DK0819113T3 - Benzamider til behandling af neurodegenerative forstyrrelser - Google Patents

Benzamider til behandling af neurodegenerative forstyrrelser

Info

Publication number
DK0819113T3
DK0819113T3 DK96911550T DK96911550T DK0819113T3 DK 0819113 T3 DK0819113 T3 DK 0819113T3 DK 96911550 T DK96911550 T DK 96911550T DK 96911550 T DK96911550 T DK 96911550T DK 0819113 T3 DK0819113 T3 DK 0819113T3
Authority
DK
Denmark
Prior art keywords
benzamides
treatment
neurodegenerative disorders
neurodegenerative
disorders
Prior art date
Application number
DK96911550T
Other languages
Danish (da)
English (en)
Inventor
William David Flitter
William A Garland
Allan L Wilcox
Richard E Paylor
Original Assignee
Centaur Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/415,248 external-priority patent/US5659082A/en
Priority claimed from US08/415,847 external-priority patent/US5643965A/en
Priority claimed from US08/415,694 external-priority patent/US5658953A/en
Application filed by Centaur Pharmaceuticals Inc filed Critical Centaur Pharmaceuticals Inc
Application granted granted Critical
Publication of DK0819113T3 publication Critical patent/DK0819113T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK96911550T 1995-04-03 1996-04-03 Benzamider til behandling af neurodegenerative forstyrrelser DK0819113T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41567795A 1995-04-03 1995-04-03
US08/415,248 US5659082A (en) 1995-04-03 1995-04-03 Nitro- and aminobenzamide compounds for neurodegenerative disorders
US08/415,847 US5643965A (en) 1995-04-03 1995-04-03 Aminobenzamide compounds for the treatment of neurodegenerative disorders
US08/415,694 US5658953A (en) 1995-04-03 1995-04-03 Pharmaceutical compositions of acetamidobenzamide compounds for neurodegenerative disorders
PCT/US1996/004538 WO1996031462A1 (fr) 1995-04-03 1996-04-03 Benzamides destines au traitement de troubles neuro-degeneratifs

Publications (1)

Publication Number Publication Date
DK0819113T3 true DK0819113T3 (da) 2001-10-15

Family

ID=27503636

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96911550T DK0819113T3 (da) 1995-04-03 1996-04-03 Benzamider til behandling af neurodegenerative forstyrrelser

Country Status (39)

Country Link
EP (1) EP0819113B1 (fr)
JP (1) JP3479658B2 (fr)
KR (1) KR100429120B1 (fr)
CN (1) CN1073552C (fr)
AR (1) AR002978A1 (fr)
AT (1) ATE202552T1 (fr)
AU (1) AU721045B2 (fr)
BG (1) BG63384B1 (fr)
CA (1) CA2215166A1 (fr)
CO (1) CO4700431A1 (fr)
CZ (1) CZ295852B6 (fr)
DE (1) DE69613567T2 (fr)
DK (1) DK0819113T3 (fr)
DZ (1) DZ2012A1 (fr)
EA (1) EA002031B1 (fr)
EE (1) EE03437B1 (fr)
ES (1) ES2160240T3 (fr)
GR (1) GR3036466T3 (fr)
HK (1) HK1016964A1 (fr)
HR (1) HRP960156B1 (fr)
HU (1) HUP9801759A3 (fr)
IL (1) IL117629A (fr)
IS (1) IS1919B (fr)
MA (1) MA23837A1 (fr)
MX (1) MX9707596A (fr)
MY (1) MY121206A (fr)
NO (1) NO318441B1 (fr)
NZ (1) NZ306204A (fr)
PL (1) PL184121B1 (fr)
PT (1) PT819113E (fr)
RO (1) RO116190B1 (fr)
SA (1) SA96160739B1 (fr)
SI (1) SI0819113T1 (fr)
SK (1) SK282900B6 (fr)
TN (1) TNSN96051A1 (fr)
TR (1) TR199701114T1 (fr)
TW (1) TW381073B (fr)
WO (1) WO1996031462A1 (fr)
YU (1) YU21096A (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997038684A1 (fr) * 1996-04-17 1997-10-23 Centaur Pharmaceuticals, Inc. Traitement par benzamides de la demence associee a l'infection par le virus du sida (vih-1)
ATE284684T1 (de) 1997-10-27 2005-01-15 Sumitomo Pharma Amidderivate zur behandlung neurodegenerativer erkrankungen der netzhaut
CA2332035A1 (fr) * 1998-05-19 1999-11-25 Ian Irwin Medicament a base d'amide, destine au traitement des affections inflammatoires de l'intestin
US6194465B1 (en) 1998-05-19 2001-02-27 Centaur Pharmaceuticals, Inc. Benzamide therapeutics for the treatment of inflammatory bowel disease
AU3679800A (en) * 1999-04-23 2000-11-10 Sumitomo Pharmaceuticals Company, Limited Apoptosis inhibitors
CN101817761B (zh) * 2010-01-29 2014-06-25 浙江大学 苯甲酸酯类衍生物及制备方法和应用
EP2535059A4 (fr) * 2010-02-10 2014-03-12 Public Univ Corp Yokohama City Utilisation d'un composé se liant à msin3b qui se lie, de façon spécifique, au facteur silenceur de la spécification neuronale nrsf
WO2014155184A1 (fr) * 2013-03-28 2014-10-02 Rhenovia Pharma Traitement pour maladie de parkinson
CN115594603A (zh) * 2022-10-09 2023-01-13 湖北师范大学（Cn） 微通道反应器制备n-叔丁基-4-氨基苯甲酰胺的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1069882B (it) * 1975-12-22 1985-03-25 Mallinckrodt Inc 3 5 bis acilammino benzammidi particolarmente utili come agenti di contrasto per raffi x e procedimento per la loro preparazione
JPS5721320A (en) * 1980-07-11 1982-02-04 Chugai Pharmaceut Co Ltd Blood sugar level depressing agent
JPS5867657A (ja) * 1981-10-15 1983-04-22 Chugai Pharmaceut Co Ltd ペンズアミド誘導体
US5472983A (en) * 1994-04-14 1995-12-05 Centaur Pharmaceuticals, Inc. Benzamide-containing pharmaceutical compositions

