SI0832104T1 - Dolastatin derivatives, their preparation and use - Google Patents

Dolastatin derivatives, their preparation and use

Info

Publication number
SI0832104T1
SI0832104T1 SI9630539T SI9630539T SI0832104T1 SI 0832104 T1 SI0832104 T1 SI 0832104T1 SI 9630539 T SI9630539 T SI 9630539T SI 9630539 T SI9630539 T SI 9630539T SI 0832104 T1 SI0832104 T1 SI 0832104T1
Authority
SI
Slovenia
Prior art keywords
preparation
dolastatin derivatives
dolastatin
derivatives
Prior art date
Application number
SI9630539T
Other languages
English (en)
Slovenian (sl)
Inventor
Andreas Haupt
Franz Emling
Cynthia A. Romerdahl
Original Assignee
Abbott Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co. Kg filed Critical Abbott Gmbh & Co. Kg
Publication of SI0832104T1 publication Critical patent/SI0832104T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SI9630539T 1995-06-07 1996-06-03 Dolastatin derivatives, their preparation and use SI0832104T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/472,453 US5831002A (en) 1992-05-20 1995-06-07 Antitumor peptides
PCT/EP1996/002392 WO1996040751A1 (en) 1995-06-07 1996-06-03 Novel dolastatin derivatives, their preparation and use
EP96918660A EP0832104B1 (en) 1995-06-07 1996-06-03 Dolastatin derivatives, their preparation and use

Publications (1)

Publication Number Publication Date
SI0832104T1 true SI0832104T1 (en) 2003-08-31

Family

ID=23875567

Family Applications (2)

Application Number Title Priority Date Filing Date
SI9630550T SI0871656T1 (en) 1995-06-07 1996-06-03 Dolastatin derivatives, their preparation and use
SI9630539T SI0832104T1 (en) 1995-06-07 1996-06-03 Dolastatin derivatives, their preparation and use

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI9630550T SI0871656T1 (en) 1995-06-07 1996-06-03 Dolastatin derivatives, their preparation and use

Country Status (33)

Country Link
US (1) US5831002A (ru)
EP (2) EP0832104B1 (ru)
JP (2) JP4221062B2 (ru)
KR (2) KR100437985B1 (ru)
CN (2) CN1182153C (ru)
AR (2) AR003136A1 (ru)
AT (2) ATE223431T1 (ru)
AU (2) AU725164B2 (ru)
BG (2) BG102125A (ru)
BR (2) BR9609423A (ru)
CA (2) CA2219819C (ru)
CO (2) CO4700526A1 (ru)
CZ (2) CZ293682B6 (ru)
DE (2) DE69623472T2 (ru)
DK (2) DK0871656T3 (ru)
ES (2) ES2186783T3 (ru)
HR (2) HRP960257A2 (ru)
HU (2) HU228073B1 (ru)
IL (2) IL122215A (ru)
MX (2) MX9709146A (ru)
MY (2) MY119042A (ru)
NO (2) NO318384B1 (ru)
NZ (2) NZ310444A (ru)
PL (2) PL185762B1 (ru)
PT (2) PT871656E (ru)
RO (2) RO118953B1 (ru)
SI (2) SI0871656T1 (ru)
SK (1) SK282466B6 (ru)
TR (2) TR199701544T1 (ru)
TW (2) TW508357B (ru)
UA (2) UA46775C2 (ru)
WO (2) WO1996040752A1 (ru)
ZA (2) ZA964710B (ru)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
US20010009901A1 (en) * 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
TW474946B (en) * 1995-12-15 2002-02-01 Basf Ag Novel compounds, the preparation and use thereof
US5965537A (en) * 1997-03-10 1999-10-12 Basf Aktiengesellschaft Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
US6103698A (en) * 1997-03-13 2000-08-15 Basf Aktiengesellschaft Dolastatin-15 derivatives in combination with taxanes
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6015790A (en) * 1997-10-06 2000-01-18 Basf Aktiengesellschaft Methods and compositions for treating rheumatoid arthritis
US5985837A (en) * 1998-07-08 1999-11-16 Basf Aktiengesellschaft Dolastatin 15 derivatives
WO2000051998A1 (en) 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathepsin s
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
WO2001024763A2 (en) 1999-10-01 2001-04-12 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
CA2445591A1 (en) 2001-04-27 2002-11-07 The Procter & Gamble Company Nitrogen heterocyclic compounds and compositions for controlling biofilms
AU2002359792A1 (en) * 2001-12-18 2003-06-30 Proteologics, Inc. Methods and compositions for the inhibition of viral release
AU2003224644A1 (en) * 2002-02-27 2003-09-09 The Government Of The United States Of America, Represented By The Secretary, Department Of Healtan Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use
US8568637B2 (en) 2004-08-02 2013-10-29 Ramot At Tel-Aviv University Ltd. Method of forming a fiber made of peptide nanostructures
JP4954983B2 (ja) 2005-05-18 2012-06-20 ファーマサイエンス・インコーポレイテッド Ｂｉｒドメイン結合化合物
EP1924245A2 (en) * 2005-08-19 2008-05-28 Government of the United States of America, Represented by the Secretary, Department of Health and Human Services Topical formulations of histone deacetylase inhibitors and methods of using the same
US10004828B2 (en) * 2005-10-11 2018-06-26 Romat at Tel-Aviv University Ltd. Self-assembled Fmoc-ff hydrogels
WO2007131366A1 (en) 2006-05-16 2007-11-22 Aegera Therapeutics Inc. Iap bir domain binding compounds
US8143426B2 (en) * 2006-07-24 2012-03-27 Tetralogic Pharmaceuticals Corporation IAP inhibitors
SI2146719T1 (sl) * 2007-04-12 2013-10-30 Scinopharm Taiwan Ltd. Postopek za pripravo galantamina
UY32099A (es) 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
US8283372B2 (en) 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
AU2011214057B2 (en) 2010-02-12 2016-11-17 Pharmascience Inc. IAP BIR domain binding compounds
CA2821340A1 (en) 2010-12-30 2012-07-05 Enanta Pharmaceuticals, Inc. Phenanthridine macrocyclic hepatitis c serine protease inhibitors
WO2012092409A2 (en) 2010-12-30 2012-07-05 Enanta Phararmaceuticals, Inc Macrocyclic hepatitis c serine protease inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
CN110078787A (zh) * 2011-05-27 2019-08-02 Ambrx 公司 含有非天然氨基酸连接的海兔毒素衍生物的组合物、涉及该海兔毒素衍生物的方法及其用途
WO2015103490A1 (en) 2014-01-03 2015-07-09 Abbvie, Inc. Solid antiviral dosage forms
WO2023033129A1 (ja) 2021-09-03 2023-03-09 東レ株式会社 癌の治療及び／又は予防用医薬組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4879278A (en) * 1989-05-16 1989-11-07 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
KR0185440B1 (ko) * 1991-08-09 1999-04-01 야마구찌 다까시 신규의 테트라 펩티트 유도체
RU2116312C1 (ru) * 1992-05-20 1998-07-27 Басф Акциенгезельшафт Производные пептида или их соли, фармацевтическая композиция
US5530097A (en) * 1994-08-01 1996-06-25 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory peptide amides
US5504191A (en) * 1994-08-01 1996-04-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide methyl esters

