SI2834258T1 - 2'-substituirani karba-nukleozidni analogi za protivirusno zdravljenje - Google Patents

2'-substituirani karba-nukleozidni analogi za protivirusno zdravljenje

Info

Publication number
SI2834258T1
SI2834258T1 SI201330567A SI201330567A SI2834258T1 SI 2834258 T1 SI2834258 T1 SI 2834258T1 SI 201330567 A SI201330567 A SI 201330567A SI 201330567 A SI201330567 A SI 201330567A SI 2834258 T1 SI2834258 T1 SI 2834258T1
Authority
SI
Slovenia
Prior art keywords
nucleoside analogs
antiviral treatment
substituted carba
carba
substituted
Prior art date
Application number
SI201330567A
Other languages
English (en)
Slovenian (sl)
Inventor
Michael O' Neil Hanrahan Clarke
Original Assignee
Gilead Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences, Inc. filed Critical Gilead Sciences, Inc.
Publication of SI2834258T1 publication Critical patent/SI2834258T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/30—Vaccines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI201330567A 2012-03-13 2013-03-11 2'-substituirani karba-nukleozidni analogi za protivirusno zdravljenje SI2834258T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261610411P 2012-03-13 2012-03-13
PCT/US2013/030196 WO2013138236A1 (en) 2012-03-13 2013-03-11 2'- substituted carba-nucleoside analogs for antiviral treatment
EP13712043.2A EP2834258B1 (en) 2012-03-13 2013-03-11 2'- substituted carba-nucleoside analogs for antiviral treatment

Publications (1)

Publication Number Publication Date
SI2834258T1 true SI2834258T1 (sl) 2017-04-26

Family

ID=47997868

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201330567A SI2834258T1 (sl) 2012-03-13 2013-03-11 2'-substituirani karba-nukleozidni analogi za protivirusno zdravljenje

Country Status (18)

Country Link
US (4) US9481704B2 (OSRAM)
EP (4) EP3210993B1 (OSRAM)
JP (3) JP6242378B2 (OSRAM)
KR (1) KR102068856B1 (OSRAM)
CN (2) CN104185638A (OSRAM)
AU (2) AU2013232378B2 (OSRAM)
CA (1) CA2866381C (OSRAM)
EA (2) EA201791916A1 (OSRAM)
ES (4) ES2709071T3 (OSRAM)
IL (2) IL234586A (OSRAM)
IN (1) IN2014DN08505A (OSRAM)
MD (1) MD4496C1 (OSRAM)
MX (1) MX355267B (OSRAM)
NZ (1) NZ629996A (OSRAM)
PL (1) PL2834258T3 (OSRAM)
PT (1) PT2834258T (OSRAM)
SI (1) SI2834258T1 (OSRAM)
WO (1) WO2013138236A1 (OSRAM)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2015151857A (ru) 2008-12-02 2019-01-15 Уэйв Лайф Сайенсес Джапан, Инк. Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
MX342945B (es) 2009-07-06 2016-10-18 Ontorii Inc * Profármacos de ácido nucleico novedosos y métodos de uso de los mismos.
US10428019B2 (en) 2010-09-24 2019-10-01 Wave Life Sciences Ltd. Chiral auxiliaries
EP3248982A1 (en) 2011-07-19 2017-11-29 Wave Life Sciences Ltd. Thiosulfonate reagents for the synthesis of functionalized nucleic acids
US8633198B1 (en) 2011-09-20 2014-01-21 Nant Holdings Ip, Llc Small molecule inhibitors of influenza A RNA-dependent RNA polymerase
AU2012358803C1 (en) 2011-12-22 2019-12-19 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2013138236A1 (en) 2012-03-13 2013-09-19 Gilead Sciences , Inc. 2'- substituted carba-nucleoside analogs for antiviral treatment
SG10201804571TA (en) * 2012-03-21 2018-07-30 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
CA2879023C (en) 2012-07-13 2017-03-28 Wave Life Sciences Japan Asymmetric auxiliary group
UA119050C2 (uk) * 2013-11-11 2019-04-25 Ґілеад Саєнсиз, Інк. ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ
JP6415568B2 (ja) * 2013-12-11 2018-10-31 ナント ホールディングス アイピー，エルエルシー Ａ型インフルエンザｒｎａ依存性ｒｎａポリメラーゼの低分子阻害剤
MX2016009290A (es) 2014-01-16 2017-02-28 Wave Life Sciences Ltd Diseño quiral.
AR099312A1 (es) * 2014-02-06 2016-07-13 Riboscience Llc Derivados de nucleósidos sustituidos con 4-difluorometil como inhibidores de la replicación del arn de influenza
WO2015143712A1 (en) * 2014-03-28 2015-10-01 Merck Sharp & Dohme Corp. 4'-substituted nucleoside reverse transcriptase inhibitors
TWI678369B (zh) 2014-07-28 2019-12-01 美商基利科學股份有限公司 用於治療呼吸道合胞病毒感染之噻吩並［３,２-ｄ］嘧啶、呋喃並［３,２-ｄ］嘧啶及吡咯並［３,２-ｄ］嘧啶化合物類
EP3197457B1 (en) 2014-09-26 2022-11-09 Riboscience LLC 4'-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus rna replication
SG11201705069YA (en) 2014-12-26 2017-07-28 Univ Emory N4-hydroxycytidine and derivatives and anti-viral uses related thereto
WO2017053216A2 (en) 2015-09-23 2017-03-30 Merck Sharp & Dohme Corp. 4'-substituted nucleoside reverse transcriptase inhibitors and preparations thereof
US10202412B2 (en) 2016-07-08 2019-02-12 Atea Pharmaceuticals, Inc. β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections
NZ757442A (en) 2017-04-24 2022-10-28 Cocrystal Pharma Inc Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication
PL3706762T3 (pl) 2017-12-07 2025-02-10 Emory University N4-hydroksycytydyna i pochodne oraz związane z nimi zastosowania przeciwwirusowe
US11040975B2 (en) 2017-12-08 2021-06-22 Merck Sharp & Dohme Corp. Carbocyclic nucleoside reverse transcriptase inhibitors
EP3829719B1 (en) 2018-07-27 2025-04-02 Cocrystal Pharma, Inc. Pyrrolo[2,3-b]pyridin derivatives as inhibitors of influenza virus replication
CN113286793B (zh) 2018-09-10 2024-04-05 共结晶制药公司 吡咯并吡嗪和吡啶并三嗪类流感病毒复制抑制剂
US20220048897A1 (en) 2018-11-26 2022-02-17 Cocrystal Pharma, Inc. Inhibitors of influenza virus replication
AR121356A1 (es) 2020-02-18 2022-05-11 Gilead Sciences Inc Compuestos antivirales
TWI775313B (zh) 2020-02-18 2022-08-21 美商基利科學股份有限公司 抗病毒化合物
TWI794742B (zh) 2020-02-18 2023-03-01 美商基利科學股份有限公司 抗病毒化合物
CN115315252A (zh) * 2020-03-22 2022-11-08 盈擘医药股份有限公司 用于预防或暴露后治疗感染或呼吸疾病的抗病毒组合物
AU2021245634A1 (en) * 2020-03-30 2022-10-20 Fujifilm Toyama Chemical Co., Ltd. Coronavirus infection treatment drug
CN111956630A (zh) * 2020-08-20 2020-11-20 大连理工大学 一种瑞德西韦供雾化器用的液体制剂、制备方法及其应用
ES3028915T3 (en) 2021-04-16 2025-06-20 Gilead Sciences Inc Methods of preparing carbanucleosides using amides
EP4387977A1 (en) 2021-08-18 2024-06-26 Gilead Sciences, Inc. Phospholipid compounds and methods of making and using the same
PE20240654A1 (es) * 2021-08-20 2024-04-04 Shionogi & Co Derivados de nucleosido y profarmacos de los mismos que tienen accion inhibidora del crecimiento viral

