SI1404673T1 - Tehnični sintezni postopek za proizvodnjo tropenola - Google Patents

Tehnični sintezni postopek za proizvodnjo tropenola

Info

Publication number
SI1404673T1
SI1404673T1 SI200230153T SI200230153T SI1404673T1 SI 1404673 T1 SI1404673 T1 SI 1404673T1 SI 200230153 T SI200230153 T SI 200230153T SI 200230153 T SI200230153 T SI 200230153T SI 1404673 T1 SI1404673 T1 SI 1404673T1
Authority
SI
Slovenia
Prior art keywords
tropenol
production
synthesis process
technical synthesis
technical
Prior art date
Application number
SI200230153T
Other languages
English (en)
Slovenian (sl)
Inventor
Armin Walter Rapp
Rainer Sobotta
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7689774&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1404673(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg
Publication of SI1404673T1 publication Critical patent/SI1404673T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Lock And Its Accessories (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Catalysts (AREA)
SI200230153T 2001-06-28 2002-06-08 Tehnični sintezni postopek za proizvodnjo tropenola SI1404673T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10131200 2001-06-28
EP02727610A EP1404673B1 (de) 2001-06-28 2002-06-08 Technische syntheseverfahren zur herstellung von tropenol
PCT/EP2002/006290 WO2003002562A1 (de) 2001-06-28 2002-06-08 Technische syntheseverfahren zur herstellung von tropenol

Publications (1)

Publication Number Publication Date
SI1404673T1 true SI1404673T1 (sl) 2005-10-31

Family

ID=7689774

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200230153T SI1404673T1 (sl) 2001-06-28 2002-06-08 Tehnični sintezni postopek za proizvodnjo tropenola
SI200230540T SI1475379T1 (sl) 2001-06-28 2002-06-08 Uporaba derivatov skopinskega estra za pripravo zdravil

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200230540T SI1475379T1 (sl) 2001-06-28 2002-06-08 Uporaba derivatov skopinskega estra za pripravo zdravil

Country Status (40)

Country Link
US (1) US6610849B2 (cs)
EP (3) EP1475379B1 (cs)
JP (2) JP4485192B2 (cs)
KR (3) KR100886342B1 (cs)
CN (2) CN1982309B (cs)
AR (1) AR039056A1 (cs)
AT (3) ATE527257T1 (cs)
AU (2) AU2002257820B2 (cs)
BG (2) BG66398B1 (cs)
BR (1) BR0210664B1 (cs)
CA (1) CA2451573C (cs)
CO (1) CO5650166A2 (cs)
CY (1) CY1107681T1 (cs)
CZ (1) CZ296187B6 (cs)
DE (2) DE50209948D1 (cs)
DK (3) DK1404673T3 (cs)
EA (2) EA006393B1 (cs)
EC (1) ECSP034927A (cs)
EE (1) EE05403B1 (cs)
EG (1) EG23203A (cs)
ES (3) ES2285318T3 (cs)
HR (2) HRP20031085B1 (cs)
HU (2) HU230379B1 (cs)
IL (2) IL159239A0 (cs)
ME (1) MEP42608A (cs)
MX (1) MXPA03011516A (cs)
MY (1) MY122932A (cs)
NO (1) NO328154B1 (cs)
NZ (2) NZ530770A (cs)
PE (1) PE20030123A1 (cs)
PL (1) PL209520B1 (cs)
PT (2) PT1475379E (cs)
RS (1) RS50436B (cs)
SA (1) SA02230194B1 (cs)
SI (2) SI1404673T1 (cs)
SK (1) SK288022B6 (cs)
TW (1) TW574220B (cs)
UA (2) UA76761C2 (cs)
WO (1) WO2003002562A1 (cs)
ZA (1) ZA200308895B (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141377A1 (de) 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6747153B2 (en) * 2002-05-31 2004-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Industrial process for preparing tropenol
US20090162562A1 (en) * 2007-12-24 2009-06-25 Bangalore Aswatha Nagaraj Methods for Applying Thermal Barrier Coating Systems
WO2009087419A1 (en) * 2008-01-10 2009-07-16 Generics [Uk] Limited Novel process for the preparation of scopine esters
WO2011015882A2 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Novel anhydrate
WO2011015884A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Process to prepare scopine esters
CN102351856B (zh) * 2011-08-24 2013-05-01 商丘市韶华药业有限公司 一种α-托品醇的纯化方法
ITRM20110508A1 (it) 2011-09-27 2013-03-28 Lusochimica Spa Processo per la preparazione degli esteri della scopina.
PT2607351T (pt) * 2011-12-22 2017-05-26 Cerbios-Pharma S A Processo contínuo para a alquilação de aminas terciárias cíclicas
CN113292574B (zh) * 2020-02-21 2022-05-03 四川大学 一类手性多环的托品烷化合物及其制备方法和用途
CN111269226B (zh) * 2020-04-13 2021-09-21 石家庄四药有限公司 异丙托溴铵的合成方法
CN113264929B (zh) * 2021-05-02 2023-10-10 润生药业有限公司 一种噻托溴铵的制备方法
CN115925534B (zh) * 2023-01-03 2025-03-07 绍兴民生医药股份有限公司 高纯度托品酸的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
BR9507489A (pt) * 1994-04-19 1997-08-12 Neurosearch As Derivados tropano sua preparacão e uso
DE19515625C2 (de) * 1995-04-28 1998-02-19 Boehringer Ingelheim Kg Verfahren zur Herstellung von enantiomerenreinen Tropasäureestern

