CO5650166A2 - Procedimiento para la preparacion de tropenol - Google Patents
Procedimiento para la preparacion de tropenolInfo
- Publication number
- CO5650166A2 CO5650166A2 CO03112174A CO03112174A CO5650166A2 CO 5650166 A2 CO5650166 A2 CO 5650166A2 CO 03112174 A CO03112174 A CO 03112174A CO 03112174 A CO03112174 A CO 03112174A CO 5650166 A2 CO5650166 A2 CO 5650166A2
- Authority
- CO
- Colombia
- Prior art keywords
- tropenol
- salts
- procedure
- preparation
- possibly
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Lock And Its Accessories (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1.- Procedimiento para la preparación de tropenol eventualmente en forma de sus sales por adición de ácidos, caracterizado porque ésteres escopínicos de la fórmula (II) en la cual R significa un radical seleccionado de alquilo(C1-C4) y alquilen(C1-C4) -fenilo, los cuales pueden estar sustituidos, cada uno, con hidroxi o alcoxi(C1-C4), eventualmente en forma de sus sales por adición de ácidos, así como eventualmente en forma de sus hidratos, se reducen en un disolvente adecuado mediante cinc en presencia de sales metálicas activantes, preferentemente sales de hierro o cobre activantes y, a continuación, se saponifican utilizando bases adecuadas para dar tropenol de la fórmula (I).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10131200 | 2001-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5650166A2 true CO5650166A2 (es) | 2006-06-30 |
Family
ID=7689774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO03112174A CO5650166A2 (es) | 2001-06-28 | 2003-12-23 | Procedimiento para la preparacion de tropenol |
Country Status (41)
| Country | Link |
|---|---|
| US (1) | US6610849B2 (es) |
| EP (3) | EP1404673B1 (es) |
| JP (2) | JP4485192B2 (es) |
| KR (3) | KR100886342B1 (es) |
| CN (2) | CN1982309B (es) |
| AR (1) | AR039056A1 (es) |
| AT (3) | ATE527257T1 (es) |
| AU (2) | AU2002257820B2 (es) |
| BG (2) | BG66398B1 (es) |
| BR (1) | BR0210664B1 (es) |
| CA (1) | CA2451573C (es) |
| CO (1) | CO5650166A2 (es) |
| CY (1) | CY1107681T1 (es) |
| CZ (1) | CZ296187B6 (es) |
| DE (2) | DE50203015D1 (es) |
| DK (3) | DK1808435T3 (es) |
| EA (2) | EA009808B1 (es) |
| EC (1) | ECSP034927A (es) |
| EE (1) | EE05403B1 (es) |
| EG (1) | EG23203A (es) |
| ES (3) | ES2374981T3 (es) |
| HK (2) | HK1068613A1 (es) |
| HR (2) | HRP20031085B1 (es) |
| HU (2) | HU230379B1 (es) |
| IL (2) | IL159239A0 (es) |
| ME (1) | MEP42608A (es) |
| MX (1) | MXPA03011516A (es) |
| MY (1) | MY122932A (es) |
| NO (1) | NO328154B1 (es) |
| NZ (2) | NZ530770A (es) |
| PE (1) | PE20030123A1 (es) |
| PL (1) | PL209520B1 (es) |
| PT (2) | PT1404673E (es) |
| RS (1) | RS50436B (es) |
| SA (1) | SA02230194B1 (es) |
| SI (2) | SI1404673T1 (es) |
| SK (1) | SK288022B6 (es) |
| TW (1) | TW574220B (es) |
| UA (2) | UA76761C2 (es) |
| WO (1) | WO2003002562A1 (es) |
| ZA (1) | ZA200308895B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10141377A1 (de) | 2001-08-23 | 2003-03-13 | Boehringer Ingelheim Pharma | Aufstreuverfahren zur Herstellung von Pulverformulierungen |
| US6747153B2 (en) * | 2002-05-31 | 2004-06-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Industrial process for preparing tropenol |
| US20090162562A1 (en) * | 2007-12-24 | 2009-06-25 | Bangalore Aswatha Nagaraj | Methods for Applying Thermal Barrier Coating Systems |
| CN101918401A (zh) * | 2008-01-10 | 2010-12-15 | 基因里克斯(英国)有限公司 | 用于制备东莨菪醇酯的新方法 |
| WO2011015884A1 (en) | 2009-08-07 | 2011-02-10 | Generics [Uk] Limited | Process to prepare scopine esters |
| US8697719B2 (en) | 2009-08-07 | 2014-04-15 | Generics [Uk] Limited | Anhydrate of tiotropium bromide |
| CN102351856B (zh) * | 2011-08-24 | 2013-05-01 | 商丘市韶华药业有限公司 | 一种α-托品醇的纯化方法 |
| ITRM20110508A1 (it) | 2011-09-27 | 2013-03-28 | Lusochimica Spa | Processo per la preparazione degli esteri della scopina. |
| RS55996B1 (sr) * | 2011-12-22 | 2017-09-29 | Cerbios-Pharma S A | Kontinuirani postupak za alkilaciju cikličnih tercijarnih amina |
| CN113292574B (zh) * | 2020-02-21 | 2022-05-03 | 四川大学 | 一类手性多环的托品烷化合物及其制备方法和用途 |
| CN111269226B (zh) * | 2020-04-13 | 2021-09-21 | 石家庄四药有限公司 | 异丙托溴铵的合成方法 |
| CN113264929B (zh) * | 2021-05-02 | 2023-10-10 | 润生药业有限公司 | 一种噻托溴铵的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3931041C2 (de) * | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| HU215830B (hu) * | 1994-04-19 | 2001-05-28 | Neurosearch A/S | Tropán-2-aldoxim-származékok, e vegyületeket tartalmazó gyógyászati készítmények, valamint e vegyületek előállítása és alkalmazása gyógyszerkészítmények előállítására |
| DE19515625C2 (de) * | 1995-04-28 | 1998-02-19 | Boehringer Ingelheim Kg | Verfahren zur Herstellung von enantiomerenreinen Tropasäureestern |
-
2002
- 2002-06-03 US US10/160,702 patent/US6610849B2/en not_active Expired - Lifetime
- 2002-06-08 DK DK07101821.2T patent/DK1808435T3/da active
- 2002-06-08 WO PCT/EP2002/006290 patent/WO2003002562A1/de active Application Filing
- 2002-06-08 EA EA200501081A patent/EA009808B1/ru not_active IP Right Cessation
- 2002-06-08 ES ES07101821T patent/ES2374981T3/es not_active Expired - Lifetime
- 2002-06-08 AT AT07101821T patent/ATE527257T1/de active
- 2002-06-08 SI SI200230153T patent/SI1404673T1/xx unknown
- 2002-06-08 AU AU2002257820A patent/AU2002257820B2/en not_active Expired
- 2002-06-08 HU HU1400554A patent/HU230379B1/hu unknown
- 2002-06-08 MX MXPA03011516A patent/MXPA03011516A/es active IP Right Grant
- 2002-06-08 PT PT02727610T patent/PT1404673E/pt unknown
- 2002-06-08 EA EA200301292A patent/EA006393B1/ru not_active IP Right Cessation
- 2002-06-08 IL IL15923902A patent/IL159239A0/xx unknown
- 2002-06-08 CN CN2006101604057A patent/CN1982309B/zh not_active Expired - Lifetime
- 2002-06-08 CN CNB028128672A patent/CN1288154C/zh not_active Expired - Lifetime
- 2002-06-08 SK SK66-2004A patent/SK288022B6/sk not_active IP Right Cessation
- 2002-06-08 DE DE50203015T patent/DE50203015D1/de not_active Expired - Lifetime
- 2002-06-08 RS YUP-1011/03A patent/RS50436B/sr unknown
- 2002-06-08 BR BRPI0210664-7B1A patent/BR0210664B1/pt active IP Right Grant
- 2002-06-08 SI SI200230540T patent/SI1475379T1/sl unknown
- 2002-06-08 EP EP02727610A patent/EP1404673B1/de not_active Expired - Lifetime
- 2002-06-08 PL PL366942A patent/PL209520B1/pl unknown