Also Published As

Publication number Publication date
ATE202552T1 (de) 2001-07-15
AR002978A1 (es) 1998-05-27
JP3479658B2 (ja) 2003-12-15
NO974569D0 (no) 1997-10-02
HK1016964A1 (en) 1999-11-12
EP0819113B1 (fr) 2001-06-27
IL117629A0 (en) 1996-07-23
EP0819113A1 (fr) 1998-01-21
MA23837A1 (fr) 1996-12-31
SA96160739B1 (ar) 2005-10-15
BG101929A (en) 1998-04-30
IL117629A (en) 2000-08-13
HUP9801759A3 (en) 2001-06-28
NO318441B1 (no) 2005-03-21
PT819113E (pt) 2001-10-30
IS1919B (is) 2004-03-15
IS4569A (is) 1997-09-25
EE9700235A (et) 1998-04-15
WO1996031462A1 (fr) 1996-10-10
GR3036466T3 (en) 2001-11-30
EA199700287A1 (ru) 1998-04-30
EE03437B1 (et) 2001-06-15
CZ309897A3 (cs) 1998-12-16
TW381073B (en) 2000-02-01
HRP960156A2 (en) 1997-10-31
NZ306204A (en) 1999-01-28
CN1182416A (zh) 1998-05-20
RO116190B1 (ro) 2000-11-30
TNSN96051A1 (fr) 2005-03-15
AU5440496A (en) 1996-10-23
SK132597A3 (en) 1998-09-09
JPH11501319A (ja) 1999-02-02
KR19980703562A (ko) 1998-11-05
CZ295852B6 (cs) 2005-11-16
HRP960156B1 (en) 2002-04-30
CN1073552C (zh) 2001-10-24
MY121206A (en) 2006-01-28
HUP9801759A2 (hu) 1998-12-28
PL184121B1 (pl) 2002-09-30
DZ2012A1 (fr) 2002-07-21
TR199701114T1 (xx) 1998-02-21
SI0819113T1 (en) 2001-10-31
AU721045B2 (en) 2000-06-22
ES2160240T3 (es) 2001-11-01
KR100429120B1 (ko) 2004-08-18
BG63384B1 (bg) 2001-12-29
SK282900B6 (sk) 2003-01-09
MX9707596A (es) 1998-06-30
CO4700431A1 (es) 1998-12-29
CA2215166A1 (fr) 1996-10-10
YU21096A (sh) 1999-03-04
NO974569L (no) 1997-11-21
DE69613567T2 (de) 2002-04-18
EA002031B1 (ru) 2001-12-24
PL322625A1 (en) 1998-02-02
DE69613567D1 (de) 2001-08-02

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