SI1015459T1 - Tetrazole-containing rapamycin analogs with shortened half-lives - Google Patents

Tetrazole-containing rapamycin analogs with shortened half-lives

Info

Publication number
SI1015459T1
SI1015459T1 SI9830781T SI9830781T SI1015459T1 SI 1015459 T1 SI1015459 T1 SI 1015459T1 SI 9830781 T SI9830781 T SI 9830781T SI 9830781 T SI9830781 T SI 9830781T SI 1015459 T1 SI1015459 T1 SI 1015459T1
Authority
SI
Slovenia
Prior art keywords
tetrazole
lives
rapamycin analogs
containing rapamycin
shortened half
Prior art date
Application number
SI9830781T
Other languages
English (en)
Slovenian (sl)
Inventor
Karl W. Mollison
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25470968&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1015459(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of SI1015459T1 publication Critical patent/SI1015459T1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
SI9830781T 1997-09-26 1998-09-24 Tetrazole-containing rapamycin analogs with shortened half-lives SI1015459T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93814497A 1997-09-26 1997-09-26
PCT/US1998/020111 WO1999015530A1 (en) 1997-09-26 1998-09-24 Tetrazole-containing rapamycin analogs with shortened half-lives
EP98949512A EP1015459B9 (de) 1997-09-26 1998-09-24 Tetrazol-enthaltende rapamycin analoga mit verkürzten halbwertszeiten

Publications (1)

Publication Number Publication Date
SI1015459T1 true SI1015459T1 (en) 2005-10-31

Family

ID=25470968

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9830781T SI1015459T1 (en) 1997-09-26 1998-09-24 Tetrazole-containing rapamycin analogs with shortened half-lives

Country Status (28)

