SG99853A1 - Tropane-derivatives, their preparation and use - Google Patents

Tropane-derivatives, their preparation and use

Info

Publication number
SG99853A1
SG99853A1 SG9903902A SG1999003902A SG99853A1 SG 99853 A1 SG99853 A1 SG 99853A1 SG 9903902 A SG9903902 A SG 9903902A SG 1999003902 A SG1999003902 A SG 1999003902A SG 99853 A1 SG99853 A1 SG 99853A1
Authority
SG
Singapore
Prior art keywords
disorders
derivatives
tropane
monoamine neurotransmitter
uptake
Prior art date
Application number
SG9903902A
Other languages
English (en)
Inventor
Jorgen Scheel-Kruger
Peter Moldt
Frank Watjen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of SG99853A1 publication Critical patent/SG99853A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG9903902A 1996-02-22 1997-02-21 Tropane-derivatives, their preparation and use SG99853A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK19496 1996-02-22
PCT/EP1997/000850 WO1997030997A1 (en) 1996-02-22 1997-02-21 Tropane-derivatives, their preparation and use

Publications (1)

Publication Number Publication Date
SG99853A1 true SG99853A1 (en) 2003-11-27

Family

ID=8090830

Family Applications (1)

Application Number Title Priority Date Filing Date
SG9903902A SG99853A1 (en) 1996-02-22 1997-02-21 Tropane-derivatives, their preparation and use

Country Status (31)

Country Link
US (3) US6288079B1 (cs)
EP (2) EP1130020A1 (cs)
JP (1) JP3238414B2 (cs)
KR (1) KR100446571B1 (cs)
CN (1) CN1077574C (cs)
AT (1) ATE203023T1 (cs)
AU (1) AU720358B2 (cs)
BG (1) BG63945B1 (cs)
BR (1) BR9707636A (cs)
CA (1) CA2244773C (cs)
CZ (1) CZ287007B6 (cs)
DE (1) DE69705608T2 (cs)
DK (1) DK0885220T3 (cs)
EE (1) EE04751B1 (cs)
ES (1) ES2159839T3 (cs)
GR (1) GR3036829T3 (cs)
HU (1) HU228356B1 (cs)
IL (1) IL125146A (cs)
IS (1) IS1824B (cs)
NO (1) NO318731B1 (cs)
NZ (1) NZ330886A (cs)
PL (1) PL185132B1 (cs)
PT (1) PT885220E (cs)
RU (1) RU2167876C2 (cs)
SG (1) SG99853A1 (cs)
SI (1) SI0885220T1 (cs)
SK (1) SK281813B6 (cs)
TR (1) TR199801641T2 (cs)
UA (1) UA49872C2 (cs)
WO (1) WO1997030997A1 (cs)
ZA (1) ZA971525B (cs)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2356225T3 (es) * 1998-09-30 2011-04-06 Nihon Medi-Physics Co., Ltd. Procedimiento para producir un derivado de ácido tropinona-monocarboxílico ópticamente activo.
AUPP627498A0 (en) 1998-10-02 1998-10-22 University Of Queensland, The Novel peptides - i
US20040106643A1 (en) * 2001-05-23 2004-06-03 Gouliaev Alex Haarh Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
CA2506646A1 (en) * 2001-10-11 2003-04-11 Organix, Inc. Serotonin transport inhibitors
US20030114475A1 (en) * 2001-10-31 2003-06-19 Addiction Therapies, Inc. Methods for the treatment of addiction
EP1453511B1 (en) * 2001-11-30 2006-11-15 Neurosearch A/S Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases
NZ536415A (en) * 2002-05-30 2006-10-27 Neurosearch As Triple monoamine reuptake inhibitors for the treatment of chronic pain
ATE461174T1 (de) 2002-11-01 2010-04-15 Neurosearch As Neue piperidinderivate und deren verwendung als monoaminneurotransmitter-wiederaufnahmehemmer
JP4565087B2 (ja) 2002-12-02 2010-10-20 ゼノム リミティッド 新規なχ−コノトキシン・ペプチド（−Ｉ）
EP2386566A3 (en) 2002-12-02 2012-02-15 Xenome Ltd Chi-conotoxin peptides (II)
JP2006517567A (ja) 2003-02-12 2006-07-27 ニューロサーチ、アクティーゼルスカブ 新規８−アザ−ビシクロ［３．２．１］オクタン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法
CN100551924C (zh) * 2003-02-12 2009-10-21 神经研究公司 8-氮杂-双环[3.2.1]辛烷衍生物和它们作为单胺神经递质再摄取抑制剂的用途
NZ541249A (en) 2003-02-12 2008-04-30 Neurosearch As Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
CN100372850C (zh) * 2003-02-12 2008-03-05 神经研究公司 新的8-氮杂-双环[3.2.1]辛烷衍生物和它们作为单胺神经递质再摄取抑制剂的用途
CA2530023A1 (en) 2003-06-24 2004-12-29 Neurosearch A/S Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
AR045141A1 (es) * 2003-07-31 2005-10-19 Neurosearch As Sales de tartrato de 2- metoximetil-3-(3,4-diclorofenil)-8-azabiciclo (3,2,1) octano. composiciones farmaceuticas que los contienen y usos de las mismas.
ATE380813T1 (de) 2003-10-03 2007-12-15 Pfizer Imidazopyridinsubstituierte tropanderivate mit ccr5-rezeptorantagonistischer wirkung zur behandlung von hiv und entzündungen
CA2542442C (en) * 2003-10-16 2012-08-21 Boehringer Ingelheim International Gmbh Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor
JP2007511559A (ja) * 2003-11-18 2007-05-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 固形医薬製剤
WO2005070427A1 (en) 2004-01-22 2005-08-04 Neurosearch A/S Compounds for the sustained reduction of body weight
WO2005070428A1 (en) * 2004-01-22 2005-08-04 Boehringer Ingelheim International Gmbh Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and a dopamine agonist
EP1708707A1 (en) * 2004-01-22 2006-10-11 Neurosearch A/S Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist
DE102004004965B4 (de) * 2004-01-31 2006-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung eines 2-(Ethoxymethyl)-tropanderivates
EP1755602A1 (en) * 2004-06-04 2007-02-28 Neurosearch A/S Monoamine neurotransmitter re-uptake inhibitor for the inhibition of beta-amyloid (a beta 40 and a beta 42) generation
EP1761493A2 (en) 2004-06-18 2007-03-14 Neurosearch A/S Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US7524958B2 (en) 2004-06-18 2009-04-28 Neurosearch A/S Certain 9-aza-bicyclo[3.3.1] nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
EP1761527A1 (en) * 2004-06-18 2007-03-14 Neurosearch A/S Novel 9-aza-bicyclo¬3.3.1|nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
MX2007002384A (es) 2004-09-30 2007-05-11 Neurosearch As Nuevos derivados de cromen-2-ona y su uso como inhibidores de la reabsorcion del neurotransmisor de monoamina.
WO2006035034A1 (en) * 2004-09-30 2006-04-06 Neurosearch A/S Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US7923444B2 (en) 2005-02-10 2011-04-12 Neurosearch A/S Alkyl substituted homopiperazine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US7704991B2 (en) * 2005-04-04 2010-04-27 Neurosearch A/S Substituted diazabicyclo derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
JP2008534653A (ja) 2005-04-08 2008-08-28 ノイロサーチ アクティーゼルスカブ 新規エナンチオマー及びモノアミン神経伝達物質再取り込み阻害剤としてのそれらの使用
US8093388B2 (en) * 2005-06-28 2012-01-10 Neurosearch A/S 3-aza spiro[5,5]undec-8-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
EP1899301B1 (en) * 2005-06-28 2010-09-15 NeuroSearch A/S Novel 3-aza-spiro[5.5]undec-8-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
JP2008546826A (ja) * 2005-06-28 2008-12-25 ノイロサーチ アクティーゼルスカブ 新規な３，９−ジアザ−スピロ［５．５］ウンデカン誘導体及びモノアミン神経伝達物質再取り込み阻害剤としてのこれらの使用