Also Published As

Publication number Publication date
AU2008201565B2 (en) 2012-03-01
AR039056A1 (es) 2005-02-09
CN1288154C (zh) 2006-12-06
EP1404673B1 (de) 2005-05-04
HUP0400332A2 (hu) 2004-08-30
KR20080065313A (ko) 2008-07-11
CO5650166A2 (es) 2006-06-30
EE05403B1 (et) 2011-04-15
EA200501081A1 (ru) 2006-06-30
PT1404673E (pt) 2005-07-29
SI1475379T1 (sl) 2007-08-31
CZ2004149A3 (cs) 2004-05-12
MXPA03011516A (es) 2004-03-18
US6610849B2 (en) 2003-08-26
KR20040023631A (ko) 2004-03-18
KR100866272B1 (ko) 2008-11-03
CY1107681T1 (el) 2013-04-18
CN1982309A (zh) 2007-06-20
HUP0400332A3 (en) 2007-06-28
KR20030078793A (ko) 2003-10-08
UA76761C2 (uk) 2006-09-15
DE50203015D1 (de) 2005-06-09
EA009808B1 (ru) 2008-04-28
PL209520B1 (pl) 2011-09-30
CN1520413A (zh) 2004-08-11
JP2010043116A (ja) 2010-02-25
TW574220B (en) 2004-02-01
JP4485192B2 (ja) 2010-06-16
DK1475379T3 (da) 2007-09-03
MY122932A (en) 2006-05-31
BG66398B1 (bg) 2013-12-31
ATE359285T1 (de) 2007-05-15
UA86031C2 (ru) 2009-03-25
BR0210664B1 (pt) 2013-12-03
HK1103404A1 (zh) 2007-12-21
HK1068613A1 (en) 2005-04-29
NZ541395A (en) 2007-03-30
EP1404673A1 (de) 2004-04-07
HRP20031085A2 (en) 2004-04-30
EG23203A (en) 2004-07-31
YU101103A (en) 2006-05-25
DK1404673T3 (da) 2005-06-13
EP1475379A1 (de) 2004-11-10
ATE527257T1 (de) 2011-10-15
ECSP034927A (es) 2004-02-26
IL159239A (en) 2010-05-17
RS50436B (sr) 2009-12-31
DE50209948D1 (de) 2007-05-24
MEP42608A (en) 2011-02-10
HRP20031085B1 (en) 2011-12-31
ZA200308895B (en) 2004-06-09
BG111461A (en) 2013-08-30
EE200400045A (et) 2004-04-15
CA2451573C (en) 2010-09-21
AU2008201565A1 (en) 2008-05-01
PE20030123A1 (es) 2003-03-31
ES2285318T3 (es) 2007-11-16
NO328154B1 (no) 2009-12-21
BG108462A (bg) 2005-01-31
PT1475379E (pt) 2007-05-31
BR0210664A (pt) 2004-08-10
HU230036B1 (hu) 2015-05-28
IL159239A0 (en) 2004-06-01
NO20035633D0 (no) 2003-12-17
CZ296187B6 (cs) 2006-01-11
ATE294801T1 (de) 2005-05-15
SA02230194B1 (ar) 2008-03-08
US20030022917A1 (en) 2003-01-30
EA006393B1 (ru) 2005-12-29
SK288022B6 (sk) 2012-12-03
HRP20090110A2 (en) 2009-04-30
CA2451573A1 (en) 2003-01-09
EP1808435B1 (de) 2011-10-05
NZ530770A (en) 2005-11-25
AU2002257820B2 (en) 2008-05-08
EP1475379B1 (de) 2007-04-11
KR100886342B1 (ko) 2009-03-03
KR100530661B1 (ko) 2005-11-22
SK662004A3 (en) 2004-06-08
ES2374981T3 (es) 2012-02-23
JP2004536830A (ja) 2004-12-09
WO2003002562A1 (de) 2003-01-09
ES2242022T3 (es) 2005-11-01
HU230379B1 (hu) 2016-03-29
CN1982309B (zh) 2010-06-09
EA200301292A1 (ru) 2004-06-24
DK1808435T3 (da) 2012-01-16
EP1808435A1 (de) 2007-07-18
PL366942A1 (en) 2005-02-07

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