HUP9801759A3 - Benzamides for neurodegenerative disorder treatment - Google Patents

Benzamides for neurodegenerative disorder treatment

Info

Publication number
HUP9801759A3
HUP9801759A3 HU9801759A HUP9801759A HUP9801759A3 HU P9801759 A3 HUP9801759 A3 HU P9801759A3 HU 9801759 A HU9801759 A HU 9801759A HU P9801759 A HUP9801759 A HU P9801759A HU P9801759 A3 HUP9801759 A3 HU P9801759A3
Authority
HU
Hungary
Prior art keywords
benzamides
neurodegenerative disorder
disorder treatment
treatment
neurodegenerative
Prior art date
Application number
HU9801759A
Other languages
English (en)
Original Assignee
Renovis Inc South San Francisc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/415,694 external-priority patent/US5658953A/en
Priority claimed from US08/415,847 external-priority patent/US5643965A/en
Priority claimed from US08/415,248 external-priority patent/US5659082A/en
Application filed by Renovis Inc South San Francisc filed Critical Renovis Inc South San Francisc
Publication of HUP9801759A2 publication Critical patent/HUP9801759A2/hu
Publication of HUP9801759A3 publication Critical patent/HUP9801759A3/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/38Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/64Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HU9801759A 1995-04-03 1996-04-03 Benzamides for neurodegenerative disorder treatment HUP9801759A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41567795A 1995-04-03 1995-04-03
US08/415,694 US5658953A (en) 1995-04-03 1995-04-03 Pharmaceutical compositions of acetamidobenzamide compounds for neurodegenerative disorders
US08/415,847 US5643965A (en) 1995-04-03 1995-04-03 Aminobenzamide compounds for the treatment of neurodegenerative disorders
US08/415,248 US5659082A (en) 1995-04-03 1995-04-03 Nitro- and aminobenzamide compounds for neurodegenerative disorders

Publications (2)

Publication Number Publication Date
HUP9801759A2 HUP9801759A2 (hu) 1998-12-28
HUP9801759A3 true HUP9801759A3 (en) 2001-06-28

Family

ID=27503636

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9801759A HUP9801759A3 (en) 1995-04-03 1996-04-03 Benzamides for neurodegenerative disorder treatment

Country Status (39)

Country Link
EP (1) EP0819113B1 (hu)
JP (1) JP3479658B2 (hu)
KR (1) KR100429120B1 (hu)
CN (1) CN1073552C (hu)
AR (1) AR002978A1 (hu)
AT (1) ATE202552T1 (hu)
AU (1) AU721045B2 (hu)
BG (1) BG63384B1 (hu)
CA (1) CA2215166A1 (hu)
CO (1) CO4700431A1 (hu)
CZ (1) CZ295852B6 (hu)
DE (1) DE69613567T2 (hu)
DK (1) DK0819113T3 (hu)
DZ (1) DZ2012A1 (hu)
EA (1) EA002031B1 (hu)
EE (1) EE03437B1 (hu)
ES (1) ES2160240T3 (hu)
GR (1) GR3036466T3 (hu)
HK (1) HK1016964A1 (hu)
HR (1) HRP960156B1 (hu)
HU (1) HUP9801759A3 (hu)
IL (1) IL117629A (hu)
IS (1) IS1919B (hu)
MA (1) MA23837A1 (hu)
MX (1) MX9707596A (hu)
MY (1) MY121206A (hu)
NO (1) NO318441B1 (hu)
NZ (1) NZ306204A (hu)
PL (1) PL184121B1 (hu)
PT (1) PT819113E (hu)
RO (1) RO116190B1 (hu)
SA (1) SA96160739B1 (hu)
SI (1) SI0819113T1 (hu)
SK (1) SK282900B6 (hu)
TN (1) TNSN96051A1 (hu)
TR (1) TR199701114T1 (hu)
TW (1) TW381073B (hu)
WO (1) WO1996031462A1 (hu)
YU (1) YU21096A (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW412421B (en) * 1996-04-17 2000-11-21 Centaur Pharmaceuticals Inc Benzamide treatment of dementia associated with AIDS virus (HIV-1) infection
EP1034783B1 (en) * 1997-10-27 2004-12-15 Sumitomo Pharmaceuticals Company, Limited Amide derivatives for the treatment of retinal neurodegenerative disorders
US6271265B1 (en) 1998-05-19 2001-08-07 Centaur Pharmaceuticals, Inc. Amide therapeutics for the treatment of inflammatory bowel disease
EP1079820A1 (en) * 1998-05-19 2001-03-07 Centaur Pharmaceuticals, Inc. Benzamide therapeutics for the treatment of inflammatory bowel disease
WO2000064430A1 (fr) * 1999-04-23 2000-11-02 Sumitomo Pharmaceuticals Co., Ltd. Inhibiteurs de l'apoptose
CN101817761B (zh) * 2010-01-29 2014-06-25 浙江大学 苯甲酸酯类衍生物及制备方法和应用
US9206125B2 (en) 2010-02-10 2015-12-08 Public University Corporation Yokohama City University Use of compound binding to mSin3B that specifically binds to neuron restrictive silencer factor (NRSF)
WO2014155184A1 (en) * 2013-03-28 2014-10-02 Rhenovia Pharma Treatment for parkinson's disease
CN115594603A (zh) * 2022-10-09 2023-01-13 湖北师范大学(Cn) 微通道反应器制备n-叔丁基-4-氨基苯甲酰胺的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1069882B (it) * 1975-12-22 1985-03-25 Mallinckrodt Inc 3 5 bis acilammino benzammidi particolarmente utili come agenti di contrasto per raffi x e procedimento per la loro preparazione
JPS5721320A (en) * 1980-07-11 1982-02-04 Chugai Pharmaceut Co Ltd Blood sugar level depressing agent
JPS5867657A (ja) * 1981-10-15 1983-04-22 Chugai Pharmaceut Co Ltd ペンズアミド誘導体
US5472983A (en) * 1994-04-14 1995-12-05 Centaur Pharmaceuticals, Inc. Benzamide-containing pharmaceutical compositions