EP1899303B1 (en) * 2005-06-28 2010-09-15 NeuroSearch A/S Novel 3-aza-spiro[5.5]undecane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
JP2009500440A (ja) * 2005-07-12 2009-01-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 性欲障害治療用医薬組成物
BRPI0613403A2 (pt) 2005-07-15 2009-02-10 Amr Technology Inc tetrahidrobenzodiazepinas aril- e heteroarila-substituÍdas e uso das mesmas para bloquear a recaptaÇço de norepinefrina, dopamina e serotonina
US8383817B2 (en) * 2005-08-24 2013-02-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Benztropine compounds and uses thereof
WO2007028769A1 (en) * 2005-09-05 2007-03-15 Neurosearch A/S Monoamine neurotransmitter re-uptake inhibitor for neuroprotection
WO2007028770A1 (en) * 2005-09-05 2007-03-15 Neurosearch A/S Monoamine neurotransmitter re-uptake inhibitors for neuroprotection in patients suffering from an advanced stage of a mental disease
EP1779851A1 (en) 2005-10-31 2007-05-02 Boehringer Ingelheim Pharma GmbH & Co.KG Treatment of diabetes
TW200804367A (en) * 2005-11-11 2008-01-16 Neurosearch As Novel compounds
CA2641678A1 (en) 2006-02-10 2007-08-16 Neurosearch A/S 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
TW200800980A (en) * 2006-02-17 2008-01-01 Neurosearch As Novel compounds
US20100234349A1 (en) 2006-09-04 2010-09-16 Olsen Gunnar M Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer
EA200970266A1 (ru) * 2006-09-11 2009-08-28 Глэксо Груп Лимитед Азабициклические соединения в качестве ингибиторов повторного поглощения моноаминов
GB0703998D0 (en) * 2007-03-01 2007-04-11 Glaxo Group Ltd Novel salt
TW200904815A (en) 2007-05-09 2009-02-01 Neurosearch As Novel compounds
JP2010539075A (ja) * 2007-09-10 2010-12-16 ノイロサーチ アクティーゼルスカブ フェノキサジン−３−オンの新規誘導体、並びにモノアミン神経伝達物質再取り込み阻害剤としてのその使用
US20100286195A1 (en) * 2007-09-10 2010-11-11 Neurosearch A/S Novel benzooxazol-and benzooxathiol-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
EP2222303A1 (en) * 2007-11-20 2010-09-01 NeuroSearch A/S A method for treating addiction
US20110118304A1 (en) * 2007-11-20 2011-05-19 Neurosearch A/S Method for treating over-eating disorders
AU2010247735B2 (en) 2009-05-12 2015-07-16 Albany Molecular Research, Inc. Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydroisoquinoline and use thereof
ES2662072T3 (es) 2009-05-12 2018-04-05 Albany Molecular Research, Inc. 7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y uso de la misma
US8697721B2 (en) 2009-05-15 2014-04-15 Aniona Aps Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2011032903A1 (en) 2009-09-21 2011-03-24 Neurosearch A/S Piperazinyl-alkyl-benzoimidazol-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US20130040985A1 (en) 2010-01-29 2013-02-14 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2011117289A1 (en) 2010-03-25 2011-09-29 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neuro-transmitter re-uptake inhibitors
US8153653B2 (en) * 2010-06-22 2012-04-10 Hoffmann-La Roche Inc. Amido-tropane derivatives
WO2012000881A1 (en) 2010-07-02 2012-01-05 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US9045468B2 (en) 2010-08-17 2015-06-02 Albany Molecular Research, Inc. 2,5-methano- and 2,5-ethano-tetrahydrobenzazepine derivatives and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
MX2013003749A (es) 2010-10-07 2013-05-09 Takeda Pharmaceutical Derivados de 1,4-oxazepano.
CN108434129A (zh) 2012-02-16 2018-08-24 萨尼奥纳有限责任公司 用于联合治疗的药物组合物
EP3265126B1 (en) 2015-03-03 2021-06-02 Saniona A/S Tesofensine and metoprolol combination formulation
EA026727B1 (ru) * 2015-09-10 2017-05-31 Замертон Холдингс Лимитед Соль (1r,2r,3s)-3-(3,4-дихлорфенил)-2-(этоксиметил)-8-метил-8-азабицикло[3.2.1]октана и фталевой кислоты, способ её получения, продукт способа, фармацевтические композиции для лечения и/или профилактики нарушений, связанных с ожирением, их применение и способы лечения и/или профилактики нарушений, связанных с ожирением
WO2017121432A1 (en) 2016-01-15 2017-07-20 Saniona A/S Tesofensine and metoprolol for treatment of hypertension
EA028995B1 (ru) * 2016-02-25 2018-01-31 Замертон Холдингс Лимитед Соль тезофензина и оптически активных ацетиламинокислот, их применение для лечения и/или профилактики нарушений, связанных с ожирением
AU2017324406A1 (en) * 2016-09-07 2019-05-02 Saniona A/S Tesofensine compositions
DE102017210141A1 (de) 2017-06-16 2018-12-20 Henkel Ag & Co. Kgaa Portion zur Bereitstellung tensidhaltiger Flotten
US20220160658A1 (en) 2019-01-07 2022-05-26 Saniona A/S Tesofensine for reduction of body weight in prader-willi patients
EP4138830A1 (en) 2020-04-22 2023-03-01 Saniona A/S Treatment of hypothalamic obesity
TWI772928B (zh) * 2020-10-21 2022-08-01 行政院原子能委員會核能研究所 非放射性標準品β-CFT之製備方法
CN119584965A (zh) 2022-07-08 2025-03-07 创始人制药股份有限公司 治疗女性性功能异常的化合物
CN115572289A (zh) * 2022-10-24 2023-01-06 龙曦宁（上海）医药科技有限公司 一种特索芬辛的合成方法
IL319787A (en) 2022-10-28 2025-05-01 Initiator Pharma As Compound for pain treatment
WO2024146892A1 (en) 2023-01-03 2024-07-11 Initiator Pharma A/S Compound for treatment of erectile dysfunction
WO2025051846A1 (en) 2023-09-05 2025-03-13 Initiator Pharma A/S Compound for treatment of female sexual dysfunction