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3361306A (en) 1966-03-31 1968-01-02 Merck & Co Inc Aerosol unit dispensing uniform amounts of a medically active ingredient
US3565070A (en) 1969-02-28 1971-02-23 Riker Laboratories Inc Inhalation actuable aerosol dispenser
FR2224175B1 (OSRAM) 1973-04-04 1978-04-14 Isf Spa
US4069819A (en) 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
IT1017153B (it) * 1974-07-15 1977-07-20 Isf Spa Apparecchio per inalazioni
SE438261B (sv) 1981-07-08 1985-04-15 Draco Ab Anvendning i dosinhalator av ett perforerat membran
US4816570A (en) * 1982-11-30 1989-03-28 The Board Of Regents Of The University Of Texas System Biologically reversible phosphate and phosphonate protective groups
US4805811A (en) * 1985-03-29 1989-02-21 Aktiebolaget Draco Dosage device
SE448277B (sv) 1985-04-12 1987-02-09 Draco Ab Indikeringsanordning vid en doseringsanordning for lekemedel
US4968788A (en) 1986-04-04 1990-11-06 Board Of Regents, The University Of Texas System Biologically reversible phosphate and phosphonate protective gruops
US5388571A (en) * 1987-07-17 1995-02-14 Roberts; Josephine A. Positive-pressure ventilator system with controlled access for nebulizer component servicing
IT1228459B (it) 1989-02-23 1991-06-19 Phidea S R L Inalatore con svuotamento regolare e completo della capsula.
US4955371A (en) 1989-05-08 1990-09-11 Transtech Scientific, Inc. Disposable inhalation activated, aerosol device for pulmonary medicine
DE10399025I2 (de) * 1990-09-14 2007-11-08 Acad Of Science Czech Republic Wirkstoffvorläufer von Phosphonaten
CA2112674C (en) 1991-07-02 2005-10-04 John S. Patton Method and device for delivering aerosolized medicaments
US5261538A (en) 1992-04-21 1993-11-16 Glaxo Inc. Aerosol testing method
US5785049A (en) 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
US5388572A (en) 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5522385A (en) * 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US5622163A (en) 1994-11-29 1997-04-22 Iep Group, Inc. Counter for fluid dispensers
US5544647A (en) 1994-11-29 1996-08-13 Iep Group, Inc. Metered dose inhalator
US6116234A (en) 1999-02-01 2000-09-12 Iep Pharmaceutical Devices Inc. Metered dose inhaler agitator
DE19912636A1 (de) 1999-03-20 2000-09-21 Aventis Cropscience Gmbh Bicyclische Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und pharmazeutische Mittel
KR101005299B1 (ko) 2000-10-18 2011-01-04 파마셋 인코포레이티드 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드
HUP0400726A3 (en) * 2001-01-22 2007-05-29 Merck & Co Inc Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
GB0112617D0 (en) * 2001-05-23 2001-07-18 Hoffmann La Roche Antiviral nucleoside derivatives
WO2003062256A1 (en) * 2002-01-17 2003-07-31 Ribapharm Inc. 2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents
JP4398631B2 (ja) * 2002-07-12 2010-01-13 富山化学工業株式会社 新規なピラジン誘導体またはその塩並びにそれらを含有する抗ウイルス剤
US20050196382A1 (en) 2002-09-13 2005-09-08 Replicor, Inc. Antiviral oligonucleotides targeting viral families
CN101084232A (zh) * 2004-10-19 2007-12-05 里普利科股份有限公司 抗病毒寡核苷酸
SG177974A1 (en) * 2007-01-12 2012-02-28 Biocryst Pharm Inc Antiviral nucleoside analogs
CA2685520A1 (en) * 2007-05-10 2008-11-20 Biocryst Pharmaceuticals, Inc. Tetrahydrofuro [3 4-d] dioxolane compounds for use in the treatment of viral infections and cancer
AR071395A1 (es) 2008-04-23 2010-06-16 Gilead Sciences Inc Analogos carba-nucleosidos 1'-sustituidos para tratamiento antiviral
WO2010036407A2 (en) * 2008-05-15 2010-04-01 Biocryst Pharmaceuticals, Inc. Antiviral nucleoside analogs
EP2313102A2 (en) 2008-07-03 2011-04-27 Biota Scientific Management Bycyclic nucleosides and nucleotides as therapeutic agents
HRP20130862T1 (hr) * 2009-09-21 2013-10-25 Gilead Sciences, Inc. Procesi i intermedijeri za pripravu analoga 1'-cijanokarbanukleozida
ES2730805T3 (es) * 2009-09-21 2019-11-12 Gilead Sciences Inc Análogos de carba-nucleósido sustituido por 2'-fluoro para el tratamiento antiviral
US8455451B2 (en) * 2009-09-21 2013-06-04 Gilead Sciences, Inc. 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
UA111163C2 (uk) * 2010-07-22 2016-04-11 Гайлід Сайєнсіз, Інк. Способи й сполуки для лікування вірусних інфекцій paramyxoviridae
TW201305185A (zh) * 2010-09-13 2013-02-01 Gilead Sciences Inc 用於抗病毒治療之２’－氟取代之碳－核苷類似物
WO2013138236A1 (en) 2012-03-13 2013-09-19 Gilead Sciences , Inc. 2'- substituted carba-nucleoside analogs for antiviral treatment