Also Published As

Publication number Publication date
KR100437986B1 (ko) 2004-09-18
BG102125A (en) 1998-09-30
BR9609423A (pt) 1999-06-29
NO975710D0 (no) 1997-12-05
HUP9801910A3 (en) 1999-06-28
CZ376597A3 (cs) 1998-06-17
EP0871656B1 (en) 2002-09-25
TW508357B (en) 2002-11-01
PT832104E (pt) 2002-12-31
CZ293682B6 (cs) 2004-07-14
ATE223431T1 (de) 2002-09-15
ATE224910T1 (de) 2002-10-15
CN1187198A (zh) 1998-07-08
DK0832104T3 (da) 2003-01-06
CN1182153C (zh) 2004-12-29
DE69623472D1 (de) 2002-10-10
RO118953B1 (ro) 2004-01-30
DK0871656T3 (da) 2003-01-27
IL122215A0 (en) 1998-04-05
PL185763B1 (pl) 2003-07-31
CN1182154C (zh) 2004-12-29
WO1996040752A1 (en) 1996-12-19
PT871656E (pt) 2002-12-31
AR003427A1 (es) 1998-08-05
ZA964711B (en) 1997-12-08
AU725164B2 (en) 2000-10-05
HUP9801910A2 (hu) 1999-01-28
DE69623992T2 (de) 2003-05-22
BG102152A (en) 1998-09-30
UA46776C2 (uk) 2002-06-17
AU6124196A (en) 1996-12-30
MX9709147A (es) 1998-03-31
EP0871656A1 (en) 1998-10-21
ES2186783T3 (es) 2003-05-16
JP4221062B2 (ja) 2009-02-12
JP3957751B2 (ja) 2007-08-15
CN1187199A (zh) 1998-07-08
HRP960257A2 (en) 1998-02-28
HU228071B1 (hu) 2012-09-28
MY119042A (en) 2005-03-31
KR100437985B1 (ko) 2004-09-18
AR003136A1 (es) 1998-07-08
AU6124296A (en) 1996-12-30
PL185762B1 (pl) 2003-07-31
IL122215A (en) 2001-08-26
CO4700526A1 (es) 1998-12-29
CA2219819C (en) 2008-05-20
US5831002A (en) 1998-11-03
CA2219818A1 (en) 1996-12-19
PL323726A1 (en) 1998-04-14
ZA964710B (en) 1997-12-08
DE69623472T2 (de) 2003-08-21
DE69623992D1 (de) 2002-10-31
RO119783B1 (ro) 2005-03-30
SK165397A3 (en) 1998-10-07
NO318384B1 (no) 2005-03-14
NO975710L (no) 1998-02-02
PL323723A1 (en) 1998-04-14
KR19990022582A (ko) 1999-03-25
EP0832104B1 (en) 2002-09-04
CO4700527A1 (es) 1998-12-29
UA46775C2 (uk) 2002-06-17
HU228073B1 (hu) 2012-09-28
NO975711D0 (no) 1997-12-05
WO1996040751A1 (en) 1996-12-19
NZ310443A (en) 1999-10-28
MY124487A (en) 2006-06-30
CZ293683B6 (cs) 2004-07-14
EP0832104A1 (en) 1998-04-01
HUP9801817A2 (hu) 1998-11-30
NO317670B1 (no) 2004-11-29
BR9609424A (pt) 2000-03-28
IL122216A (en) 2002-02-10
JPH11504652A (ja) 1999-04-27
JPH11504653A (ja) 1999-04-27
HRP960277A2 (en) 1997-10-31
CZ376397A3 (cs) 1998-06-17
TR199701544T1 (xx) 1998-03-21
NO975711L (no) 1998-01-30
IL122216A0 (en) 1998-04-05
CA2219818C (en) 2008-05-20
MX9709146A (es) 1998-03-31
NZ310444A (en) 1999-11-29
TR199701545T1 (xx) 1998-04-21
ES2188759T3 (es) 2003-07-01
TW424096B (en) 2001-03-01
SI0871656T1 (en) 2003-08-31
KR19990022583A (ko) 1999-03-25
SK282466B6 (sk) 2002-02-05
HUP9801817A3 (en) 1999-06-28
AU725170B2 (en) 2000-10-05
CA2219819A1 (en) 1996-12-19

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