Country Link
EP (1) EP1015459B9 (de)
JP (1) JP3790424B2 (de)
KR (3) KR100700319B1 (de)
CN (1) CN1161360C (de)
AR (1) AR015940A1 (de)
AT (1) ATE297398T1 (de)
AU (1) AU745576B2 (de)
BG (1) BG64955B1 (de)
BR (1) BR9812305A (de)
CA (1) CA2303934C (de)
CO (1) CO5070656A1 (de)
CZ (1) CZ299365B6 (de)
DE (1) DE69830502T2 (de)
DK (1) DK1015459T3 (de)
ES (1) ES2244087T3 (de)
HK (1) HK1030771A1 (de)
HU (1) HU228368B1 (de)
IL (2) IL134607A0 (de)
NO (1) NO325813B1 (de)
NZ (2) NZ514778A (de)
PL (1) PL191212B1 (de)
PT (1) PT1015459E (de)
SI (1) SI1015459T1 (de)
SK (1) SK285408B6 (de)
TR (1) TR200000778T2 (de)
TW (1) TW557297B (de)
WO (1) WO1999015530A1 (de)
ZA (1) ZA988750B (de)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6890546B2 (en) * 1998-09-24 2005-05-10 Abbott Laboratories Medical devices containing rapamycin analogs
US7399480B2 (en) 1997-09-26 2008-07-15 Abbott Laboratories Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances using medical devices
US7357942B2 (en) * 1997-09-26 2008-04-15 Abbott Laboratories Compositions, systems, and kits for administering zotarolimus and paclitaxel to blood vessel lumens
US7960405B2 (en) 1998-09-24 2011-06-14 Abbott Laboratories Compounds and methods for treatment and prevention of diseases
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
WO2003063904A2 (en) * 2002-01-29 2003-08-07 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Tissue adhesion formation control
US20030176455A1 (en) * 2002-03-13 2003-09-18 Wyeth Method of inhibiting cell death
JP5227492B2 (ja) 2002-05-16 2013-07-03 ノバルティス アーゲー 癌におけるedgレセプター結合剤の使用
AU2003240714B2 (en) 2002-05-27 2006-09-28 Irm Llc Bis-aromatic alkanols
CN100349627C (zh) * 2002-09-06 2007-11-21 艾博特公司 含有水合抑制剂的医疗装置及其制备方法
RU2391094C2 (ru) 2002-09-24 2010-06-10 Новартис Аг Применение агониста рецептора s1p и способ лечения, облегчения или задержки прогрессирования неврита зрительного нерва или демиелинизационных заболеваний
JP4944613B2 (ja) 2003-05-19 2012-06-06 アイアールエム・リミテッド・ライアビリティ・カンパニー 免疫抑制化合物および組成物
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
MX2007005153A (es) 2004-10-28 2007-06-26 Wyeth Corp Uso de un inhibidor del mtor en el tratamiento de leiomioma del utero.
GB0504544D0 (en) 2005-03-04 2005-04-13 Novartis Ag Organic compounds
WO2007011708A2 (en) 2005-07-15 2007-01-25 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
KR101406415B1 (ko) 2005-07-15 2014-06-19 미셀 테크놀로지즈, 인코포레이티드 제어된 형태의 약물 분말을 함유하는 중합체 코팅
PL1912675T3 (pl) 2005-07-25 2014-10-31 Emergent Product Dev Seattle Zmniejszanie liczby komórek B za pomocą cząsteczek wiążących swoistych dla antygenów CD37 i CD20
JP5164167B2 (ja) 2005-08-30 2013-03-13 ユニバーシティー オブ マイアミ 免疫調節性腫瘍壊死因子受容体25(tnfr25)のアゴニスト、アンタゴニスト及び免疫毒素
JP2009514870A (ja) 2005-11-04 2009-04-09 ワイス mTORインヒビター、ハーセプチン、および/またはHKI−272の抗悪性腫瘍性組み合わせ
US7700614B2 (en) * 2005-12-14 2010-04-20 Abbott Laboratories One pot synthesis of tetrazole derivatives of rapamycin
AU2007243268B2 (en) 2006-04-26 2013-06-13 Micell Technologies, Inc. Coatings containing multiple drugs
US7820812B2 (en) 2006-07-25 2010-10-26 Abbott Laboratories Methods of manufacturing crystalline forms of rapamycin analogs
US7812032B2 (en) 2006-07-25 2010-10-12 Abbott Laboratories Crystalline forms of rapamycin analogs
CA2658896A1 (en) 2006-07-25 2008-01-31 Abbott Laboratories Crystalline forms of rapamycin analogs
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
CN101711137B (zh) 2007-01-08 2014-10-22 米歇尔技术公司 具有可生物降解层的支架
TW200901989A (en) 2007-04-10 2009-01-16 Wyeth Corp Anti-tumor activity of CCI-779 in papillary renal cell cancer
US8685995B2 (en) 2008-03-21 2014-04-01 The University Of Chicago Treatment with opioid antagonists and mTOR inhibitors
