SI0650965T1 - Asymmetric synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine an intermediate in the preparation of duloxetine - Google Patents

Asymmetric synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine an intermediate in the preparation of duloxetine

Info

Publication number
SI0650965T1
SI0650965T1 SI9430360T SI9430360T SI0650965T1 SI 0650965 T1 SI0650965 T1 SI 0650965T1 SI 9430360 T SI9430360 T SI 9430360T SI 9430360 T SI9430360 T SI 9430360T SI 0650965 T1 SI0650965 T1 SI 0650965T1
Authority
SI
Slovenia
Prior art keywords
propanamine
thienyl
dimethyl
equiv
stirring
Prior art date
Application number
SI9430360T
Other languages
English (en)
Inventor
Richard Alan Berglund
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SI0650965T1 publication Critical patent/SI0650965T1/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SI9430360T 1993-10-12 1994-10-07 Asymmetric synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine an intermediate in the preparation of duloxetine SI0650965T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/135,032 US5362886A (en) 1993-10-12 1993-10-12 Asymmetric synthesis
EP94307394A EP0650965B1 (en) 1993-10-12 1994-10-07 Asymmetric synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine an intermediate in the preparation of duloxetine

Publications (1)

Publication Number Publication Date
SI0650965T1 true SI0650965T1 (en) 2001-06-30

Family

ID=22466186

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9430360T SI0650965T1 (en) 1993-10-12 1994-10-07 Asymmetric synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine an intermediate in the preparation of duloxetine

Country Status (30)

Country Link
US (2) US5362886A (zh)
EP (1) EP0650965B1 (zh)
JP (1) JP3644986B2 (zh)
KR (1) KR100334585B1 (zh)
CN (1) CN1067681C (zh)
AT (1) ATE199084T1 (zh)
AU (1) AU685494B2 (zh)
BR (1) BR9404045A (zh)
CA (1) CA2133899C (zh)
CO (1) CO4290349A1 (zh)
CZ (1) CZ286122B6 (zh)
DE (1) DE69426663T2 (zh)
DK (1) DK0650965T3 (zh)
ES (1) ES2153850T3 (zh)
FI (1) FI944773A (zh)
GR (1) GR3035715T3 (zh)
HU (2) HU220673B1 (zh)
IL (1) IL111188A (zh)
MY (1) MY112254A (zh)
NO (1) NO301758B1 (zh)
NZ (1) NZ264633A (zh)
PE (1) PE18595A1 (zh)
PH (1) PH31595A (zh)
PL (1) PL179600B1 (zh)
PT (1) PT650965E (zh)
RU (1) RU2127269C1 (zh)
SI (1) SI0650965T1 (zh)
TW (1) TW381090B (zh)
YU (1) YU49027B (zh)
ZA (1) ZA947839B (zh)

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Also Published As

Publication number Publication date
HUT68943A (en) 1995-08-28
PH31595A (en) 1998-11-03
CN1067681C (zh) 2001-06-27
NZ264633A (en) 1997-09-22
JP3644986B2 (ja) 2005-05-11
ZA947839B (en) 1996-04-09
CN1109470A (zh) 1995-10-04
AU685494B2 (en) 1998-01-22
NO943825D0 (no) 1994-10-10
CA2133899A1 (en) 1995-04-13
DK0650965T3 (da) 2001-02-26
KR100334585B1 (ko) 2005-07-28
CO4290349A1 (es) 1996-04-17
RU94035996A (ru) 1996-08-20
GR3035715T3 (en) 2001-07-31
MY112254A (en) 2001-05-31
KR950011434A (ko) 1995-05-15
EP0650965B1 (en) 2001-02-07
CZ246594A3 (en) 1995-05-17
IL111188A (en) 1998-06-15
ES2153850T3 (es) 2001-03-16
NO943825L (no) 1995-04-18
IL111188A0 (en) 1994-12-29
PT650965E (pt) 2001-05-31
PL305326A1 (en) 1995-04-18
US5362886A (en) 1994-11-08
HU9402936D0 (en) 1995-01-30
EP0650965A1 (en) 1995-05-03
CZ286122B6 (cs) 2000-01-12
US5491243A (en) 1996-02-13
BR9404045A (pt) 1995-06-13
PE18595A1 (es) 1995-07-13
TW381090B (en) 2000-02-01
FI944773A0 (fi) 1994-10-11
RU2127269C1 (ru) 1999-03-10
DE69426663T2 (de) 2001-06-21
ATE199084T1 (de) 2001-02-15
DE69426663D1 (de) 2001-03-15
YU59194A (sh) 1997-03-07
NO301758B1 (no) 1997-12-08
HU68943D0 (en) 2000-04-28
PL179600B1 (pl) 2000-09-29
YU49027B (sh) 2003-07-07
AU7572094A (en) 1995-05-04
HU220673B1 (hu) 2002-04-29
FI944773A (fi) 1995-04-13
CA2133899C (en) 2007-02-13
JPH07188065A (ja) 1995-07-25

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