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993009814A1 (en) * 1991-11-15 1993-05-27 Research Triangle Institute Cocaine receptor binding ligands
US5413779A (en) * 1990-08-09 1995-05-09 Research Triangle Institute Cocaine receptor binding ligands
US5496953A (en) * 1990-08-09 1996-03-05 Research Triangle Institute Cocaine receptor binding ligands
WO1998028401A1 (en) * 1996-12-20 1998-07-02 Crosfield Limited Agglomerated silicas

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281130A (en) * 1979-05-24 1981-07-28 Sterling Drug Inc. Lower-alkyl 4,6,7,8,8a-9-hexahydro-6,9-ethanothieno[3,2-f]indolizine-10-carboxylate
US5380848A (en) * 1990-08-09 1995-01-10 Research Triangle Institute Cocaine receptor binding ligands
AU672052B2 (en) 1992-12-23 1996-09-19 Neurosearch A/S Antidepressant and antiparkinsonian compounds
AU672644B2 (en) * 1992-12-23 1996-10-10 Neurosearch A/S Aryl substituted heterocyclic compounds
AU671163B2 (en) * 1992-12-23 1996-08-15 Neurosearch A/S Alkyl substituted heterocyclic compounds
CZ284379B6 (cs) * 1994-04-19 1998-11-11 Neurosearch A/S Tropanové deriváty, způsob jejich přípravy a jejich použití

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5413779A (en) * 1990-08-09 1995-05-09 Research Triangle Institute Cocaine receptor binding ligands
US5496953A (en) * 1990-08-09 1996-03-05 Research Triangle Institute Cocaine receptor binding ligands
WO1993009814A1 (en) * 1991-11-15 1993-05-27 Research Triangle Institute Cocaine receptor binding ligands
WO1998028401A1 (en) * 1996-12-20 1998-07-02 Crosfield Limited Agglomerated silicas