CN102099377A (zh) 2008-04-11 2011-06-15 新兴产品开发西雅图有限公司 Cd37免疫治疗剂及其与双功能化学治疗剂的联合
MX2010011485A (es) 2008-04-17 2011-03-01 Micell Technologies Inc Stents que contienen capas bioadsorbibles.
CN104800196A (zh) 2008-06-20 2015-07-29 诺华股份有限公司 用于治疗多发性硬化的儿科组合物
EP2313122B1 (de) 2008-07-17 2019-03-06 Micell Technologies, Inc. Medizinische wirkstofffreisetzungsvorrichtung
US9510856B2 (en) 2008-07-17 2016-12-06 Micell Technologies, Inc. Drug delivery medical device
RU2011129230A (ru) 2008-12-18 2013-01-27 Новартис Аг Новая полиморфная форма 1-[4-[1-(4-циклогексил-3-трифторметилбензилоксиимино)этил]-2-этилбензил]азетидин-3-карбоновой кислоты
CN103204794A (zh) 2008-12-18 2013-07-17 诺瓦提斯公司 新的盐
KR20110096584A (ko) 2008-12-18 2011-08-30 노파르티스 아게 1-[4-[1-(4-시클로헥실-3-트리플루오로메틸-벤질옥시이미노)-에틸]-2-에틸-벤질]-아제티딘-3-카르복실산의 헤미푸마레이트 염
US9981072B2 (en) 2009-04-01 2018-05-29 Micell Technologies, Inc. Coated stents
EP2419058B1 (de) 2009-04-17 2018-02-28 Micell Technologies, Inc. Stents mit gesteuerter elution
EP2462165B1 (de) 2009-08-03 2016-05-11 University of Miami Verfahren zur in-vivo-expansion regulatorischer t-zellen
EP2762142A1 (de) 2009-10-30 2014-08-06 ARIAD Pharmaceuticals, Inc. Zusammensetzungen zur Behandlung von Krebs
WO2011097103A1 (en) 2010-02-02 2011-08-11 Micell Technologies, Inc. Stent and stent delivery system with improved deliverability
MX2012008874A (es) 2010-02-11 2012-08-31 Bristol Myers Squibb Co Macrociclos como inhibidores del factor de coagulacion (fxia).
US10232092B2 (en) 2010-04-22 2019-03-19 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
WO2011134899A1 (en) 2010-04-27 2011-11-03 Roche Glycart Ag Combination therapy of an afucosylated cd20 antibody with a mtor inhibitor
CN102234288B (zh) * 2010-05-06 2014-07-02 上海医药工业研究院 唑他莫司的制备方法
CA2805631C (en) 2010-07-16 2018-07-31 Micell Technologies, Inc. Drug delivery medical device
WO2012112847A1 (en) 2011-02-18 2012-08-23 Novartis Pharma Ag mTOR/JAK INHIBITOR COMBINATION THERAPY
JP2014519813A (ja) 2011-04-25 2014-08-21 オーエスアイ・ファーマシューティカルズ,エルエルシー 癌薬剤発見、診断、および治療におけるemt遺伝子シグネチャーの使用
US10117972B2 (en) 2011-07-15 2018-11-06 Micell Technologies, Inc. Drug delivery medical device
DK2766346T3 (en) 2011-10-14 2017-07-03 Bristol Myers Squibb Co SUBSTITUTED TETRAHYDROISOQUINOL COMPOUNDS AS FACTOR XIA INHIBITORS
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
TR201807316T4 (tr) 2012-10-12 2018-06-21 Squibb Bristol Myers Co Bir faktör XIa inhibitörünün kristalli formları.
EP2906541B1 (de) 2012-10-12 2017-11-22 Bristol-Myers Squibb Company Guanidin- und aminsubstituierte tetrahydroisochinoline als factor xia inhibitoren
WO2014059202A1 (en) 2012-10-12 2014-04-17 Bristol-Myers Squibb Company Guanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
CA2863243A1 (en) * 2012-11-30 2014-06-05 Hangzhou Zylox Pharma Co., Ltd. Rafamycin analogs and methods for making same
AU2014205366B2 (en) 2013-01-09 2018-12-20 Eckhard R. Podack Compositions and methods for the regulation of T regulatory cells using Tl1a-Ig fusion protein
KR20150143476A (ko) 2013-03-12 2015-12-23 미셀 테크놀로지즈, 인코포레이티드 생흡수성 생체의학적 임플란트
US9738655B2 (en) 2013-03-25 2017-08-22 Bristol-Myers Squibb Company Tetrahydroisoquinolines containing substituted azoles as factor XIa inhibitors
KR20180059584A (ko) 2013-05-15 2018-06-04 미셀 테크놀로지즈, 인코포레이티드 생흡수성 생체의학적 임플란트
CN105899232A (zh) 2013-11-13 2016-08-24 诺华股份有限公司 用于增强免疫应答的mTOR抑制剂
ES2918501T3 (es) 2013-12-19 2022-07-18 Novartis Ag Receptores de antígenos quiméricos de mesotelina humana y usos de los mismos
WO2015090229A1 (en) 2013-12-20 2015-06-25 Novartis Ag Regulatable chimeric antigen receptor
CN103739616B (zh) * 2013-12-27 2015-12-30 福建省微生物研究所 含噻唑基雷帕霉素类衍生物及其应用
CA2935167C (en) 2014-01-16 2022-02-22 Musc Foundation For Research Development Targeted nanocarriers for the administration of immunosuppressive agents
SG11201606209PA (en) 2014-01-31 2016-08-30 Bristol Myers Squibb Co Macrocycles with hetrocyclic p2' groups as factor xia inhibitors
NO2760821T3 (de) 2014-01-31 2018-03-10
EP3119425B1 (de) 2014-03-15 2020-09-23 Novartis AG Regulierbarer chimärer antigenrezeptor
CN106163547A (zh) 2014-03-15 2016-11-23 诺华股份有限公司 使用嵌合抗原受体治疗癌症
EP3122376A4 (de) 2014-03-27 2017-12-20 The Brigham and Women's Hospital, Inc. Metabolisch aktivierte wirkstoffkonjugate zur überwindung der resistenz in der krebstherapie
JP6765966B2 (ja) 2014-04-07 2020-10-07 ノバルティス アーゲー 抗cd19キメラ抗原受容体を使用する癌の処置
JP2017518307A (ja) 2014-06-02 2017-07-06 チルドレンズ メディカル センター コーポレーション 免疫調節のための方法および組成物
WO2016014553A1 (en) 2014-07-21 2016-01-28 Novartis Ag Sortase synthesized chimeric antigen receptors
SG10201913765YA (en) 2014-07-21 2020-03-30 Novartis Ag Treatment of cancer using a cd33 chimeric antigen receptor
WO2016014530A1 (en) 2014-07-21 2016-01-28 Novartis Ag Combinations of low, immune enhancing. doses of mtor inhibitors and cars
EP3660042B1 (de) 2014-07-31 2023-01-11 Novartis AG T-zellen mit teilmengenoptimierten chimären antigenrezeptoren
AU2015301460B2 (en) 2014-08-14 2021-04-08 Novartis Ag Treatment of cancer using GFR alpha-4 chimeric antigen receptor
LT3183268T (lt) 2014-08-19 2020-06-10 Novartis Ag Anti-cd123 chimerinis antigeno receptorius (car), skirtas naudoti vėžio gydymui
WO2016036893A1 (en) 2014-09-04 2016-03-10 Bristol-Myers Squibb Company Diamide macrocycles that are fxia inhibitors
JP6839074B2 (ja) 2014-09-17 2021-03-03 ノバルティス アーゲー 養子免疫療法のためのキメラ受容体での細胞毒性細胞のターゲティング
US9453018B2 (en) 2014-10-01 2016-09-27 Bristol-Myers Squibb Company Pyrimidinones as factor XIa inhibitors
JP6815992B2 (ja) 2014-10-08 2021-01-20 ノバルティス アーゲー キメラ抗原受容体療法に対する治療応答性を予測するバイオマーカーおよびその使用
CA2982996A1 (en) 2015-04-17 2016-10-20 David Maxwell Barrett Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
EP3286211A1 (de) 2015-04-23 2018-02-28 Novartis AG Behandlung von krebs mit chimärem antigenrezeptor- und proteinkinase-a-blocker
AU2016263176A1 (en) 2015-05-20 2017-12-07 Novartis Ag Pharmaceutical combination of everolimus with dactolisib
KR20180080230A (ko) 2015-11-11 2018-07-11 노파르티스 아게 미오스타틴 길항제의 용도, 이들을 함유하는 조합물 및 그의 용도
KR102565885B1 (ko) 2016-07-20 2023-08-09 유니버시티 오브 유타 리서치 파운데이션 Cd229 car t 세포 및 이의 사용 방법
US10525083B2 (en) 2016-10-07 2020-01-07 Novartis Ag Nucleic acid molecules encoding chimeric antigen receptors comprising a CD20 binding domain
BR112019010470A2 (pt) 2016-11-23 2019-09-10 Novartis Ag métodos de realce de resposta imune com everolimo, dactolisib ou ambos
EP3615055A1 (de) 2017-04-28 2020-03-04 Novartis AG Zellen, die einen auf bcma abzielenden chimären antigenrezeptor exprimieren, und kombinationsbehandlung mit einem gamma-sekretase-inhibitor
US10596165B2 (en) 2018-02-12 2020-03-24 resTORbio, Inc. Combination therapies
US20210047405A1 (en) 2018-04-27 2021-02-18 Novartis Ag Car t cell therapies with enhanced efficacy
WO2019213282A1 (en) 2018-05-01 2019-11-07 Novartis Ag Biomarkers for evaluating car-t cells to predict clinical outcome
JP2022510573A (ja) 2018-07-23 2022-01-27 エンクリアー セラピーズ, インク. 神経障害の治療方法
CN113164557A (zh) 2018-07-23 2021-07-23 因柯利尔疗法公司 治疗神经性病症的方法
CN114007665A (zh) 2019-04-11 2022-02-01 因柯利尔疗法公司 改善脑脊液的方法及其装置和系统
JP2023550544A (ja) 2020-11-03 2023-12-01 アールディスカバリー エルエルシー がんおよびファゴサイトーシス不全に関連する疾患の処置のための療法
WO2023288046A1 (en) 2021-07-15 2023-01-19 President And Fellows Of Harvard College Compositions and methods relating to cells with adhered particles

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2175215C (en) * 1993-11-19 2008-06-03 Yat Sun Or Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
JP2001500126A (ja) * 1996-09-09 2001-01-09 アメリカン・ホーム・プロダクツ・コーポレイション アルキル化ラパマイシン誘導体
WO1998009972A1 (en) * 1996-09-09 1998-03-12 American Home Products Corporation Rapamycin derivatives with unnatural stereochemistries

Also Published As

Publication number Publication date
DE69830502T2 (de) 2006-05-11
DK1015459T3 (da) 2005-10-10
CO5070656A1 (es) 2001-08-28
SK285408B6 (sk) 2007-01-04
AU9581998A (en) 1999-04-12
IL134607A (en) 2006-04-10
KR100700319B1 (ko) 2007-03-29
ES2244087T3 (es) 2005-12-01
CZ20001014A3 (cs) 2000-07-12
IL134607A0 (en) 2001-04-30
HUP0004556A3 (en) 2001-12-28
CN1271361A (zh) 2000-10-25
KR20070086925A (ko) 2007-08-27
KR100803639B1 (ko) 2008-02-19
KR20010024298A (ko) 2001-03-26
JP3790424B2 (ja) 2006-06-28
CZ299365B6 (cs) 2008-07-02
BG104316A (en) 2000-12-29
PL339455A1 (en) 2000-12-18
AR015940A1 (es) 2001-05-30
HU228368B1 (en) 2013-03-28
JP2001517671A (ja) 2001-10-09
BG64955B1 (bg) 2006-10-31
NZ514778A (en) 2005-01-28
PL191212B1 (pl) 2006-03-31
NO325813B1 (no) 2008-07-21
AU745576B2 (en) 2002-03-21
NZ502896A (en) 2001-12-21
ZA988750B (en) 1999-04-01
TR200000778T2 (tr) 2000-07-21
NO20001438D0 (no) 2000-03-20
SK4172000A3 (en) 2000-08-14
HK1030771A1 (en) 2001-05-18
WO1999015530A1 (en) 1999-04-01
EP1015459A1 (de) 2000-07-05
KR20060071092A (ko) 2006-06-26
EP1015459B1 (de) 2005-06-08
CA2303934C (en) 2010-01-26
PT1015459E (pt) 2005-09-30
KR100833812B1 (ko) 2008-05-30
BR9812305A (pt) 2000-09-05
ATE297398T1 (de) 2005-06-15
NO20001438L (no) 2000-05-26
TW557297B (en) 2003-10-11
CN1161360C (zh) 2004-08-11
EP1015459B9 (de) 2005-10-12
CA2303934A1 (en) 1999-04-01
HUP0004556A2 (hu) 2001-10-28
DE69830502D1 (de) 2005-07-14

Similar Documents

Publication Publication Date Title
ZA988750B (en) Tetrazole-containing rapamycin analogs with shortened half-lives
GB9720997D0 (en) Shock absorber
GB2345698B (en) Phthalocyanine analogs
DE59814003D1 (en) Thienopyrimidine
GB9809594D0 (en) Shock absorber
GB2328999B (en) Shock absorber
GB2325719B (en) Shock absorbing support
TW396962U (en) Mechanical pencil
TW389171U (en) Mechanical pencil
PL336307A1 (en) Crambescidin compounds
TW356768U (en) Double-chuck type mechanical pencil
GB9811463D0 (en) A body support
GB9719216D0 (en) Pen
GB9706700D0 (en) Absorber
TW322017U (en) Improved motocycle shock absorber
CA79779S (en) Banc
TW352699U (en) Improved structure for shock absorber
TW371922U (en) Pens
PL106250U1 (en) Derailer
TW322846U (en) Different-axis non-sharpening pencil
PL319446A1 (en) External stabiliser
GB9723837D0 (en) Bicycle stabiliser
GB9719305D0 (en) Pencil extension
GB9710441D0 (en) Pencils
GB9722718D0 (en) Lock-seal external