IL159239A0 - Technical synthesis method for producing tropenol - Google Patents

Technical synthesis method for producing tropenol

Info

Publication number
IL159239A0
IL159239A0 IL15923902A IL15923902A IL159239A0 IL 159239 A0 IL159239 A0 IL 159239A0 IL 15923902 A IL15923902 A IL 15923902A IL 15923902 A IL15923902 A IL 15923902A IL 159239 A0 IL159239 A0 IL 159239A0
Authority
IL
Israel
Prior art keywords
synthesis method
technical synthesis
tropenol
producing
producing tropenol
Prior art date
Application number
IL15923902A
Other languages
English (en)
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7689774&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL159239(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of IL159239A0 publication Critical patent/IL159239A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06Oxygen atoms
    • C07D451/10Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Lock And Its Accessories (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Catalysts (AREA)
IL15923902A 2001-06-28 2002-06-08 Technical synthesis method for producing tropenol IL159239A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10131200 2001-06-28
PCT/EP2002/006290 WO2003002562A1 (de) 2001-06-28 2002-06-08 Technische syntheseverfahren zur herstellung von tropenol

Publications (1)

Publication Number Publication Date
IL159239A0 true IL159239A0 (en) 2004-06-01

Family

ID=7689774

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15923902A IL159239A0 (en) 2001-06-28 2002-06-08 Technical synthesis method for producing tropenol
IL159239A IL159239A (en) 2001-06-28 2003-12-08 Process for preparing tropenol and its use for preparing salts

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL159239A IL159239A (en) 2001-06-28 2003-12-08 Process for preparing tropenol and its use for preparing salts

Country Status (40)

Country Link
US (1) US6610849B2 (cs)
EP (3) EP1475379B1 (cs)
JP (2) JP4485192B2 (cs)
KR (3) KR100886342B1 (cs)
CN (2) CN1982309B (cs)
AR (1) AR039056A1 (cs)
AT (3) ATE527257T1 (cs)
AU (2) AU2002257820B2 (cs)
BG (2) BG66398B1 (cs)
BR (1) BR0210664B1 (cs)
CA (1) CA2451573C (cs)
CO (1) CO5650166A2 (cs)
CY (1) CY1107681T1 (cs)
CZ (1) CZ296187B6 (cs)
DE (2) DE50203015D1 (cs)
DK (3) DK1404673T3 (cs)
EA (2) EA006393B1 (cs)
EC (1) ECSP034927A (cs)
EE (1) EE05403B1 (cs)
EG (1) EG23203A (cs)
ES (3) ES2374981T3 (cs)
HR (2) HRP20031085B1 (cs)
HU (2) HU230036B1 (cs)
IL (2) IL159239A0 (cs)
ME (1) MEP42608A (cs)
MX (1) MXPA03011516A (cs)
MY (1) MY122932A (cs)
NO (1) NO328154B1 (cs)
NZ (2) NZ541395A (cs)
PE (1) PE20030123A1 (cs)
PL (1) PL209520B1 (cs)
PT (2) PT1404673E (cs)
RS (1) RS50436B (cs)
SA (1) SA02230194B1 (cs)
SI (2) SI1404673T1 (cs)
SK (1) SK288022B6 (cs)
TW (1) TW574220B (cs)
UA (2) UA76761C2 (cs)
WO (1) WO2003002562A1 (cs)
ZA (1) ZA200308895B (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141377A1 (de) 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6747153B2 (en) * 2002-05-31 2004-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Industrial process for preparing tropenol
US20090162562A1 (en) * 2007-12-24 2009-06-25 Bangalore Aswatha Nagaraj Methods for Applying Thermal Barrier Coating Systems
EP2240477B8 (en) * 2008-01-10 2014-12-10 Generics [UK] Limited Novel process for the preparation of scopine esters
AU2010280497B2 (en) 2009-08-07 2015-10-22 Generics [Uk] Limited Anhydrate of tiotropium bromide
WO2011015884A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Process to prepare scopine esters
CN102351856B (zh) * 2011-08-24 2013-05-01 商丘市韶华药业有限公司 一种α-托品醇的纯化方法
ITRM20110508A1 (it) 2011-09-27 2013-03-28 Lusochimica Spa Processo per la preparazione degli esteri della scopina.
PT2607351T (pt) * 2011-12-22 2017-05-26 Cerbios-Pharma S A Processo contínuo para a alquilação de aminas terciárias cíclicas
CN113292574B (zh) * 2020-02-21 2022-05-03 四川大学 一类手性多环的托品烷化合物及其制备方法和用途
CN111269226B (zh) * 2020-04-13 2021-09-21 石家庄四药有限公司 异丙托溴铵的合成方法
CN113264929B (zh) * 2021-05-02 2023-10-10 润生药业有限公司 一种噻托溴铵的制备方法
CN115925534B (zh) * 2023-01-03 2025-03-07 绍兴民生医药股份有限公司 高纯度托品酸的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
CZ284379B6 (cs) * 1994-04-19 1998-11-11 Neurosearch A/S Tropanové deriváty, způsob jejich přípravy a jejich použití
DE19515625C2 (de) * 1995-04-28 1998-02-19 Boehringer Ingelheim Kg Verfahren zur Herstellung von enantiomerenreinen Tropasäureestern