Also Published As

Publication number Publication date
CO4700431A1 (es) 1998-12-29
EE9700235A (et) 1998-04-15
DE69613567D1 (de) 2001-08-02
AU721045B2 (en) 2000-06-22
JP3479658B2 (ja) 2003-12-15
PL184121B1 (pl) 2002-09-30
TW381073B (en) 2000-02-01
YU21096A (sh) 1999-03-04
CN1073552C (zh) 2001-10-24
IS1919B (is) 2004-03-15
EP0819113B1 (en) 2001-06-27
EE03437B1 (et) 2001-06-15
ATE202552T1 (de) 2001-07-15
GR3036466T3 (en) 2001-11-30
IL117629A (en) 2000-08-13
EA002031B1 (ru) 2001-12-24
DZ2012A1 (fr) 2002-07-21
HUP9801759A2 (hu) 1998-12-28
KR100429120B1 (ko) 2004-08-18
HRP960156B1 (en) 2002-04-30
AU5440496A (en) 1996-10-23
ES2160240T3 (es) 2001-11-01
MX9707596A (es) 1998-06-30
BG63384B1 (bg) 2001-12-29
WO1996031462A1 (en) 1996-10-10
JPH11501319A (ja) 1999-02-02
PL322625A1 (en) 1998-02-02
TR199701114T1 (xx) 1998-02-21
NO318441B1 (no) 2005-03-21
CN1182416A (zh) 1998-05-20
SK132597A3 (en) 1998-09-09
EA199700287A1 (ru) 1998-04-30
SK282900B6 (sk) 2003-01-09
MA23837A1 (fr) 1996-12-31
BG101929A (en) 1998-04-30
KR19980703562A (ko) 1998-11-05
CA2215166A1 (en) 1996-10-10
IS4569A (is) 1997-09-25
NO974569L (no) 1997-11-21
HRP960156A2 (en) 1997-10-31
PT819113E (pt) 2001-10-30
TNSN96051A1 (fr) 2005-03-15
HK1016964A1 (en) 1999-11-12
EP0819113A1 (en) 1998-01-21
AR002978A1 (es) 1998-05-27
NO974569D0 (no) 1997-10-02
SI0819113T1 (en) 2001-10-31
CZ295852B6 (cs) 2005-11-16
DK0819113T3 (da) 2001-10-15
NZ306204A (en) 1999-01-28
SA96160739B1 (ar) 2005-10-15
DE69613567T2 (de) 2002-04-18
CZ309897A3 (cs) 1998-12-16
IL117629A0 (en) 1996-07-23
MY121206A (en) 2006-01-28
RO116190B1 (ro) 2000-11-30

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees