SMT201400048B - Profarmaci carba-nucleosidici 1'-sostutuiti per iltrattamento antivirale - Google Patents

Profarmaci carba-nucleosidici 1'-sostutuiti per iltrattamento antivirale

Info

Publication number
SMT201400048B
SMT201400048B SM201400048T SM201400048T SMT201400048B SM T201400048 B SMT201400048 B SM T201400048B SM 201400048 T SM201400048 T SM 201400048T SM 201400048 T SM201400048 T SM 201400048T SM T201400048 B SMT201400048 B SM T201400048B
Authority
SM
San Marino
Prior art keywords
antiviral treatment
substituted beta
nucleoside prodrugs
nucleoside
prodrugs
Prior art date
Application number
SM201400048T
Other languages
English (en)
Italian (it)
Inventor
Choung U Kim
Aesop Cho
Lijun Zhang
Adrian S Ray
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of SMT201400048B publication Critical patent/SMT201400048B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
SM201400048T 2010-05-28 2014-04-11 Profarmaci carba-nucleosidici 1'-sostutuiti per iltrattamento antivirale SMT201400048B (it)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US34959710P 2010-05-28 2010-05-28
US35335110P 2010-06-10 2010-06-10
US36604110P 2010-07-20 2010-07-20
PCT/US2011/038253 WO2011150288A1 (en) 2010-05-28 2011-05-26 1'-substituted-carba-nucleoside prodrugs for antiviral treatment

Publications (1)

Publication Number Publication Date
SMT201400048B true SMT201400048B (it) 2014-05-07

Family

ID=45375840

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201400048T SMT201400048B (it) 2010-05-28 2014-04-11 Profarmaci carba-nucleosidici 1'-sostutuiti per iltrattamento antivirale

Country Status (18)

Country Link
US (1) US8415308B2 (xx)
EP (1) EP2576534B1 (xx)
JP (4) JP5837577B2 (xx)
AR (1) AR084389A1 (xx)
CY (1) CY1115479T1 (xx)
DK (1) DK2576534T3 (xx)
ES (1) ES2465265T3 (xx)
HK (1) HK1182387A1 (xx)
HR (1) HRP20140370T1 (xx)
ME (1) ME01882B (xx)
PL (1) PL2576534T3 (xx)
PT (1) PT2576534E (xx)
RS (1) RS53244B (xx)
SI (1) SI2576534T1 (xx)
SM (1) SMT201400048B (xx)
TW (1) TW201201815A (xx)
UY (1) UY33414A (xx)
WO (1) WO2011150288A1 (xx)

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Also Published As

Publication number Publication date
UY33414A (es) 2011-12-30
DK2576534T3 (da) 2014-04-22
PL2576534T3 (pl) 2014-07-31
HK1182387A1 (en) 2013-11-29
JP2018162268A (ja) 2018-10-18
JP2018012706A (ja) 2018-01-25
AR084389A1 (es) 2013-05-15
SI2576534T1 (sl) 2014-06-30
HRP20140370T1 (hr) 2014-05-23
US20120020921A1 (en) 2012-01-26
ME01882B (me) 2014-12-20
JP2013528184A (ja) 2013-07-08
WO2011150288A1 (en) 2011-12-01
JP2016094404A (ja) 2016-05-26
EP2576534B1 (en) 2014-03-19
JP6193332B2 (ja) 2017-09-06
EP2576534A1 (en) 2013-04-10
TW201201815A (en) 2012-01-16
US8415308B2 (en) 2013-04-09
PT2576534E (pt) 2014-05-29
CY1115479T1 (el) 2017-01-04
JP5837577B2 (ja) 2015-12-24
RS53244B (en) 2014-08-29
ES2465265T3 (es) 2014-06-05

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