Also Published As

Publication number Publication date
AU2013232378A1 (en) 2014-09-25
CA2866381C (en) 2020-03-24
JP6242378B2 (ja) 2017-12-06
MX2014011009A (es) 2014-10-13
JP2019069986A (ja) 2019-05-09
EP2834258A1 (en) 2015-02-11
ES2621217T3 (es) 2017-07-03
ES2878087T3 (es) 2021-11-18
EP3210993A1 (en) 2017-08-30
EP3351552B1 (en) 2021-05-19
KR20140135820A (ko) 2014-11-26
JP6525441B2 (ja) 2019-06-05
EA201491548A1 (ru) 2015-02-27
JP2017206528A (ja) 2017-11-24
KR102068856B1 (ko) 2020-01-21
CA2866381A1 (en) 2013-09-19
AU2013232378B2 (en) 2017-09-28
EA028928B9 (ru) 2018-05-31
CN104185638A (zh) 2014-12-03
EP3932931B1 (en) 2024-11-20
US20210253622A1 (en) 2021-08-19
US9481704B2 (en) 2016-11-01
EP3932931A1 (en) 2022-01-05
PL2834258T3 (pl) 2017-07-31
US20170114086A1 (en) 2017-04-27
MD4496B1 (ro) 2017-07-31
EP3351552A1 (en) 2018-07-25
IL256397A (en) 2018-02-28
US20130243725A1 (en) 2013-09-19
US20190016749A1 (en) 2019-01-17
IL234586A (en) 2017-12-31
EP2834258B1 (en) 2017-01-04
IN2014DN08505A (OSRAM) 2015-05-15
MD20140112A2 (ro) 2015-02-28
ES2709071T3 (es) 2019-04-15
MD4496C1 (ro) 2018-02-28
HK1256856A1 (en) 2019-10-04
EA201791916A1 (ru) 2018-07-31
NZ629996A (en) 2016-10-28
US10941177B2 (en) 2021-03-09
EA028928B1 (ru) 2018-01-31
HK1207083A1 (en) 2016-01-22
AU2017279590A1 (en) 2018-01-18
MX355267B (es) 2018-04-12
CN106749272B (zh) 2019-08-30
CN106749272A (zh) 2017-05-31
ES3005115T3 (en) 2025-03-13
EP3932931C0 (en) 2024-11-20
WO2013138236A1 (en) 2013-09-19
US11787832B2 (en) 2023-10-17
EP3210993B1 (en) 2018-12-12
JP2015509983A (ja) 2015-04-02
PT2834258T (pt) 2017-04-07

Similar Documents

Publication Publication Date Title
IL256397A (en) Carba-nucleoside '2-converted analogs for antiviral therapy
IL228680A0 (en) Analogues of n nucleoside pyrimidine 1' - converted to antiviral therapy
AP3699A (en) 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
IL252345A0 (en) Antiviral compounds
IL238578B (en) Spliceostatin analogs
IL239496A0 (en) Antiviral compounds
IL235062A0 (en) Compounds and methods for antiviral therapy
IL238785A0 (en) Nucleosides containing antiviral azasaccharides
SG10201703451RA (en) Antiviral compounds
IL232206A0 (en) Respiratory feedback device
PL3333173T3 (pl) Sposoby wytwarzania przeciwwirusowych analogów nukleotydów
SI2576534T1 (sl) 1'-substituirana-karba-nukleozidna predzdravila za antivirusno zdravljenje
GB201500662D0 (en) Biofeedback system
EP2699241A4 (en) ANTIVIRAL COMPOUNDS
EP2782585A4 (en) ANTIVIRAL PREPARATIONS
ZA201402374B (en) Antiviral compounds