PT2576534E - Pró-fármacos substituídos em 1' com carba-nucleósido para tratamento antiviral - Google Patents

Pró-fármacos substituídos em 1' com carba-nucleósido para tratamento antiviral Download PDF

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Publication number
PT2576534E
PT2576534E PT117258384T PT11725838T PT2576534E PT 2576534 E PT2576534 E PT 2576534E PT 117258384 T PT117258384 T PT 117258384T PT 11725838 T PT11725838 T PT 11725838T PT 2576534 E PT2576534 E PT 2576534E
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PT
Portugal
Prior art keywords
carba
substituted
antiviral treatment
nucleoside prodrugs
nucleoside
Prior art date
Application number
PT117258384T
Other languages
English (en)
Inventor
Choung U Kim
Aesop Cho
Adrian S Ray
Lijun Zhang
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of PT2576534E publication Critical patent/PT2576534E/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
PT117258384T 2010-05-28 2011-05-26 Pró-fármacos substituídos em 1' com carba-nucleósido para tratamento antiviral PT2576534E (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US34959710P 2010-05-28 2010-05-28
US35335110P 2010-06-10 2010-06-10
US36604110P 2010-07-20 2010-07-20
US13/117,060 US8415308B2 (en) 2010-05-28 2011-05-26 1′-substituted-carba-nucleoside prodrugs for antiviral treatment

Publications (1)

Publication Number Publication Date
PT2576534E true PT2576534E (pt) 2014-05-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PT117258384T PT2576534E (pt) 2010-05-28 2011-05-26 Pró-fármacos substituídos em 1' com carba-nucleósido para tratamento antiviral

Country Status (18)

Country Link
US (1) US8415308B2 (pt)
EP (1) EP2576534B1 (pt)
JP (4) JP5837577B2 (pt)
AR (1) AR084389A1 (pt)
CY (1) CY1115479T1 (pt)
DK (1) DK2576534T3 (pt)
ES (1) ES2465265T3 (pt)
HK (1) HK1182387A1 (pt)
HR (1) HRP20140370T1 (pt)
ME (1) ME01882B (pt)
PL (1) PL2576534T3 (pt)
PT (1) PT2576534E (pt)
RS (1) RS53244B (pt)
SI (1) SI2576534T1 (pt)
SM (1) SMT201400048B (pt)
TW (1) TW201201815A (pt)
UY (1) UY33414A (pt)
WO (1) WO2011150288A1 (pt)

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Also Published As

Publication number Publication date
SI2576534T1 (sl) 2014-06-30
EP2576534B1 (en) 2014-03-19
DK2576534T3 (da) 2014-04-22
PL2576534T3 (pl) 2014-07-31
US8415308B2 (en) 2013-04-09
JP2013528184A (ja) 2013-07-08
RS53244B (en) 2014-08-29
EP2576534A1 (en) 2013-04-10
CY1115479T1 (el) 2017-01-04
HRP20140370T1 (hr) 2014-05-23
JP6193332B2 (ja) 2017-09-06
SMT201400048B (it) 2014-05-07
JP2018162268A (ja) 2018-10-18
UY33414A (es) 2011-12-30
JP2018012706A (ja) 2018-01-25
ME01882B (me) 2014-12-20
TW201201815A (en) 2012-01-16
WO2011150288A1 (en) 2011-12-01
JP5837577B2 (ja) 2015-12-24
JP2016094404A (ja) 2016-05-26
HK1182387A1 (en) 2013-11-29
US20120020921A1 (en) 2012-01-26
AR084389A1 (es) 2013-05-15
ES2465265T3 (es) 2014-06-05

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