SI0819113T1 - Benzamides for neurodegenerative disorder treatment - Google Patents

Benzamides for neurodegenerative disorder treatment

Info

Publication number
SI0819113T1
SI0819113T1 SI9630313T SI9630313T SI0819113T1 SI 0819113 T1 SI0819113 T1 SI 0819113T1 SI 9630313 T SI9630313 T SI 9630313T SI 9630313 T SI9630313 T SI 9630313T SI 0819113 T1 SI0819113 T1 SI 0819113T1
Authority
SI
Slovenia
Prior art keywords
benzamides
neurodegenerative disorder
disorder treatment
treatment
neurodegenerative
Prior art date
Application number
SI9630313T
Other languages
English (en)
Inventor
William David Flitter
William A Garland
Allan L Wilcox
Richard E Paylor
Original Assignee
Centaur Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/415,248 external-priority patent/US5659082A/en
Priority claimed from US08/415,847 external-priority patent/US5643965A/en
Priority claimed from US08/415,694 external-priority patent/US5658953A/en
Application filed by Centaur Pharmaceuticals Inc filed Critical Centaur Pharmaceuticals Inc
Publication of SI0819113T1 publication Critical patent/SI0819113T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SI9630313T 1995-04-03 1996-04-03 Benzamides for neurodegenerative disorder treatment SI0819113T1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US41567795A 1995-04-03 1995-04-03
US08/415,248 US5659082A (en) 1995-04-03 1995-04-03 Nitro- and aminobenzamide compounds for neurodegenerative disorders
US08/415,847 US5643965A (en) 1995-04-03 1995-04-03 Aminobenzamide compounds for the treatment of neurodegenerative disorders
US08/415,694 US5658953A (en) 1995-04-03 1995-04-03 Pharmaceutical compositions of acetamidobenzamide compounds for neurodegenerative disorders
PCT/US1996/004538 WO1996031462A1 (fr) 1995-04-03 1996-04-03 Benzamides destines au traitement de troubles neuro-degeneratifs
EP96911550A EP0819113B1 (fr) 1995-04-03 1996-04-03 Benzamides destines au traitement de troubles neuro-degeneratifs

Publications (1)

Publication Number Publication Date
SI0819113T1 true SI0819113T1 (en) 2001-10-31

Family

ID=27503636

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9630313T SI0819113T1 (en) 1995-04-03 1996-04-03 Benzamides for neurodegenerative disorder treatment

Country Status (39)

Country Link
EP (1) EP0819113B1 (fr)
JP (1) JP3479658B2 (fr)
KR (1) KR100429120B1 (fr)
CN (1) CN1073552C (fr)
AR (1) AR002978A1 (fr)
AT (1) ATE202552T1 (fr)
AU (1) AU721045B2 (fr)
BG (1) BG63384B1 (fr)
CA (1) CA2215166A1 (fr)
CO (1) CO4700431A1 (fr)
CZ (1) CZ295852B6 (fr)
DE (1) DE69613567T2 (fr)
DK (1) DK0819113T3 (fr)
DZ (1) DZ2012A1 (fr)
EA (1) EA002031B1 (fr)
EE (1) EE03437B1 (fr)
ES (1) ES2160240T3 (fr)
GR (1) GR3036466T3 (fr)
HK (1) HK1016964A1 (fr)
HR (1) HRP960156B1 (fr)
HU (1) HUP9801759A3 (fr)
IL (1) IL117629A (fr)
IS (1) IS1919B (fr)
MA (1) MA23837A1 (fr)
MX (1) MX9707596A (fr)
MY (1) MY121206A (fr)
NO (1) NO318441B1 (fr)
NZ (1) NZ306204A (fr)
PL (1) PL184121B1 (fr)
PT (1) PT819113E (fr)
RO (1) RO116190B1 (fr)
SA (1) SA96160739B1 (fr)
SI (1) SI0819113T1 (fr)
SK (1) SK282900B6 (fr)
TN (1) TNSN96051A1 (fr)
TR (1) TR199701114T1 (fr)
TW (1) TW381073B (fr)
WO (1) WO1996031462A1 (fr)
YU (1) YU21096A (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997038684A1 (fr) * 1996-04-17 1997-10-23 Centaur Pharmaceuticals, Inc. Traitement par benzamides de la demence associee a l'infection par le virus du sida (vih-1)
ATE284684T1 (de) 1997-10-27 2005-01-15 Sumitomo Pharma Amidderivate zur behandlung neurodegenerativer erkrankungen der netzhaut
CA2332035A1 (fr) * 1998-05-19 1999-11-25 Ian Irwin Medicament a base d'amide, destine au traitement des affections inflammatoires de l'intestin
US6194465B1 (en) 1998-05-19 2001-02-27 Centaur Pharmaceuticals, Inc. Benzamide therapeutics for the treatment of inflammatory bowel disease
AU3679800A (en) * 1999-04-23 2000-11-10 Sumitomo Pharmaceuticals Company, Limited Apoptosis inhibitors
CN101817761B (zh) * 2010-01-29 2014-06-25 浙江大学 苯甲酸酯类衍生物及制备方法和应用
EP2535059A4 (fr) * 2010-02-10 2014-03-12 Public Univ Corp Yokohama City Utilisation d'un composé se liant à msin3b qui se lie, de façon spécifique, au facteur silenceur de la spécification neuronale nrsf
WO2014155184A1 (fr) * 2013-03-28 2014-10-02 Rhenovia Pharma Traitement pour maladie de parkinson
CN115594603A (zh) * 2022-10-09 2023-01-13 湖北师范大学（Cn） 微通道反应器制备n-叔丁基-4-氨基苯甲酰胺的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1069882B (it) * 1975-12-22 1985-03-25 Mallinckrodt Inc 3 5 bis acilammino benzammidi particolarmente utili come agenti di contrasto per raffi x e procedimento per la loro preparazione
JPS5721320A (en) * 1980-07-11 1982-02-04 Chugai Pharmaceut Co Ltd Blood sugar level depressing agent
JPS5867657A (ja) * 1981-10-15 1983-04-22 Chugai Pharmaceut Co Ltd ペンズアミド誘導体
US5472983A (en) * 1994-04-14 1995-12-05 Centaur Pharmaceuticals, Inc. Benzamide-containing pharmaceutical compositions

Also Published As

Publication number Publication date
ATE202552T1 (de) 2001-07-15
AR002978A1 (es) 1998-05-27
JP3479658B2 (ja) 2003-12-15
NO974569D0 (no) 1997-10-02
HK1016964A1 (en) 1999-11-12
EP0819113B1 (fr) 2001-06-27
IL117629A0 (en) 1996-07-23
EP0819113A1 (fr) 1998-01-21
MA23837A1 (fr) 1996-12-31
SA96160739B1 (ar) 2005-10-15
BG101929A (en) 1998-04-30
IL117629A (en) 2000-08-13
HUP9801759A3 (en) 2001-06-28
NO318441B1 (no) 2005-03-21
PT819113E (pt) 2001-10-30
IS1919B (is) 2004-03-15
IS4569A (is) 1997-09-25
EE9700235A (et) 1998-04-15
WO1996031462A1 (fr) 1996-10-10
GR3036466T3 (en) 2001-11-30
EA199700287A1 (ru) 1998-04-30
EE03437B1 (et) 2001-06-15
CZ309897A3 (cs) 1998-12-16
TW381073B (en) 2000-02-01
HRP960156A2 (en) 1997-10-31
NZ306204A (en) 1999-01-28
CN1182416A (zh) 1998-05-20
RO116190B1 (ro) 2000-11-30
TNSN96051A1 (fr) 2005-03-15
AU5440496A (en) 1996-10-23
SK132597A3 (en) 1998-09-09
JPH11501319A (ja) 1999-02-02
KR19980703562A (ko) 1998-11-05
CZ295852B6 (cs) 2005-11-16
HRP960156B1 (en) 2002-04-30
CN1073552C (zh) 2001-10-24
MY121206A (en) 2006-01-28
HUP9801759A2 (hu) 1998-12-28
PL184121B1 (pl) 2002-09-30
DZ2012A1 (fr) 2002-07-21
TR199701114T1 (xx) 1998-02-21
AU721045B2 (en) 2000-06-22
ES2160240T3 (es) 2001-11-01
KR100429120B1 (ko) 2004-08-18
BG63384B1 (bg) 2001-12-29
SK282900B6 (sk) 2003-01-09
MX9707596A (es) 1998-06-30
CO4700431A1 (es) 1998-12-29
CA2215166A1 (fr) 1996-10-10
YU21096A (sh) 1999-03-04
NO974569L (no) 1997-11-21
DE69613567T2 (de) 2002-04-18
EA002031B1 (ru) 2001-12-24
PL322625A1 (en) 1998-02-02
DE69613567D1 (de) 2001-08-02
DK0819113T3 (da) 2001-10-15

Similar Documents

Publication Publication Date Title
GB2304196B (en) Electroconvulsive therapy
IL114162A0 (en) Submersive therapy apparatus
GB2298440B (en) Well treatment
IL118484A0 (en) Therapeutic amides
GB9411080D0 (en) Treatment
EP0874828A4 (fr) Compositions de traitement de la douleur
GB2299652B (en) Steering apparatus
GB9519033D0 (en) Treatment
NZ283957A (en) Benzamide-containing medicaments suitable for treating neurodegenerative diseases
EP0830317A4 (fr) Systeme de traitement des effluents
HUP9801759A3 (en) Benzamides for neurodegenerative disorder treatment
ZA962689B (en) Benzamides for neurodegenerative disorder treatment
EP0871445A4 (fr) Composition servant a traiter la douleur
PL324647A1 (en) Polyhydroxyalkyl amidobetains
GB2325512B (en) Steering apparatus
SI0876818T1 (en) Agent for treating neuro-degenerative disorders
GB9518241D0 (en) Treatment system
GB9510065D0 (en) Treatment
ZA9610204B (en) Therapeutic apparatus
GB9418170D0 (en) Treatment system
KR960006881Y1 (en) Hand-ring for acupuncture
ZA964727B (en) Therapeutic Amides.
KR0112621Y1 (en) Gap maintaining device
GB9525909D0 (en) Treatment of attention-defecit/hyperactivity disorder
GB9505272D0 (en) Combination therapy