Also Published As

Publication number Publication date
DE50209948D1 (de) 2007-05-24
CA2451573A1 (en) 2003-01-09
EP1808435B1 (de) 2011-10-05
EP1404673B1 (de) 2005-05-04
UA86031C2 (ru) 2009-03-25
HK1103404A1 (zh) 2007-12-21
HRP20090110A2 (en) 2009-04-30
BR0210664A (pt) 2004-08-10
RS50436B (sr) 2009-12-31
CZ296187B6 (cs) 2006-01-11
HRP20031085B1 (en) 2011-12-31
CY1107681T1 (el) 2013-04-18
BG66398B1 (bg) 2013-12-31
MXPA03011516A (es) 2004-03-18
KR20040023631A (ko) 2004-03-18
PL366942A1 (en) 2005-02-07
US6610849B2 (en) 2003-08-26
KR100886342B1 (ko) 2009-03-03
NO328154B1 (no) 2009-12-21
HUP0400332A3 (en) 2007-06-28
HUP0400332A2 (hu) 2004-08-30
CZ2004149A3 (cs) 2004-05-12
CN1982309A (zh) 2007-06-20
HU230379B1 (hu) 2016-03-29
CA2451573C (en) 2010-09-21
KR100530661B1 (ko) 2005-11-22
ES2285318T3 (es) 2007-11-16
EA200501081A1 (ru) 2006-06-30
ATE527257T1 (de) 2011-10-15
AR039056A1 (es) 2005-02-09
ATE359285T1 (de) 2007-05-15
BG108462A (bg) 2005-01-31
HU230036B1 (hu) 2015-05-28
EP1475379A1 (de) 2004-11-10
HRP20031085A2 (en) 2004-04-30
DK1475379T3 (da) 2007-09-03
AU2008201565A1 (en) 2008-05-01
DK1808435T3 (da) 2012-01-16
SI1475379T1 (sl) 2007-08-31
CN1288154C (zh) 2006-12-06
SK288022B6 (sk) 2012-12-03
KR20030078793A (ko) 2003-10-08
SA02230194B1 (ar) 2008-03-08
US20030022917A1 (en) 2003-01-30
SK662004A3 (en) 2004-06-08
IL159239A (en) 2010-05-17
NZ530770A (en) 2005-11-25
WO2003002562A1 (de) 2003-01-09
CN1982309B (zh) 2010-06-09
EG23203A (en) 2004-07-31
NO20035633D0 (no) 2003-12-17
DE50203015D1 (de) 2005-06-09
ES2242022T3 (es) 2005-11-01
EP1808435A1 (de) 2007-07-18
EE05403B1 (et) 2011-04-15
EA009808B1 (ru) 2008-04-28
EP1404673A1 (de) 2004-04-07
BR0210664B1 (pt) 2013-12-03
KR20080065313A (ko) 2008-07-11
YU101103A (en) 2006-05-25
MEP42608A (en) 2011-02-10
NZ541395A (en) 2007-03-30
EA200301292A1 (ru) 2004-06-24
UA76761C2 (uk) 2006-09-15
JP4485192B2 (ja) 2010-06-16
ECSP034927A (es) 2004-02-26
SI1404673T1 (sl) 2005-10-31
AU2002257820B2 (en) 2008-05-08
ATE294801T1 (de) 2005-05-15
PT1404673E (pt) 2005-07-29
DK1404673T3 (da) 2005-06-13
EP1475379B1 (de) 2007-04-11
AU2008201565B2 (en) 2012-03-01
PL209520B1 (pl) 2011-09-30
TW574220B (en) 2004-02-01
EA006393B1 (ru) 2005-12-29
ZA200308895B (en) 2004-06-09
ES2374981T3 (es) 2012-02-23
JP2004536830A (ja) 2004-12-09
PE20030123A1 (es) 2003-03-31
MY122932A (en) 2006-05-31
HK1068613A1 (en) 2005-04-29
BG111461A (en) 2013-08-30
PT1475379E (pt) 2007-05-31
JP2010043116A (ja) 2010-02-25
EE200400045A (et) 2004-04-15
CO5650166A2 (es) 2006-06-30
CN1520413A (zh) 2004-08-11
KR100866272B1 (ko) 2008-11-03

Similar Documents

Publication Publication Date Title
EP1277717A4 (en) PROCESS FOR THE PRODUCTION OF CERAMIC STRUCTURES
EP1514928A4 (en) METHOD FOR CONSTRUCTING ANTIBODIES
IL158203A0 (en) Method for producing blanks having a fine-grain structure
HUP0401296A3 (en) Novel processes for producing pyrimidinon derivatives
SG102022A1 (en) A process for producing polycarbonate
TWI318623B (en) Process for producing bisphenol a
GB2387599B (en) Methods for producing antibodies
HUP0400332A3 (en) Technical synthesis method for producing tropenol
HUP0104566A3 (en) Process for producing n-carboxi-anhidrides
AU1708902A (en) Method for producing sulfonamide-substituted imidazotriazinones
HUP0401486A3 (en) Process for producing pyridine compound
AU2002257820A1 (en) Technical synthesis method for producing tropenol
AU2003294647A8 (en) Method for producing hydrogen
SG118141A1 (en) Process for producing alpha-olefin
PL361146A1 (en) Method for producing isocyanato-organosilanes
HUP0400129A3 (en) Method for producing isocyanates
AU2003268698A8 (en) Method for producing dust core
HUP0102967A3 (en) Method for producing organosilylalkyl-polysulphanes
IL158288A0 (en) Process for producing thiosemicarbazides
EP1394174A4 (en) PROCESS FOR THE PREPARATION OF METHYLCOBALAMINE
HU0200237D0 (en) Process for producing cyclopropanecarboxylates
AU4273501A (en) Process for producing camptothecin
EP1457568A4 (en) PROCESS FOR PRODUCING 2&#39;-DESOXYGUANOSINE
EP1577279A4 (en) METHOD FOR PRODUCING A CERAMIC STRUCTURE
AU7265900A (en) Method for producing otoplastics