Also Published As

Publication number Publication date
US6288079B1 (en) 2001-09-11
JP2000504739A (ja) 2000-04-18
NO318731B1 (no) 2005-05-02
IL125146A0 (en) 1999-01-26
SI0885220T1 (en) 2001-12-31
US6395748B2 (en) 2002-05-28
BR9707636A (pt) 1999-07-27
EE9800254A (et) 1999-02-15
WO1997030997A1 (en) 1997-08-28
ES2159839T3 (es) 2001-10-16
EP1130020A1 (en) 2001-09-05
ZA971525B (en) 1997-10-21
JP3238414B2 (ja) 2001-12-17
CA2244773C (en) 2006-01-03
HU228356B1 (en) 2013-03-28
DE69705608D1 (de) 2001-08-16
DE69705608T2 (de) 2002-05-16
KR19990087127A (ko) 1999-12-15
NZ330886A (en) 1999-02-25
CN1211982A (zh) 1999-03-24
US20010018444A1 (en) 2001-08-30
IS4825A (is) 1998-08-17
AU1794097A (en) 1997-09-10
NO983877L (no) 1998-08-21
UA49872C2 (uk) 2002-10-15
CZ287007B6 (en) 2000-08-16
SK281813B6 (sk) 2001-08-06
TR199801641T2 (xx) 1998-11-23
CZ252098A3 (cs) 1998-11-11
HUP9901199A3 (en) 2001-02-28
PL185132B1 (pl) 2003-02-28
SK92998A3 (en) 1998-11-04
EP0885220A1 (en) 1998-12-23
ATE203023T1 (de) 2001-07-15
HUP9901199A2 (hu) 1999-08-30
IS1824B (is) 2002-10-01
CA2244773A1 (en) 1997-08-28
DK0885220T3 (da) 2001-10-15
AU720358B2 (en) 2000-06-01
HK1018957A1 (en) 2000-01-14
BG63945B1 (bg) 2003-07-31
EE04751B1 (et) 2006-12-15
RU2167876C2 (ru) 2001-05-27
GR3036829T3 (en) 2002-01-31
CN1077574C (zh) 2002-01-09
BG102637A (en) 1999-06-30
KR100446571B1 (ko) 2004-11-03
IL125146A (en) 2002-03-10
PL328503A1 (en) 1999-02-01
PT885220E (pt) 2001-11-30
US20020128284A1 (en) 2002-09-12
EP0885220B1 (en) 2001-07-11
NO983877D0 (no) 1998-08-21

Similar Documents

Publication Publication Date Title
GR3036829T3 (en) Tropane-derivatives, their preparation and use
IS6350A (is) ß2-adrenvirk viðtaka gerandefni
UA105629C2 (uk) Похідні арилсульфоніл піразолін карбоксамідину як антагоністи 5-нт6
MX2009003183A (es) Derivados de sulfonilpirazolincarboxamidina como antagonistas de 5-ht6.
FI961016A0 (fi) Bisykliset aromaattiset yhdisteet hoidollisina aineina
WO2007028083A3 (en) 6-arylalkylamino- 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists
MX2009005509A (es) 2-aminoquinolina como los antagonistas de los receptores 5-hidroxitriptamina 5a (5-ht5a).
CA2498291A1 (en) Diazabicyclic compounds useful in the treatment of cns and other disorders
WO2007058805A3 (en) Compositions and methods for treating cns disorders
ATE478052T1 (de) 1,3,4-substituierte pyrazole als 5-ht rezeptor- antagonisten zur behandlung von psychosen und neurologischen störungen
DE602007013275D1 (de) Verbindungen mit kombinierten cannabinoid-cb1-antagonismus und acetylcholinesterasehemmung
JP2008526706A5 (cs)
PT1635828E (pt) Derivados de 4-(2-feniloxifenil) piperidina ou de 1,2,3,6-tetrahidropiridina como inibidores da recaptação da serotonina
IL188115A0 (en) 8-alkoxy-4-methyl-3,4-dihdro-quinazolin-2-
UA81469C2 (en) 4-(2-phenyloxyphenyl)-piperidine or -1,2,3,6-tetrahydropyridine derivatives as serotonin reuptake inhibitors
WO2003100435A3 (en) Diagnostics and therapeutic use of neuromedin u receptor 2 (nmu2)
MY128351A (en) ß2-ADRENERGIC RECEPTOR AGONISTS
CA2521030A1 (en) 4-(2-phenyloxyphenyl)-piperidine or -1,2,3,6-tetrahydropyridine derivatives as serotonin reuptake inhibitors