sh) 1998-09-18
EG21091A (en) 2000-10-31
DZ2024A1 (fr) 2002-10-21
JPH11503744A (ja) 1999-03-30
DK0821687T3 (da) 2003-08-18
EP0821687B1 (en) 2003-05-07
US6369219B2 (en) 2002-04-09
HUP9901055A3 (en) 2000-02-28
EP0821687A1 (en) 1998-02-04
CZ293279B6 (cs) 2004-03-17
CN1185158A (zh) 1998-06-17
SI9500134A1 (en) 1996-10-31
TNSN96061A1 (fr) 2005-03-15
RO116195B1 (ro) 2000-11-30
UA54389C2 (uk) 2003-03-17
YU49113B (sh) 2004-03-12

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Effective date: 20070306