SG182304A1 - Antibody formulation - Google Patents
Antibody formulation Download PDFInfo
- Publication number
- SG182304A1 SG182304A1 SG2012048591A SG2012048591A SG182304A1 SG 182304 A1 SG182304 A1 SG 182304A1 SG 2012048591 A SG2012048591 A SG 2012048591A SG 2012048591 A SG2012048591 A SG 2012048591A SG 182304 A1 SG182304 A1 SG 182304A1
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- SG
- Singapore
- Prior art keywords
- formulation according
- stabilizer
- igg
- antibody
- seq
- Prior art date
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- 238000001262 western blot Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09180840 | 2009-12-29 | ||
| PCT/EP2010/070625 WO2011080209A2 (en) | 2009-12-29 | 2010-12-23 | Novel antibody formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG182304A1 true SG182304A1 (en) | 2012-08-30 |
Family
ID=43618150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2012048591A SG182304A1 (en) | 2009-12-29 | 2010-12-23 | Antibody formulation |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20110158987A1 (ja) |
| EP (1) | EP2519262A2 (ja) |
| JP (1) | JP2013515754A (ja) |
| KR (1) | KR20120110175A (ja) |
| CN (1) | CN102686241A (ja) |
| AR (1) | AR079746A1 (ja) |
| AU (1) | AU2010338305A1 (ja) |
| BR (1) | BR112012013148A2 (ja) |
| CA (1) | CA2783715A1 (ja) |
| IL (1) | IL219592A0 (ja) |
| MX (1) | MX2012007676A (ja) |
| RU (1) | RU2012131099A (ja) |
| SG (1) | SG182304A1 (ja) |
| TW (1) | TW201200152A (ja) |
| WO (1) | WO2011080209A2 (ja) |
| ZA (1) | ZA201204266B (ja) |
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| LT2741740T (lt) * | 2011-08-12 | 2017-08-10 | Merial, Inc. | Biologinių produktų, ypatingai vakcinų, vakuuminis konservavimas |
| EP2879712B1 (en) | 2012-07-31 | 2018-04-25 | Crown Bioscience, Inc. (Taicang) | Histological markers for identifying non-small cell lung carcinoma patients for treatment with an anti-egfr drug |
| EA201791717A1 (ru) | 2012-09-07 | 2018-03-30 | Кохерус Байосайенсис, Инк. | Стабильные водные составы адалимумаба |
| US9833410B2 (en) | 2012-10-31 | 2017-12-05 | Takeda Gmbh | Lyophilized formulation comprising GM-CSF neutralizing compound |
| AR093297A1 (es) * | 2012-10-31 | 2015-05-27 | Amgen Res (Munich) Gmbh | Formulacion liquida que comprende un compuesto neutralizante de gm-csf |
| UA117466C2 (uk) * | 2012-12-13 | 2018-08-10 | Мерк Шарп Енд Доме Корп. | СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19 |
| JP2016515515A (ja) | 2013-03-15 | 2016-05-30 | バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ | 抗プロラクチン受容体抗体製剤 |
| US10745475B2 (en) | 2013-08-30 | 2020-08-18 | Takeda Gmbh | Antibodies neutralizing GM-CSF for use in the treatment of rheumatoid arthritis or as analgesics |
| SG11201606624WA (en) | 2014-02-11 | 2016-09-29 | Visterra Inc | Antibody moleules to dengue virus and uses thereof |
| US20150274819A1 (en) * | 2014-03-03 | 2015-10-01 | La Jolla Biologics, Inc. | Stable aqueous recombinant protein formulations |
| BR112016025126B1 (pt) * | 2014-05-07 | 2024-02-15 | Takeda Pharmaceutical Company Limited | Composição aquosa compreendendo anticorpo neutralizante de gmcsf, e uso da mesma |
| CN105651848A (zh) * | 2014-11-13 | 2016-06-08 | 浙江海正药业股份有限公司 | 一种含有保护剂的毛细管凝胶电泳检测试剂盒 |
| KR101776879B1 (ko) * | 2015-01-19 | 2017-09-08 | 주식회사 녹십자 | 항-egfr 항체를 포함하는 약학 제제 |
| US11091543B2 (en) | 2015-05-07 | 2021-08-17 | Swedish Orphan Biovitrum Ag | Methods, compositions and dosing regimens for treating or preventing interferon-gamma related indications |
| KR20180004254A (ko) * | 2015-05-07 | 2018-01-10 | 노비뮨 에스 에이 | 높은 수준의 cxcl9 및 다른 바이오마커를 갖는 환자에서의 질병의 진단 및 치료를 위한 방법 및 조성물 |
| AU2016329960A1 (en) * | 2015-09-28 | 2018-04-26 | Jiangsu Hengrui Medicine Co., Ltd. | Stable anti-PD-1 antibody pharmaceutical preparation and application thereof in medicine |
| US11229702B1 (en) | 2015-10-28 | 2022-01-25 | Coherus Biosciences, Inc. | High concentration formulations of adalimumab |
| PT3386541T (pt) * | 2015-12-07 | 2020-10-12 | Merck Patent Gmbh | Formulação farmacêutica aquosa compreendendo o anticorpo anti-pd-1 avelumab |
| CA3018216A1 (en) * | 2016-03-25 | 2017-09-28 | Visterra, Inc. | Formulations of antibody molecules to dengue virus |
| US11071782B2 (en) | 2016-04-20 | 2021-07-27 | Coherus Biosciences, Inc. | Method of filling a container with no headspace |
| IT201600077232A1 (it) * | 2016-07-22 | 2018-01-22 | Bio Optica Milano S P A | Una preparazione liquida acquosa per la conservazione di un campione istologico |
| IL301948B2 (en) * | 2016-08-29 | 2024-09-01 | Tiziana Life Sciences Plc | Anti-CD3 antibody formulations |
| CN107773755B (zh) * | 2016-08-31 | 2021-06-22 | 上海津曼特生物科技有限公司 | 抗表皮生长因子受体单克隆抗体的注射液制剂 |
| CN109862880A (zh) * | 2016-09-27 | 2019-06-07 | 德国费森尤斯卡比有限公司 | 液体药物组合物 |
| CN107987161B (zh) * | 2016-10-26 | 2021-04-16 | 泰州迈博太科药业有限公司 | 一种抗egfr单克隆抗体制剂 |
| WO2018204374A1 (en) | 2017-05-02 | 2018-11-08 | Merck Sharp & Dohme Corp. | Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies |
| JP2020521788A (ja) * | 2017-06-02 | 2020-07-27 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 免疫アゴニストの投与経路 |
| AU2018308930A1 (en) * | 2017-07-28 | 2020-02-06 | F. Hoffmann-La Roche Ag | Bispecific antibody formulation |
| KR102208378B1 (ko) * | 2017-08-17 | 2021-01-28 | 주식회사 녹십자 | 항-egfr 항체를 포함하는 약학 제제 |
| GB201719447D0 (en) | 2017-11-23 | 2018-01-10 | Ucb Biopharma Sprl | Pharmaceutical composition |
| CN110960490A (zh) * | 2018-09-28 | 2020-04-07 | 江苏恒瑞医药股份有限公司 | 一种抗egfr抗体偶联药物组合物及其用途 |
| JP7522106B2 (ja) * | 2018-10-04 | 2024-07-24 | ジェンマブ ホールディング ビー．ブイ． | 二重特異性抗ｃｄ３７抗体を含む医薬組成物 |
| EP3876978A4 (en) * | 2018-11-07 | 2022-09-28 | Merck Sharp & Dohme Corp. | STABLE FORMULATIONS OF PROGRAMMED DEATH RECEPTOR 1 (MP-1) ANTIBODIES AND THEIR METHODS OF USE |
| CN113474360A (zh) | 2019-02-18 | 2021-10-01 | 伊莱利利公司 | 治疗性抗体制剂 |
| CN114126647A (zh) * | 2019-06-07 | 2022-03-01 | 阿尔金克斯有限公司 | 适用于皮下施用的FcRn抑制剂的药物制剂 |
| CU20190104A7 (es) * | 2019-12-17 | 2021-08-06 | Ct Inmunologia Molecular | Formulación estable del anticuerpo nimotuzumab |
| CN113967195A (zh) * | 2020-07-22 | 2022-01-25 | 三生国健药业（上海）股份有限公司 | 抗her2/pd1双特异性抗体冻干制剂及其制备方法 |
| EP4272756A1 (en) * | 2021-02-05 | 2023-11-08 | Bio-Thera Solutions, Ltd. | Anti-il-5 antibody formulation, preparation method therefor and use thereof |
| TW202308689A (zh) * | 2021-04-21 | 2023-03-01 | 美商健生生物科技公司 | 高濃度的雙特異性抗體調配物 |
| CN117257935A (zh) * | 2022-06-21 | 2023-12-22 | 广东菲鹏制药股份有限公司 | 一种含抗cd47抗体或其抗原结合片段的制剂及其制备方法和应用 |
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| SI2275119T1 (sl) * | 1995-07-27 | 2013-12-31 | Genentech, Inc. | Stabilna izotonična liofilizirana proteinska formulacija |
| US6267958B1 (en) * | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| AU3657899A (en) | 1998-04-20 | 1999-11-08 | James E. Bailey | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
| US20030104996A1 (en) * | 2001-08-30 | 2003-06-05 | Tiansheng Li | L-methionine as a stabilizer for NESP/EPO in HSA-free formulations |
| JP5290489B2 (ja) * | 2001-11-08 | 2013-09-18 | アッヴィ・バイオセラピューティクス・インコーポレイテッド | Ｉｇｇ抗体の安定な液体医薬製剤 |
| ES2542885T3 (es) | 2003-01-22 | 2015-08-12 | Roche Glycart Ag | Constructos de fusión y uso de los mismos para producir anticuerpos con mayor afinidad de unión al receptor de Fc y función efectora |
| DE10355251A1 (de) * | 2003-11-26 | 2005-06-23 | Merck Patent Gmbh | Pharmazeutische Zubereitung enthaltend einen Antikörper gegen den EGF-Rezeptor |
| SV2008002394A (es) * | 2005-01-28 | 2008-02-08 | Wyeth Corp | Formulaciones liquidas estabilizadas de polipeptido ref. ahn- 072sv |
| SI1871805T1 (sl) * | 2005-02-07 | 2020-02-28 | Roche Glycart Ag | Antigen vezavne molekule, ki vežejo EGFR, vektorji, ki te kodirajo in uporabe le-teh |
| CN103146708A (zh) * | 2005-06-30 | 2013-06-12 | Abbvie公司 | Il-12/p40结合蛋白 |
| ES2546069T3 (es) * | 2005-09-07 | 2015-09-18 | Amgen Fremont Inc. | Anticuerpos monoclonales humanos para quinasa-1 de tipo receptor de activina (ALK-1) |
| BRPI0620316A2 (pt) * | 2005-12-21 | 2011-11-08 | Wyeth Corp | formulações de proteìnas com viscosidades reduzida e seus usos |
| EP1998806A1 (en) * | 2006-03-28 | 2008-12-10 | F. Hoffmann-Roche AG | Anti-igf-1r human monoclonal antibody formulation |
| US20100158925A1 (en) * | 2006-06-14 | 2010-06-24 | Meera Agarkhed | Lyophilized formulations of anti-egfr antibodies |
| AR062223A1 (es) * | 2006-08-09 | 2008-10-22 | Glycart Biotechnology Ag | Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas |
| ES2925992T3 (es) * | 2006-10-20 | 2022-10-20 | Amgen Inc | Formulaciones estables de polipéptidos |
| CN101553504A (zh) * | 2006-12-11 | 2009-10-07 | 豪夫迈·罗氏有限公司 | Aβ抗体胃肠外制剂 |
| EP2167127A1 (en) * | 2007-07-10 | 2010-03-31 | F. Hoffmann-Roche AG | Novel formulation |
| PT2234600E (pt) * | 2007-12-21 | 2014-09-25 | Hoffmann La Roche | Formulação de anticorpos |
| US9345661B2 (en) * | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
-
2010
- 2010-12-23 JP JP2012546422A patent/JP2013515754A/ja active Pending
- 2010-12-23 CN CN201080059591XA patent/CN102686241A/zh active Pending
- 2010-12-23 WO PCT/EP2010/070625 patent/WO2011080209A2/en active Application Filing
- 2010-12-23 US US12/977,509 patent/US20110158987A1/en not_active Abandoned
- 2010-12-23 CA CA2783715A patent/CA2783715A1/en not_active Abandoned
- 2010-12-23 EP EP10795400A patent/EP2519262A2/en not_active Withdrawn
- 2010-12-23 AU AU2010338305A patent/AU2010338305A1/en not_active Abandoned
- 2010-12-23 MX MX2012007676A patent/MX2012007676A/es not_active Application Discontinuation
- 2010-12-23 RU RU2012131099/15A patent/RU2012131099A/ru unknown
- 2010-12-23 KR KR1020127019717A patent/KR20120110175A/ko not_active Application Discontinuation
- 2010-12-23 SG SG2012048591A patent/SG182304A1/en unknown
- 2010-12-23 BR BR112012013148A patent/BR112012013148A2/pt not_active IP Right Cessation
- 2010-12-27 AR ARP100104954A patent/AR079746A1/es unknown
- 2010-12-27 TW TW099146170A patent/TW201200152A/zh unknown
-
2012
- 2012-05-03 IL IL219592A patent/IL219592A0/en unknown
- 2012-06-11 ZA ZA2012/04266A patent/ZA201204266B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201204266B (en) | 2014-11-26 |
| AR079746A1 (es) | 2012-02-15 |
| BR112012013148A2 (pt) | 2017-03-21 |
| CN102686241A (zh) | 2012-09-19 |
| KR20120110175A (ko) | 2012-10-09 |
| EP2519262A2 (en) | 2012-11-07 |
| RU2012131099A (ru) | 2014-02-10 |
| US20110158987A1 (en) | 2011-06-30 |
| WO2011080209A2 (en) | 2011-07-07 |
| CA2783715A1 (en) | 2011-07-07 |
| IL219592A0 (en) | 2012-06-28 |
| WO2011080209A3 (en) | 2012-03-15 |
| JP2013515754A (ja) | 2013-05-09 |
| TW201200152A (en) | 2012-01-01 |
| MX2012007676A (es) | 2012-08-03 |
| AU2010338305A1 (en) | 2012-05-24 |
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