- 2002-06-08 EP EP07101821A patent/EP1808435B1/de not_active Expired - Lifetime
- 2002-06-08 KR KR1020087014692A patent/KR100886342B1/ko active IP Right Grant
- 2002-06-08 DK DK02727610T patent/DK1404673T3/da active
- 2002-06-08 DK DK04018550T patent/DK1475379T3/da active
- 2002-06-08 NZ NZ530770A patent/NZ530770A/en not_active IP Right Cessation
- 2002-06-08 HU HU0400332A patent/HU230036B1/hu unknown
- 2002-06-08 JP JP2003508943A patent/JP4485192B2/ja not_active Expired - Lifetime
- 2002-06-08 PT PT04018550T patent/PT1475379E/pt unknown
- 2002-06-08 CZ CZ20040149A patent/CZ296187B6/cs not_active IP Right Cessation
- 2002-06-08 ME MEP-426/08A patent/MEP42608A/xx unknown
- 2002-06-08 ES ES02727610T patent/ES2242022T3/es not_active Expired - Lifetime
- 2002-06-08 KR KR1020037017010A patent/KR100866272B1/ko active IP Right Grant
- 2002-06-08 EE EEP200400045A patent/EE05403B1/xx not_active IP Right Cessation
- 2002-06-08 NZ NZ541395A patent/NZ541395A/en not_active IP Right Cessation
- 2002-06-08 AT AT02727610T patent/ATE294801T1/de active
- 2002-06-08 AT AT04018550T patent/ATE359285T1/de active
- 2002-06-08 EP EP04018550A patent/EP1475379B1/de not_active Revoked
- 2002-06-08 ES ES04018550T patent/ES2285318T3/es not_active Expired - Lifetime
- 2002-06-08 DE DE50209948T patent/DE50209948D1/de not_active Expired - Lifetime
- 2002-06-08 CA CA2451573A patent/CA2451573C/en not_active Expired - Fee Related
- 2002-06-25 PE PE2002000553A patent/PE20030123A1/es not_active Application Discontinuation
- 2002-06-26 TW TW91114026A patent/TW574220B/zh not_active IP Right Cessation
- 2002-06-26 MY MYPI20022420A patent/MY122932A/en unknown
- 2002-06-26 EG EG2002060738A patent/EG23203A/xx active
- 2002-06-28 AR ARP020102453A patent/AR039056A1/es active Pending
- 2002-07-10 SA SA2230194A patent/SA02230194B1/ar unknown
- 2002-08-06 UA UA2004010605A patent/UA76761C2/uk unknown
-
2003
- 2003-03-28 KR KR10-2003-0019708A patent/KR100530661B1/ko not_active IP Right Cessation
- 2003-11-14 ZA ZA200308895A patent/ZA200308895B/en unknown
- 2003-12-08 IL IL159239A patent/IL159239A/en active IP Right Grant
- 2003-12-17 BG BG108462A patent/BG66398B1/bg active Active
- 2003-12-17 NO NO20035633A patent/NO328154B1/no not_active IP Right Cessation
- 2003-12-23 CO CO03112174A patent/CO5650166A2/es active IP Right Grant
- 2003-12-24 HR HR20031085A patent/HRP20031085B1/xx not_active IP Right Cessation
- 2003-12-24 EC EC2003004927A patent/ECSP034927A/es unknown
-
2005
- 2005-01-29 HK HK05100781A patent/HK1068613A1/xx not_active IP Right Cessation
-
2006
- 2006-03-09 UA UAA200602562A patent/UA86031C2/ru unknown
-
2007
- 2007-06-21 CY CY20071100822T patent/CY1107681T1/el unknown
- 2007-10-31 HK HK07111732.3A patent/HK1103404A1/xx not_active IP Right Cessation
-
2008
- 2008-04-08 AU AU2008201565A patent/AU2008201565B2/en not_active Expired
-
2009
- 2009-02-23 HR HR20090110A patent/HRP20090110A2/xx not_active Application Discontinuation
- 2009-10-13 JP JP2009236400A patent/JP2010043116A/ja active Pending
-
2013
- 2013-05-07 BG BG10111461A patent/BG111461A/en active Pending
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted |